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पञ्चाष्टौ सप्त दश वा पिप्पलीमधुसर्पिषा । रसायनगुणान्वेषी समामेकां प्रयोजयेत् ॥ ३२ ॥
तिस्रस्तिस्रस्तु पूर्वाह्ने भुक्त्वाऽग्रे भोजनस्य च । पिप्पल्यः किंशुकक्षारभाषिता घृतभर्जिताः ॥ ३३ ॥
प्रयोज्या मधुसंमिश्रा रसायनगुणैषिणा । जेतुं कालं क्षयं शोषं श्वासं हिक्कां गलामयान् ॥ ३४ ॥
अर्शासि ग्रहणीदोषं पाण्डुतां विषमज्वरम् । वैस्वर्य पीनसं शोफं गुल्मं वातबलासकम् ॥ ३५ ॥

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{"source": "Samhita : Charaka Samhita Part 2, Chapter :1, Sthanam :Chikitsasthanam, Shloka Number: 32 to 35", "explanation": "These verses (32-35) detail the use of Pippali (long pepper) as a Rasayana (rejuvenative therapy). Two distinct methods are described:\n\n**Method 1: Annual Regimen**\n\n* **Dosage:** 5, 7, 8, or 10 Pippali fruits daily.\n* **Anupana (Vehicle):** Honey and ghee.\n* **Duration:** One year.\n* **Purpose:** General Rasayana benefits.\n\n**Method 2: Three-Times-Daily Regimen**\n\n* **Dosage:** 3 Pippali fruits each time.\n* **Preparation:**\n    1. Treat Pippali fruits with Kinshuka Kshara (alkali of Palasha tree).\n    2. Fry the treated fruits in ghee.\n* **Anupana (Vehicle):** Honey.\n* **Timing:**\n    1. Morning (Purvahna)\n    2. After a meal (Bhuktava)\n    3. Before a meal (Agre Bhojanasya)\n* **Purpose:** Rasayana benefits and addressing specific health conditions.\n\n**Therapeutic Indications:**\n\nBoth methods are indicated for various ailments, including:\n\n* Respiratory Issues: Kasa (cough), Shosha (wasting), Shwasa (dyspnea, asthma), Hikka (hiccups), and Galamanya (throat disorders).\n* Digestive Problems: Arshas (piles, hemorrhoids) and Grahani Dosha (irritable bowel syndrome).\n* Other Conditions: Panduta (anemia), Vishama Jwara (intermittent fever), Vaiswarya (dysphonia), Pinasam (chronic rhinitis), Shopha (swelling, edema), Gulma (abdominal tumors), and Vatabalāsaka (a type of rheumatism).\n\n**Key Points:**\n\n* **Kinshuka Kshara:** The use of alkali is crucial in Method 2. It likely helps in reducing the Kapha aggravating properties of Pippali and enhances its bioavailability.\n* **Honey and Ghee:** These act as Yogavahis, carrying the medicinal properties of Pippali to the targeted tissues.\n* **Dosage Variation:** The variation in dosage in Method 1 may be based on individual constitution and specific health needs.\n* **Timing in Method 2:** The different timings of administration in Method 2 may be related to optimizing digestion and absorption, as well as addressing specific symptoms."}
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