Along its 122 kilometers course, National Route 246 passes from Chiyoda through Minato, Shibuya, Meguro, Setagaya in Tokyo (called or in part of this section), and into Kanagawa Prefecture, entering Kawasaki (Takatsu and Miyamae), Yokohama (Tsuzuki, Aoba and Midori), Machida (Tokyo), Yamato, Atsugi, Isehara, Matsuda and Yamakita (called or in part of this section).