MD 648E begins at an intersection with MD 177 (Mountain Road) and Jumpers Hole Road at Lipins Corner near Pasadena, about 1.0 miles west of the intersection of MD 177 and MD 648H. This intersection is a short distance to the east of MD 177's partial interchanges with MD 10 and MD 100 (Paul T. Pitcher Highway) and the highway's western terminus at MD 2.