SR 151 passes through the hamlet of Piney River and intersects SR 56 (Tye Brook Highway) at a wye intersection; the southeast leg of the wye is unsigned, 0.23 miles long SR 151Y. SR 151 and SR 56 run concurrently northeast through Hendersons Store to Roseland, where SR 56 (Crabtree Falls Highway) splits northwest to ascend the spine of the Blue Ridge Mountains.