It flows through the Red Hills, the Jackson Bluff Dam, Talquin State Forest, Lake Talquin State Park and the Apalachicola National Forest, and past Ochlockonee River State Park, where it is tidally influenced and a mixture of fresh, brackish, and salt water, on the way to its terminus in Ochlockonee Bay, which then empties into Apalachee Bay, with tidal influences extending upstream over 15 miles from the river's mouth.