Through the Lawton/Fort Sill metropolitan area, US 281 again overlaps a toll-free section of I-44, while the former US 281 alignment through the city of Lawton is designated as Business US 281 between I-44 exits 34 and 39B. About 8 miles north of downtown Lawton, US 281 departs from I-44 to continue north through the cities of Apache, Anadarko, Gracemont, Binger and Hinton.