The two main characters of the show are Killface, who is a naked, bone-white, red-eyed, earless, talon-toed, spur-heeled, 7 feet , hairless, muscular humanoid supervillain focused on destroying Earth with his invention, the Annihilatrix; and billionaire tycoon Xander Crews, who fights crime under the superhero alias Awesome X. Both Killface and Xander are voiced by co-creator Adam Reed.