The park protects nearly 40000 hectares surrounding Mexico's second- and third-highest peaks, the Popocatépetl and Iztaccíhuatl volcanoes, as well as the areas of the Hacienda de Zoquiapán and its annexed areas (anexas) of Zoquiapan, Ixtlahuacán, and the Río Frío de Juárez river.