Question: Cotton Mather was politically influential in what oldest defined region in the US?
Related documents: [0]  [DOC] The history of New England is the history of the New England region of North America in the current-day United States. New England is the oldest clearly defined region of the United States, and it predates the history of the United States by over 150 years. While New England was originally inhabited by Indigenous peoples, English Pilgrims and especially Puritans, fleeing religious persecution in England, arrived in the 1620-1660 era. They dominated the region; their religion was later called Congregationalism. They and their descendants are called Yankees. Farming, fishing and lumbering prospered, as did whaling, sea trading, and merchandising. [END] 
[1]  [DOC] Cotton Mather, FRS (February 12, 1663 – February 13, 1728; A.B. 1678, Harvard College; A.M. 1681, honorary doctorate 1710, University of Glasgow) was a socially and politically influential New England Puritan minister, prolific author, and pamphleteer. He left a scientific legacy due to his hybridization experiments and his promotion of inoculation for disease prevention, though he is most frequently remembered today for his vigorous support for the Salem witch trials. He was subsequently denied the Presidency of Harvard College which his father, Increase Mather, had held. [END] 
Answer: 
New England
New England