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  We downloaded a total of 2525 ClinVar datasets from the official ProteinGym. Since the official did not provide the corresponding structure files, we performed the following operations to obtain the structures:
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- 1. According to the sequence, we retrieved the corresponding UniProt id from the UniProt website and downloaded 2302 corresponding AlphaFold2 structures.
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  2. For the remaining proteins, we first folded them using ColabFold 1.5.5.
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- 3. Among them, 12 proteins were too long to fold, and we solved this problem using the AlphaFold3 server.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  We downloaded a total of 2525 ClinVar datasets from the official ProteinGym. Since the official did not provide the corresponding structure files, we performed the following operations to obtain the structures:
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+ 1. According to the sequence, we retrieved the corresponding UniProt ID from the UniProt website and downloaded 2302 corresponding AlphaFold2 structures.
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  2. For the remaining proteins, we first folded them using ColabFold 1.5.5.
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+ 3. Among them, 12 proteins were too long to fold, and we solved this problem using the AlphaFold3 server.
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+
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+ ## 📑 Github
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+
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+ https://github.com/tyang816/ProtSSN
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+
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+ ## 🙌 Citation
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+ Please cite our work if you have used our code or data for **dry experiment testing/wet experiment directed evolution**. We are pleased to see improvements in the subsequent work.
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+ ```
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+ @article{tan2023protssn,
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+ title={Semantical and Topological Protein Encoding Toward Enhanced Bioactivity and Thermostability},
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+ author={Tan, Yang and Zhou, Bingxin and Zheng, Lirong and Fan, Guisheng and Hong, Liang},
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+ journal={bioRxiv},
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+ pages={2023--12},
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+ year={2023},
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+ publisher={Cold Spring Harbor Laboratory}
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+ }