text: The University of Vermont is in the process of constructing a new major facility to house various biotechnology research laboratories and offices. This five-storey, 65000 square foot concrete structure, named the Stafford Building, is being equipped with fiber optic and conventional sensors embedded into the concrete superstructure. These sensors will allow monitoring of stresses incurred during the construction phase and monitoring of concrete curing as well as vibration sensing and internal crack sensing. Longitudinal studies of the building's in-service performance and overall health will also be carried out. A description of the sensor choices, physical placements, use and review of relevant construction practices are presented in this paper.