The Gunners have a 2-1 lead over Potsdam from the first leg and are favourites to reach the quarter-finals.
Captain Katie Chapman said: "We dominated Thursday's game and could have put the tie to bed if we'd finished a few more chances.
"We'll go to Germany believing we can get the result we need to go through."
Arsenal, who won the competition in 2007, are in their 11th season in European football's elite competition and have never failed to reach the last eight.
But twice-winners Potsdam, who last lifted the trophy in 2010, have likewise always made it through to at least the quarter-finals.
Chapman, one of the first-leg goalscorers, added: "Potsdam are one of the very best teams in Europe and it's going to be really tough over there.
"But we've beaten them once, and if we can maybe get an early goal it will make it very difficult for them."

Mark Boleat said London would remain a leading financial hub, with only a few banking jobs likely to move.
Urging speedy trade talks, he added: "We would hope that the negotiations go quickly and go well."
The triggering of Article 50 of the Lisbon Treaty last month began the two year countdown to the UK's EU exit.
Before the referendum, the financial services sector largely backed the Remain campaign, warning that quitting the bloc could spur an exodus of City jobs.
The City of London, the council that covers London's financial centre, itself backed EU membership.
Since then, banks including Goldman Sachs, HSBC and UBS have said they will move some jobs out of London as a result of Brexit.
The historic insurance market Lloyd's of London has announced plans to open a Brussels subsidiary in early 2019.
But in an interview with the AFP news agency, Mr Boleat said that while a few people would be moved, "no one is going to say 'we are closing down in London'".
"Banks have had contingency plans since before the Brexit referendum in some cases," he said.
"They have known there is a possibility that Britain will not be in the single market - that has now been confirmed."
He said banks would need to "restructure what they are doing - perhaps cease doing a few things, in some cases build up business elsewhere in the European Union. They are getting on and doing that."
Mr Boleat also said it was important the UK reached an early agreement over the terms of its exit from the bloc and on the rights of EU nationals.
That would minimise disruption to "business and consumers in this country - and in Europe," he said.
On Friday, the Bank of England governor warned of sector-wide consequences if the UK left without a trade deal.
Mark Carney said the "vast majority" of City firms already had contingency plans in place.
However, he said some financial firms still needed to prepare in case of a "more extreme" outcome.
The Bank has written to the UK's biggest financial firms, urging them to plan for "all eventualities" from the UK leaving the bloc.
Arsenal Ladies will aim to become the first British side to knock out German opposition in the Women's Champions League on Wednesday.
[NEXT_CONCEPT]
The outlook for the UK financial sector has improved since Brexit was triggered, the policy chief for the City of London Corporation has said.