Pamela Shimwell-Mayo, receives an MBE for services to Parkinson's and said she was "incredibly emotional".
Financial expert Tim Cullen, 70, also receives an MBE for services to International Financial Management.
Meanwhile, Judy Arnold, 67, has been awarded the British Empire Medal (BEM) for services to Cruse Bereavement Care.
Mrs Shimwell-Mayo, whose late husband suffered with the disease for 30 years, has campaigned to raise awareness since 1989.
The Isle of Man Parkinson's Disease Society Chairman said: "I am in shock. My husband Derek and my mother would have been so proud.
"I can't wait to tell my daughters the news."
Mr Cullen conceived and established the Small Countries' Financial Management Centre (SCFMC) in 2009.
The initiative helps equip government officials from smaller developing countries with skills in financial regulation, public sector management, leadership and negotiation.
The 70-year-old, who spent 21 years with the World Bank, said: "It has been enormously satisfying and we have achieved remarkable things on a shoestring budget.
"I am absolutely delighted to be honoured, this programme has made a real difference."
Since its formation the SCFMC has helped more than 100 people from about 30 countries.
Mrs Arnold founded Cruse Bereavement Care in a friend's front room and has gone on to help hundreds of people.
She said: "It is wonderful and completely out of the blue. This is testament to the organisation itself and all the people we have helped."

It is believed Darren Rodgers, who was 24 and from Ballymena, was on his own and fell about 26ft (8m) from a promenade onto a rocky beach in Nice.
Supt Nigel Goddard, who is leading the PSNI team in France, said he was told it was an accident and not in any way disorder related.
Tributes have been paid to Mr Rodgers by his friends, fellow fans, and by the Irish Football Association (IFA).
The accident happened in the early hours of Monday, shortly after Northern Ireland played its first match of the Euro 2016 finals against Poland in the city on Sunday night.
Mr Rodgers was from the Meadowvale area of the County Antrim town and was a former pupil of Cambridge House Grammar School.
In a statement, his family thanked the local community for their support.
Supt Goddard said: "I was informed this morning by my French counterparts of this tragic news
"I believe it was an accident."
Northern Ireland's first and deputy first ministers, Arlene Foster and Martin McGuinness, issued a joint statement.
"It was with great shock and sadness we learned this morning of the death of Darren Rodgers in Nice last night as the result of a tragic accident," they said.
"The loss of a young life in these circumstances is truly heartbreaking and our thoughts and prayers are with his friends and family at this extremely difficult time.
"This sad news is in stark contrast to the jovial carnival atmosphere just hours before at the game against Poland."
DUP North Antrim MLA Paul Frew said he had spoken to Mr Rodgers on Sunday.
He described him as a "great lad with a big heart".
"Darren played for Braid Utd. Would have ran through a brick wall for his mates. Whole team is in shock, simply can't believe it," Mr Frew tweeted.
Patrick Nelson, the chief executive, of the IFA said: "On behalf of the board, management, players and staff of the Irish Football Association, I would like to express my deep sadness at the tragic death of a Northern Ireland supporter in Nice in the early hours of this morning.
"The thoughts of everyone at the association are with his family and friends at this time."
Gary McAllister of the Amalgamation of Northern Ireland Supporters Clubs said: "I'm sure that every Northern Ireland fan, both here in France and at home, will be thinking of Darren and his loved ones at this very sad time."
A founder member of the Isle of Man's Parkinson's Disease Society is one of three Manx residents recognised in the 2014 Queen's Birthday Honours list.
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A Northern Ireland football fan has died in an accident in France.