The first attack targeted a police station in the eastern city of Van, killing one police officer and two civilians. Some 73 people were hurt.
Hours later, a police station in Elazig was hit, killing at least three police officers and wounding 146 people.
Turkish officials blamed the Kurdish militant group, the PKK.
The PKK has carried a series of bombings targeting the police in the largely Kurdish south-east since a ceasefire with the government broke down last year.
Television footage showed plumes of smoke rising above the destroyed police building in Elazig.
The force of the blast blew out nearby cars, uprooted trees and left a large crater outside the building.
At least eight people were killed in two attacks on police vehicles in nearby Diyarbakir and Kiziltepe last week.
Since last month's failed coup in Turkey, there has been much talk of national unity.
But this has not included the pro-Kurdish political party which the Turkish authorities say supports the PKK, reports the BBC's Turkey correspondent Mark Lowen. The pro-Kurdish HDP denies any link to the militants.

The 28-year-old will play Arsenal in a competitive fixture for the first time when Forest face the Gunners in the EFL Cup third round on Tuesday.
"Most people don't celebrate when they score and some go absolutely crazy and start chaos, which is fun," he said.
"For me out of respect I will celebrate a little bit, but it won't be crazy."
Bendtner began his senior with Arsenal and spent nine years with the club, before moving to German side Wolfsburg in 2014.
"[Arsenal] feels like a long time away. I had been there a long time but so much has happened since, so it's a little bit of a distant memory," he told BBC Radio Nottingham.
"Things happen in football, it's a quick career and you have 15 or 20 years.
"I was there at an early age and there's many things - ups and downs - that have happened but it's in the past and I only look to the future."
The Denmark international says he has good memories of his time at Arsenal, but hopes his new club can progress to the fourth round of the EFL Cup for the first time since 2004-05.
"I am sure I will probably pop into the dressing room after the match," he continued.
"In 90 minutes when I go onto the pitch I am focused on Forest to win the match for them and after all the emotions it's a different story."
Two big car bombs have hit police stations in separate cities in Turkey, killing six people and wounding at least 219 others.
[NEXT_CONCEPT]
Nottingham Forest forward Nicklas Bendtner will not "go crazy" if he scores against Arsenal despite his time at the club being a distant memory.