The event consists of three strokeplay rounds and two cuts, before the top 24 play off in six-hole matchplay duels.
"It will be a mindset thing where you've got to realise that the strokeplay is just a qualifier to get into Sunday," said Oosthuizen.
"It's a bit like when I played the qualifying school."
Oosthuizen is effectively the defending champion having won the event's predecessor - the Perth International - at the same Lake Karrinyup Country Club venue last season.
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The 34-year-old South African believes that the format will create a climatic final day's action as the final 24 take each other on in a knockout matchplay tournament.
"You'll see probably a few more riskier shots which you wouldn't see in stroke play. It should be a very exciting Sunday," added Oosthuizen.
The top eight go straight into the last 16, while the remaining 16 will be drawn together in head-to-head matches to decide the other eight spots. From there it is straight knockout until there is a winner.
According to the World Super 6 website, any knockout matches 'not decided after six holes of matchplay will be decided by playing the new shootout hole'.
The 'shootout hole' will be 90m long and see 'a new tee placed adjacent to the 18th fairway and utilising the 18th green'.
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The new-look tournament is part of a drive to reverse the decline in the number of people playing the sport.
In England, there were 860,900 adults playing in 2009-10 compared to 740,000 in 2014-15 according to Sport England.
The British Golf Industry Association is attempting to make courses more family friendly.

It is not known who shot Ansar Beit al-Maqdis commander Shadi el-Menei.
But several other members of the al-Qaeda-inspired group, which is suspected of a string of recent attacks, were also reportedly killed.
The deaths of more than 200 Egyptian soldiers and officials have been blamed on Ansar Beit al-Maqdis since President Mohammed Morsi was ousted in July 2013.
Profile: Ansar Beit al-Maqdis
There are conflicting reports as to who was responsible for the killing of the militants.
Unnamed officials were quoted by AFP news agency as saying security forces opened fire on the men as they were about to carry out an attack on a gas pipeline in central Sinai.
A different account came from officials who told the Associated Press that Shadi el-Menei and at least three associates were killed by 15 attackers in revenge for the killings of tribesmen by Ansar Beit al-Maqdis.
Islamist groups in the Sinai have stepped up their attacks against Egypt's army and police forces in the past year.
The Egyptian army launched a major operation against militants in the Sinai but attacks have continued.
However, the security operation has come at a cost to authorities. A police officer died of his wounds on Friday after being shot the previous day by militants near the border with the Gaza Strip.
Last week, two army officers and five militants were said to have died in a gunfight during a raid on a warehouse linked to Islamist militants north of Cairo.
Officials said the militants in that attack were from Ansar Beit al-Maqdis.
The US state department designated the group a "foreign terrorist organisation" earlier this year.
Former Open champion Louis Oosthuizen says he will need a different mindset for the inaugural World Super 6 event that begins in Perth on Thursday.
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Egyptian security officials say a key leader of a militant group has been shot dead in the Sinai peninsula.