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Louloudis, 23, missed the event in 2012 as he competed for Great Britain at the London Olympics, winning a bronze medal in the men's eight competition.
Cambridge will again have the heavier crew, at 5.25 kilograms per man more.
And for the first time in its 90-year history, the women crews compete on the same day and course as the men.
Racing along the River Thames from Putney to Mortlake, Cambridge will have the heavier team in the women's Boat Race, 0.9 kg per rower more than Oxford.
Oxford are the reigning men's champions after powering to their fifth triumph in seven years in 2014.

The move reflects concerns from local residents and businesses about air quality, Westminster City Council said.
A team of traffic marshals will patrol the borough and ask car idlers to switch off their engines, it said.
The London Taxi Drivers' Association (LTDA) said the move would not help abate London's air pollution problem.
The penalties will come into force on 1 May, as a "last resort".
The new policy follows Camden Council's fines for buses which idle for too long, introduced in 2011, and Islington Council's fines for idling vehicles introduced in August last year.
Westminster has the highest proportion of deaths attributable to air pollution, excluding the City of London, in the country, a report by the council said.
An air pollution monitoring station in Oxford Street, in the borough, recorded the acceptable limit set for air pollution - 200 micrograms per cubic metre - was broken 1,503 times in 2014.
A comparable station in Sutton did not break the limit at all last year.
Steve McNamara, general secretary of the LTDA said the fines were "absolute tosh" and a public relations and money raising exercise from the council.
He said: "It is not going to do anything constructive to tackle the pollution crisis in London. When was the last time you saw someone idling in the city? It doesn't happen.
"One of the real problems is cars stuck in traffic - research has shown pollution is up by 30% in areas of heavy traffic. Do something to help get the traffic moving."
Mr McNamara said another key factor was the number of diesel cars in the capital which emit greater levels of nitrogen oxides - which can cause health problems.
He said the move was "ironic" considering Chancellor George Osborne's incentives to diesel vehicles which were exacerbating the problem.
Neil Greig, director of policy and research at the Institute of Advanced Motorists, said the "key issue" would be how the marshals enforced the fines.
He said: "If they target private car drivers pulling up for a moment in relatively clean, modern cars in a draconian way - whilst ignoring old buses, coaches, large trucks, utility company vans or taxis idling for long periods - then it will quickly be seen as yet another revenue-raising exercise."

The younger girl was found with life-threatening injuries near an address in Alness Drive, in the Woodthorpe area of the city.
She was taken to hospital but died a short time later, North Yorkshire Police said.
The teenager remains in police custody and is being questioned by officers, the force added.
A spokesman said officers found the seven-year-old after police were called at about 16:30 GMT.
The investigation into the circumstances surrounding the girl's death continues, he added.
Earlier, the York City and East policing team posted a message about the incident.
In a tweet, they said: "Difficult late shift for all York staff with tragic death of a seven-year-old. Thoughts go out to family members."
Constantine Louloudis will go for a fourth Boat Race win in five years for Oxford when they face rivals Cambridge in April live on BBC TV.
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Motorists in Westminster who sit in a stationary car with the engine running and refuse to turn it off are to be fined £20.
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A 15-year-old girl has been arrested after the death of a seven-year-old girl in York, police have said.