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A German television documentary claimed to present evidence of systematic doping and corruption in Russian sport.
IAAF chief Lamine Diack told BBC Sport athletics is "in crisis" but said "90% to 95%" of athletes are clean.
Meadows, 33, was beaten to European gold by a Russian drug cheat in 2011.
German television station WDR broadcast three documentaries alleging that 99% of Russian athletes are doping and that IAAF officials were implicated in covering it up.
The claims have been rejected as a "pack of lies" by the Russian Athletics Federation and Diack told BBC Sport that the figure was "a joke" and "ridiculous".
Meadows, from Wigan, said: "If it is as widespread as those allegations do deem, I just think it would just kill our sport.
"Sponsors may walk away from the sport and fans may walk away from the sport. We may never get a 100% accuracy of the scale of doping.
"I really hope it isn't true to that scale but I do think doping is widespread in athletics."
In 2011 Meadows finished second in the 800m to Yevgeniya Zinurova in the European Indoor Championships, only to be upgraded to gold the following year when the Russian was banned for two years for doping.
Meadows added: "It might be the case that we have to prove how many people are doping, destroy the image of the sport and then rebuild it again and look for positive role models who can succeed and win medals on the international stage who are clean athletes."
The BBC has not independently verified the documentary's allegations and is awaiting responses from athletes targeted in the programme.

Thieves stole about 12 tonnes of lead from the roof St Mary's Church, Great Brington, Northamptonshire, in the early hours of Tuesday morning.
They stripped more than 3,000 sq ft of lead from the church.
Princess Diana's father, the 8th Earl Spencer, is buried at the church, which also includes the Spencer Chapel.
The church is sited near the Princess's ancestral seat of Althorp, which was inherited by her brother Charles Spencer, 9th Earl Spencer, in 1992.
Northamptonshire Police said it was believed the thieves broke through a gate then drove a vehicle into the churchyard, knocking over a gravestone on the way.
Officers investigating the theft have asked anyone who was in the area at the time or who knows anything about the theft to contact police.
Rev Sue Kipling, rector of the Spencer benefice - which includes the church of St Mary the Virgin with St John in Great Brington - said: "It's a huge loss to us. It will cost more than £40,000 to replace.
"You can now see the sunlight coming into the church through the roof, although the Althorp estate has provided tarpaulin to protect the inside of the building in the short term."
She said the church held a service and prayed for the thieves.
The church is also connected to the first president of the US. George Washington's great-great-grandfather Lawrence Washington is buried in the chancel.
British athlete Jenny Meadows fears the Russian doping allegations could "kill" the sport if proven by an ongoing International Association of Athletics Federations (IAAF) investigation.
[NEXT_CONCEPT]
More £40,000 of lead has been stolen from a 13th Century church with links to the family of the late Princess Diana.