The Dow Jones hit a new record high closing up 24.45 points to 18,372.12.
The S&P 500 climbed just 0.29 points to 2,152.43, while the tech-heavy Nasdaq index slipped 17.09 to 5,005.73.
Investors remained cautious ahead of the corporate earnings season, with major firms due to release results over the next few weeks, starting with JP Morgan on Thursday.
Shares in JP Morgan Chase slipped 0.2%.
Delta Airlines which also reports quarterly results on Thursday closed 1.5% lower.
Health insurance providers saw a rise in their share price after a report said healthcare spending in the US would rise by 5.8% per year over the next decade.
Insurance provider Humana gained 4.3%, while Aetna climbed 3.2%.
Shares of Juno Therapeutics added 9.5% despite a lawsuit that was filed against it this week.
The lawsuit alleges that Juno and its chief executive Hans Bishop misled investors about the death of a patient in a drug trial.
Global oil prices fell by 4%. Brent crude oil dropped to $46.48 per barrel and West Texas crude slipped to $45 per barrel.

The brawl on Saturday began after the families objected to photos being taken, witnesses say. Stones and bottles were thrown.
Reports say some of the brawlers were armed with hatchets and harpoons.
Unrest continued on Sunday at a protest in the regional capital.
The head of the regional executive, Gilles Simeoni, has appealed for calm.
The incident took place on a creek near the village of Sisco, Upper Corsica.
Tension has grown this summer between local communities and Muslims of North African origin in the south of France, especially following the massacre of 85 people by a lorry driver in the city of Nice on 14 July.
At the end of last month, an outlawed Corsican paramilitary group warned Islamist militants against targeting their island.
Earlier this week, the resort town of Cannes controversially banned the wearing of the Islamic bathing costume for women, the burkini.
Three of the injured have been released from hospital in Bastia and the other two were due to be sent home shortly, prosecutors said in a statement (in French).
They described the brawl as being of "great violence".
French media report that the trouble began around 18:15 (16:15 GMT) when tourists took photos of women bathing. Reports say the women were wearing burkinis.
Ange Vivoni, mayor of Sisco, told reporters that when a local teenager was stabbed, the victim's "family and all the people of Sisco got together".
According to the newspaper Le Figaro (in French), some of the older men in the bathing party had attacked a group of local teenagers on the beach with hatchets.
When the teenagers' parents arrived from the village, two of them were reportedly injured with harpoons. Villagers allegedly then set alight cars belonging to the bathers.
Another French daily, Le Monde, reports (in French) that one man was injured twice by a harpoon after his son was beaten up. Stones and bottles were also thrown.
Two fathers from among the bathing party were also injured during the brawl, the paper adds.
According to Le Monde newspaper, the three involved in the brawl are all Muslims.
Interior Minister Bernard Cazeneuve condemned the violence and also appealed for calm.
Hundreds of people held a protest in Bastia, heading for a housing estate, where some of those involved in Saturday's brawl are said to live.
Riot police could be seen pushing them back and tear gas was reportedly fired when stones were thrown.
(Closed): Wall Street finished with mixed results as a three-day rally showed signs of slowing.
[NEXT_CONCEPT]
A beach brawl on the French island of Corsica between three families of North African descent and local youths has left five people injured and three cars burnt out, regional prosecutors say.