The Tongan-born cousins are set to face-off after Vunipola's man-of-the-match show for England against Ireland.
"A lot's been made of Billy's carrying, and Toby's been absolutely phenomenal in defence for us," said Owens.
"So it'll be an interesting battle that'll get the ground shaking!"
Vunipola made 18 carries for a total gain of 96 metres against Ireland, while Faletau was Wales's top tackler with 20 against France.
Faletau and the Vunipola brothers, Billy and prop Mako, grew up together in Pontypool before the Vunipola family moved to England.
"They're both world-class number eights who are both at the top of their game at the moment," said Owens.
Owens says he won't be out to wind-up England captain Dylan Hartley at Twickenham, despite his opponent's poor disciplinary record.
Hartley has totalled more than a year in bans for gouging, biting, butting and swearing at an official - missing the 2013 British and Irish Lions tour and the 2015 World Cup as a result.
But Owens says he won't try to incite anything if they come head-to-head.
"I don't think you ever go on the pitch to try to wind anybody up, you concentrate on your own game. I've played against him once this season (for Scarlets against Northampton), he's definitely a slightly different character but that's the way he plays the game," he said.
"He's right on the edge and that's what makes him the player he is in terms of ball-carrying and being a big tackler."
The 29 year-old Owens, who has 37 caps but only eight starts to his credit, is trying to claim underdog status for Wales despite their World Cup victory at Twickenham in October.
"They're obviously favourites aren't they, they're top of the table and we're going to their home patch- a new coach comes in, they get a freshen-up and a new environment.
"They've got a more settled side, they're consistent in some of their selections and they've got some good youngsters coming through- some of them quite unknown to us, so we're going to have to be on the money."

The offence referred to Aki's behaviour to and remarks directed toward referee Ian Davies during and after Connacht's defeat by Leinster on 15 April.
The 27-year-old will miss his side's remaining Pro12 games of the regular season against Scarlets and Munster.
Aki will also sit out Connacht's Champions Cup play-off match on the weekend of 19-21 May.
The Kiwi can return to play from Monday, 22 May so he would be available to return for the following week's play-off final should Pat Lam's side progress.
Aki faced a two-man disciplinary panel on Thursday via video link after a misconduct complaint was made against him by the disciplinary officer of Pro12 Rugby.
He received a warning about his behaviour from Davies in the 76th minute of the 37-24 loss in the interprovincial derby and then further remonstrated with the Welsh referee after full-time.
If Connacht remain in eighth place in the Pro12, they will face the English Premiership's seventh-placed team.
If they were to win that game, as it stands, they would face the winner of the encounter between the seventh-placed Top 14 side and Cardiff Blues for a place in Europe's premier club competition next season.
Aki will become eligible to play for Ireland under the three-year residency rule in October 2017.
The collision between rival number eights Taulupe Faletau and Billy Vunipola could be a highlight of England versus Wales, according to Welsh hooker Ken Owens.
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Connacht centre Bundee Aki has been banned for three matches after admitting a charge of misconduct.