Seka Ritchie, 32, and Tracey McLean, 29, are accused of killing Alexander Duncan at his home in Leith on 16 April 2015.
It is claimed the 59-year-old was hit with a bottle and stabbed with a knife or similar item.
Prosecutors also allege the pair robbed Mr Duncan of his wallet and its contents.
They also face charges of attempting to defeat the ends of justice and attempting to pervert the course of justice.
Ms Ritchie is further accused of four separate assaults in Edinburgh between 2010-2013.
Lawyers for the pair entered not guilty pleas on Friday during a short hearing at the High Court in Glasgow.
Judge Lord Burns set a trial due to start next June in Edinburgh. The case will last about 10 days.

Bath led 38-10 at the interval, with Tom Dunn, Tom Homer, Robbie Fruean, Kahn Fotuali'i and Ford all going over.
Samoan Fotuali'i crossed for his second try, as Rokoduguni and Chris Cook also scored at Ashton Gate for the visitors.
Tom Varndell, Rhodri Williams and Jack Tovey went over for Bristol, but they remain third in the pool.
Fly-half Ford, who has been strongly linked with a move to Premiership rivals Sale at the end of the season, contributed 20 points as Bath did the damage in the first half.
Fotuali'i's double on return from an eye injury was another plus, with Todd Blackadder's team five points clear at the top of their European Challenge Cup group ahead of Cardiff Blues' trip to French Top 14 side Pau on Saturday.
Bristol: Arscott; Wallace, Palamo, Pisi, Varndell; Searle, Williams; Traynor, Crumpton, Ford-Robinson, Phillips, Glynn, Lam, Robinson (capt), Eadie.
Replacements: Jones, Bevington, Cortes, Nemsadze, Joyce, Cliff, Jarvis, Tovey.
Bath: Homer; Rokoduguni, Joseph, Fruean, Watson; Ford (co-capt), Fotuali'i; Catt, Dunn, Lahiff, Ewels, Stooke, Mercer, Louw (co-capt), Grant.
Replacements: Walker, Obano, Palma-Newport, Douglas, Mercer, Cook, Priestland, Tapuai.
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Prime Minister Recep Tayyip Erdogan travelled aboard the first train in the service from Ankara, stopping at a town en route to make a campaign speech.
The tracks allow trains to reach speeds of up to 250 km (155 miles) per hour.
Mr Erdogan, a candidate in presidential elections in August, has pledged to overhaul Turkey's transport network.
"We made a promise. We worked hard. We crossed the mountains, and passed over rivers," Mr Erdogan said, at a campaign stop in the town of Eskisehir.
"Despite all the attempts of sabotage, blockade, and slowdown, we completed the line and opened it for service today."
The inauguration of the train link has been beset by hitches and delays, most recently when a train crashed into a maintenance vehicle.
The new service will terminate in the Istanbul suburb of Pendik, on the Asian side of the Bosphorus.
The government plans to build a further rail link, under the Bosphorus, to the centre of the city, but it is unclear when this will happen.
Two women are to stand trial charged with murdering and robbing a man in his Edinburgh flat.
[NEXT_CONCEPT]
England internationals George Ford and Semesa Rokoduguni were among the try-scorers as Bath thrashed local rivals Bristol to close in on qualification.
[NEXT_CONCEPT]
Turkey has inaugurated a high-speed rail link between Istanbul and Ankara, slashing by half the seven-hour journey time between the two cities.