The All Blacks ran in 12 tries, with Sonny Bill Williams and Julian Savea both touching down twice.
Over 61,000 fans were in attendance, more than three times the previous best crowd for a rugby match in the USA.
New Zealand fielded an inexperienced line-up, but were impressive ahead of their meeting with Stuart Lancaster's England at Twickenham next Saturday.
The match - the first on US soil between the two sides since 1980 - was broadcast live on NBC in America.
Bob Latham, chairman of USA Rugby, described the match as "monumental" for rugby in the United States.
New Zealand Rugby Union's chief executive Steve Tew told BBC World Service Sportsworld: "Our guys finished the game with a lot of respect for the US boys. They took it to us for periods of the game, but unfortunately when we had the ball they weren't able to match us for pace and power.
"I think we've done our bit - we've given them a profile they haven't had here before.
"The primary reason we wanted a game on the way, we've got to play England next Saturday at Twickenham - a little bit like the World Cup will be next year for us.
"We have a pool that doesn't have the hardest opposition in it and then we hit a quarter-final at Cardiff and we'll see either France or Ireland play us if we finish first - so this replicates that to a degree.
"We know we've got a big battle in front us at Twickenham."

Mr Kejriwal spent Monday night in the open and conducted business with cabinet members from the street.
His administration had accused the police of failing to deal with an alleged drugs and prostitution ring - something they denied.
The chief minister says he has won concessions from central government.
By Soutik BiswasIndia correspondent
India's Arvind Kejriwal's 'anarchic' politics
The government, which commands Delhi's police force, has agreed to send on leave two police officers Mr Kejriwal wants suspended on allegations of misconduct.
"I'm very happy today. Today the people of Delhi have won. I want to congratulate the people of Delhi," AFP news agency quotes Mr Kejriwal as telling supporters.
The protest began on Monday when Mr Kejriwal was prevented from going to the home minister's office to demand the officers' suspension.
He was acting in response to an incident which threatened to become a diplomatic issue, putting his Aam Aadmi Party, the police and members of Delhi's African community at loggerheads.
Last Wednesday Mr Kejriwal's Law Minister, Somnath Bharti, and various party supporters allegedly confronted four Ugandan women in a Delhi neighbourhood, accusing them of prostitution.
Police refused to search a nearby house for evidence of the suspected drugs and prostitution ring because they did not have a warrant.
Mr Bharti and supporters of the Aam Aadmi Party were accused of threatening and intimidating the women, forcing their way into homes and making racist remarks - allegations they deny.
Mr Kejriwal's wider demands include police reform and transferring control of Delhi's police force from the federal authorities.
The chief minister also accuses the police of failing to protect women, following the fatal gang-rape of a student in December 2012.
The Aam Aadmi Party, or Common Man's Party, performed unexpectedly well in state elections on an anti-corruption platform, propelling Mr Kejriwal to the post of chief minister last month.
India's general election must take place by May and the party, only one year old, is expected to field a large number of candidates. The protest in Delhi is thought likely to raise its profile as the national poll approaches.
While hailed as a victory by some, Mr Kejriwal's protest has been criticised by others, who urged him to get off the streets in order to govern as he was elected to do.
His sit-in had caused congestion in central Delhi as police barricaded roads to the site. Police clashed with protesters who had gathered to join him on Tuesday.
New Zealand secured a resounding win over the USA in front of a capacity crowd at Chicago's Soldier Field.
[NEXT_CONCEPT]
Delhi Chief Minister Arvind Kejriwal has called off a sit-in protest in the city centre which was sparked by a row over who controls Delhi's police force.