The broadcaster is still promoting trailers, clips and interviews on the website but users trying to access shows are instead met with a statement.
"As a not-for-profit broadcaster funded by advertising, we put our money back into the programmes themselves," it reads.
It says it is directing viewers to its 4oD catch-up services instead.
The statement adds: "To make the best of this investment, we've decided to focus on bringing online viewers of our full-length shows to our own 4oD apps - such as those on iOS, Android and channel4.com.
"These apps also allow us to encourage more viewing by recommending programmes we think people will appreciate and to provide viewers with additional services."
Programmes on 4oD are still available across a range of platforms including Sky, Virgin Media and Freesat, on consoles such as Sony's PS3 and Microsoft's Xbox One and on apps for Windows 8, Windows Phone, iOS and Android devices.
The television brand says it will still maintain a presence on YouTube, with a press statement revealing some of its plans.
"Reflecting the ways in which our viewers consume Channel 4 content across digital and mobile platforms, our relationship with YouTube will now focus on short-form content," it says.
The move ends the previous deal Channel 4 had with the online streaming service, where its 4oD catch-up service was available on YouTube's UK site.
In 2009, when the partnership was announced, a joint statement said it was the "first time that a broadcaster anywhere in the world has made a comprehensive catch-up schedule available".
Popular Channel 4 series including Peep Show, Skins and Misfits had been available to view free of charge, as were other programmes from its sister stations, including E4.
Under the deal, each company took a share of revenues from any advertising sold around the programmes.
YouTube, bought by Google in 2006, is the biggest video-streaming site in the world.
Other UK broadcasters, including the BBC and ITV, currently make clips available on the video-sharing website.
Channel 4 was the first UK broadcaster to launch a video on demand service in late 2006, and was also the first to sell advertising around TV content online.
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The Telegraph reported that players would be given permission to compete in the lucrative Twenty20 competition.
But Strauss, 38, said: "I can't foresee any circumstances in which we would weaken our Test team in order to allow a player to play in the IPL or any other franchise-based competition."
The IPL takes place in April and May.
England play Sri Lanka in two Tests in May 2016, their first action of the domestic summer.
Strauss told BBC Test Match Special on Wednesday that "more separation" of the Test and one-day teams will improve their chances of winning the World Cup.
Asked about the IPL and the Big Bash, Australia's Twenty20 tournament, he said: "I'm a massive fan.
"If you are an overseas player, what those Twenty20 competitions do is put you under real pressure. You have to stand up and deliver."
England players, including current ODI captain Eoin Morgan, have competed in the IPL, although they have never missed Tests to do so.
Strauss has returned to the UK from the United Arab Emirates, where England lost the first game in the four-match one-day series against Pakistan.
One man quick to air his views on the subject was former England batsman Kevin Pietersen, who found himself at odds with the England and Wales Cricket Board over his desire to play in the IPL and commented on Twitter about the developments.
"With this decision now, the whole situation is proving to be personal!" he wrote.
"[Eoin] Morgan missed an international this year as captain! Missing any Eng cricket for IPL is what I'm on about! Such hypocrisy!"
Pietersen was told by Strauss in May that he would not be part of the team's plans for the summer because there was a "massive trust issue".
The South African-born batsman was instead offered an advisory role with the England one-day team, but rejected the opportunity.
He referred to that offer on Friday when he added: "Why should I advise when I'm still good enough to walk into any England side if there wasn't personal grudges?!"
Channel 4 has removed all its full-length programmes from the video-streaming site YouTube.
[NEXT_CONCEPT]
England players will not be allowed to miss Test matches to play in the Indian Premier League, says director of cricket Andrew Strauss.