Since docking with the ISS in a Soyuz craft in December, the 53-year-old station commander has kept hundreds of thousands of followers back on Earth informed and entertained from orbit.
He has tweeted from the space station at least 1,500 times, capturing remarkable images of many corners of the world.
His first photograph came in his first tweet from the ISS: "Space Station! Floating free, buoyed up even more by my smile :)"
His first days were marked by a series of photos detailing life inside the space station.
But he soon branched out into striking orbital landscapes of the planet below.
We have collected just a few of Cmdr Hadfield's tweeted shots and captions here - more are available by browsing his Twitter feed @Cmdr_Hadfield.
A former fighter pilot, Chris Hadfield became a trainee astronaut in 1992 after winning selection from a field of 5,330 applicants, according to Nasa.
He flew on board the space shuttle, docking with the Russian space station Mir and as part of an assembly flight to the ISS in 2001.
He eventually won his own slot on board the ISS in 2010, training for his current mission until lift-off in December 2012.
After gathering hundreds of thousands of Twitter followers during his months on board, he made one final hit as the time came for his departure from the ISS.
He posted a striking video to YouTube of him performing a version of David Bowie's renowned 1969 hit song Space Oddity.
The video quickly went viral, and even prompted a response from Bowie's own official account: "Hallo Spaceboy..."

The department, which employs 247 staff, said it plans to shut the office by 2018 but has not said how many, if any, redundancies there may be.
It said the decision was aimed at cutting costs by creating a combined central HQ and policy centre in London.
PCS, the union, say a further 100 jobs in the UK are threatened by the move.
Permanent secretary Martin Donnelly said the move was intended to "modernise the way we work, reduce operating costs and deliver a simpler, smaller department that is more flexible and responsive to stakeholders and businesses.
"The decision to close Sheffield by 2018 has not been taken lightly.
"We will provide comprehensive support to all those facing a potential change or loss of job."
However, he said the department was planning to create "around six business centres" across the country.
The department currently employs about 2,500 people in total across 10 locations.
Mark Serwotka, general secretary of the Public and Commercial Services union, said: "The business department is supposed to lead the way in helping local economies grow after the recession, yet it is retreating from towns and cities across the country.
"We do not accept the need for these offices to close and for jobs to be at risk and will be opposing these moves."
The union has not said where the other 100 jobs could be lost.
Julie Dore, leader of Sheffield City Council, described the plan as "appalling" and said she would be writing to the Secretary of State to "make it clear that this is unacceptable".
Nick Clegg, Liberal Democrat MP for Sheffield Hallam, said the decision "flies directly in the face of the Northern Powerhouse agenda".
Canadian astronaut Chris Hadfield is due to return to Earth on Tuesday from a five-month stint on board the International Space Station.
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Nearly 250 jobs have been put at risk after the Department for Business, Innovation and Skills announced it will close its office in Sheffield.