An estimated 30,000 runners took to the city's streets with both the 10k event and half-marathon taking place on Sunday.
Haile Gebrselassie was forced to abandon the defence of his title won in last year's half-marathon event.
The Ethiopian pulled up at the roadside with breathing problems 20 minutes after starting.
He told the BBC: "I'm OK now, after I dropped out at 20 minutes I was struggling a bit with the breathing and I'm OK, not too bad actually."
Last year the 41-year-old  set a new world age group record by completing the race in  61 minutes nine seconds.
The half-marathon was won by South African Stephen Mokoka with a time of 61 minutes 25 seconds.
Kenyan Edna Kiplagat was the first woman to finish, setting a new race record for the women's event in 67 minutes, 57 seconds.
Sean Fontana from Victoria Park ACC was first across the finish line in the 10k with a time of 31 minutes, three seconds.
Simon Lawson won the wheelchair race with a time of 29 minutes, 10 seconds.
After starting from George Square, the half-marathon runners passed through Â­Bellahouston and Pollok parks then back to the city centre towards the finish at Glasgow Green.
On "Super Saturday" more than 3,000 people took part in a number of junior and family races. The run is described as Scotland's biggest mass participation event.
Councillor Archie Graham, chairman of Glasgow Life said: "Congratulations to everyone who took part in the Bank of Scotland Great Scottish Run.
"Whether this was their first time taking part in Scotland's premier celebration of running or the latest of many, the achievement of completing the course will live with them for the rest of their lives."

Surrey Police said bottles were thrown in the disturbance at the Epsom Downs Racecourse on 4 June.
The all-male group, charged in connection with disorder near a music stage, is due in court over the next four weeks.
During the violence a police officer's tooth was knocked out. He had to be treated in hospital for his injuries.
Those charged are aged between 16 and 20.
About 100,000 race-goers attended the two-day festival.
Thousands of people have been taking part in the Bank of Scotland Great Scottish Run in Glasgow.
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Eleven people have been charged following a fracas at last year's Epsom Derby.