In his closing speech, prosecutor Philip Evans told Woolwich Crown Court the men had given "lies" and "half truths" as evidence during the trial.
Carl Wood, William Lincoln, Jon Harbinson and Hugh Doyle all deny being part in the Â£14m theft.
Four other men have already pleaded guilty to taking part in the raid.
Summing up the case against the accused men, Mr Evans said the robbery had involved a "staggering sum of money" and had been a carefully planned operation by men who knew what they were doing.
He asked the jury to consider whether the "ringleaders" - who had already pleaded guilty - would have trusted those on trial to look after their jewel-laden bags and not take a "peek" inside.
"The men who have pleaded guilty were a group who thrived on acquisitive crime - taking people's money and possessions, greed in reality.
"What they needed were people who wouldn't question that," he said.
Referring to Mr Lincoln's claim that he did not know what was in the bags he helped move, he asked the jury whether they could "believe that for one second?"
"They were never going to let that significant commodity go into the hands of someone they did not trust," he said.
Mr Evans insisted the four men had not told the truth to the court.
"On each of the four occasions that you have heard the defendants give evidence, each of them have told you lies," Mr Evans said.
He added that it did not matter what size role each of the men had played because "if you take part knowingly, you're guilty".
The case continues.
Daniel Jones, 60, of Park Avenue, Enfield; John Collins, 75, of Bletsoe Walk, Islington; Terry Perkins, 67, of Heene Road, Enfield, and Brian Reader, 76, of Dartford Road, Dartford, have all previously pleaded guilty to conspiracy to commit burglary.

The company said it was looking into the matter, which could be caused by wireless interference, and suggested gamers sat closer to the console.
It comes after some players complained about their screens containing dead pixels that created black squares.
The console has received largely positive reviews and is selling well.
Reports about problems with the controllers, known as Joy-Con, have been around since before the launch of the console, among those who had pre-release review units.
It seems to affect play when the console is connected to the TV and the controllers are being used wirelessly.
On its support page, Nintendo advised users to make sure that the Switch console was placed "out in the open" and not behind a TV, in or under a metal object or near an aquarium.
It also advised users to make sure the console had the latest software update and to "try to decrease the distance" between the Joy-Con and the console.
The problem seems to be worse in the left-hand controller and some, including games writer Jeff Gerstmann, report it is affected by how close users sit to the TV.
A video posted on YouTube suggested that while the right-hand Joy-Con had a dedicated antenna, the left-hand one was harder to find.
"The antenna is printed directly on the controller's circuit board; it's not a separate unit inside the device. Second, the antenna is located beneath the controller's shoulder button and next to the housing for the controller's joystick," said gaming website Polygon.
"All of that could block or weaken the Bluetooth signal," it added.
A straw poll on the social media platform Reddit suggested that 20% of respondents (out of a total of 6,300) had experienced some kind of issue with their Switch console.
Piers Harding-Rolls, an analyst at research firm IHS Markit said: "Obviously, if this does occur when gaming it can be frustrating, but generally I don't think this is impacting people's enjoyment of the platform too heavily."
"What is perhaps making it worse is that the right Joy-Con has better connectivity which is highlighting the left's relative weakness.
"If this is a design issue, I expect Nintendo to look closely at adjusting the lay-out of the antenna in the left Joy-Con to help solve the issue, as the fix would appear relatively straightforward."
Four men accused of being part of the Hatton Garden raid were trusted to be involved because of their "connections to the ringleaders", a court has heard.
[NEXT_CONCEPT]
Nintendo is facing more complaints about its new console, Switch, this time about the controllers failing to connect.