Lewis White, Michael Jones, Rebecca Redfern, Ellie Robinson and Zara Mullooly are all in the 25-strong team.
Bethany Firth, Jonathan Fox and Steph Slater, who missed last summer's World Championships because of injury, return to the international scene.
The competition takes place from 30 April-8 May in Funchal, Madeira.
The GB team also includes Paralympic champions Ollie Hynd, Jessica-Jane Applegate and Josef Craig, as well as world champions Tully Kearney and Hannah Russell.
However, a number of GB swimmers, including Ellie Simmonds and Sascha Kindred, have not been included as the event comes straight after the Rio Paralympic trials, which take place in Glasgow from 23-27 April.
GB team: Josef Craig, James Crisp, Jonathan Fox, Thomas Hamer, Ollie Hynd, Michael Jones, Andrew Mullen, Scott Quin, Lewis White, Matthew Wylie, Jessica-Jane Applegate, Claire Cashmore, Bethany Firth, Charlotte Henshaw, Tully Kearney, Harriet Lee, Amy Marren, Stephanie Millward, Zara Mullooly, Rebecca Redfern, Eleanor Robinson, Susie Rodgers, Hannah Russell, Stephanie Slater, Alice Tai.

The girl, aged 15 at the time, was a "frequent runaway" and had met a man called David Ayrton on the day of the attack more than 10 years ago.
The 34-year-old, now called Davina, denies raping the teenager in a garage in Portsmouth in the autumn of 2004.
Portsmouth Crown Court was told the alleged incident happened while two others were asleep in the garage.
The teenager, who cannot be identified, stayed there when hiding from her parents.
She told the court although she had shouted and sworn at the defendant to stop the attack, her friend and her boyfriend had not woken up.
She added that she had "only drunk a can and a half of Foster's" and had a clear recollection of the events.
The friend who was with her in the garage at the time told the court the alleged victim was a "vulnerable" girl at the time.
She said she was eventually woken up by the teenager who was "screaming and crying and asking for help".
The person alleged to be Ms Ayrton was then "ejected" from the garage by the girl's boyfriend.
The court heard the victim made a complaint to police in December 2004 but had not assisted officers because she was "anti-police" at the time.
Chris Stopa, prosecuting, said Ms Ayrton has learning difficulties and told a worker at the care home in Fordingbridge where she lives about the incident in 2014.
Police then contacted the alleged victim, leading to the prosecution.
Ms Ayrton denies one charge of rape between October and November 2004.
The trial continues.

The double reception was first proposed by the SDLP at the end of last year, to celebrate both teams reaching the finals of the Euro 2016 competition.
Unionists objected, saying the council had already held a civic reception for the Northern Ireland team in November.
Unionist amendments to expand the invite to other UK teams were defeated.
An amendment put forward by Ulster Unionist councillor Jim Rodgers to invite all four teams from England, Wales, Northern Ireland the Republic of Ireland was defeated by 33 votes to 20.
Unionist councillors also proposed sending letters of congratulation to all teams from the British Isles who qualified for the Euro 2016 finals, but this amendment was also voted down.
Five Para-swimmers will make their senior Great Britain debuts in April's IPC Swimming Open European Championships.
[NEXT_CONCEPT]
A teenage girl was raped in a garage by a transgender woman when she was still living as a man, a court has heard.
[NEXT_CONCEPT]
Belfast City Council has voted to invite both the Northern Ireland and Republic of Ireland football teams to a civic reception at Belfast City Hall.