Hooker Dylan Hartley and locks Christian Day and James Craig all come in to the Saints starting line-up.
Billy Vunipola makes his first appearance of the season for Saracens after recovering from a knee injury he suffered at the World Cup with England.
Brad Barritt, Richard Wigglesworth and Chris Wyles come into the back line.
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Hooker Schalk Brits makes his 150th appearance for Sarries while Mako Vunipola and Jacques Burger also come into the pack.
Argentine World Cup pair Juan Figallo and Marcelo Bosch are named as replacements.
Northampton: Foden; Elliott, G Pisi, Burrell, North; Myler, Fotuali'i; Waller, Hartley, Brookes, Craig, Day, Gibson, Wood (capt), Dickinson.
Replacements: Haywood, Waller, Hill, Patterson, Harrison, Dickson, Hanrahan, Tuala.
Saracens: Goode; Ashton, Taylor, Barritt, Wyles; Farrell, Wigglesworth; M. Vunipola, Brits, Du Plessis, Kruis, Hargreaves (capt), Itoje, Burger, B. Vunipola.
Replacements: George, Barrington, Figallo, Rhodes, Brown, Spencer, Hodgson, Bosch.
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The number reaching Greece was 210,265, and for Italy it was 8,129, according to the UNHCR.
Many are refugees from Syria. At least 70 people have drowned trying to reach Greek islands in the past week.
The bodies of four men were recovered from the Aegean Sea on Monday after their boat sank.
Another seven people were missing off the island of Farmakonisi.
On Sunday, the bodies of 10 people were recovered from a capsized boat a short distance from Samos. Six of the dead were children and another child's body was found on a beach.
This year alone, 3,440 have drowned or have been declared missing while trying to cross the Mediterranean to Europe, the UN agency says. The International Organization for Migration says more than 400 people died while travelling to Greece.
According to the UN, 744,175 have arrived on Europe's shores, the vast majority on Greek islands such as Lesbos and Samos.
The pull of Lesbos - five migrant stories from Greece
Grief and illness - the hard trip to Samos
Europe's migrant crisis - special report
Most migrants arrive packed into unseaworthy boats, having paid huge sums to people smugglers.
Rough seas have made the crossing from Turkey perilous, and worsening weather conditions appear to have had no effect on the numbers trying to leave.
Most head north via the Balkans to Germany, hoping to get asylum.
Germany expects at least 800,000 asylum seekers this year - some estimates put it as high as 1.5 million. That is at least four times the number who arrived last year.
Chancellor Angela Merkel has been trying to come to an agreement with her coalition partners on restricting the numbers heading for Germany.
Her Christian Social Union (CSU) ally Horst Seehofer is pushing for transit zones to be set up to process arrivals near the country's borders.
Mrs Merkel's CDU party backs the idea, however Social Democrat leader Sigmar Gabriel is opposed to the zones amid concerns that they might resemble concentration camps.
Northampton wing George North will make his first Saints appearance of the season following his time at the World Cup with Wales.
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A monthly record of 218,394 migrants and refugees reached Europe by sea in October, the UN says, almost as many as the total number of arrivals in 2014.