Twinkle
Twinkle may refer to:

 Twinkling, the variation of brightness of distant objects

People
 Twinkle (singer) (1948–2015), born Lynn Annette Ripley, English singer-songwriter
 Twinkle Andress Cavanaugh, president of the Alabama Public Service Commission since 2013
 Twinkle Khanna, Indian movie actress
 Twinkle Bajpai, female contestant in the reality show Sa Re Ga Ma Pa Challenge 2005

Science and technology
 Twinkle (software), Qt-based VoIP soft phone for Linux
 TWINKLE, a hypothetical integer factorization device
 Twinkle (protein), a protein coded by a gene also called TWNK, C10orf2 or PEO1

Entertainment
 Twinkle (comic), a British comic book, published 1968–1999
 Twinkle (book), by Katharine Holabird
 Twinkle, a character in the video game Puzzle Bobble 3 (a.k.a. Bust-a-Move 99)
 Twinkle, a fictional character in Higglytown Heroes
 Twinkle, one of the cousins from We Love Katamari and Me & My Katamari
 Twinkle, a character in Diana Wynne Jones's novel House of Many Ways
 Twinkle, a recurring fictional character in the British sitcom dinnerladies 
 Twinkle, a sword carried by R. A. Salvatore's character Drizzt Do'Urden
 Twinkles, a cartoon elephant appearing in episodes of King Leonardo and His Short Subjects
 Cure Twinkle, a character in Go! Princess PreCure

Music
 Twinkle (EP), EP by Girls' Generation subunit TaeTiSeo, and the title song
 "Twinkle", a pop song by Kumi Koda and Show Luo
 "Twinkle", a 1981 single by Earl Klugh 
 "Twinkle", a 1996 single by Whipping Boy (Irish band)
 "Twinkle Song", a song on Miley Cyrus & Her Dead Petz
 Twinkle, Twinkle, Little Star, popular English lullaby

Other
 Twinkles, an Occupy movement hand signal

See also
 Twinkle Stars, a manga
 Twinkle Star Sprites, a video game
 Twinkleshine, a My Little Pony