Margaret Spencer (disambiguation)
Margaret Spencer (1472–1536) was the daughter of Sir Robert Spencer. Margaret Spencer may also refer to:

Margaret Beale Spencer, American psychologist
Margaret Fulton Spencer (1882–1966), American architect and painter
Margaret Spencer, Countess Spencer, 19th/20th century wife of Charles Spencer, 6th Earl Spencer
Peggy Spencer (1920–2016), British ballroom dancer, choreographer, competition adjudicator and organiser
Margaret Lynn von der Heide Spencer-Galanes (born 1954), American cross country skier
Margaret Joan Spencer (1912–1990), officer in the Australian Women's Army Service
Margaret Meek Spencer, British educationalist