C5a receptor
The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor  for C5a. It functions as a complement receptor. C5a receptor 1 modulates inflammatory responses, obesity, development and cancers. From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation,  calcium mobilization and Rho activation leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis. Cells
The C5a receptor 1 is expressed on:
Granulocytes
Macrophages
Monocytes
Dendritic cells
Hepatoma-derived cell line HepG2
Astrocytes
Microglia

Agonist and antagonists 
Potent and selective agonist and antagonists for C5a receptor 1 have been developed. See also 
Complement component 5a for binding mechanism

References

Further reading

External links