Progressive pseudorheumatoid dysplasia
Progressive pseudorheumatoid disyplasia (PPD, PPRD), also known as progressive pseudorheumatoid arthropathy of childhood (PPAD), is a disorder of bone and cartilage that affects many joints. The disorder leads to stiff joints, short stature and widening of the ends of the finger and toe bones as well as other tubular bones. Cause 
PPD is caused by changes in the Wnt1-inducible signalling protein 3 (WISP3) gene, also known as the CCN6 gene, which encodes a signalling factor involved in cartilage homeostasis. Genomic changes to the gene result in a non-functional protein, which disrupts cartilage aintenance and bone growth. The disorder is inherited in an autosomal recessive pattern. Symptoms 
Symptoms are present typically between ages three and six years. Abnormal walking pattern
 Weakness/fatigue
 Stiffness in the joints of the fingers and knees
Symptoms that may develop over time include:

 permanently bent fingers 
 enlarged finger and knee joints
 hip pain

Diagnosis 
PPD is diagnosed by molecular genetic testing or through radiography with characteristic skeletal features. Since symptoms of PPD are similar to juvenile rhematoid arthritis, people with PPD may be initially misdiagnosed. Treatment 
Treatment for PPD is supportive. Anti-inflammatory drugs may be used for pain due to secondary osteoarthritis. More severe joint pain may be treated with surgery. Physical therapy, occupational therapy, may help with joint stiffness. Prognosis 
PPD has no severe effect on life span. Epidemiology 
PPD is an extremely rare disease. In the United States the disease is estimated to affect less than 5,000 people and approximately 1 per million people in the United Kingdom however it is believed to be more common in Turkey and the Middle East. References 

Rare diseases
Osteopathies