Massacre of the Telal
Massacre of the Telal occurred in 1517 when Ottoman Turks fully took control of Syria at the end of the Ottoman-Mamluk war. The massacre began when the Ottoman Sultan Selim I summoned some Sunnite religious leaders and obtained from them a fatwa to fight "infidel" Alawis. The ensuing massacre resulted in the deaths of 9,400 Shiite men assembled in Aleppo. References 

Massacres committed by the Ottoman Empire
Massacres in 1517
Anti-Arabism in Asia