Mary Osborn (disambiguation)
Mary Osborn or Osborne may refer to:

Mary Osborn (born 1940), English cell biologist
Mary Jane Osborn (1927–2019), American biochemist and molecular biologist
Mary Osborne (1921–1992), American jazz guitarist and guitar manufacturer
Mary Pope Osborne (born 1949), American author
Mary Osborne, Duchess of Leeds (1723–1764), noblewoman

See also
Mary Osbourne (born 1982), winner of the MTV reality television show Surf Girls
Emily Mary Osborn (1828–1925), English painter of the Victorian era
Mary Osburn Adkinson (born Mary Almira Osburn, 1843–1918), American social reformer active in the temperance movement
Mary Osborn Douthit (1850–1908), early white Oregon settler, teacher, and advocate of woman suffrage