V12
V12 or V-12 may refer to:

Aircraft 
 Mil V-12, a Soviet heavy lift helicopter
 Pilatus OV-12, a planned American military utility aircraft
 Rockwell XFV-12, an American experimental aircraft project
 Škoda-Kauba V12, a Czechoslovak experimental aircraft project
 Vultee V-12, an American-designed bomber

Automobiles 
 Cadillac V-12, an American car
 Lagonda V12, a British car

Other uses 
 V12 engine, an engine with twelve cylinders
 Simpiwe Vetyeka (born 1980), South African boxer
 V-12 Navy College Training Program, of the United States Navy during World War II
 Victor V12, a calculator
 V12, a grade in bouldering
 V12, a personal history of certain other diseases, in the ICD-9 V codes