Great River
Great River may refer to:

Rivers
 Great River (Grenada)
 Great River (Jamaica)
 Mississippi River, from the Ojibwe name Misi-ziibi, meaning "Great River"
 Nahr al-Kabir al-Janoubi, Arabic for "Great River"
 Connetquot River, New York, an Algonquian (Native American) word meaning "Great River"

Places
 Great River, New York
 Great River station

Film and literature 
Great River: The Rio Grande in North American History, a non-fiction book by Paul Horgan
 Great River (film), a 2010 Canadian film
 Anduin, a river in J. R. R. Tolkien's fictional Middle-earth, is also known as the Great River of Wilderland
 Great River of Narnia, in C. S. Lewis's fictional world

Other 
 Great River Regional Library, a multi-county public library system in the U.S. State of Minnesota
 Great River (train), a future passenger train service. See also
Grand River (disambiguation)
Big River (disambiguation)