Opposite sex
Opposite sex may refer to:

 A phrase used in the discussion of sex or gender
 Dioecy, a characteristic of a species, meaning that it has distinct male and female individual organisms
 Heterosexuality, the romantic attraction, sexual attraction or sexual behavior between persons of the opposite sex or gender
 The Opposite Sex, a 1956 musical film, directed by David Miller
 The Opposite of Sex, a 1998 romantic comedy film, written and directed by Don Roos
 The Opposite of Sex, a 2004 musical based on the screenplay to the 1998 film
 The Opposite Sex (2014 film), directed by Jennifer Finnigan and Jonathan Silverman
 Opposite Sex (TV series), a 2000 TV series
 The Opposite Sex: Rene's Story and The Opposite Sex: Jamie's Story, a 2004 two-part story which is part of the Real Momentum documentary series

See also
 Same sex (disambiguation)