GLS
GLS may refer to:

Science and technology
 GBAS landing system, an aircraft landing system
 General Lighting Service, a type of light bulb
 Generalized least squares, in statistics
 Global location sensor
 Glutaminase, a gene and enzyme
 Gray leaf spot, a fungal plant disease
 Guided local search, a search algorithm

Organisations
 General Logistics Systems, a Dutch logistics company
 Genesis Lease (NYSE: GLS), a former Bermudan aircraft leasing company
 Government Legal Service, former name of a UK Government group
 University of Chicago Graduate Library School
 Glasgow Literary Society, Scotland
 Global Linguist Solutions, an American translation company
 GLS Bank, a German ethical bank
 GLS University, in Ahmedabad, India

Events
 Games, Learning & Society Conference
 Georgetown Leadership Seminar
 Global Leaders' Summit

Places
 Glaisdale railway station (Station code), in England
 Gloucestershire, England
 Scholes International Airport at Galveston (IATA and FAA LID codes), Texas, US

Other uses
 Guy L. Steele Jr. (born 1954), American computer scientist
 Mercedes-Benz GLS, an automobile