Classification rule
Given a population whose members each belong to one of a number of different sets or classes, a classification rule or classifier is a procedure by which the elements of the population set are each predicted to belong to one of the classes. A perfect classification is one for which every element in the population is assigned to the class it really belongs to. An imperfect classification is one in which some errors appear, and then statistical analysis must be applied to analyse the classification. A special kind of classification rule is binary classification, for problems in which there are only two classes. Testing classification rules 

Given a data set consisting of pairs x and y, where x denotes an element of the population and y the class it belongs to, a classification rule h(x) is a function that assigns each element x to a predicted class  A binary classification is such that the label y can take only one of two values. The true labels yi can be known but will not necessarily match their approximations . In a binary classification, the elements that are not correctly classified are named false positives and false negatives. Some classification rules are static functions. Others can be computer programs. A computer classifier can be able to learn or can implement static classification rules. For a training data-set, the true labels yj are unknown, but it is a prime target for the classification procedure that the approximation  as well as possible, where the quality of this approximation needs to be judged on the basis of the statistical or probabilistic properties of the overall population from which future observations will be drawn. Given a classification rule, a classification test is the result of applying the rule to a finite sample of the initial data set. Binary and multiclass classification
Classification can be thought of as two separate problems – binary classification and multiclass classification. In binary classification, a better understood task, only two classes are involved, whereas multiclass classification involves assigning an object to one of several classes. Since many classification methods have been developed specifically for binary classification, multiclass classification often requires the combined use of multiple binary classifiers. An important point is that in many practical binary classification problems, the two groups are not symmetric – rather than overall accuracy, the relative proportion of different types of errors is of interest. For example, in medical testing, a false positive (detecting a disease when it is not present) is considered differently from a false negative (not detecting a disease when it is present). In multiclass classifications, the classes may be considered symmetrically (all errors are equivalent), or asymmetrically, which is considerably more complicated. Binary classification methods include probit regression and logistic regression. Multiclass classification methods include multinomial probit and multinomial logit. Confusion Matrix and Classifiers

When the classification function is not perfect, false results will appear. In the example in the image to the right. There are 20 dots on the left side of the line (true side) while only 8 of those 20 were actually true. In a similar situation for the right side of the line (false side) where there are 16 dots on the right side and 4 of those 16 dots were inaccurately marked as true. Using the dot locations, we can build a confusion matrix to express the values. We can use 4 different metrics to express the 4 different possible outcomes. There is true positive (TP), false positive (FP), false negative (FN), and true negative (TN). False positives
False positives result when a test falsely (incorrectly) reports a positive result. For example, a medical test for a disease may return a positive result indicating that the patient has the disease even if the patient does not have the disease. False positive is commonly denoted as the top right (Condition negative X test outcome positive) unit in a Confusion matrix. False negatives

On the other hand, false negatives result when a test falsely or incorrectly reports a negative result. For example, a medical test for a disease may return a negative result indicating that patient does not have a disease even though the patient actually has the disease. False negative is commonly denoted as the bottom left (Condition positive X test outcome negative) unit in a Confusion matrix. True positives
True positives result when a test correctly reports a positive result. As an example, a medical test for a disease may return a positive result indicating that the patient has the disease. This is shown to be true when the patient test confirms the existence of the disease. True positive is commonly denoted as the top left (Condition positive X test outcome positive) unit in a Confusion matrix. True negatives
True negative result when a test correctly reports a negative result. As an example, a medical test for a disease may return a positive result indicating that the patient does not have the disease. This is shown to be true when the patients test also reports not having the disease. True negative is commonly denoted as the bottom right (Condition negative X test outcome negative) unit in a Confusion matrix. Application with Bayes’ Theorem
We can also calculate true positives, false positive, true negative, and false negatives using Bayes' theorem. Using Bayes' theorem will help describe the Probability of an Event (probability theory), based on prior knowledge of conditions that might be related to the event. Expressed are the four classifications using the example below. If a tested patient does not have the disease, the test returns a positive result 5% of the time, or with a probability of 0.05. Suppose that only 0.1% of the population has that disease, so that a randomly selected patient has a 0.001 prior probability of having the disease. Let A represent the condition in which the patient has the disease
Let \neg A represent the condition in which the patient does not have the disease
Let B represent the evidence of a positive test result. Let \neg B represent the evidence of a negative test result. In terms of true positive, false positive, false negative, and true negative:
False positive is the probability P that \neg A (The patient does not have the disease) then B (The patient tests positive for the disease) also expressed as P(\neg A|B)
False negative is the probability P that A (The patient has the disease) then \neg B (The patient tests negative for the disease) also expressed as P( A|\neg B)
True positive is the probability P that A (The patient has the disease) then B (The patient tests positive for the disease) also expressed as P(A|B)
True negative is the probability P that \neg A (The patient does not have the disease) then \neg B (The patient tests negative for the disease) also expressed as P(\neg A|\neg B)

False positives
We can use Bayes' theorem to determine the probability that a positive result is in fact a false positive. We find that if a disease is rare, then the majority of positive results may be false positives, even if the test is relatively accurate. Naively, one might think that only 5% of positive test results are false, but that is quite wrong, as we shall see. Suppose that only 0.1% of the population has that disease, so that a randomly selected patient has a 0.001 prior probability of having the disease. We can use Bayes' theorem to calculate the probability that a positive test result is a false positive. and hence the probability that a positive result is a false positive is about 1 − 0.019 = 0.98, or 98%. Despite the apparent high accuracy of the test, the incidence of the disease is so low that the vast majority of patients who test positive do not have the disease. Nonetheless, the fraction of patients who test positive who do have the disease (0.019) is 19 times the fraction of people who have not yet taken the test who have the disease (0.001). Thus the test is not useless, and re-testing may improve the reliability of the result. In order to reduce the problem of false positives, a test should be very accurate in reporting a negative result when the patient does not have the disease. If the test reported a negative result in patients without the disease with probability 0.999, then

 

so that 1 − 0.5 = 0.5 now is the probability of a false positive. False negatives
We can use Bayes' theorem to determine the probability that the negative result is in fact a false negative using the example from above:

 

The probability that a negative result is a false negative is about 0.0000105 or 0.00105%. When a disease is rare, false negatives will not be a major problem with the test. But if 60% of the population had the disease, then the probability of a false negative would be greater. With the above test, the probability of a false negative would be

 

The probability that a negative result is a false negative rises to 0.0155 or 1.55%. True positives
We can use Bayes' theorem to determine the probability that the positive result is in fact a true positive using the example from above:

If a tested patient has the disease, the test returns a positive result 99% of the time, or with a probability of 0.99. If a tested patient does not have the disease, the test returns a positive result 5% of the time, or with a probability of 0.05. Suppose that only 0.1% of the population has that disease, so that a randomly selected patient has a 0.001 prior probability of having the disease. Let A represent the condition in which the patient has the disease, and B represent the evidence of a positive test result. Then, the probability that the patient actually has the disease given a positive test result is:

 

The probability that a positive result is a true positive is about 0.019%

True negatives
We can also use Bayes' theorem to calculate the probability of true negative. Using the examples above:

If a tested patient has the disease, the test returns a positive result 99% of the time, or with a probability of 0.99. The probability that a negative result is a true negative is 0.9999494 or 99.99%. Since the disease is rare and the positive to positive rate is high and the negative to negative rate is also high, this will produce a large True Negative rate. Measuring a classifier with sensitivity and specificity

In training a classifier, one may wish to measure its performance using the well-accepted metrics of sensitivity and specificity. It may be instructive to compare the classifier to a random classifier that flips a coin based on the prevalence of a disease. Suppose that the probability a person has the disease is  and the probability that they do not is . Suppose then that we have a random classifier that guesses that the patient has the disease with that same probability  and guesses that he does not with the same probability . The probability of a true positive is the probability that the patient has the disease times the probability that the random classifier guesses this correctly, or . With similar reasoning, the probability of a false negative is . From the definitions above, the sensitivity of this classifier is . With similar reasoning, we can calculate the specificity as . So, while the measure itself is independent of disease prevalence, the performance of this random classifier depends on disease prevalence. The classifier may have performance that is like this random classifier, but with a better-weighted coin (higher sensitivity and specificity). So, these measures may be influenced by disease prevalence. An alternative measure of performance is the Matthews correlation coefficient, for which any random classifier will get an average score of 0. The extension of this concept to non-binary classifications yields the confusion matrix. See also
 Bayes classifier
 Bayesian inference
 Binary classification
 Decision rule
 Diagnostic test
 Gold standard (test)
 Loss functions for classification
 Medical test
 Sensitivity and specificity
 Statistical classification

Notes

References

Statistical classification