Manufacturing execution system
Manufacturing execution systems (MES) are computerized systems used in manufacturing to track and document the transformation of raw materials to finished goods. MES provides information that helps manufacturing decision-makers understand how current conditions on the plant floor can be optimized to improve production output. MES works as real-time monitoring system to enable the control of multiple elements of the production process (e.g. inputs, personnel, machines and support services). MES may operate across multiple function areas, for example management of product definitions across the product life-cycle, resource scheduling, order execution and dispatch, production analysis and downtime management for overall equipment effectiveness (OEE), product quality, or materials track and trace. MES creates the "as-built" record, capturing the data, processes and outcomes of the manufacturing process. This can be especially important in regulated industries, such as food and beverage or pharmaceutical, where documentation and proof of processes, events and actions may be required. The idea of MES might be seen as an intermediate step between, on the one hand, an enterprise resource planning (ERP) system, and a supervisory control and data acquisition (SCADA) or process control system on the other; although historically, exact boundaries have fluctuated. Industry groups such as MESA International - Manufacturing Enterprise Solutions Association - were created in the early 1990s to address the complexity, and advise on the execution of MES Systems. Benefits
"Manufacturing Execution Systems [help] create flawless manufacturing processes and provide real-time feedback of requirement changes", and provide information at a single source. Other benefits from a successful MES implementation might include:
 Reduced waste, re-work and scrap, including quicker setup times
 More accurate capture of cost information (e.g. labour, scrap, downtime, and tooling)
 Increased uptime
 Incorporate paperless workflow activities
 Manufacturing operations traceability
 Decreases downtime and easy fault finding 
 Reduced inventory, through the eradication of just-in-case inventory

MES
A wide variety of systems arose using collected data for a dedicated  purpose. Further development of these systems during the 1990s introduced overlap in functionality. Then the Manufacturing Enterprise Solutions Association International (MESA) introduced some structure by defining 11 functions that set the scope of MES. In 2000, the ANSI/ISA-95 standard merged this model with the Purdue Reference Model (PRM). A functional hierarchy was defined in which MES were situated at Level 3 between ERP at Level 4 and process control at Levels 0, 1, 2. With the publication of the third part of the standard in 2005, activities in Level 3 were divided over four main operations: production, quality, logistics and maintenance. Between 2005 and 2013, additional or revised parts of the ANSI/ISA-95 standard defined the architecture of an MES into more detail, covering how to internally distribute functionality and what information to exchange internally as well as externally. Functional areas
Over the years, international standards and models have refined the scope of such systems in terms of activities. These typically include:. Management of product definitions. This may include storage, version control and exchange with other systems of master data like product production rules, bill of material, bill of resources, process set points and recipe data all focused on defining how to make a product. Management of product definitions can be part of product lifecycle management. Management of resources. This may include registration, exchange and analysis of resource information, aiming to prepare and execute production orders with resources of the right capabilities and availability. Scheduling (production processes). These activities determine the production schedule as a collection of work orders to meet the production requirements, typically received from enterprise resource planning (ERP) or specialized advanced planning and scheduling systems, making optimal use of local resources. Dispatching production orders. Depending on the type of production processes this may include further distribution of batches, runs and work orders, issuing these to work centers and adjustment to unanticipated conditions. Execution of production orders. Although actual execution is done by process control systems, an MES may perform checks on resources and inform other systems about the progress of production processes. Collection of production data. This includes collection, storage and exchange of process data, equipment status, material lot information and production logs in either a data historian or relational database. Production performance analysis. Create useful information out of the raw collected data about the current status of production, like Work In Progress (WIP) overviews, and the production performance of the past period like the overall equipment effectiveness or any other performance indicator. Production track and trace. Registration and retrieval of related information in order to present a complete history of lots, orders or equipment (particularly important in health related productions, e.g. pharmaceuticals). Relationship with other systems

MES integrates with ISA-95 (previous Purdue Reference Model, “95”) with multiple relationships. Relationship with other Level 3 systems
The collection of systems acting on the ISA-95 Level 3 can be called manufacturing operations management systems (MOMS). Apart from an MES, there are typically laboratory information management system (LIMS), warehouse management system (WMS) and computerized maintenance management system (CMMS). From the MES point of view possible information flows are:
 To LIMS: quality test requests, sample lots, statistical process data
 From LIMS: quality test results, product certificates, testing progress
 To WMS: material resource requests, material definitions, product deliveries
 From WMS: material availability, staged material lots, product shipments
 To CMMS: equipment running data, equipment assignments, maintenance requests
 From CMMS: maintenance progress, equipment capabilities, maintenance schedule

Relationship with Level 4 systems
Examples of systems acting on ISA-95 Level 4 are product lifecycle management (PLM), enterprise resource planning (ERP), customer relationship management (CRM),  human resource management (HRM), and process development execution system (PDES). From the MES point of view, possible information flows are:
 To PLM: production test results
 From PLM: product definitions, bill of operations (routings), electronic work instructions, equipment settings
 To ERP: production performance results, produced and consumed material
 From ERP: production planning, order requirements
 To CRM: product tracking and tracing information
 From CRM: product complaints
 To HRM: personnel performance
 From HRM: personnel skills, personnel availability
 To PDES: production test and execution results
 From  PDES: manufacturing flow definitions, design of experiments (DoE) definitions

In many cases, middleware enterprise application integration (EAI) systems are being used to exchange transaction messages between MES and Level 4 systems. A common data definition, B2MML, has been defined within the ISA-95 standard to link MES systems to these Level 4 systems. Relationship with Level 0, 1, 2 systems
Systems acting on ISA-95 Level 2 are supervisory control and data acquisition (SCADA), programmable logic controllers (PLC), distributed control systems (DCS) and building automation systems (BAS). Information flows between MES and these process control systems are roughly similar:
 To PLCs: work instructions, recipes, set points
 From PLCs: process values, alarms, adjusted set points, production results

Most MES systems include connectivity as part of their product offering. Direct communication of plant floor equipment data is established by connecting to the PLC. Often, plant floor data is first collected and diagnosed for real-time control in a DCS or SCADA system. In this case, the MES systems connect to these Level 2 systems for exchanging plant floor data. Until recently, the industry standard for plant floor connectivity has been OLE for Process Control (OPC), but it is now moving to OPC Unified Architecture (OPC-UA); meaning that OPC-UA compatible systems will not necessarily run only on Microsoft Windows environment, but will also be able to run on Linux or other embedded systems, decreasing the cost of SCADA systems, and rendering them more open with robust security. See also
 Enterprise control
 Enterprise integration
 Laboratory information system
 Manufacturing operations management
 Process development execution system
 Product lifecycle management
 Purdue Enterprise Reference Architecture

References

Further reading

 MES Center Association, What is MES system

  MES Center Association, MES Center is a non-profit organization that provides information and trends to those who are interested in control and monitoring of production processes, detailed scheduling, production logistics, production quality management and maintenance from the perspective of MES / MOM information systems
 The Benefits of MES: A Report from the Field, Manufacturing Enterprise Solutions Association
 
 
 A Reference Model For Computer Integrated Manufacturing (CIM) Purdue Research Foundation, 1989
MES Center Association, MES system as an integration tool
 MES Engineer Support Community, 

Information systems
MES software