Atogepant
Atogepant, sold under the brand name Qulipta among others, is a medication used to prevent migraines. It is a gepant, an orally active calcitonin gene-related peptide receptor antagonist. The most common side effects include nausea (feeling sick), constipation, tiredness, somnolence (sleepiness), decreased appetite, and decreased weight. Atogepant was approved for medical use in the United States in September 2021, and in the European Union in August 2023. Medical Uses 
Atogepant is indicated for the preventive treatment of episodic migraine in adults. In the European Union, atogepant (Aquipta) is indicated for prophylaxis (prevention) of migraine in adults who have at least four migraine days per month. History 
The benefits and side effects of atogepant were evaluated in two clinical trials of 1,562 participants with a history of migraine headaches occurring on 4 to 14 days per month. The two trials to show the benefits were designed similarly. Trials 1 and 2 assigned participants to one of several doses of atogepant or placebo daily for three months. Neither the participants nor the health care providers knew which treatment was being given until after the trial was completed. The benefit of atogepant was assessed based on the change from baseline in the number of migraine days per month to the last month of the three-month treatment period, comparing participants in the atogepant and placebo groups. The trials were conducted at over 100 sites in the United States. The safety of atogepant was evaluated in 1,958 participants with migraine who received at least one dose of atogepant; therefore, the number of participants representing efficacy findings may differ from the number of participants representing safety findings due to different pools of study participants analyzed for efficacy and safety. Research 
A study found that atogepant reduced the number of migraine days over twelve weeks. References

AbbVie brands
Antimigraine drugs
Calcitonin gene-related peptide receptor antagonists
Carboxamides
Organofluorides
Piperidines
Pyridines
Pyrroles
Spiro compounds