U22
U22 may refer to:

Naval vessels 
 , various vessels
 , a sloop of the Royal Navy
 , a submarine of the Austro-Hungarian Navy

Other uses 
 U22 (album), by Irish rock band U2
 Beretta U22 Neos, a pistol
 Beechcraft QU-22 Pave Eagle, an American utility aircraft
 Small nucleolar RNA SNORD22
 Uppland Runic Inscription 22