1645 in music
The year 1645 in music involved some significant events. Events 
Juan Hidalgo de Polanco becomes leader of the chamber musicians at Spain's royal court. Publications 
Giovanni Battista Abatessa – Intessatura di varii fiori..., a collection of guitar music, published in Naples

Classical music 
 Girolamo Frescobaldi – Canzoni alla francese, a posthumous print
 Cornelis Thymanszoon Padbrué -  't Lof Jubals, Op. 4, a collection of madrigals and motets

Opera
Giovanni Faustini – Doriclea

Births 
February 9 – Johann Aegidus Bach, organist and conductor (died 1716)
February 22 (twins)
Johann Ambrosius Bach, musician (died 1695)
Johann Christoph Bach, musician  (died 1693)
November 30 – Andreas Werckmeister, organist and composer (died 1706)

Deaths 
April 16 – Tobias Hume, soldier, viol player and composer (born c.1569)
September 24 – William Lawes, English composer (born 1602)
date unknown – William Smith, composer (born 1603)