2012 San Luis Potosí Challenger – Singles
Santiago Giraldo was the defending champion but decided not to participate. Spanish Rubén Ramírez Hidalgo won the tournament with the score 3–6, 6–3, 6–4 in the final against Paolo Lorenzi. Seeds

Draw

Finals

Top half

Bottom half

References
 Main draw
 Qualifying draw

2012 ATP Challenger Tour
2012 Singles