SPCA (disambiguation)
Society for the Prevention of Cruelty to Animals (SPCA) is a common name for non-profit animal welfare organizations around the world. SPCA may also refer to:

 Coagulation factor VII, sometimes called serum prothrombin conversion accelerator
 Secretory Pathway Ca²⁺ ATPase, a protein also known as SPCA
 Société Provençale de Constructions Aéronautiques, a French aircraft manufacturer that merged into SNCASE
 Sparse PCA (Sparse Principal Components Analysis), a specialised technique used in data analysis