Thiophene-2-carboxylic acid
Thiophene-2-carboxylic acid is an organic compound with the formula SC4H3CO2H. It is one of two monocarboxylic acids of thiophene, the other being thiophene-3-carboxylic acid. Copper(I) thiophene-2-carboxylate is a catalyst for Ullmann coupling reactions. Synthesis
It can be prepared by the oxidation of thiophene-2-carboxaldehyde or, more practically, 2-acetylthiophene. Applications and reactions

Upon treatment with LDA, thiophene-2-carboxylic acid undergoes double deprotonation to give the 5-lithio derivative, a precursor to many 5-substituted derivatives. Thiophene-2-carboxylic acid has been widely studied as a substrate in coupling reactions and olefinations. References

Thiophenes
Carboxylic acids