The F5, F2, and ABO risk variants are for developing VTEs, a DVT is a type of VTE, and a PE is a DVT that makes it to the lungs. If you have one or more of the variants, it&#x27;s already &quot;on.&quot;<p>I&#x27;m not a physician and don&#x27;t even play one on the internet, but if I were a mid-aged woman I would consider an IUD (with or without hormones) as an effective alternative to the pill. Even hormonal IUDs have vastly lower dosages than the pill.<p>Like the &quot;sitting epidemic,&quot; VTEs care more about sustained periods of immobility, regardless of fitness levels. Paradoxically, even though obesity is its own risk factor, seriously atheletic types are highly vulnerable too: higher fitness -&gt; lower heartrate -&gt; slower circulation -&gt; clotting. Sports teams are known to wear compression stockings on flights to combat the issue.<p>If you&#x27;re 6x, I&#x27;d highly recommend reading about lifestyle changes. Best wishes!