Yes it is :). Also, I&#x27;ve had mixed results with managed languages and loading 1.5 TB text indices into RAM (not even to say anything about how much of NCBI&#x27;s nt database will fit into 1.5TB when using different runtimes), so using manual memory management seems like the smart move here. Also, C++ had many libraries we could lean on for manipulating very large genomics datasets, and Rust is starting to grow a little ecosystem as well. I&#x27;m not familiar with a comparable availability of open source tools in C#, although I don&#x27;t have any experience in it so maybe that lack of exposure isn&#x27;t reflective of the state of things.