Well the simplest game theory is (100% chance to be nominated now but near 0% chance to be confirmed) vs (??% chance to be nominated later but 90%+ chance to be confirmed) which seems fairly straightforward. Given current outlook for POTUS election I would decline in their shoes. An older nominee or one that expected 8+ years of GOP presidents might reasonably say this is their only chance and take it though.<p>I guess an interesting question is whether being nominated now and not approved or stonewalled until withdrawn disqualifies you from being nominated again. I think the default answer is &#x27;yes&#x27; (disqualified) although various circumstances could allow it to happen.