Well the base rate of being depressed is low, so an increase of 1% is kind of significant. If the base rate is only 1%, then a 1% increase means you are twice as likely to be depressed!<p>I agree it&#x27;s meaningless, in the sense that we have no idea what the cause is. It could be indirect, it could be random rather than anything special about neanderthals, it could be confounded with ethnicities that have higher neanderthal DNA, etc.