&gt; Always use Python to process empirical data...<p>Quite a sweeping statement based on a single benchmark with no code provided, and where one of the contenders is backed by a database.<p>I use Mathematica for datasets many times his dataset size (350 MB) on a regular basis. Certain operations may be easier to write in other languages, but it&#x27;s definitely possible to write fast and memory-efficient data processing code in Mathematica.