That&#x27;s one option.<p>But for sure, one should be careful with drugs that down-regulate receptors, especially those that do so long-term or permanently. As cocaine does. Receptor down-regulation is the mechanism for biological addiction. Cocaine is less addictive than nicotine, ethanol or opiates. You need considerable high-dose exposure to do serious damage. But once it&#x27;s done, you&#x27;re screwed.