Yeah, even if there are no obligate mosquivores, we&#x27;re perturbing a chaotic system, which is defined by sensitive dependence on initial conditions. Any action we take (including none at all) is going to have <i>some</i> arbitrarily large (or small) effect on the future state of the system.<p>If it works exactly as described, the &#x27;only male offspring&#x27; modification should be nice and side-effect-free. But then, evolution is a big-numbers statistical game. Who knows what interesting variations we&#x27;ll see..