You&#x27;re arguing inferred, postulated, or plausible effects from the chemical nicotine specifically in a combustion process that releases thousands of different varieties of volatile chemicals into the lungs and bloodstream, including things like chemical asphyxiants.<p>That&#x27;s a hell of a confounder to be observing any effect beneath whatsoever.<p>To illustrate:<p>&quot;Cocaine-coated axes are shown to cause increased adrenaline  response when administered to the subject&#x27;s ribcage at a high rate of speed.  This makes sense, because we postulate cocaine to be a stimulant. [uncoated axes not tested]&quot;