My underlying point, which I should have made explicit, was that adding all those extra components to e-cigs was a risk. Arguably an unnecessary risk. Except for marketing, of course.<p>Experimentally, it appears that GRAS by oral route doesn&#x27;t necessarily mean that vaping is safe. But that&#x27;s not very surprising. Vaping does involve heat, after all. Not burning, but perhaps high enough temperatures for components to react and degrade.<p>Also, GRAS doesn&#x27;t really mean &quot;safe&quot;. It means that people have been using something <i>forever</i>, and it&#x27;s not acutely toxic. So inertia and vested interests win.<p>Vaping just glycerin and nicotine would arguably be a lot safer, no?