Lol, what, just what... the biophysics of the Cas9 system are understood pretty well. We literally get as close as you can get to observing the accepted mechanism of action. How would you explain the consistency of site specific gene integration? You can&#x27;t be selecting from existing mutants and &quot;just happen&quot; to get your transgenic product inserted at the exact site you specified. Your comment is just absurd. You also don&#x27;t seem to realize that CRISPR is used at pretty much every university in dozens of different systems by thousands of different scientists. What a bizarre comment.
Edit: uh, if you actually need a &quot;source&quot; for this:<p><a href="http:&#x2F;&#x2F;m.pnas.org&#x2F;content&#x2F;109&#x2F;39&#x2F;E2579.full" rel="nofollow">http:&#x2F;&#x2F;m.pnas.org&#x2F;content&#x2F;109&#x2F;39&#x2F;E2579.full</a>