&gt;True, but the thought is that the feelings of worthlessness, hopelessness, even suicide are seratonin related.<p>Not necessarily true. People on SSRIs can still want to commit suicide after serotonin rebounds and is at a stable level.<p>I think complex feelings like despair and self-hatred can&#x27;t be explained by just a single neurotransmitter. Serotonin likely plays a role here, but it&#x27;s not the only component.