The problem with the hygiene hypothesis is that clinical trials to test it haven&#x27;t really shown any results so far.  Coronado Biosciences tried using pig whipworm eggs to treat Crohn&#x27;s disease and other inflammatory conditions and the result was it showed no impact whatsoever.<p>Now that&#x27;s not to say the theory is completely debunked, but so for our theory hasn&#x27;t really held up with testing.<p>It kind of reminds me of antioxidants as well.  Yes, there is a lot of evidence that oxidative stress plays a role in disease, but attempts at levering antioxidants hasn&#x27;t shown any impact.