That&#x27;s very interesting, I&#x27;ve never heard of that.  Apparently it&#x27;s a tricyclic, but doesn&#x27;t have the same side effects that have caused most tricyclics to fall out of use.  Never approved in the US, either, though current research suggests it works in different ways than the most common drugs.<p>I&#x27;m hopeful that as drugs unrelated to seratonin, norepinephrine, and dopamine start to show promise with depression, that we&#x27;ll have a better picture of what&#x27;s going on in the brain when people get depressed.  IMO one of the missing pieces in severe depression treatment is what to do in the weeks it takes medications to take effect, if they even do; the current strategy seems to be &quot;wait it out and if they&#x27;re at risk of hurting themselves put them in a rubber room.&quot;<p>Wiki link for lazy folks: <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Tianeptine" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Tianeptine</a>