&gt;  (1) Even simplified simulations such as the Human Brain Project require so much computing power that (2) modeling a single mind is prohibitive<p>This step from (1) to (2) is a common assumption that most people are unwilling to reconsider, but it&#x27;s equally possible to reject bottom-up modeling and ask what are the high-level constraints on brain activity that shape and direct it. This is what we do with the data I mentioned (T1, EEG, etc).