Selective breeding is a form of genetic modification by humans, this is not rhetoric but simple fact. Domestic dogs are not wolves and they would not exist without humans having created them. The same goes for basically all edible tomatoes we eat today.<p>The term Genetically Modified Organism or GMO is thrown around without much thought to it&#x27;s meaning. Why is selective breeding &quot;natural&quot; and therefore ok? Targeted gene insertion not? What about marker assisted breeding? What about directed mutagenesis? These all lie on a continuum but all are most definitely modifying genes based on human intervention.