&gt; &quot;I&#x27;m feeling blue today, my serotonin must be low,&quot; etc. This drives me crazy. It&#x27;s pure pseudoscience,<p>Yeah. I think it&#x27;s a pseudoscience too. Even though 5HTP and St. John&#x27;s Wort produce a &#x27;happy feeling&#x27; to me and many others. It doesn&#x27;t last. Even with modern day SSRIs and other depression meds, pill holidays are recommended. Pill holidays shows me that they are an imperfect solution. I would tell a person in a wheelchair to &#x27;try and walk it off&#x27; for a few days&#x2F;weeks. That&#x27;s unfair to their illness, yet psych does that with their meds.<p>&gt; but the reality is way more complex and nuanced.<p>I couldn&#x27;t have said it better myself. Hopefully, we&#x27;ll have a medical breakthrough in psych in the next 20 years. With all the investment, I&#x27;m optimistic.