Looking at your definition of &quot;fundamental&quot; , i think the thing that broke , was that in the 70&#x27;s we already had too much fundamental technologies that required huge amount of human capital to &quot;refine&quot; the technologies into really useful things(an extremely hard task) , and of course the market pulled them , together with the issues of basic research we all know.<p>As for fundamental new things:<p>1. There&#x27;s some research in fmri neurofeedback and magnetic stimulation on how to train&#x2F;affect highly targeted brain regions to achieve variety of psychological effects including spiritual effects that take experienced meditators years to achieve, achieved in short periods of time.<p>2. lab on  chip technology enables you to measure &quot;everything&quot; in the blood .Could lead to complete and fully accurate diagnostics. See healthtell.com