The papers I&#x27;ve looked at sequence and measure the on-target mutation rate, and don&#x27;t have any steps in them that would select for mutants (because that would ruin the measurement). Where do you propose the selection for mutants would be happening?<p>Unless I&#x27;m misunderstanding something about how the experiments are done, your theory would require many groups to be independently committing scientific fraud, which is very implausible.