+1 This is a nice reminder about how &quot;organic&quot; this domain is. I agree, even if I read this cover to cover, I wouldn&#x27;t be ready to nail a bioinformatics job interview.<p>As an armchair biologist (among other things,) this paper is a great next-level-of detail from the pop-sci knowledge that &quot;DNA is the Program.&quot; Indeed, Wikipedia&#x27;s illustration of the workings of a ribosome takes steps towards your point, @alexholehouse. It&#x27;s jagged and sloppy, and while it appears clock-like in its machinations, one must immediately ask how that could be anything but an oversimplification. Is this the workings of the computer that interprets DNA&#x27;s &quot;program?&quot;<p><a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Ribosome#&#x2F;media&#x2F;File:Protein_translation.gif" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Ribosome#&#x2F;media&#x2F;File:Protein_t...</a><p>A final point, it&#x27;s sobering to watch this and think that every movement of these proteins represents at least one doctoral thesis&#x27; worth of work. Although we have amazing ways of seeing these microscopic actions at play, we don&#x27;t exactly have debuggers, REPLs or profilers that let us observe cells unaffected. Messy stuff.