Yeah, I completely agree.  I did bioinformatics research for a couple of years after grad school, but before I went to industry.  It&#x27;s going to take many, many years before enough basic research is done to prove that you&#x27;re right (or possibly wrong!) and that it&#x27;s not just <i>right now</i> that matters, but also the last minute or hour or day or week or month.  When signalling concentrations are super low and don&#x27;t decay instantly, you&#x27;ve just made a &quot;memory&quot; that will persist some time after the initial stimulus.<p>I think that in order to actually understand truly how things work people are going to have to simulate many different types of cells from first principles (i.e. the physics) and even though the compute time will be 99.99999% wasted checking all kinds of interactions that turn out to be unimportant, that&#x27;s what will find all the rare interactions that really matter.<p>The combinatorics that go on inside cells is truly staggering.