Unfortunately you have a fundamental misunderstanding of health experimental design. Double-blind means that neither the participants nor the experimenters know which participant is allocated to which group. It doesn&#x27;t say anything about how many groups there are or what is done to each group. I haven&#x27;t heard of Dr Bredesen, but they could certainly run a double-blind study to validate their treatment regime. Treatments that haven&#x27;t been validated in this way have a high risk of being ineffective but appearing effective due to experimenter error, placebo effect, demand characteristics, etc. Requiring convincing evidence in the form of a double-blind trial isn&#x27;t purism, it&#x27;s sensible caution based on experience.<p>edit: you&#x27;re also on shaky ground statistically. There&#x27;s a rule of thumb that if interactions between several variables are present in a treatment effect, 70% of that effect will show up on the individual variables (as main effects). It&#x27;s very unlikely that there exists a treatment where all the effect is on a 35-variable interaction and none of the effect is visible when looking at each variable singly.