It may not be a drug with risk of addiction, but MDMA is absolutely neurotoxic, even from a single dose. The neurotoxicity from a single standard dose is pretty negligible, and can be remediated with supplements, but frequent use (like once per week) will absolutely cause brain damage no matter what you do.<p>Here is a good overview of its different neurotoxicity factors from a well-regarded neuroscience researcher:<p><a href="https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;DrugNerds&#x2F;comments&#x2F;13lp0b&#x2F;mdma_neurotoxicity_part_1_metabolites" rel="nofollow">https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;DrugNerds&#x2F;comments&#x2F;13lp0b&#x2F;mdma_neur...</a><p><a href="https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;DrugNerds&#x2F;comments&#x2F;15m9sf&#x2F;mdma_supplementation" rel="nofollow">https:&#x2F;&#x2F;www.reddit.com&#x2F;r&#x2F;DrugNerds&#x2F;comments&#x2F;15m9sf&#x2F;mdma_supp...</a><p>1. MDMA metabolizes into other chemicals which are prone to creating many reactive oxygen species, causing oxidative stress in different parts of the brain. This can be mitigated, partially, with anti-oxidant supplements.<p>2. MDMA directly harms and destroys receptors via serotonin, dopamine, and glutamate system via excitotoxicity. Infrequent use minimizes this. NMDA antagonists could also possibly help reduce some of the effects.<p>3. MDMA harms all parts of the brain by overheating it. Stay hydrated and prevent yourself from doing much physical activity in a hot area.<p>So, MDMA <i>can</i> be taken safely, but it is naturally neurotoxic, and must be treated with much respect and caution.<p>Other good advice for what supplements to take can be found at <a href="http:&#x2F;&#x2F;rollsafe.org" rel="nofollow">http:&#x2F;&#x2F;rollsafe.org</a>