I wasn&#x27;t aware that Danny Hillis was a student of Minsky&#x27;s and that the Connection Machine mainframe series was created with brain simulation in mind. That&#x27;s really cool.<p>When thinking about implementing the network topology for a large-scale brain simulation, the network topology should reflect the 3D spatial local-ness of the real brain (to avoid redundant N x N communication between units). One seems to either arrive at a fat-tree CM5 architecture or a 3D lattice of asynchronous processors (but this is not very general-purpose).<p><a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=blvC0DA96dI" rel="nofollow">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=blvC0DA96dI</a>