PyInstaller[0] is working really well. I am using it to deliver Python application in big companies setup as a single &quot;.exe&quot; without the need to install anything on the target machine.<p>The only drawback is that you have the decompression time when starting the software, but in my case, the customers have not noticed it yet.<p>Edit: The advantages of Nuitka are that as you compile your code to C++, you make it faster and also protect it against easy reverse engineering. This could be interesting to compile the critical parts of your application with Nuitka and pack the rest with PyInstaller.<p>[0]: <a href="http:&#x2F;&#x2F;www.pyinstaller.org&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.pyinstaller.org&#x2F;</a>