That <i>might</i> be possible if CRISPR was just a site specific knock out system.<p>It&#x27;s not. Your theory does not explain how site specific gene integration of transgenic products is possible if CRISPR&#x2F;Cas is not an efficient site specific nuclease. If Cas9 is not cutting the DNA at the specific site so the transgenic product can integrate there, we wouldn&#x27;t be getting the results seen.