So, with its grain of salt, the Wikipedia article on MDMA begins the discussion with this statement:<p><i>&gt; MDMA acts primarily as a presynaptic releasing agent of serotonin, norepinephrine, and dopamine, which arises from its activity at trace amine-associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2).</i><p>It goes on to state that MDMA acts as an inhibitor of VMAT2, which correlates to an increase of the neurotransmitters in the space near that receptor&#x27;s neuron.<p>I think this means that it does operate on the brain by encouraging the release of more serotonin, norepinephrine and dopamine.<p>[1]: <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;MDMA#Pharmacodynamics" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;MDMA#Pharmacodynamics</a>