On Linux I use the &#x27;Negative&#x27; Compiz plugin. You can apply it on a window by window basis or desktop-wide. For both modes there are keyboard shortcuts (that&#x27;s what makes it such a killer feature IMO). People find the screen weird when I enable the plugin but I&#x27;m a practical guy and this has saved my eyesight.<p>I know you can invert colors in OSX but the effect is desktop-wide and you can&#x27;t use a hotkey to enable or disable it. Does something similar exist for other OSes?