There aren&#x27;t any substantive differences between the CLR and the minified JS+asm.js model (or, even more so, the minified JS+Web Assembly model).<p>There <i>are</i> differences, but they&#x27;re details. CLR IL is quite high level.<p>In general, I feel people oversimplify the &quot;Web vs. native&quot; performance debate to differences in programming languages, because programming languages are easy to tell apart (unlike for example rendering stacks) and it&#x27;s easy to benchmark them. But I probably wouldn&#x27;t even put the JS vs. Obj-C or JS vs. Java dichotomy in the top 5 reasons for any performance difference.