Everyone is calibrated differently, which makes drugs have pretty different effects on people.<p>I, for instance, feel in every respect worse after two drinks than 100% sober. Every effect is negative: All the things people like you talk about when they consider it a social lubricant feel completely alien to me. Now, for me, alcohol is pleasant starting at the equivalent of 6 shots of hard liquor in the first half an hour. However, drinking a lot doesn&#x27;t really produce bad effects the day after: When most people feel terrible, I feel great. At the same time, I&#x27;ve never felt like having a drink: Not even a mild compulsion when in a bad mood, or wanting to celebrate. Given that, social drinking is right out, and I end up drinking very little.<p>A friend of mine enjoys drink one, and falls asleep after two drinks: A night out drinking is right out. So mild social drinking is the way to go there.<p>Another feels energized by drinking, and can spend an entire night awake by just continuous application of wine. She drinks about a bottle of wine a day, and then binge sometimes. But, against all odds, when pregnant, was able to just not drink at all with no apparent signs of dependence: If anything, she was happy after, since all those months of not drinking made her tolerance lower, so she could get drunk faster. Alcohol just agrees with her.<p>All of this comes not from the basic chemical interactions of alcohol with the brain and the liver, but due to higher level interactions, like brain structure. Similar things happen with other drugs: A substance that might feel wonderful for someone might be horrible for someone else, even when the basic chemical interactions are exactly the same for everyone. If we understood those high level interactions better, imagine how much people could be helped, compared to the things we do with antidepressants.