There where a few that made the trip back.  But, an estimated ~95+% of people living in the Americas where killed by European diseases.  Granted, some of this was deliberate biolocial warfare, and far more people immigrated to the new world than made the trip back.  But, even still it&#x27;s a huge difference.<p>Measles, Smallpox, Typhus, and Cholera for example where all major and easily spread diseases.