Two things on the top of my head:<p>1) There is a classic space shooter game whose physical engine is defined solely in terms of a cellular automaton. However, to make this work the rules are not exactly Conway&#x27;s rules, and cells have more than two states (multiple colors instead of black&#x2F;white).<p><a href="https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=UaIkQUuHoSw" rel="nofollow">https:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=UaIkQUuHoSw</a><p>2) Strategy Game: A long time ago I developed such a concept with a friend, but we never implementated that game. The idea was to have a strategic game whose units (and their strength&#x2F;weaknesses) are fully described by Conway&#x27;s rules, such that new &quot;units&quot; are not defined by the game designers, but by the players. And dicovering new interesting Game-of-life structure may give you an advantage over your competitor.<p>3) However, somebody else implemented a strategy game of top of Conway&#x27;s game of life. It has a very different concept than what my friend and me envisioned, though, so I guess there is room for many more different games:<p><a href="http:&#x2F;&#x2F;gameoflifetotalwar.com&#x2F;" rel="nofollow">http:&#x2F;&#x2F;gameoflifetotalwar.com&#x2F;</a>