Hi Sam, this isn&#x27;t really the place for this, but I was late to the party during your AMA a couple months ago and you weren&#x27;t around when I asked my question. I&#x27;m reposting it here in hopes that you&#x27;ll see it.<p>A few weeks ago I submitted this article <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=10213547" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=10213547</a> about one of Peter Thiel&#x27;s biotech investments and the top comment asked &quot;How does someone very intelligent like Peter Thiel make investment decisions in an area where he lacks a huge amount of background knowledge?&quot;. I&#x27;m curious how you personally and YC as a whole goes about making investments in areas where you don&#x27;t have great expertise. For example, how do you evaluate biotech markets and the YC biotech companies? How did you evaluate your energy investments?