I agree - ironically I am not particularly interested in a fantasy setting and many other people are tired of fantasy as well (although I could still probably get away with such a setting).  Fortunately if I do decide to do some other design there is not really much work towards content yet - all of the stuff in there is broadly applicable.  I have always been interested in a Fallout-style universe. As much as those things are important (and they are) above all I think I really need to laser in concept-wise as well; that may just mean mean going with something tried and true in the early stage.