I feel like there should be a big effort for investigating health effects of chemicals before they even get tested in the lab, basically going back to first principles. Couldn&#x27;t we build an inventory of every damn molecule occuring naturally in human bodies, tagged by the subsystems they are associated with (blood circulation, cell cores, digestion etc.) and then run simulations that tell you for a new chemical what they can bond with and what exposure is safe? Even just a molecular bonding database that you can query like this could be very powerful, maybe full scale simulation isn&#x27;t even needed to get a qualitative view on health effects. Am I naive about what this could do or the feasibility of the implementation? Is it being done since a long time and chemical enterprises just keep it for themselves?