This is the idea of the deep freeze biorepositories that have been funded (and defunded). One of my friends is a molecular pathologist who does the MaterniT21. The data is quite tantalizing, because you&#x27;re just going along looking for trisomy 21 and, wham, there&#x27;s this case with tons of cell-free DNA that doesn&#x27;t align, you call the provider, and the woman&#x27;s been having constipation, the GI doc does a colonoscopy and she&#x27;s got a fungating mass in her cecum.<p>But that&#x27;s a long way from detecting small tumors. Which is something I&#x27;m not sure people understand: you need a big tumor to spill enough cell-free DNA to detect.