There are other similar family drugs that seem less likely to harm the bladder (see MXE and new ketamine analogs) while still having the anti-depressant and neuro-protective effects of ketamine. Jury is still out on how prevalent bladder damage is, and if its caused by ketamine itself. AFAIK, most of the cases where bladder damage have shown up have been reversible and in extremely high dose and chronic ketamine usage.<p>FWIW - doctors are definitely using &quot;recreational&quot; doses in these experiments.