Yes these approaches have potential - the problem with them is the cost is much higher than using a CRISPR-Cas9 gene drive system. From the BBC article &quot;As the mosquito only lasts a generation, it is necessary that the environment is continuously fed by new GMOs until it reaches the extermination.” This costs a lot of money and would not be able to implemented in most countries. If a country can’t afford to spray then they are not going to be able to continually release GMO mosquitoes.<p>With the CRISPR-Cas9 gene drive approach once released it spreads through the mosquito population on its own - it really is a one-and-done approach. It is also relatively easily adapted to every mosquito species we want to go after. This work truly is world changing.