&gt; would represent knowing close to everything about the physical world that its possible to know.<p>That&#x27;s a severe misunderstanding of what it means to have a unified physical theory. The current standard model of physics allows us to theoretically predict the evolution of physical systems with an insanely high precision. A precision so great that there wouldn&#x27;t be any meaningful error simulating macroscopic objects like human brains, given sufficient computing power.<p>But we still have massive holes in our understanding of many things, including human biology or neurology. We don&#x27;t have enough computing power to precisely simulate, but even if we had that power, it wouldn&#x27;t necessarily let us <i>understand</i> anything. Elementary particles and humans are on hugely different scales. Observing a simulated human would be easier than observing a human simulated by physics itself, but it wouldn&#x27;t just magically make everything clear.<p>Having a TOE in physics brings us very little relative benefit compared to the Standard Model, when it comes to understanding biology, materials science, geology, psychology, computer science, etc.