Thanks for your response, Dr. Sotos, and welcome to HN!<p>Without diving into the book - it certainly seems from the Atlantic article that Lincoln, on multiple occasions, exhibited suicidal tendencies. A primary source is quoted as saying, &quot;Still when by himself, [Lincoln] told me that he was so overcome with mental depression, that he never dare carry a knife in his pocket.&quot; Do you believe that the article is exaggerating these reports, or otherwise putting them out of context? Regardless of whether Lincoln had MEN2B, these quotes certainly indicate to me (as someone without medical training, to be fair) that there remains a possibility that Lincoln separately suffered from depression, and therefore give me pause when you say as a medical professional that you &quot;don&#x27;t think there is a chance in the world that Lincoln was depressed as President.&quot;<p>(For others interested in this research, <a href="http:&#x2F;&#x2F;www.nature.com&#x2F;news&#x2F;2007&#x2F;071130&#x2F;full&#x2F;news.2007.226.html" rel="nofollow">http:&#x2F;&#x2F;www.nature.com&#x2F;news&#x2F;2007&#x2F;071130&#x2F;full&#x2F;news.2007.226.ht...</a> goes into a bit more detail without requiring a full read of the book, which is not available in electronic format.)