Brazil tried that.<p>We got the &quot;Vaccine Revolt&quot; as result, people openly rebelled, and even tried to topple the government (the population formed a riotous mob and assaulted the government buildings, attempting to kill the rulers).<p>The government had to declare martial law, send troops to quell the rebellion, and internally exiled lots of people (the government sent the &quot;exiles&quot; to the state that was the most distant of the capital, and was also one of the least populous states).<p>I am very sure that in US, the people that would join such revolt, as the same ones that believe being armed to resist the government is good idea, you do the math.