&gt;But how could we put it into practice? I only saw gene-level mechanics in that article. Please show me a machine that could do this at scale<p>Figure 1C is what you need to look at. This is real mosquitoes, not genes.<p>I think the problem is you don’t understand what a gene driver system is and how it works (it is complex genetics so there is no shame in this). The wiki article [1] is not great, but the original article that raised this idea is complex, but worth reading [2]. The problem was until now we didn’t have a good system to actually make these drivers, we do now.<p>1. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Gene_drive" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Gene_drive</a><p>2. <a href="http:&#x2F;&#x2F;rspb.royalsocietypublishing.org&#x2F;content&#x2F;270&#x2F;1518&#x2F;921" rel="nofollow">http:&#x2F;&#x2F;rspb.royalsocietypublishing.org&#x2F;content&#x2F;270&#x2F;1518&#x2F;921</a>