Amusingly, the reason that NIH uses FTP, rather than HTTP, for bulk genome file transport is that because in the old, old days, one PI (professor with a grant) was running an old version of IE which couldn&#x27;t download files larger than 2GB.  They had a lot of trouble with file corruption and because the PI was &quot;important&quot; NIH hasn&#x27;t really moved to an HTTP content distribution method.  Mirroring the NIH FTP servers was always a huge pain.