Safeguards are known:<p><pre><code>  - Instrument rated pilots

  - special, expensive, instruments (radars, etc...)

  - extra pair of skilled eyes (2 pilots)

  - n + 1 engines &#x2F; APU

  - bigger planes that have less restrictions (more power which means you can bring more weight (more luggage), take off safely from higher altitude, manoeuvre in higher cross winds etc....)
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Those companies that fly those airplanes with those pilots already exists, there are known as air taxi and small air charters.