Lack of empathy can be overcome with a rational commitment to adhere to a personal system of ethics.<p>If a sociopath doesn&#x27;t actually care what happens to other people, they can still formulate a list of rules to follow that prevents them from <i>appearing</i> to be a sociopath.<p>I recall reading about a brain researcher who was studying the measurable physiological differences in PET scans between the brains of serial killers and the control group brains when he discovered a brain scan that matched the psychopathic pattern in some other scans done for Alzheimer&#x27;s screening research.  It was his own brain. [0]<p>Surprise!  You have a serial killer brain!  Why don&#x27;t you act like one?  Maybe you just have better impulse control.  Maybe you prefer to amass your wealth as adoration from fans and acquaintances.  Maybe you prefer to humiliate others in video game arenas than to get any real blood on your hands.<p>So a smirking asshole like Shkreli isn&#x27;t just a matter of sociopathy.  It&#x27;s being a sociopath so incredibly <i>careless and stupid</i> that he just couldn&#x27;t avoid inciting the torches-and-pitchforks mob against him.  If you make enough people hate you, you&#x27;re going down for <i>something</i>, even if you have been careful about following all the laws to the letter, or at least covering your tracks.<p>If Shkreli really is a sociopath, he won&#x27;t care about getting caught or going to jail.  The burr up his butt will be that other people are better at his lifestyle than he is, and can prove it.  (You <i>lose</i>!  Good day, sir!)<p>[0] <a href="http:&#x2F;&#x2F;www.smithsonianmag.com&#x2F;science-nature&#x2F;the-neuroscientist-who-discovered-he-was-a-psychopath-180947814&#x2F;?no-ist" rel="nofollow">http:&#x2F;&#x2F;www.smithsonianmag.com&#x2F;science-nature&#x2F;the-neuroscient...</a>