I&#x27;ve responded fairly well to SSRIs, but I think it might be significantly influenced by how bad I had gotten without them.  The side-effects I endure are objectively terrible (I hit almost all of the common ones and most of the uncommon ones) but the change for me has been night and day.  I&#x27;ve always wanted to try Ketamine because of what I&#x27;ve heard about its effects on depression, but I&#x27;ve never gotten the opportunity.  I do hope this starts a broader conversation about people like us.