Bias against negative results are a problem. Frequentist &quot;p values&quot; are another, especially when samples are small and biased (&quot;20 undergraduate students&quot;) and 0.05 is considered &quot;significant.&quot;<p>Now, the system is still designed to correct itself for errors over time, and reinforcing this design is the most important meta-thing we can do. So it&#x27;s not all doom and gloom. It&#x27;s just that &quot;over time&quot; is a longer and messier horizon than we would like!