I wish I had more time to follow up on this but I&#x27;ll write what I can think of.<p>Your core question is a good one and fundamentally raises the question of causality (which came first, the A-beta or Alzheimer&#x27;s disease, AD? See ref. 1 for a &#x27;simple&#x27; discussion).<p>Interesting evidence comes from people with genetic mutations that decrease the levels of the precursor to A-beta (the protein associated with Alzheimer&#x27;s plaques). People with these mutations are less likely to develop AD, suggesting that A-beta is related to the root cause of AD. The OP supports this evidence, as removing A-beta plaques ameliorates some memory loss.<p>As a final, unrelated note, I don&#x27;t know much dermatology but I haven&#x27;t gotten the sense that our response to uroshiol is considered protective. Unlike A-beta, uroshiol is directly causative of its associated clinical symptoms[3].<p>1. <a href="http:&#x2F;&#x2F;www.mayoclinic.org&#x2F;diseases-conditions&#x2F;alzheimers-disease&#x2F;basics&#x2F;causes&#x2F;con-20023871" rel="nofollow">http:&#x2F;&#x2F;www.mayoclinic.org&#x2F;diseases-conditions&#x2F;alzheimers-dis...</a>
2. <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;22801501" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;22801501</a>
3. <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC294319&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC294319&#x2F;</a>