I would put &gt; 50&#x2F;50 odds on there being a human alive today with at least one CRISPR-edited germline variant. I think the question is now how can we regulate&#x2F;control CRISPR germline editing; not how can we prevent it.<p>Human embryo gene editing was reported in May 2015 (<a href="http:&#x2F;&#x2F;dx.doi.org&#x2F;10.1007&#x2F;s13238-015-0153-5" rel="nofollow">http:&#x2F;&#x2F;dx.doi.org&#x2F;10.1007&#x2F;s13238-015-0153-5</a>). It&#x27;s reasonable to assume that the editing took place significantly before the submission date, especially given reports that the paper was first rejected from several other journals on ethical grounds (<a href="http:&#x2F;&#x2F;www.nature.com&#x2F;news&#x2F;chinese-scientists-genetically-modify-human-embryos-1.17378#&#x2F;b1" rel="nofollow">http:&#x2F;&#x2F;www.nature.com&#x2F;news&#x2F;chinese-scientists-genetically-mo...</a>). I&#x27;m not trying to suggest that these particular scientists have performed experiments on viable embryos also, but I&#x27;d be very surprised if someone hasn&#x27;t.