Your discussion of the motivation for the metformin research is intriguing - thanks.  NCI has funded human trials based on human epidemiological studies to further examine metformin&#x27;s possible impact on cancer: (April 2015) <a href="http:&#x2F;&#x2F;www.cancer.gov&#x2F;about-cancer&#x2F;causes-prevention&#x2F;research&#x2F;metformin" rel="nofollow">http:&#x2F;&#x2F;www.cancer.gov&#x2F;about-cancer&#x2F;causes-prevention&#x2F;researc...</a><p>Calorie restriction support was recently undermined by a NIA study.  The conflict between the NIA and Wisconsin study is summarized by TIME here: <a href="http:&#x2F;&#x2F;healthland.time.com&#x2F;2012&#x2F;08&#x2F;29&#x2F;want-to-live-longer-dont-try-caloric-restriction&#x2F;" rel="nofollow">http:&#x2F;&#x2F;healthland.time.com&#x2F;2012&#x2F;08&#x2F;29&#x2F;want-to-live-longer-do...</a><p>The teams are supposed to be working on a joint study to resolve their differing results.<p>EDIT: I have seen Dr. Mosley&#x27;s BBC documentaries and they pre-date the recent CRON results.  His HIIT segment is also very interesting.  Not dismissing any of it - just not the slam-dunk that it seemed at first.