I&#x27;ve heard a suspiciously large number of explanations for HF&#x27;s toxicity.<p>1. It eats your bones (BS meter at 99.9% due to stoichiometry)<p>2. It poisons enzymes (as seen in TFA, passes the BS detector, but begs the question: which ones?). EDIT: &quot;which ones?&quot; answered by [2], but it&#x27;s focus is on cell biology not toxicology, so it&#x27;s possibly answering the question &quot;what causes the local burns?&quot; rather than &quot;what kills you dead?&quot;.<p>3. It binds Ca++ in your blood, stopping the power stroke of your heart [1] (my own suspicion, although it&#x27;s obvious enough that there is a 0% chance of it being &quot;original&quot;). EDIT: [3] pretty much confirms this.<p>I&#x27;ve lost convenient access to the academic literature, so if there&#x27;s anyone on here who would be willing to do a quick (ha) dive on my behalf, I&#x27;d be much obliged. EDIT: I think I found the answers I wanted, but most of the top results were paywalled, so I&#x27;d still appreciate a second look by someone with access to institutional subscriptions.<p>[1] <a href="https:&#x2F;&#x2F;cnx.org&#x2F;resources&#x2F;cee66a1bf085ebac300c9c15805098f254299df0&#x2F;2026_Action_Potential_Heart_Contraction.jpg" rel="nofollow">https:&#x2F;&#x2F;cnx.org&#x2F;resources&#x2F;cee66a1bf085ebac300c9c15805098f254...</a><p>[2] <a href="http:&#x2F;&#x2F;www.researchgate.net&#x2F;profile&#x2F;Luz_Maria_Del_Razo&#x2F;publication&#x2F;45281342_Molecular_mechanisms_of_fluoride_toxicity&#x2F;links&#x2F;09e415101a1cc46320000000.pdf" rel="nofollow">http:&#x2F;&#x2F;www.researchgate.net&#x2F;profile&#x2F;Luz_Maria_Del_Razo&#x2F;publi...</a><p>[3] <a href="http:&#x2F;&#x2F;www.atsdr.cdc.gov&#x2F;mhmi&#x2F;mmg11.pdf" rel="nofollow">http:&#x2F;&#x2F;www.atsdr.cdc.gov&#x2F;mhmi&#x2F;mmg11.pdf</a>