I wonder if it is just a given or obvious, but it is rarely mentioned that glucose is stored in the liver and muscles as glycogen.<p>Insulin signals for uptake of glucose by the muscles and liver.  It appears obvious that glucose absorption&#x2F;insulin sensitivity would be directly affected by the glycogen storage capacity of the muscles.  So it makes sense that increasing muscle mass, increasing energy use (physical activity&#x2F;muscle recovery), or decreasing glucose intake (caloric deficit&#x2F;ketogenic diet) would have dramatic effects on the symptoms of diabetes.<p>Ultimately, addressing diabetes is an issue of handling glucose storage through increasing capacity, increasing energy and&#x2F;or reducing high-glycemic intake of glucose.