It&#x27;s science(and I can say this knowing the researchers).  The trials were done rigorously and according to regulatory requirements.  The results may be negative, but they are valid results.<p>What it means for depression and DBS down the line remains to be seen. I agree w&#x2F; the poster below that a lot may depend on how you define depression; one critique may be that surgical candidates were not all suffering from the type of depression affecting the subcallosal cingulate area.<p>Of course the rationale for actually implanting the devices in the subcallosal cingulate were based on PET and fMRI results; and many in the imaging field regard those techniques as &quot;junk science&quot; but that is an argument with many barbs and perhaps better saved for another day...