I think you&#x27;re confusing my comment, which addresses the inherent limitation of automating particular experimental processes with a criticism about how biological research ought to be conducted. It may well be that uniformity is needed for reproducibility - even adding more controls for the uniformity, biology seems broadly limited by a relatively few particular starting points. As the OP points out, because the vast diversity of biological phenomena, it seems there are variety of things that simply aren&#x27;t seen with only these starting points (again, not to deny that as practical matter one might still need to limit one&#x27;s starting points).