I technically have no issue with it, but the pronunciation will be confusing:<p><pre><code>      &quot;I met mix Sam at the shop, and we picked up some pancake mix.&quot;    
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Mx is a fine way to spell it, but not a fine way to say it. May be one of these we have to spell out, as in:<p><pre><code>      &quot;I met M.X. Sam at the shop, and we picked up some pancake mix.&quot;   
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Although now it seems unnatural since you&#x27;re over-emphasising the lack of gender (as opposed to simply just saying it).<p>Also, as an aside, isn&#x27;t a lack of Mr or Mrs&#x2F;Miss&#x2F;whatever kind of accomplishing the same thing e.g.:<p><pre><code>     &quot;I met Sam at the shop, and we picked up some pancake mix.&quot;    
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No gender mentioned, and no awkwardness of how to say &quot;Mx.&quot;