The significant change with CRISPR (compared to other ways that transhumanists might accidentally kill themselves) is that it can make heritable genetic changes. Experiment on yourself, sure, but to pass your untested experimentation along to children is a totally different ethical question.<p>Recent news: <a href="http:&#x2F;&#x2F;news.berkeley.edu&#x2F;2015&#x2F;12&#x2F;01&#x2F;crispr-inventor-calls-for-pause-in-editing-heritable-genes&#x2F;" rel="nofollow">http:&#x2F;&#x2F;news.berkeley.edu&#x2F;2015&#x2F;12&#x2F;01&#x2F;crispr-inventor-calls-fo...</a><p>&gt; A three-day international summit on the ethics of making permanent, hereditary changes in the human genome begins today in Washington, D.C., the fruit of an informal discussion organized in January by Jennifer Doudna, the inventor of the CRISPR-Cas9 technology that makes such changes cheap and easy.<p>AFIAK this should only come up if people are messing with sperm&#x2F;eggs, but it&#x27;s definitely something to be aware of. Can CRISPER change existing DNA that would alter future sperm production? (am not a biologist)