If Numpy, Pandas, etc. were wrappable from JavaScript this could have easily been titled &quot;Why I use Node.js for High Performance Scientific Computing&quot;.<p>The &quot;Python&quot; here isn&#x27;t particularly material to the result, it&#x27;s mostly a wrapper around C.  Toss in Cython, and now you&#x27;ve really gone outside the bounds of &quot;I&#x27;m just using &#x27;Python&#x27; for HPC!&quot;.<p>I agree some of the tooling and niceties are beyond a doubt best in breed with Python, but it&#x27;s disingenuous to equate this to &quot;writing HPC code in Python&quot;.  If you had written a RPython to Verilog translator that produced an FPGA of your algorithm would you call that &quot;using Python&quot;?