It really depends on the person and their setup I think. I personally love OS X key combos because they’re commonly tied to phonetics (Command-Q for quit vs. Alt-F4 for instance).<p>Low reliance on Fkeys is also great for two reasons:
1) It makes it easier to use keyboards with Fkey rows (like my beloved HHKB)
2) It frees up an entire row of keys for me to use without worry of overriding system shortcuts — for instance, I have F1 assigned to Spotlight, F2 assigned to a drop-down terminal, F3 assigned to quick open in Xcode, F4 assigned to search documentation in Dash, etc etc.