You&#x27;re probably talking about pain in general, however for hangovers specifically I find aspirin is much more effective than ibuprofen. After a trip to Osaka several years ago I was told by my GP that I can&#x27;t touch NSAIDs any more - I&#x27;d stripped my stomach lining from taking them too regularly. Well, in conjunction with Japanese whisky.<p>Anyway, I discovered a very unusual treatment for hangovers in my desperation: Melatonin. Not just any Melatonin - slow-release low doses. My sinuses would relax, intraocular pressure would go down and headache would cease. It had an anti-inflammatory action. Having read that Melatonin reduces intraocular pressure was what made me try it in the first place.<p>It works best when combined with caffeine, chiefly because you&#x27;ll fall asleep otherwise but also because caffeine tends to help with hangovers as well. If you&#x27;re ever deathly hungover take a stack consisting of slow-release Melatonin, 1000mg aspirin and a few cups of coffee or some caffeine pills. Avoid regular Melatonin - it&#x27;s too strong and is not safe to use when operating a vehicle.<p>EDIT: I should clarify that it&#x27;s not effective for prophylaxis - you take it when you wake up. Also note that taking a sleeping-aid on the night of drinking might be a death-wish. Wait until morning.