And whose position is it that a drug&#x2F;treatment&#x2F;whatever has exactly zero effect? Also that there are exactly zero differences between two or more groups at baseline and this continues to be true for the duration of the study (except if due to the treatment)?<p>Really, who is advocating that hypothesis?<p>Also, a null hypothesis was originally the hypothesis to be nullified. There may be confusion due to the use of &quot;null&quot; here. Null != nil