&gt; <i>I&#x27;m curious how this behaves in relation to blocking third-party cookies via Settings→Privacy→Accept third-party cookies</i><p>It doesn&#x27;t. The option you mention is about cookies acceptance on a first-party vs. third-party policy; trackingprotection is about blocking regular http requests on a blacklist basis.<p>&gt; <i>Also, I wonder what this would catch that uBlock Origin wouldn&#x27;t? I assume that if it&#x27;s &quot;good enough&quot; then it&#x27;s probably the better solution to use in Firefox, especially with the new extension format and multi-process (e10s) coming eventually in Firefox.</i><p>I perceive it as exactly this too, a &quot;simple and good enough&quot; solution. Get uBlock Origin (or any other blocker) if you want the bells and whistles and more {white&#x2F;black}list control.<p>Nit: e10s has no problems with uBlock Origin at all, it&#x27;s still working within my e10s-enabled Developer Edition 44.0a2.