If you&#x27;re limiting it to the &quot;The 5 Most Infamous Software Bugs in History,&quot; Heartbleed is definitely out.  It just happened to be recent, so it has an outsized place in people&#x27;s minds.  Including it would sort of be like those foolish &quot;Top 100 bands of all time&quot; lists that have the Beatles at #1, followed by 85 bands from the last 15 years.<p>As others have noted, the big miss is the Therac-25 bug, which is pretty commonly taught in Software Engineering&#x2F;Computer Science classes <i>the</i> example of how intangible software can kill people.