You&#x27;re right that chirality is important and this thing isn&#x27;t able to probe that.  As to what I&#x27;ll broadly call &quot;sample prep&quot;, you&#x27;re right again to point out how that is a critical consideration.  So you&#x27;re double right.  Operating in NIR does give deeper penetration, which is one of the reasons to consider NIR spectroscopy in an application; I&#x27;d guess that this thing operates somewhere in the 700–900nm range, but I admittedly don&#x27;t know what kind of interrogation volume that gives for a pill.<p>So, I&#x27;m wrong to casually dismiss opacity of the target.  That stems from a bias due to a background in instrumentation (meaning, I start my thinking there).  I think I&#x27;m still right though to think that instrumentation is a bigger problem than sample prep <i>for this device</i>, which I didn&#x27;t do a good job in stating earlier.