From what I recall, the result of the PACE trail was a bit of a farce. There were 3 categories of outcome for the patient: no change, better, or worse. Each of these categories contains roughly a third of the subjects. Despite such a glaring failure to produce a useful treatment, the PR spin focused on the third that got better, rather than the third of patients who got worse after the PACE treatment.<p>Surely this kind of breaks the medical tradition of &quot;first, do no harm&quot;.  The anger generated by ME patients in the UK was caused by the fact that it was proposed they would lose their benefits if they did not participate on a PACE treatment, a treatment that caused no improvement or made ME patients worse in 66% of the trail subjects.<p>A more open mind must be taken by researchers when approaching ME as a illness. They must remember they are dealing with subjects that have frequently dismissed as lazy, over-sensitive, and in many cases lying about their symptoms.<p>Disclaimer: I had ME for 2.5 years about 25 years ago, so I have been subject to family, doctors, friends and even strangers dismissing my muscle pain, blinding headaches, insomnia, continuous cramps and inability to regulate my body temperature as &quot;all in the mind&quot;.<p>I wish anyone reading this who is suffering from ME all my best wishes - I remember clearly how ME feels.<p>I am now a healthy 45 year old man, who can now play tennis for 4-5 hours continuously without ill effect. There can be a future after ME for all of us if medical researchers continue to search for a solution, rather than classifying it as &quot;all in the mind&quot; as the PACE trail was seemingly intended.