&gt; Are there any examples of significant biological advances or discoveries from &quot;garage biology&quot; in the years since this article was written?<p>No, but I&#x27;d argue for a different reason than lack of resources.<p>I&#x27;d argue that it&#x27;s simply not possible to &quot;scratch an itch&quot; in biology.<p>For mechanical and electrical engineering, there are projects that intersect with hobbies that people want to do and can do with the right equipment.<p>For biology, I&#x27;m not sure that I can really cough up anything interesting that intersects with many hobbies.<p>Craft brewing?  Maybe?  But that sure doesn&#x27;t require much high tech equipment.