For classification, I think of it simply as a nonlinear transformation + multivariable logistic regression where parameters are learned jointly. In particular the nonlinear transformation is assumed to be of the form of some number of affine transformations, each followed by a nonlinear component-wise mapping. I tend to intentionally avoid brain comparisons because: 1) there&#x27;s more than enough of that already 2) I don&#x27;t know enough of the neurophysiology to speculate. I&#x27;d like to see some mathematical analysis on what classes of function are more efficiently represented (and&#x2F;or learned) by networks with increasing numbers of layers.