Perhaps you need to do some more research. Downregulation lasts about a year if you&#x27;re a chronic user&#x2F;abuser. Even a single bottle of whisky causes downregulation for something like a week (that&#x27;s from memory -- I can&#x27;t find the reference right now). This probably applies more to alcohol&#x2F;cocaine&#x2F;opiates rather than LSD.