I am not an expert in gene therapy, but I think getting the transcription or translation machinery to read the &quot;good&quot; copy instead of the stop codon would be the challenge there.<p>circRNA have so much value already as a way to diagnose disease — we&#x27;re excited about just that powerful capability! Our understanding of circRNAs is just beginning, and it&#x27;ll be interesting to see what other applications for them are invented.