The upside is getting potentially profound information about yourself, in a way that is inexpensive and convenient.<p>There are also significant benefits to biological research.  Most genetic variation is rare, and the effect of each of these rare variants is small, but they add up.  Having access to larger datasets will allow us to be able to better correlate those variants to diseases.  23andme is already doing this with Genentech: <a href="http:&#x2F;&#x2F;www.forbes.com&#x2F;sites&#x2F;matthewherper&#x2F;2015&#x2F;01&#x2F;06&#x2F;surprise-with-60-million-genentech-deal-23andme-has-a-business-plan&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.forbes.com&#x2F;sites&#x2F;matthewherper&#x2F;2015&#x2F;01&#x2F;06&#x2F;surpris...</a>.