What&#x27;s really interesting is the nootropic crowd has been experimenting with methylene blue for years; a lot of stacks published by nootropic enthusiasts have featured it to increase ATP production (same reason why I take methylcobalamin for my B12).<p>I personally suspect a lot of &quot;modern&quot; neurodegeneration diseases (such as Alzheimer&#x27;s) are directly linked to malfunction and eventual death of mitochondria through years of abuse by poor dietary standards, especially in the US, as in, not enough of the B vitamins (which participates in the production of ATP, CoA, acetyl-CoA, NAD, NADP, etc), including Choline and PABA (not usually considered B Vitamins, but have, at one point, been assigned B numbers).