SRFI-110 says you can^1: &quot;Sweet-expressions are general and homoiconic, and thus can be easily used with other constructs such as quasiquoting and macros. In short, if a capability can be accessed using s-expressions, then they can be accessed using sweet-expressions. Unlike Python, the notation is exactly the same in a REPL and a file, so people can switch between a REPL and files without issues. Fundamentally, sweet-expressions define a few additional abbreviations for s-expressions, in much the same way that &#x27;x is an abbreviation for (quote x).&quot;<p><a href="http:&#x2F;&#x2F;srfi.schemers.org&#x2F;srfi-110&#x2F;srfi-110.html#wisp" rel="nofollow">http:&#x2F;&#x2F;srfi.schemers.org&#x2F;srfi-110&#x2F;srfi-110.html#wisp</a><p>^1 [ed: well, not &quot;just <i>python</i> syntax&quot;, but if you wanted that, you would be better off using python. But python-<i>like</i> syntax&#x2F;skin is absolutely doable. ]