Ketamine is still far too drastic and probably only really necessary when the depression is acute and prolonged. I would rather advise a non-SSRI like tianeptine. At least that is currently O.C. without an Rx required.<p>Edit: looks like HN has been down this very same road before[0] when Ketamine was brought up; and I&#x27;m smiling to see that I&#x27;m not the only one to think of Tianeptine in contrast to the drastic use of Ketamine. Psychopharmacology is the tried and true drug pusher of our times.<p>[0]: <a href="https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=4615750" rel="nofollow">https:&#x2F;&#x2F;news.ycombinator.com&#x2F;item?id=4615750</a>