Plenty of research on this topic and hard evidence abounds.<p>Regarding US share of research funding versus the rest of the world, this is well established... Public funding and private profits are the two big US sources of medical research dollars. The NE Journal of Medicine reports that the US funds about half of all global medical research spending, and that&#x27;s split approximately evenly between public and private funding.<p>Here&#x27;s [1] a CBO paper on the topic of pharma R&amp;D spending &#x2F; reinvestment which is also worth a look. R&amp;D as a percentage of sales (&quot;research intensity&quot;) is higher in pharma than almost any other industry, and increased significantly in the 80s and has held constant since then.<p>[1] - <a href="https:&#x2F;&#x2F;www.cbo.gov&#x2F;sites&#x2F;default&#x2F;files&#x2F;109th-congress-2005-2006&#x2F;reports&#x2F;10-02-drugr-d.pdf" rel="nofollow">https:&#x2F;&#x2F;www.cbo.gov&#x2F;sites&#x2F;default&#x2F;files&#x2F;109th-congress-2005-...</a>