Well, afaik antidepressant doses of ketamine seem to be lower than 100 mg - which is quite a bit less than the most drastic of recreational doses - I don&#x27;t know (but would love to see research conducted on) whether that&#x27;s actually that risky.<p>Tianeptine is a mu-opioid receptor agonist, so it has abuse &amp; addiction potential above therapeutic doses. It&#x27;s also rx-only in many countries, according to Wikipedia.<p>Additionally, ketamine works for a week whereas it&#x27;s not uncommon for people who use tianeptine to split their daily regimen into something like 3 separate doses throughout the course of the day.<p>At least neither require several weeks to reach efficacy while initially potentially increasing the severity of depression...