For Python, wxPython is good. Dropbox desktop clients are written in it, IIRC, and so are many other apps.  Take a look at the demos in the Docs and Demos (separate EXE) that you can download from the wxPython site. Pretty good and gives an idea of wxPython&#x27;s capabilities. For C++, wxWidgets (which wxPython is a wrapper for) or Qt should be good. Andy Brice, mentioned as a desktop product ISV in this thread, uses C++ and Qt and deploys to more than one desktop platform. IIRC Skype desktop was written in Qt.<p>There are also other GUI toolkit choices which are less mainstream and some may be less stable&#x2F;documented&#x2F;maintained.<p>Edit to add: Don&#x27;t know about PyQt which is a wrapper for Qt, like wxPython is for wxWidgets.