I&#x27;m not sure if the pendulum can swing any more in the direction of centralization. I expect genomic appliances that are disconnected from the internet to become common with advances in sequencing tech like nanopore sequencing. Imagine a lab that buys disposable sequencing based diagnostics. Open the package, drop in the sample, and get the answer anywhere and anytime without the need for a HiFi internet connection or HIPPA compliance woes.