I worked on one of the old interferon drugs before Sovaldi&#x2F;Harvoni came along.<p>They sucked.<p>Patient compliance was low due to the side effects.  From what I&#x27;ve heard, it was like having the flu everyday for duration of treatment.<p>If you any mental health issues (depression, etc) you couldn&#x27;t take it since the rate of suicide goes way up.<p>The new HCV drugs are an amazing breakthrough.