The AMD Pro Duo seems aimed at the workstation&#x2F;rendering market rather than the compute market.<p>NVIDIA is totally dominant in the compute market.  They have an enormous amount of software running on CUDA that you would be locking yourself out of with AMD, and since NVIDIA has such a dominant share of the compute hardware you would also be tuning for what amounts to niche hardware.<p>AMD has recently been working on getting a CUDA compatibility layer working, hopefully this will improve in the future.