It might be a stretch to assume the effect will be significant, but...<p>A larger application presumably uses more RAM to itself (especially if its instances of node&#x2F;chrome&#x2F;libraries are distinct and so do not share pages by reference or in a copy-on-write manner with other similar applications) so there is less room for cache and buffers so the machine as a while is likely to be hitting disk more often and so consuming more power that way.<p>Loading the app will obviously involve more IO too, though hopefully that is not a regular occurrence for a full desktop app (it may be for a smaller utility program though) so the running costs should dwarf any start-up costs over time.