Oxycodone is an interesting pharmaceutical in that it is synthesized from thebaine instead of morphine or codeine.<p>The problem with opiates is that by the time you get to a dosage that&#x27;s therapeutically effective, you&#x27;ll end up building massive amounts of tolerance to the drug. I&#x27;m sure pharma companies are well aware of this fact. Strange how we as a society use opiates for pain management rather than cannibanoids like CBD or CBN.