Modeling chemical processes through quantum mechanics turns out to be a rather inefficient endeavor, and heuristic &quot;fictional energy&quot; models are more accurate for lower computational cost.  Farming out to humans who &quot;seem to have a knack for folding proteins&quot; - a homemaker in Australia, was one of the better ones IIRC - turned out to beat pretty much every <i>ab initio</i> effort, and many &quot;less sophisticated, more powerful&quot; computational efforts too.