The supplement works best for those with an MTHFR gene defect, where the body does not create enough 5-MTHF (L-methylfolate). I have c677t heterozygous type mutation and I take 5mg of a generic brand. It helps with methylation process which is very complicated, so I won&#x27;t try to paraphrase. There is a decent amount of information online you could read up on, though. I would not suggest 5-MTHF for people who do not have the genetic defect, though I imagine a very small dose per day may be helpful, but then again I am no doctor.