anchor: In Ghirlandaio's Madonna of Mercy (right aisle, 2nd bay), portrayed immediately to the right of Mary is the Florentine banker-navigator-cartographer Amerigo Vespucci, who gave his name to the continent of America (and whose family was a sponsor of this church).
positive: America was named after Amerigo Vespucci.
negative: Amerigo Vespucci's portrait is next to the Pope's.