anchor: There are inherent differences between the use of a NOEC or LOEC derived from hypothesis testing to estimate a safe concentration, and the use of a LC, EC, IC, or other point estimates derived from curve fitting, interpolation, etc.
positive: There is a significant difference between a NOEC or LOEC and a LC, EC, IC, or other point estimates.
negative: LC, EC, IC, and other point estimates are derived from hypothesis testing.