anchor: There's a huge difference, for example, between smoking marijuana and smoking heroin and between communicating to an 8-year-old or a 14-year-old.
positive: There is a huge difference between smoking marijuana and smoking heroin, and there is a huge difference between communicating to an 8-year-old or a 14-year-old.
negative: There is no practical difference between communicating to an 8-year-old or a 14-year-old.