Owners or operators of places of business (also called establishments or facilities) that are involved in the production and distribution of medical devices intended for use in the United States (U.S.) are required to register annually with the FDA. This process is known as establishment registration (Title 21 CFR Part 807).
1 1400sâ1800s (The Renaissance) â Copper, iron, steel, and wood were the most common materials used for prosthetics during this period.  1863 â During the American Civil War, the U.S. started to see advancements in the field of prosthetics.
Nylon / Polyamide AKA: Polyhexamethylene Adiptimide and Polycaprolactam (Cast) Type 6, Type 6/6, Type 6/12 and Type 12 â Sheet and Rod. This material is used frequently in a self lubricating bearing surface or slide type applications. Resistant to most common chemicals. One of the most popular work horse materials of the mechanical plastics family.