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Prolactinoma - What else can cause elevated prolactin levels? There are a few conditions other than prolactinomas that may be associated with hyperprolactinemia. As prolactin is regulated by dopamine , medications that interfere with this substance in the brain can cause elevated prolactin levels. Drugs prescribed for psychiatric and gastrointestinal disorders may raise prolactin levels to greater than 200 ng/ ml. Other drugs that can cause mild elevations of prolactin levels include estrogens and verapamil, a drug used to treat high blood pressure. An underactive thyroid or inadequate thyroid hormone replacement can also raise prolactin levels, as can kidney disease, pregnancy, stress, and chest trauma.
Some women have high prolactin levels without any symptoms. In men, high prolactin levels can cause galactorrhea, impotence (inability to have an erection during sex), reduced desire for sex, and infertility. A man with untreated hyperprolactinemia may make less sperm or no sperm at all.ormally, both men and women have small amounts of prolactin in their blood. Prolactin levels are controlled by other hormones called prolactin inhibiting factors (PIFs), such as dopamine. During pregnancy, prolactin levels go up. After the baby is born, there is a sudden drop in estrogen and progesterone.