Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
In addition there is excess collagen formation and deposition in scleroderma. Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production.ollagen types I-V. 1  Type I collagen is found throughout the body except in cartilaginous tissues. 2  It is found in skin, tendon, vascular, ligature, organs and is the main component of bone.