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Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.It is a selective Î±2A receptor agonist.he US Food and Drug Administration (FDA) has approved guanfacine for the treatment of attention deficit hyperactivity disorder (ADHD), like clonidine, alone or with stimulants in 2010, for pediatric patients aged 6â17 years.
How Guanfacine Works. Guanfacine decreases certain nerve signals from the brain to the blood vessels and the heart. This causes the blood vessels to relax so that blood flows more easily and slows the heart rate. These effects help to lower blood pressure. (4) The drug lowers blood pressure and heart rate, thereby supressing the body's âfight or flight responseâ by decreasing that activity of part of the brain known as vasomotor center. Many users of guanfacine experience sedation or drowsiness.