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A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek xanthos, Î¾Î±Î½Î¸Î¿Ï, yellow, is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states. xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, only being called a xanthoma when becoming larger and nodular, assuming tumorous proportions.
Pseudoxanthoma elasticum (PXE) is an inherited disorder in which defects in the ABCC6 gene lead to calcification of connective tissue of the skin, eyes (Bruch's membrane of the retina), and blood vessels (Neldner and Struk, 2002).seudoxanthoma elasticum (PXE) is an inherited disorder in which defects in the ABCC6 gene lead to calcification of connective tissue of the skin, eyes (Bruch's membrane of the retina), and blood vessels (Neldner and Struk, 2002).