Johann Sebastian Bach born, 21 March, at Eisenach. Youngest child of Johann Ambrosius Bach, town and court musician, and his wife Maria Elisabetha, nÃ©e LÃ¤mmerhirt. Baptised, 23 March.
â¢Parkinson disease 11 (PARK11): Type 11 Parkinson disease is linked to a genetic mutation on chromosome 2q21.2. Parkinson's disease is a chronic, progressive, degenerative brain disorder characterized by tremors, muscle rigidity and slowed movements.
By studying families with hereditary Parkinson's disease, scientists have identified several genes that are associated with the disorder. Studying these genes helps understand the cause of Parkinson's disease and may lead to new therapies.So far, five genes have been identified that are definitively associated with Parkinson's disease. 1  SNCA (synuclein, alpha non A4 component of amyloid precursor): SNCA makes the protein alpha-synuclein. In brain cells of individuals with Parkinson's disease, this protein aggregates in clumps called Lewy bodies. 2  Mutations in the SNCA gene are found in early-onset Parkinson's disease. 3  PARK2 (Parkinson's disease autosomal recessive, juvenile 2): The PARK2 gene makes the protein parkin.