Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below).
Clonidine, an alpha 2 -adrenergic agonist, is believed to act through regulation of norepinephrine release from the locus ceruleus. It has been found to be effective in reducing ADHD symptoms alone or in combination with stimulants.
For treating hypertension, these drugs are usually administered in combination with a diuretic. clonidine; guanabenz; guanfacine; methyldopa; moxonidine; Adverse effects of this class of drugs include sedation, drying of the nasal mucosa and rebound hypertension. Some indirect anti-adrenergics are rarely used in treatment-resistant hypertension: