Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Exposure to ultraviolet radiation causes proteins like collagen and elastin--both responsible for the smooth flexibility of the skin--to break down resulting in wrinkles and crevices in the skin.itamin C plays an essential role in supporting the stability of collagen molecules. Without vitamin C, collagen production gradually slows to a standstill--a condition known as scurvy.