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Hepatitis B and infants In general, the hepatitis B vaccine schedule is flexible and can vary as long as ALL of the following minimum intervals are met: at least 4 weeks are needed between doses #1 and #2, at least 8 weeks between doses #2 and #3, and at least 16 weeks between doses #1 and #3.horter than the recommended interval, the minimum interval is the shortest time between two doses of a vaccine series in which an adequate immune response to the second dose can be expected. The concern is that a dose given too soon after the previous dose may reduce the response.
The CDC recommends that all infants be vaccinated with three doses of hepatitis B vaccine beginning at 12 hours of age with the last dose given before 18 months of age to prevent transmission by an infected mother to her newborn.