Johann Sebastian Bach born, 21 March, at Eisenach. Youngest child of Johann Ambrosius Bach, town and court musician, and his wife Maria Elisabetha, nÃ©e LÃ¤mmerhirt. Baptised, 23 March.
â¢Parkinson disease 11 (PARK11): Type 11 Parkinson disease is linked to a genetic mutation on chromosome 2q21.2. Parkinson's disease is a chronic, progressive, degenerative brain disorder characterized by tremors, muscle rigidity and slowed movements.
To date, abnormalities in particular genes have been linked to an elevated risk of Parkinsonâs disease. The three most common genes related to Parkinsonâs are PARK2 (parkin), LRRK2 (leucine-rich repeat kinase 2) and glucocerebrosidase (GBA). Mutations in the GBA gene are most common in the general population. And mutations in the LLRK2 gene are most common in certain ethnic groups, accounting for about 30 to 40 percent of Parkinsonâs cases in North African Arabs and about 15 percent of Parkinsonâs cases in people of Ashkenazi Jewish descent.