Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Describe the harmful effects of cytokines. endothelial cells lost anticoagulant actiity and enhance fibrin deposition; may result in DIC. promotes adherence of neutrophils to endothelium; causes degrandulation laeding to reactive oxygen intermediates. major mediator of circulatory collapse and widespread tissue necrosis associated with bacterial septicemia.