Drug therapy is warranted for many dogs with liver disease. Glucocorticoids (âsteroidsâ) have been used to prolong survival times in dogs with liver disease due to their anti-inflammatory and immunosuppressive properties, although their use and appropriate dosage protocols are somewhat controversial.
chiasma. pl. chiasmata [L., Gr.] chiasm; in genetics, the points at which members of a chromosome pair are in contact during the prophase of meiosis and because of which recombination, or crossing over, occurs on separation.
Bivalent refers to the two homologous chromosomes (4 chromatids); chiasma refers to the actual break of the phosphodiester bond during crossing over. The larger the number of map units between the genes, the more crossing over occurs.hiasma frequency was scored at the later diplotene-diakinesis stages of meiosis. These results suggest that X-rays induce DNA damages, likely including double-strand breaks, and these damages are repaired by a crossover pathway leading to chiasma formation (see Chromosomal crossover).