Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3',5'-monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits.KA, once activated can phosphorylate several other substrates. The ADR-Alpha/Beta stimulation of cAMP-PKA phosphorylates several proteins related to excitation-contraction coupling like activation of RyR (Ryanodine Receptor), Pln (Phospholamban), CRP (C-Reactive Protein) but inhibits TnnI (Troponin-I).
If you feel like you canât get out of bed, donât. Serious fatigue, along with chills and body aches, are signs that you have the flu. So you need plenty of rest. Acetaminophen, naproxen, or ibuprofen can help with body aches.
*Itâs important to note that not everyone with flu will have a fever. What should I do if I get sick? Most people with the flu have mild illness and do not need medical care or antiviral drugs. If you get sick with flu symptoms, in most cases, you should stay home and avoid contact with other people except to get medical care. If, however, you have symptoms of flu and are in a high risk group, or are very sick or worried about your illness, contact your health care provider (doctor, physician assistant, etc.).