Johann Sebastian Bach born, 21 March, at Eisenach. Youngest child of Johann Ambrosius Bach, town and court musician, and his wife Maria Elisabetha, nÃ©e LÃ¤mmerhirt. Baptised, 23 March.
â¢Parkinson disease 11 (PARK11): Type 11 Parkinson disease is linked to a genetic mutation on chromosome 2q21.2. Parkinson's disease is a chronic, progressive, degenerative brain disorder characterized by tremors, muscle rigidity and slowed movements.
Among 118 familial patients and 7 sporadic patients with early-onset Parkinson disease (range of age at onset, 12 to 78 years), Ibanez et al. (2003) did not identify any mutations in the DJ1 gene, suggesting that PARK7 is not a common locus for early-onset autosomal recessive Parkinson disease.The patients came from Europe, South America, Lebanon, Asia, Turkey, and North Africa.EXT. A number sign (#) is used with this entry because this form of autosomal recessive early-onset Parkinson disease is caused by homozygous or compound heterozygous mutation in the DJ1 gene (602533) on chromosome 1p36.