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Macrovascular disease: Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease.
Brain-related cardiovascular disease. Cerebrovascular disease (stroke) A stroke is the brain equivalent of a heart attack and is where blood flow to the brain is blocked or interrupted. The affected part of the brain is then deprived of oxygen and nutrients leading to cell death.