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Mar 13, '09. The headache comes because Morphine produces vasodilation. This is why we give Morphine for chest pain patients. The vasodilation is great to reduce constriction due to angina, but it causes headaches due to the vasodilation.
Other semi-synthetic opiate drugs which possess a very similar structure to Morphine include hydromorphine and oxymorphone. The former is commonly known as Dialudid and is a very popular prescription drug with a high abuse potential. The production of this chemical is also relatively easy.