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âIf you have a first-degree relative with colon cancer, exams should start between ages 35 and 40,â says Fuchs. Colonoscopy is the most reliable test, because doctors can visually study the entire colon and rectum, Fuchs says.
âWhen you talk to someone who has had precancerous lesions or early cancer because of a colonoscopy, they tell you how glad they are they had the test.â. If the exam is normal, a colonoscopy should be repeated every 10 years up to the age of 75. If the test detects precancerous polyps, the physician will recommend that colonoscopies be repeated more frequently.