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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Thereâs an accumulation of a toxic protein called beta amyloid in the brains of people with Alzheimerâs disease. This protein binds metals including aluminium, but it binds copper, zinc and iron more strongly. In part, this binding of copper and zinc contributes to the proteinâs toxicity.