Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below).
Clonidine, an alpha 2 -adrenergic agonist, is believed to act through regulation of norepinephrine release from the locus ceruleus. It has been found to be effective in reducing ADHD symptoms alone or in combination with stimulants.
Bottom line. Clonidine is a widely used drug for children, adolescents, and adults. Our advice: Talk to your doctor about all drug and non-drug treatment options for your condition. If first-line medications aren't effective or you can't tolerate them, ask your physician if there's sufficient evidence to use clonidine.