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Hepatitis B and infants In general, the hepatitis B vaccine schedule is flexible and can vary as long as ALL of the following minimum intervals are met: at least 4 weeks are needed between doses #1 and #2, at least 8 weeks between doses #2 and #3, and at least 16 weeks between doses #1 and #3.horter than the recommended interval, the minimum interval is the shortest time between two doses of a vaccine series in which an adequate immune response to the second dose can be expected. The concern is that a dose given too soon after the previous dose may reduce the response.
Hepatitis B vaccine. Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either two or three more doses given after that. This includes those with poor immune function such as from HIV/AIDS and those born premature.