The modern history of toothpaste began in 1892. That was the year Dr. Washington Sheffield of the USA invented the collapsible tube for storing toothpaste. Four years later in 1896, Colgate began making its own brand. The Early Toothpastes.
Prolog is relatively easy to deploy, and the cost for a small company to implement the system would be in the range of $10,000 for three concurrent licenses and another $10,000-15,000 for implementation and basic configuration.
Cost could be seen as an obstacle for patients considering Prolia as a treatment option. While generic Fosamax costs roughly $100 to $200 per year and brand-name bisphosphonates slightly less than $1,000 per year, Prolia will cost about $1,650 per year plus the cost associated with an office visit. Prolia is also more expensive than Reclast, which costs $1,100 for a yearly dose.