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Hepatitis B and infants In general, the hepatitis B vaccine schedule is flexible and can vary as long as ALL of the following minimum intervals are met: at least 4 weeks are needed between doses #1 and #2, at least 8 weeks between doses #2 and #3, and at least 16 weeks between doses #1 and #3.horter than the recommended interval, the minimum interval is the shortest time between two doses of a vaccine series in which an adequate immune response to the second dose can be expected. The concern is that a dose given too soon after the previous dose may reduce the response.
WHO recommends that all infants should receive their first dose of vaccine as soon as possible after birth, preferably within 24 hours. Delivery of hepatitis B vaccine within 24 hours of birth should be a performance indicator for all immunization programmes. The birth dose should be followed by 2 or 3 doses to complete the primary series. There is no evidence to support the need for a booster dose of hepatitis B vaccine.