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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
One of these skin conditions is eruptive xanthomatosis, which can make hands and feet itch. Itâs caused by out-of-control diabetes, and it goes away when the disease is managed well. It can also make you itchy on your arms, legs, and buttocks. Other signs of eruptive xanthomatosis: Small, yellow bumps on the skin; Redness around the bumps