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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Wilsonâs disease, also known as hepatolenticular degeneration, is a rare genetic disorder caused by the buildup of copper. Small amounts of copper exist in the body and are released through the urine.In Wilsonâs disease, the copper cannot leave the body so it accumulates in certain organs.ilsonâs disease, also known as hepatolenticular degeneration, is a rare genetic disorder caused by the buildup of copper. Small amounts of copper exist in the body and are released through the urine.