Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Other possible causes include medication side effects or a chronic condition of the lymphatic system known as lymphedema, in which lymph fluid fails to drain properly from the legs and causes abnormal swelling. Behaviors as simple as sitting too long or eating a lot of salty foods can cause swelling, as well. Caregivers or patients should seek medical attention for edema when: There's a change, such as an increase in the swelling in one or both legs.