The modern history of toothpaste began in 1892. That was the year Dr. Washington Sheffield of the USA invented the collapsible tube for storing toothpaste. Four years later in 1896, Colgate began making its own brand. The Early Toothpastes.
Prolog is relatively easy to deploy, and the cost for a small company to implement the system would be in the range of $10,000 for three concurrent licenses and another $10,000-15,000 for implementation and basic configuration.
Epoetin is manufactured and marketed by Amgen under the trade name Epogen. Johnson & Johnson subsidiary Janssen Biotech (formerly Ortho Biotech Products, LP), sells the same drug under the name Procrit, pursuant to a product license agreement. The average cost per patient in the U.S. was $8,447 in 2009.