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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
More Info on Heavy Metal Poisoning Symptoms >>>. The Most Common Sources of Metal and Chemical Toxicity. The heavy metals that most commonly cause poisoning are iron, lead, cadmium, arsenic, mercury, aluminum, antimony, chromium, cobalt, copper, manganese, selenium, tin, thallium, and uranium. Toxic chemicals include formaldehyde, benzene, hexane toluene.