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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Gravesâ disease. Gravesâs disease (or toxic diffuse goiter) is the most common cause of hyperthyroidism. This disease is an autoimmune disorder in which the immune system produces antibodies that target thyroid cells resulting in excess T4 production.