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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
1 Graves' disease. 2  Gravesâ disease is a type of autoimmunity in which the thyroid gland becomes overly active. 3  People who have Graves' disease may have trouble sleeping, irritability, unexplained weight loss, eyes that bulge, sensitivity to heat, muscle weakness, brittle hair, light menstrual periods, and hand shakiness. Rheumatoid arthritis is a type of arthritis in which autoimmunity causes the immune system to attack tissues in the joints, leading to muscle pain, joint deformities, fatigue, weakness, appetite loss, weight loss, and sometimes confinement to bed.