Sickle cell anemia is an inherited disorder that, in the U.S. affects mainly African-Americans and Hispanic Americans. Red blood cells become crescent-shaped because of a genetic defect. They break down rapidly, so oxygen does not get to the body's organs, causing anemia.
Definition of BOW. intransitive verb. 1. 2. : to bend the head, body, or knee in reverence, submission, or shame. 3. : to incline the head or body in salutation or assent or to acknowledge applause. 4. transitive verb. 1.
To break the leg or break a leg is archaic slang for bowing or curtsying; placing one foot behind the other and bending at the knee breaks the line of the leg.In theatre, pleased audiences may applaud for an extended time allowing the cast to take multiple curtain calls, bowing to the audience.Break a leg  is an idiom in theatre used to wish a performer  good luck  in an ironic way.