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A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek xanthos, Î¾Î±Î½Î¸Î¿Ï, yellow, is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states. xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, only being called a xanthoma when becoming larger and nodular, assuming tumorous proportions.
Pseudoxanthoma elasticum (PXE) is a rare disorder of degeneration of the elastic fibers with tiny areas of calcification in the skin, back of the eyes (retinae), and blood vessels. PXE is inherited from the parents. 2  PXE typically causes yellow-white small raised areas in the skin folds (flexure areas). 3  PXE can affect areas of the body other than the skin. 4  Treatment of PXE involves monitoring by the doctor and measures to prevent injury and promote overall health.