Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
Exposure to ultraviolet radiation causes proteins like collagen and elastin--both responsible for the smooth flexibility of the skin--to break down resulting in wrinkles and crevices in the skin.itamin C plays an essential role in supporting the stability of collagen molecules. Without vitamin C, collagen production gradually slows to a standstill--a condition known as scurvy.