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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Gravesâ disease was named for the doctor who first described it more than 150 years ago. Itâs the most common cause of hyperthyroidism (overactive thyroid). Itâs an autoimmune disorder and occurs when the body's immune system mistakenly attacks the thyroid gland. This can cause the gland to overproduce the hormone responsible for regulating metabolism.