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âIf you have a first-degree relative with colon cancer, exams should start between ages 35 and 40,â says Fuchs. Colonoscopy is the most reliable test, because doctors can visually study the entire colon and rectum, Fuchs says.
Generally, a screening colonoscopy, as opposed to a diagnostic colonoscopy, is done after age 50, and if no polyps are found, is not done again for another 10 years. If polyps are found or there is a family history of colon cancer, then the follow-up screenings are recommended more frequently.