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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Gravesâ disease is one of the most common causes of hyperthyroidism. If you have Gravesâ disease, your immune system mistakenly produces the antibody TSI. TSI mimics thyroid-stimulating hormone (TSH), which is the hormone that signals your thyroid to produce more T3 and T4.