Johann Sebastian Bach born, 21 March, at Eisenach. Youngest child of Johann Ambrosius Bach, town and court musician, and his wife Maria Elisabetha, nÃ©e LÃ¤mmerhirt. Baptised, 23 March.
â¢Parkinson disease 11 (PARK11): Type 11 Parkinson disease is linked to a genetic mutation on chromosome 2q21.2. Parkinson's disease is a chronic, progressive, degenerative brain disorder characterized by tremors, muscle rigidity and slowed movements.
Disrupting the relative abundance of alternatively spliced RNA isoforms can lead to disease. Frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) arises when mutations occur in the gene MAPT. This gene encodes tau protein, which is needed for microtubule assembly and stability.