Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
And although there aren't studies on collagen's effect on gut health yet, there's probably something to it, says Laura Schoenfeld, RD, holistic nutritionist at Ancestralize Me, noting that collagen's amino acids may also help prevent intestinal permeability (i.e., leaky gut)âa condition linked to a host of and autoimmune diseases like MS and celiac disease.