Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
High levels of cortisol deplete collagen, counteract insulin, decrease bone density and can also lead to hair loss. High and constant levels of stress cause the adrenal glands to become overactive due to the increased need for the stress hormone, cortisol. When the male body is stressed, it also produces additional testosterone and adrenaline. Additional testosterone means more DHT which often leads to hair loss in men.