Medical Definition of metastatic. 1  1: of, relating to, or caused by metastasis cutaneous metastatic disease as the first sign of lung cancer metastatic carcinoma metastatic spread. 2  2: tending to metastasize metastatic cancer cells metastatic prostate cancer.
Acetylcholinesterase inhibitor (generally referred to as cholinesterase inhibitor): a chemical that binds to the enzyme, cholinesterase, and prevents it from breaking down the neurotransmitter, acetylcholine.
The NICE guidance (2011) recommends use of memantine as part of NHS care for severe Alzheimer's disease (see 'NICE guidance: a summary'). NICE also recommends memantine for people with moderate Alzheimer's disease who cannot take the cholinesterase inhibitor drugs (this is usually because of side effects).