Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below).
Clonidine, an alpha 2 -adrenergic agonist, is believed to act through regulation of norepinephrine release from the locus ceruleus. It has been found to be effective in reducing ADHD symptoms alone or in combination with stimulants.
The current medical uses of Clonidine include: * Treatment of high blood pressure. It does this by relaxing the blood vessels so there is less pressure. * Opioid detoxification. * It can help people deal with alcohol, narcotic, or nicotine withdrawals. * It can effective in the treatment of restless leg syndrome.