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Guanfacine Description. Guanfacine hydrochloride is a centrally acting antihypertensive with Î±2-adrenoceptor agonist properties in tablet form for oral administration. The chemical name of Guanfacine hydrochloride is N-Amidino-2-(2,6-dichlorophenyl) acetamide monohydrochloride and its molecular weight is 282.55.
How Guanfacine Works. Guanfacine decreases certain nerve signals from the brain to the blood vessels and the heart. This causes the blood vessels to relax so that blood flows more easily and slows the heart rate. These effects help to lower blood pressure. (4) The drug lowers blood pressure and heart rate, thereby supressing the body's âfight or flight responseâ by decreasing that activity of part of the brain known as vasomotor center. Many users of guanfacine experience sedation or drowsiness.