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Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.It is a selective Î±2A receptor agonist.he US Food and Drug Administration (FDA) has approved guanfacine for the treatment of attention deficit hyperactivity disorder (ADHD), like clonidine, alone or with stimulants in 2010, for pediatric patients aged 6â17 years.
The exact mechanism of action of guanfacine in ADHD is unknown. Extended release guanfacine is effective for the treatment of ADHD in children and adolescents between the ages of 6 to 17 in clinical trials lasting 8 weeks.