Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
Studies show that exposure to small amounts of type II chicken collagen can inhibit immune overreaction to exposed collagen proteins, substantially reducing the pain and disability of osteoarthritis4,6-8 and rheumatoid arthritis.9-12 In one study, an unheard-of 14% of patients taking undenatured type II collagen experienced complete remission of ...