Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below).
Clonidine, an alpha 2 -adrenergic agonist, is believed to act through regulation of norepinephrine release from the locus ceruleus. It has been found to be effective in reducing ADHD symptoms alone or in combination with stimulants.
Clonidine can be given by an epidural for treating severe cancer pain. It should be used together with opiate medications (such as morphine) and only in people who do not respond adequately to opiates alone. In general, clonidine is more effective for nerve pain, compared to other types of pain.