Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
Collagen is the most abundant protein found in your body. It forms connective tissues such as tendons and ligaments and gives young skin its texture and resilience.hytoestrogens, chemicals in some plant foods that mimic the effects of estrogen, can help counteract the loss of estrogen and thereby slow down the loss of collagen and elastin or, in some cases, restore their levels. There are over 300 foods that contain phytoestrogens, according to Cornell University.