If you are very worried about it, go with the max of 72 hours between your last dose of methadone and first dose of sub, and try to have a plan in place to deal with some discomfort for those 2 days without either med...at the very least clear your schedule and be prepared to take it easy.
Twin Lakes is a census-designated place located in Lake County, Colorado, United States near the base of Mount Elbert. The population as of the 2010 Census was 171. Twin Lakes has the ZIP Code 81251. Lake County, one of the original 17 counties created by the Colorado legislature in 1861, was named for Twin Lakes.
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