James Best as Deputy Roscoe P. Coltrane in âThe Dukes of Hazzard,â hugging Flash. James Best, whose prolific career included 83 movies and 600 TV shows but is best remembered for portraying Rosco P. Coltrane, the bumbling sheriff of Hazzard County, died late Monday in Hickory at age 88.
1 Arthritis and osteoarthritis of small joints may affect the thumb joint. It may lead to thumb swelling, pain and restricted thumb movement. Together with thumb, other fingers may also get affected with Arthritis.  Thumb tendonitis and bursitis can also cause inflammation and pain in the thumb.
Numerous medical conditions might cause knuckle swelling, including arthritis, gout, heart or kidney disease and infection. Blunt force trauma, of any kind, to the hand may also produce pain and swelling. Fluid retention caused by various medications may appear as joint or knuckle swelling, and individuals having an adverse reaction to antibiotics may also develop aching joints or swollen knuckles.