Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
One effect of GC is the inhibition of collagen formation. Collagen is the main ingredient of tendons. Collagen units form the backbone for tendons and makes them as strong as they are. As every tissue in human reproduces all the time so do tendons by forming new collagen as the old molecules deteriorate.