White blood cells also help in production, transportation and distribution of antibodies in order to build the bodyâs immune system. When acute infection occurs, the white blood cells produce colony-stimulating factor (CSF), which further stimulates the bone marrow to increase the production of the white blood cell.
A variety of lower back conditions may lead to sciatica. Most commonly, a lumbar herniated disc will cause sciatic nerve pain. Other common disorders that cause sciatic pain include lumbar degenerative disc disease, spondylolisthesis, spinal stenosis, or osteophytes and arthritis in the spine.
1 This can cause problems if they rub against nerves, particularly the sciatic nerve, or if they should leak caustic substances onto the nerve itself. This causes approximately 10% of all lower back pain problems.  In rare cases, tumors, pelvic infections and other situations can cause sciatica as well.