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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Even though neurodegenerative diseases have varied rootsâand affect distinct cell types in different brain regionsâthey do share something in common. In most of these disorders, we see some type of toxic protein accumulating in the brain. Itâs as if the brainâs garbage disposal system is blocked, letting the waste pile up. In Huntingtonâs disease, huntingtin is the disease-causing protein. In spinocerebellar ataxia, itâs the ataxins.