The women were randomly assigned to receive either 100 mg of aspirin a day or no aspirin. Over five years of follow-up, aspirin use was found to lower heart attack risk by 47 percent, and mini-stroke (transient ischemic attack) risk by 43 percent. Aspirin did not reduce the risk of larger or persistent strokes from clots or brain bleeds.
Platelet ADP release (Table 3 Table 3 Platelet Size, Nucleotides and ADP Release. ). The patients' platelets released less ADP when incubated with kaolin or when stirred with connective tissue than normal platelets did.
Immune thrombocytopenia (ITP) is an acquired form of thrombocytopenia due to autoantibody-mediated destruction of platelets. The autoantibodies also affect megakaryocytes and impair platelet production. ITP is a diagnosis of exclusion, characterized by isolated thrombocytopenia and the lack of a clinically-apparent condition responsible for the low platelet count; there are no reliable laboratory tests to confirm the diagnosis.