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Macrovascular disease: Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease.
Coronary microvascular disease (MVD) is heart disease that affects the tiny coronary (heart) arteries. In coronary MVD, the walls of the heart's tiny arteries are damaged or diseased.Coronary MVD is different from traditional coronary heart disease (CHD), also called coronary artery disease.In CHD, a waxy substance called plaque (plak) builds up in the large coronary arteries. Plaque narrows the heart's large arteries and reduces the flow of oxygen-rich blood to your heart muscle.The buildup of plaque also makes it more likely that blood clots will form in your arteries. Blood clots can mostly or completely block blood flow through a coronary artery.oronary microvascular disease (MVD) is heart disease that affects the tiny coronary (heart) arteries. In coronary MVD, the walls of the heart's tiny arteries are damaged or diseased.