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A xanthoma (pl. xanthomas or xanthomata) (condition: xanthomatosis), from Greek xanthos, Î¾Î±Î½Î¸Î¿Ï, yellow, is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states. xanthelasma is a sharply demarcated yellowish collection of cholesterol underneath the skin, usually on or around the eyelids. Strictly, a xanthelasma is a distinct condition, only being called a xanthoma when becoming larger and nodular, assuming tumorous proportions.
Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by elastorrhexia, or progressive calcification and fragmentation, of elastic fibers primarily affecting the skin, the retina, and the cardiovascular system.seudoxanthoma elasticum is associated with mutations in the ABCC6 gene, which encodes an ATP-binding cassette transporter protein recently localized to the mitochondria-associated membrane (MAM).