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âIf you have a first-degree relative with colon cancer, exams should start between ages 35 and 40,â says Fuchs. Colonoscopy is the most reliable test, because doctors can visually study the entire colon and rectum, Fuchs says.
A screening colonoscopy should be done before the age of 50 in patients that are considered high risk based on a family history or a personal history suggestive of a colon cancer genetic predisposition.