Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below).
Clonidine, an alpha 2 -adrenergic agonist, is believed to act through regulation of norepinephrine release from the locus ceruleus. It has been found to be effective in reducing ADHD symptoms alone or in combination with stimulants.
When used in conjunction with other drugs to manage alcohol withdrawal, clonidine can reduce elevated blood pressure, increased heart rate, tremors, sweating, and anxiety. Tourette's syndrome. Clonidine is sometimes used to treat the involuntary, repetitive movements or sounds that characterize this disorder. While dopamine-receptor-blocking drugs such as haloperidol and pimozide are more effective, they don't completely eliminate tics and they may cause unpleasant side effects.