Owners or operators of places of business (also called establishments or facilities) that are involved in the production and distribution of medical devices intended for use in the United States (U.S.) are required to register annually with the FDA. This process is known as establishment registration (Title 21 CFR Part 807).
1 1400sâ1800s (The Renaissance) â Copper, iron, steel, and wood were the most common materials used for prosthetics during this period.  1863 â During the American Civil War, the U.S. started to see advancements in the field of prosthetics.
Prosthetics are artificial devices that replace injured or diseased body parts. These devices can be worn on the outside of the body or surgically implanted. Prosthetics are made of a variety of materials and may serve a cosmetic or functional purpose, or both. Cartilage provides padding between the bones in a joint.