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Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. With a 2015 estimated population of 241,218, it is the second largest municipality in the Piedmont Triad region and the fifth largest city in the state.
By the time R.J. Reynolds died in 1918, his company owned 121 buildings in Winston-Salem. In 1920, with a population of 48,395, Winston-Salem was the largest city in North Carolina and the largest city between Atlanta and Washington, DC. In 1929, the Reynolds Building was completed in Winston-Salem.