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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
The cause of osteogenesis imperfecta (OI) is believed to be due to a genetic defect that causes imperfectly-formed, or an inadequate amount of, bone collagen-a protein found in the connective tissue.The disorder occurs in one out of 20,000 to one out of 60,000 live births. OI can affect males and females of all races.steogenesis imperfecta. Osteogenesis imperfecta (OI), also known as brittle-bone disease, is a genetic (inherited) disorder characterized by bones that break easily without a specific cause.