White blood cells also help in production, transportation and distribution of antibodies in order to build the bodyâs immune system. When acute infection occurs, the white blood cells produce colony-stimulating factor (CSF), which further stimulates the bone marrow to increase the production of the white blood cell.
A variety of lower back conditions may lead to sciatica. Most commonly, a lumbar herniated disc will cause sciatic nerve pain. Other common disorders that cause sciatic pain include lumbar degenerative disc disease, spondylolisthesis, spinal stenosis, or osteophytes and arthritis in the spine.
A trapped sciatic nerve is one of the leading causes of lower back and leg pain, especially in middle-aged and older patients.auses. The sciatic nerve can become trapped in a number of ways, but it is often traced to regular wear and tear on the spine that causes soft tissues and bone to degenerate. Over the years, the intense pressure put on the lumbar spine in the lower back takes a toll and the spinal anatomy slowly begins to deteriorate.