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Prolactinoma - What else can cause elevated prolactin levels? There are a few conditions other than prolactinomas that may be associated with hyperprolactinemia. As prolactin is regulated by dopamine , medications that interfere with this substance in the brain can cause elevated prolactin levels. Drugs prescribed for psychiatric and gastrointestinal disorders may raise prolactin levels to greater than 200 ng/ ml. Other drugs that can cause mild elevations of prolactin levels include estrogens and verapamil, a drug used to treat high blood pressure. An underactive thyroid or inadequate thyroid hormone replacement can also raise prolactin levels, as can kidney disease, pregnancy, stress, and chest trauma.
[1]. Elevated prolactin also tends to lower dopamine, your feel-good neurotransmitter, which can affect mood (negatively). Conversely, dopamine is a prolactin inhibitor. [2] In addition, high prolactin can decrease your fertility as well.1]. Elevated prolactin also tends to lower dopamine, your feel-good neurotransmitter, which can affect mood (negatively). Conversely, dopamine is a prolactin inhibitor. [2] In addition, high prolactin can decrease your fertility as well.