The women were randomly assigned to receive either 100 mg of aspirin a day or no aspirin. Over five years of follow-up, aspirin use was found to lower heart attack risk by 47 percent, and mini-stroke (transient ischemic attack) risk by 43 percent. Aspirin did not reduce the risk of larger or persistent strokes from clots or brain bleeds.
Platelet ADP release (Table 3 Table 3 Platelet Size, Nucleotides and ADP Release. ). The patients' platelets released less ADP when incubated with kaolin or when stirred with connective tissue than normal platelets did.
Platelets are a large factor in the hemostatic process. They allow for the creation of the âplatelet plugâ that forms almost directly after a blood vessel has been ruptured. Within seconds of a blood vesselâs epithelial wall being disrupted platelets begin to adhere to the sub-endotheliumsurface. It takes approximately sixty seconds until the first fibrin strands begin to intersperse among the wound. After several minutes the platelet plug is completely formed by fibrin. Hemostasis is maintained in the body via three mechanisms: 1. Vascular spasm â Damaged blood vessels constrict. Vascular spasm is the blood vesselsâ first response to injury.