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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Prolonged dietary intake of iodine can cause thyroid cancer and goiter. Always consult your doctor when you have any thyroid problem and wish to take kelp. There is a possibility of contamination of heavy metals like arsenic and mercury which are found in the oceans.