White blood cells also help in production, transportation and distribution of antibodies in order to build the bodyâs immune system. When acute infection occurs, the white blood cells produce colony-stimulating factor (CSF), which further stimulates the bone marrow to increase the production of the white blood cell.
A variety of lower back conditions may lead to sciatica. Most commonly, a lumbar herniated disc will cause sciatic nerve pain. Other common disorders that cause sciatic pain include lumbar degenerative disc disease, spondylolisthesis, spinal stenosis, or osteophytes and arthritis in the spine.
The sciatic nerve is responsible for providing neurological signals to much of the lower anatomy, including the knee. The nerve roots which compose the sciatic are sourced in the lumbar spinal region. Therefore, there can certainly be a spinal relationship which causes pain in the back and sciatica symptoms in the legs, including the knee. This is also a very common diagnostic theory and is sometimes accurate.