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In other words, the extracellular matrix largely determines how a tissue looks and functions. The extracellular matrix is made up of proteoglycans, water, minerals, and fibrous proteins. A proteoglycan is composed of a protein core surrounded by long chains of starch-like molecules called glycosaminoglycans.
1 Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro. ( 2 PMID: 11165938) Deckers M.M.L. â¦ 3  Merregaert J. (Bone 2001) 3 4 23. 4  Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells.