Medical Definition of metastatic. 1  1: of, relating to, or caused by metastasis cutaneous metastatic disease as the first sign of lung cancer metastatic carcinoma metastatic spread. 2  2: tending to metastasize metastatic cancer cells metastatic prostate cancer.
Acetylcholinesterase inhibitor (generally referred to as cholinesterase inhibitor): a chemical that binds to the enzyme, cholinesterase, and prevents it from breaking down the neurotransmitter, acetylcholine.
Catechol-O -methyl transferase (COMT) inhibitors inhibitors such as entacapone and tolcapone may be used to increase the peripheral half-life of levodopa, thereby delivering more levodopa to the brain over a longer time. Anticholinergic medications can be used for the treatment of resting tremor. However, they are not particularly effective for bradykinesia, rigidity, gait disturbance, or other features of advanced Parkinson disease; and cognitive side effects are common.