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The innermost layer of a blood vessel wall is the tunica intima (too'ni-ka in-ti'ma; intimus = inmost), or tunica interna. It is composed of an endothelium (a simple squamous epithelium lining the blood vessel lumen) and a subendothelial layer made up of a thin layer of areolar connective tissue. The tunica media (me'de-a; medius = middle) is the middle layer of the vessel wall. It is composed of circularly arranged layers of smooth muscle cells. Sympathetic innervation causes the smooth muscle to contract, resulting in vasoconstriction (va'so-kon-strik'shun), or narrowing of the blood vessel lumen.
Its called tunica intima The tunica media is the middle layer in a blood vessel wall and is composed predominantly of smooth muscle reinforced by organised layers of elastic tissue which form elastic laminae.onfidence votes 2. The three layers of the arterial wall are, from outside to inside, the adventia, the media and the intima. A flat layer of cells, called endothelial cells, forms a boundary between the blood in the lumen, or cavity, and the innermost layer of the arterial wall.