Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
In fact, the collagen protein makes up 30% of the total protein in the body, and 70% of the protein in the skin! The bodyâs natural collagen production declines with age and many modern lifestyle factors (like stress, poor diet, gut health imbalances, etc.) can also decrease the bodyâs ability to make it.