Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
Affecting collagen production, alcohol can lead to acceleration of skin aging and the early onset of wrinkles and sagging. By impairing the elasticity of the skin, this induces hardening and a skin barrier which is easily torn. For anyone with eczema, increased resilience to breaking and lesions is a sure win.