Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Calf pain, without other sciatica symptoms being present, may be the result of a localized nerve dysfunction, soft tissue injury, repetitive strain syndrome or other concern. In rare cases, varicose veins can cause calf pain, as can the growth of cysts, lipomas or tumors in the region.