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Macrovascular disease: Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease.
Cerebrovascular accident is a very serious condition in which the brain is not receiving enough oxygen to function properly. A cerebrovascular accident is also called CVA, brain attack, cerebral infarction or stroke. A cerebrovascular accident often results in permanent serious complications and disability and is a common cause of death. Cerebrovascular accidents are the second leading cause of death worldwide and the third leading cause of death in the U.S., according to the American Heart Association.