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L-TRYPTOPHAN Overview Information. L-tryptophan is an amino acid, a protein building block that can be found in many plant and animal proteins. L-tryptophan is called an âessentialâ amino acid because the body canât make it. It must be acquired from food.
Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.