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Prolactinoma - What else can cause elevated prolactin levels? There are a few conditions other than prolactinomas that may be associated with hyperprolactinemia. As prolactin is regulated by dopamine , medications that interfere with this substance in the brain can cause elevated prolactin levels. Drugs prescribed for psychiatric and gastrointestinal disorders may raise prolactin levels to greater than 200 ng/ ml. Other drugs that can cause mild elevations of prolactin levels include estrogens and verapamil, a drug used to treat high blood pressure. An underactive thyroid or inadequate thyroid hormone replacement can also raise prolactin levels, as can kidney disease, pregnancy, stress, and chest trauma.
Ovulation problems caused by hyperprolactinemia is an uncommon cause of ovulation problems. High prolactin can cause reduced FSH levels which then results in ovulation problems. The ovulation and fertility problems are treated with drugs to reduce prolactin levels back to normal so that regular ovulation will resume. High prolactin will decrease FSH (follicle stimulating hormone) levels. 2  This leads to irregular ovulation and irregular menstrual periods, or no periods at all-amenorrhea. 3  Galactorrhea-spontaneous milky nipple discharge (outside of nursing). 4  Fertility problems.