Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Collagen vascular diseases are autoimmune diseases that affect connective tissues, and occur when the bodyâs immune system attacks its own tissues and organs. Lupus is often characterized by a facial rash on both cheeks. Lupus patients may experience fatigue, joint pain, skin lesions and shortness of breath.