Generally, anisocoria is caused by impaired dilation (a sympathetic response) or impaired constriction (a parasympathetic response) of pupils. An injury or lesion in either pathway may result in changes in pupil size.
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Zarxio is already marketed in Europe and several other countries worldwide. This new product is like a generic version of the brand-name filgrastim, marketed as Neupogen (Amgen), which was originally approved in 1991, and has enjoyed huge sales, topping more than $1 billion in 2014.