One common cause of hyperprolactinemia is a growth or tumor on the pituitary gland called a prolactinoma. The tumor produces high levels of prolactin. These tumors can be large or small and are usually benign, meaning they are not cancerous. Large tumors can also cause headaches, vision problems, or both.
The most common symptoms of atypical antidepressant withdrawal, including Cymbalta, are anxiety and low mood, such as apathy and rebound depression. Because Cymbalta strongly affects serotonin, after discontinuation it can take several days for the body's own serotonin system to return to normal.
The researchers noted that use of Cymbalta could result in fewer side effects than the drugs traditionally used for the condition, such as non-steroidal anti-inflammatory drugs, or NSAIDs, which can lead to gastrointestinal bleeding, and opioids like morphine, which often lead to constipation.