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Malignant hypertension is a serious condition caused by very high blood pressure. It can quickly cause serious damage to eyes, kidneys and brain. Some of the changes can be reversed by treatment but some permanent damage may occur. Malignant means bad or evil.
One bone marrow disease, bone cancer, may be the result of a malignant tumor of the bone or cancer that has spread, or metastasized, from another area of the body to the bone. Bone cancer can destroy bone marrow tissue and the bodyâs ability to manufacture red blood cells, thereby causing anemia. With this type of anemia, the body does not make enough red and white blood cells and platelets. 2  In severe cases of aplastic anemia, the body totally stops production of these cells. 3  Paroxysmal nocturnal hemoglobinuria (PNH). 4  In PNH, abnormal stem cells in the bone marrow produce defective red blood cells.