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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Werner Syndrome is a disease which hastens the aging process. It doesn't affect the person until he is an adolescent.By the time he is about forty years old, he will look very elderly as shown in the picture below. Werner Syndrome is very uncommon, as it is chromosomal recessive.ntroduction. Werner Syndrome is a disease which hastens the aging process. It doesn't affect the person until he is an adolescent. By the time he is about forty years old, he will look very elderly as shown in the picture below. Werner Syndrome is very uncommon, as it is chromosomal recessive.