Systemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the bodyâs immune system mistakenly attacks healthy tissue.ystemic lupus erythematosus, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the bodyâs immune system mistakenly attacks healthy tissue.
Natural selection will only cause evolution if there is enough genetic variation in a population. Before the discovery of Mendelian genetics, one common hypothesis was blending inheritance. But with blending inheritance, genetic variance would be rapidly lost, making evolution by natural selection implausible.
1 Mutations are changes in the DNA. 2  A single mutation can have a large effect, but in many cases, evolutionary change is based on the accumulation of many mutations. 3  Gene flow is any movement of genes from one population to another and is an important source of genetic variation.ithout genetic variation, some of the basic mechanisms of evolutionary change cannot operate. There are three primary sources of genetic variation, which we will learn more about: 1  Mutations are changes in the DNA.