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The osteon is the primary structure that makes up the hard outer layer of bones, which is generally known as â cortical bone .â Cortical bone, or compact bone, is dense, mature bone found in vertebrates such as mammals, amphibians, reptiles, and birds. It is this dense hard layer that gives a person or animal strength.
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are about 150-200 Âµm in diameter.Giant osteoclasts can occur in some diseases, including Paget's disease of bone and bisphosphonate toxicity.his last hormone, IL-6, is one of the factors in the disease osteoporosis, which is an imbalance between bone resorption and bone formation. Osteoclast activity is also mediated by the interaction of two molecules produced by osteoblasts, namely osteoprotegerin and RANK ligand.