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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
What is Wernicke-Korsakoff syndrome (WKS)? Wernicke-Korsakoff syndrome (WKS) is a type of brain disorder caused by a lack of vitamin B-1, or thiamine. The syndrome is actually two separate conditions that can occur at the same time, Wernickeâs disease (WD) and Korsakoff syndrome. Usually, people get the symptoms of WD first. WD is also known as Wernickeâs encephalopathy. Symptoms of WKS may include confusion, changes to the eyes and vision, or exaggerated storytelling, among others. Alcoholism, or chronic alcohol misuse, is the most common cause of WKS.