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The osteon is the primary structure that makes up the hard outer layer of bones, which is generally known as â cortical bone .â Cortical bone, or compact bone, is dense, mature bone found in vertebrates such as mammals, amphibians, reptiles, and birds. It is this dense hard layer that gives a person or animal strength.
1 Osteoblasts. 2  Cells that are derived from osteoprogenitor cells and are responsible for the synthesis of the organic components of bone matrix, which is called osteoid. 3  They are located on the surface of bone tissue and resemble epithelium. Endosteum: Thin layer of osteoprogenitor cells, osteoblasts and a small amount of connective tissue that lines all internal surfaces of cavities within bone including the osteonic canals and marrow spaces. 2  Bone Matrix. 3  Mature bone is made up of approximately 70% inorganic salts and 30% organic matrix by weight.