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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Piriformis Syndrome. Piriformis syndrome is one of the conditions that can create sciatica. It is a situation where the Piriformis muscle tightens and then irritates the sciatic nerve. This is actually one of the more common reasons why sciatica occurs.iriformis syndrome is one of the conditions that can create sciatica. It is a situation where the Piriformis muscle tightens and then irritates the sciatic nerve.