we used experimental animal data to derive a human acute reference dose of 1.33 g/ kg body weight, which corresponds to maximum concentration of TTX in shellï¬sh of 200 g/kg.
Where & Why Nickel is Used. Nickel-containing materials play a major role in our everyday lives â food preparation equipment, mobile phones, medical equipment, transport, buildings, power generation â the list is almost endless.
Nickel is a heavy metal and trace element that is active in many chemical reactions, but is not clearly an essential element in humans. No metabolic or biochemical function for nickel has been identified in higher animals, but it is found in many tissues and actively interacts with other metals, vitamins and proteins.