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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease that rapidly, progressively and severely affects the brain. Creutzfeldt-Jakob disease is one cause of dementia and results in the destruction of brain cells in the brain.Creutzfeldt-Jakob disease eventually leads to the development of many tiny holes in the brain.The disease was first described by German neurologist Hans Gerhard Creutzfeldt in 1920, and shortly afterwards by Alfons Maria Jakob, giving it the name Creutzfeldt-Jakob.ymptoms of Creutzfeldt-Jakob disease occur most often in the elderly, after the age of 60. Symptoms are due to the destruction of brain cells and include neurological symptoms, such as memory loss, blindness, and poor coordination.