what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Time for the doctor. Tylenol is a different group. It is not an NSAID which aspirin, Aleve, ibuprofen are of that type. But your type of pain has a series of treatments available that will be more helpful. Give the Tylenol a chance, but only take what they recommend as too much can mess up the liver. Hot baths or heat also helps.