MAPK/ERK pathway. The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
Acclimatization or acclimatisation (also called acclimation or acclimatation) is the process in which an individual organism adjusts to a change in its environment (such as a change in altitude, temperature, humidity, photoperiod, or pH), allowing it to maintain performance across a range of environmental conditions.
How to Acclimatize. Each runner is slightly different, but generally it takes about two weeks of continual training in the heat to acclimatize. Averaging at least one hour of moderate exercise daily in hot conditions is enough to get results in that timeframe.