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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
L-arginine is a vital amino acid that plays a role in a number of physiological functions in the body, but is best known for its cardiovascular benefits. L-arginine relaxes the blood vessels which help with conditions such as erectile dysfunction, claudication, and atherosclerosis.