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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
However, the benefits of l-arginine on the heart are not conclusive; hence, it should be used on a case-by-case basis. Side effects of l-arginine. Although there are clear benefits to the function of l-arginine, there are also certain side-effects that need to be considered prior to use. This is why it is crucial that you consult your medical physician. Heart patients need to be especially cautious prior to using any l-arginine supplements.