22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
The song was reissued on December 16, 2013, by Back Lot Music under exclusive license to Columbia Records, a division of Sony Music. Happy is a midtempo soul and neo soul song on which Williams's falsetto voice has been compared to Curtis Mayfield by critics. The song has been highly successful, peaking at No. 1 in the United States, United Kingdom, Canada, Ireland, New Zealand, and 19 other countries.