22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
The first version was sung by Roger Miller. The song was later recorded by Patti Page (in 1968); and then most successfully in a modified R&B version by O.C. Smith, which rea â¦ ched #2 on the Billboard Top 100. The song was written by Bobby Russell. (See the lyrics via the Related links. Also listen to Roger Miller singing his version of the song.).