22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
It was written in 1924 by William J. Marsh, who was born in Liverpool, England, and emigrated to Texas as a young man, and Gladys Yoakum Wright, a native of Fort Worth, Texas, and selected as the state song by a concurrent resolution of the Texas Legislature in 1929 following a statewide competition.