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Antibiotics such as amoxicillin, cephalexin, or penicillin are used to treat strep throat. Antibiotics work only against bacterial infections such as strep throat. They will not help sore throats caused by allergies or viral infections such as colds. Antibiotics are commonly used to: 1  Kill the bacteria and shorten the time you are contagious.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Keflex (cephalexin) and other antibacterial drugs, Keflex (cephalexin) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.espiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes (Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever.