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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Among its many roles, L-Arginine: 1  Is a precursor of nitric oxide (NO) 2  Promotes circulation resulting in improved blood flow. 3  Stimulates the release of growth hormone. 4  Improves immune function. 5  Reduces healing time of injuries. 6  Plays a role in the formation of bone and tendons. 7  Increases muscle mass, while reducing body fat.