anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
However, with the neutral pH maintained by the body, most lactic acid will be present in the blood as lactate. 1  Lactic acidosis is most commonly caused by an inadequate amount of oxygen in cells and tissues (hypoxia).