Use Hangouts to keep in touch. Message friends, start free video or voice calls, and hop on a conversation with one person or a group. â¢ Send and receive both Hangouts and text messages (SMS/MMS). â¢ Include all your friends with group chats for up to 150 people.
Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
Anthraquinones have a direct toxic effect on the epithelial cells of the colon that results in the production of lipofuscin, the dark pigment seen in macrophages in melanosis coli (Panel C, arrow). The cecum and rectum are the most common sites of melanosis coli, but it can affect the entire large bowel.