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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Believe it or not, there is no significant difference between these two medicines. They are both brand names for products with the same active ingredient: ibuprofen. Both Advil, Motrin and generic forms of ibuprofen can be used in adults and children over 6 months old to treat pain and reduce fevers. 1  Certain people should not use medications that contain ibuprofen or should check with their doctor before use.