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Nephrotic syndrome is characterized by large proteinuria (>3.5 g per 1.73 m2 body surface area per day, or > 40 mg per square meter body surface area per hour in children), hypoalbuminemia (< 2,5 g/dl), hyperlipidaemia, and edema (which is generalized and also known as anasarca or dropsy) that begins in the face.
Nephrotic syndrome is most common in young children, usually idiopathic, and most often minimal change disease. In adults, nephrotic syndrome is usually secondary, most often to diabetes or preeclampsia. Consider nephrotic syndrome in patients, particularly young children, with unexplained edema or ascites. Confirm nephrotic syndrome by finding spot protein/creatinine ratio â¥ 3 or urinary protein â¥ 3 g/24 h.