22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Oh Happy Day was one of the first pop hits whose momentum was driven by the high-school teen set. Described as a garage hit, before the song was recorded, Don Howard Kaplow sang it accompanied by his guitar before his classmates at Cleveland Heights High School, in Cleveland, Ohio. At a Saturday high-school dance, the boys and girls called 13 times for Oh Happy Day.