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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
NUTRITIONAL CNS DISORDERS. The Wernicke-Korsakoff syndrome (WKS) is a combination of oculomotor abnormalities and mental symptoms seen in malnourished patients with vitamin B1 (thiamine) deficiency.he topography of the lesions in the WKS resembles the Leigh syndrome, a metabolic disorder caused by defects of the pyruvate dehydrogenase complex and the respiratory chain. This suggests that damage of sensitive CNS structures in the WKS is due to energy failure.