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But the bottom line is that long-term, heavy cannabis use may impair the dopaminergic system, which could have a variety of negative effects on learning and behavior.. You might also like: Young Marijuana Users Show a Unique Response to Social Rejection, Study Finds.
Ecstasy 101: MDMA, acting as a synthetic psychoactive drug, primarily affects the secretion of serotonin, dopamine, and norepinephrine in the brain. The drug causes an influx of these chemicals into the body resulting in feelings of openness, energy, empathy, and euphoria.