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Antibiotics such as amoxicillin, cephalexin, or penicillin are used to treat strep throat. Antibiotics work only against bacterial infections such as strep throat. They will not help sore throats caused by allergies or viral infections such as colds. Antibiotics are commonly used to: 1  Kill the bacteria and shorten the time you are contagious.
The IDSA's newly revised guidelines for Group A streptococcal pharyngitis-strep throat-also advise that when a strep infection is confirmed by testing, it should be treated with penicillin or amoxicillin-if the patient does not have an allergy-and not azithromycin or a cephalosporin.