22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
What a Wonderful World is a pop ballad written by Bob Thiele and George David Weiss. It was first recorded by Louis Armstrong and released in 1967 as a single, which topped the pop charts in the United Kingdom. Thiele and Weiss were both prominent in the music world. Armstrong's recording was inducted in the Grammy Hall of Fame in 1999. The publishing for this song is controlled by Memory Lane Music Group, Carlin Music Corp. and BMG Rights Management.