22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
The ORIGINAL version of the song was released as a 78 RPM single in 1949 by PERRY COMO, even BEFORE the song was used in Disney's Cinderalla (1950). Como's version reached #14 on the Billboard chart. Also called The Magic Song, Bibbidi-Bobbidi-Boo was written in 1948 by Al Hoffman, Mack David, and Jerry Livingston.