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Side Effects of L-arginine Hydrochloride For most people, taking L-arginine hydrochloride is thought to be relatively safe. Possible side effects of using L-arginine HCL capsules or powder include bloating, diarrhea, abdominal pain, gout, abnormalities in blood circulation, low blood pressure, inflammation of the lungs and airways, allergies and worsening of asthma symptoms. High-doses of L-arginine may be potentially fatal in children.
Arginine may cause hyperkalemia (abnormally high levels of blood potassium). Use cautiously in people with impaired kidney function or those at risk for hyperkalemia, including those with diabetes or using drugs that elevate potassium levels, such as potassium-sparing diuretics and potassium supplements.rginine may cause low blood pressure. Avoid use in those with low blood pressure or those using blood pressure-lowering agents. Avoid with nitrates and spironolactone as well as in people with pulmonary hypertension, cancer, and those at risk for or with a history of heart attack.