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Malignant hypertension is a serious condition caused by very high blood pressure. It can quickly cause serious damage to eyes, kidneys and brain. Some of the changes can be reversed by treatment but some permanent damage may occur. Malignant means bad or evil.
CDKN2A gene. The CDKN2A gene is a regulator of cell division. Mutations in this gene are the most common cause of inherited melanoma. The risk of melanoma in CDKN2A mutation carriers is approximately 14% by age 50 years, 24% by age 70 years and 28% by age 80 years.enetics of melanoma. Malignant melanoma is a potentially serious type of skin cancer due to uncontrolled growth of pigment cells, called melanocytes. Melanoma is most common in white skinned individuals, but it may rarely develop in those with dark skin as well.