However, don't forget you can't go 60 through the towns and the border is going to take you a little bit of time, so I would budget about 18-20 hours for the drive total. I would take Mex. RT. 15 all the way down along the coast. If you want to do it in two days, I'd stop in Guaymas for an overnighter. Good luck.
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The fare with ETN is 510 pesos (5 hours). A ticket with Primera Plus costs 430 pesos; many of its trips to Guanajuato are about 30 minutes faster as there are no stops in route as is the case with ETN.