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How to Take PRISTIQ. Most people start with a once-daily 50-mg dose of PRISTIQ (taken with or without food). Your doctor may keep you on your starting dose throughout your treatment.Talk to your doctor about any health conditions you may have, as your dose might be affected.PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.our doctor may keep you on your starting dose throughout your treatment. Talk to your doctor about any health conditions you may have, as your dose might be affected. PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.
I am new to the forum. I have been on Effexor XR for 18 years and it has worked really great for me. However, I believe it has stopped working. I began getting all the feelings and symptoms of Major Depression returning. My doctor put me on Pristiq.He had me quit taking the Effexor XR 150 mg. and go straight to 50 mg.ffexor worked right away for me too. I was on it for over 15 years. I switched to pristiq. I also take abilify, it is a mood stabilizer and makes antidepressants work better.