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But the bottom line is that long-term, heavy cannabis use may impair the dopaminergic system, which could have a variety of negative effects on learning and behavior.. You might also like: Young Marijuana Users Show a Unique Response to Social Rejection, Study Finds.
However, a new study in the Journal of Alzheimer's Disease suggests long-term marijuana use may reduce blood flow to the brain, specifically the hippocampus, and increase the susceptibility for Alzheimer's disease.