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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Cause of Ectopia Cordis: The cause of this disorder is unknown though it is thought to be genetic in origin. It is often an indication of Turner Syndrome. In the course of foetal development, the sternum does not develop properly.This leads to abnormal placement of the heart in the foetus.he heart may protrude outside the body through a partially developed sternum. In extremely rare cases, the heart is located in the neck or in the abdominal cavity. Ectopia Cordis is often accompanied by other disorders like cleft palate, respiratory and pulmonary disorders and spine malformations.