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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
1 One of the most disturbing can be when you suddenly find you have little or no interest in sex. 2  Changes in hormones 3  â¦. Uses and Side Effects of Using L-Arginine to Create Nitric Oxide Arginine and nitric oxide production go hand in hand.