anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
A commonly encountered cause of elevated anion gap metabolic acidosis, particularly in the ICU is lactic acid. Lactic acidosis is characterized by a pH < 7.36 and lactate level > 5mmol/L. Lactic acid is produced under normal aerobic states in cells of the brain, retina, and erythrocytes.