22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
(March 2009) Oh Happy Day is a 1967 gospel music arrangement of an 18th-century hymn. Recorded by the Edwin Hawkins Singers, it became an international hit in 1969, reaching No. 4 on the US Singles Chart, No. 1 in France, Germany and the Netherlands and No. 2 on both the UK singles chart and Irish Singles Chart. It has since become a gospel music standard.