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Malignant hypertension is a serious condition caused by very high blood pressure. It can quickly cause serious damage to eyes, kidneys and brain. Some of the changes can be reversed by treatment but some permanent damage may occur. Malignant means bad or evil.
A number of potential factors explain the poor outcome of patients with therapy-related leukemia. The persistence of the primary malignant disease, particularly meta-static cancer or lymphoma, causes morbidity and mortality independent of the bone marrow failure caused by leukemia.