However, don't forget you can't go 60 through the towns and the border is going to take you a little bit of time, so I would budget about 18-20 hours for the drive total. I would take Mex. RT. 15 all the way down along the coast. If you want to do it in two days, I'd stop in Guaymas for an overnighter. Good luck.
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Cruise prices are typically higher during the holiday season and Spring Break. Celebrity Cruises offers a four-night Western Caribbean adventure to Cozumel, Mexico starting at $350, per person for an interior room, while a similar-sized room on Carnival to Cozumel, will cost about $180-$550, depending on sailing date.