Over 9.5 million urine drug tests were positive in the U.S. workforce in 2015. The rates increased to 4% of workers tested in 2015 versus 3.9% the year before. Workplace drug screening is primarily limited to drugs with the potential for abuse, including some prescription drugs, and alcohol.
The most frequently reported side effects with this drug are edema, acne, site pain, injection site erythema, cough or dyspnea during or immediately after injection. The most frequently reported side effects with testosterone topical are skin reaction (16.1%) and allergic contact dermatitis (up to 37%). Very common (10% or more): Testosterone topical: Skin reaction (16.1%), burn-like blisters (12%), itching, allergic contact dermatitis (up to 37%)
The sexual side effects of spironolactone have been attributed to endocrine dysfunction; spironolactone is structurally similar to the sex hormones and inhibits the binding of dihydrotestosterone to androgen receptors, thus producing an increased clearance of testosterone.