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Malignant hypertension is a serious condition caused by very high blood pressure. It can quickly cause serious damage to eyes, kidneys and brain. Some of the changes can be reversed by treatment but some permanent damage may occur. Malignant means bad or evil.
Stenosis - Causes. 1  atherosclerosis causes stenotic lesions in arteries. 2  birth defects. 3  calcification. 4  iatrogenic, e.g. secondary to radiation therapy. 5  infection. 6  inflammation. 7  neoplasm â in such cases, the stenosis is often said to be malignant or benign, although this attribute actually refers to the neoplasm itself.