You also need. to know if the pilot wants to combine the flight review with a new endorsement or. aircraft checkout. Offer an initial estimate of how much time to plan for ground and. flight training. How much time is âenoughâ will vary from pilot to pilot. Someone who. flies the same airplane 200 hours every year may not need as much time as someone. who has logged only 20 hours since the last flight review, or a pilot seeking a new. endorsement in conjunction with the flight review.
Grapefruit products, such as grapefruit, grapefruit juice, or grapefruit supplements, can interact with some cholesterol-lowering statins and increase the level of medication in your blood. LipitorÂ® (atorvastatin calcium) is one of these statins.
One or more substances in grapefruit and grapefruit juice block the action of an enzyme called cytochrome P-450 3A4 (CYP3A4). This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor). (For an extensive list of drugs affected by grapefruit juice, visit health.harvard.edu/165.) Knocking CYP3A4 out of action means higher blood levels of these medications. One glass of grapefruit juice, or eating half a grapefruit, is enough to suppress CYP3A4 activity by half, and the effect lasts up to 24 hours.