what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
NSAIDs and acetaminophen, alone or in combo, can lead side effects. Your dose of ibuprofen doesnât completely alleviate your joint pain, so you take a couple of acetaminophen tablets for added relief.