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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
And in men with heart disease, arginase is upregulated or more active. This means that more Arginine is converted to the amino acid ornithine, which, as mentioned previously, can potentially lead to herpes outbreaks and other issues. L-Citrulline, on the other hand, seems to produce equal or better results at much lower dosages.