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But the bottom line is that long-term, heavy cannabis use may impair the dopaminergic system, which could have a variety of negative effects on learning and behavior.. You might also like: Young Marijuana Users Show a Unique Response to Social Rejection, Study Finds.
Long-term marijuana use is linked to low blood flow in the brain, increasing susceptibility to Alzheimer's disease. The researchers believe marijuana use may interfere with memory formation by inhibiting activity in this part of the brain.