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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Definition. Wernicke-Korsakoff Syndrome (WKS) is a neurological disorder. Wernickeâs Encephalopathy and Korsakoffâs Psychosis are the acute and chronic phases, respectively, of the same disease. WKS is caused by a deficiency in the B vitamin thiamine.Thiamine plays a role in metabolizing glucose to produce energy for the brain.efinition. Wernicke-Korsakoff Syndrome (WKS) is a neurological disorder. Wernickeâs Encephalopathy and Korsakoffâs Psychosis are the acute and chronic phases, respectively, of the same disease. WKS is caused by a deficiency in the B vitamin thiamine.