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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
NSAIDS (Non-steroidal anti-inflammatory drugs) are used by many people for chronic pain, especially those with arthritis. Ibuprofen is one of three OTC (Over-the-counter) NSAIDs - the other two being naproxen and aspirin. There are quite a few prescription NSAIDs. Counting prescription and OTC NSAIDs together, more than 30 billion doses are consumed annually in the United States alone - so overall, they are a pretty safe class of drugs.