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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
The effects of arginine:glycine amidinotransferase deficiency are most severe in organs and tissues that require large amounts of energy, especially the brain. This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations.