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But the bottom line is that long-term, heavy cannabis use may impair the dopaminergic system, which could have a variety of negative effects on learning and behavior.. You might also like: Young Marijuana Users Show a Unique Response to Social Rejection, Study Finds.
While it is not exactly clear how marijuana may affect the fetal brain at a molecular level, it seems the brain may be particularly sensitive to THC (delta-9-tetrahydrocannabinol) during early development, when neurons are forming critical connections.