22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Wednesday 30 April 2014 06.47 EDT Last modified on Tuesday 14 February 2017 14.23 EST. Pharrell Williams has revealed that Happy was originally recorded by Cee Lo Green. The powers that be apparently vetoed Green's version of the song, declaring that the future worldwide smash wasn't a fit for their client.