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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Other common side effects are rash, constipation, diarrhea, nausea and vomiting, dry mouth, dizziness, headache, sedation, tremors, ejaculation disorder, rhinitis, and upper respiratory infection. Other serious but rare side effects are myocardial infarction, arrhythmia, anemia, lymphadenopathy, and serotonin syndrome.