Over 9.5 million urine drug tests were positive in the U.S. workforce in 2015. The rates increased to 4% of workers tested in 2015 versus 3.9% the year before. Workplace drug screening is primarily limited to drugs with the potential for abuse, including some prescription drugs, and alcohol.
The most frequently reported side effects with this drug are edema, acne, site pain, injection site erythema, cough or dyspnea during or immediately after injection. The most frequently reported side effects with testosterone topical are skin reaction (16.1%) and allergic contact dermatitis (up to 37%). Very common (10% or more): Testosterone topical: Skin reaction (16.1%), burn-like blisters (12%), itching, allergic contact dermatitis (up to 37%)
Alcohol can also increase the release of beta-opioid-endorphins from the brain and stimulate prolactin release 53, both of which can negatively affect testosterone production. Oxidative damage increases thorough the body in response to alcohol consumption 54, this leading to localized reduction of testosterone in the gonads and also indirect reduction via increased cortisol levels.