Demodectic Mange in Dogs. Save to mypetMD. Mange (demodicosis) is an inflammatory disease in dogs caused by various types of the Demodex mite. When the number of mites inhabiting the hair follicles and skin of the dog become exorbitant, it can lead to skin lesions, genetic disorders, problems with the immune system and hair loss (alopecia).
Osteoblast, large cell responsible for the synthesis and mineralization of bone during both initial bone formation and later bone remodeling. Osteoblasts form a closely packed sheet on the surface of the bone, from which cellular processes extend through the developing bone. They arise from the differentiation of osteogenic cells in the periosteum, the tissue that covers the outer surface of the bone, and in the endosteum of the marrow cavity. This cell differentiation requires a regular supply of blood, without which cartilage-forming chondroblasts, rather than osteoblasts, are formed.
Bone is remodeled and modeled by the concerted activities of 3 cell typesâosteoblasts, osteocytes, and osteoclasts. Osteoblasts are the cells that produce bone extracellular matrix and are responsible for its mineralization.Osteoblasts also have endocrine activity through secretion of osteocalcin, which regulates fat and energy metabolism. These cells also control the differentiation and activity of osteoclasts.Osteocytes are osteoblasts that have been incorporated into bone matrix and are cells with extensive dendritic processes through which the cells communicate with other osteocytes and with osteoblasts.n parallel, osteoblasts degrade the unmineralized bone matrix, which is present between the cells and the mineralized bone, and then retract from the area giving the latent osteoclasts a possibility to migrate into the area and attach to mineralized bone through the sealing zone.