The color change that occurred was directly proportional to the concentration of creatinine, however he also noted that several other organic compounds induced similar reactions. In the early 20th century, Otto Folin adapted Jaffe's research into a clinical procedure.
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Trimethoprim (TMP) is an antibiotic used mainly in the treatment of urinary tract infections. Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.rimethoprim was first used in 1962. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.