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Introduction: Coagulation defects. Description of Coagulation defects. Coagulation defects (medical condition): A general term for a number of conditions that stops the blood from clotting and hence results in ...more. Coagulation defects: See also: Bleeding disorders: Â»Introduction: Bleeding disorders. Â»Symptoms of Bleeding disorders.
Key Points. In disseminated intravascular coagulation (DIC), the coagulation cascade is activated when blood is exposed to tissue factor. In association with the coagulation system, the fibrinolytic pathway is also activated. DIC usually begins rapidly and causes bleeding and microvascular occlusion, leading to organ failure.