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Alcohol dilates peripheral blood vessels, but has been known to actually. constrict some blood vessels in the brain, lowering the oxygen content. Alcohol dilates peripheral blood vessels, but has been known to actually  constrict some blood vessels in the brain, lowering the oxygen content.
For example, physicians may prescribe aspirin or similar agents, antihistamines and other medications to help reduce flushing from substances that cause the blood vessels to dilate -- such as alcohol, certain drugs, the vitamin niacin or certain of the body's own chemicals such as histamine.