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Other factors that can sometimes cause phosphate levels to rise include excess vitamin D, decrease in magnesium levels in the body and for women, pregnancy. Low phosphate levels, on the other hand are indicative of hyperparathyroidism, osteomalacia, kidney and liver infections, lack of vitamin D and intense burns.
The pK for the phosphate buffer is 6.8, which allows this buffer to function within its optimal buffering range at physiological pH. The phosphate buffer only plays a minor role in the blood, however, because H 3 PO 4 and H 2 PO 4 - are found in very low concentration in the blood.he production and removal of CO 2 and H + , together with the use and transport of O 2, cause chemical changes in the blood. These chemical changes, unless offset by other physiological functions, cause the pH of the blood to drop. If the pH of the body gets too low (below 7.4), a condition known as acidosis results.