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Mannitol Injection USP is one of the nonelectrolyte, obligatory, osmotic diuretics. It is freely filterable at the renal glomerulus, only poorly reabsorbed by the renal tubule, not secreted by the tubule, and is pharmacologically inert.
One laboratory, Diagnos-Tech, uses two molecular markers - the sugars lactulose and mannitol. Based on recovery of these markers after a simple urine collection, Diagnos-Tech's data can allow permeability to be assessed independently of kidney or liver function, or intestinal transit time. The test shows intestinal absorptive capacity and how the mucosal intestinal lining is functioning.