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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Back to Top Causes. The tricuspid valve separates the right lower heart chamber (the right ventricle) from the right upper heart chamber (right atrium). The most common cause of tricuspid regurgitation is enlargement of the right ventricle, which pumps blood to the lungs, where it picks up oxygen.This enlargement may be a complication of any disorder that causes extra strain on the right ventricle.he most common cause of tricuspid regurgitation is enlargement of the right ventricle, which pumps blood to the lungs, where it picks up oxygen. This enlargement may be a complication of any disorder that causes extra strain on the right ventricle.