Demodectic Mange in Dogs. Save to mypetMD. Mange (demodicosis) is an inflammatory disease in dogs caused by various types of the Demodex mite. When the number of mites inhabiting the hair follicles and skin of the dog become exorbitant, it can lead to skin lesions, genetic disorders, problems with the immune system and hair loss (alopecia).
Osteoblast, large cell responsible for the synthesis and mineralization of bone during both initial bone formation and later bone remodeling. Osteoblasts form a closely packed sheet on the surface of the bone, from which cellular processes extend through the developing bone. They arise from the differentiation of osteogenic cells in the periosteum, the tissue that covers the outer surface of the bone, and in the endosteum of the marrow cavity. This cell differentiation requires a regular supply of blood, without which cartilage-forming chondroblasts, rather than osteoblasts, are formed.
There are three types of cell present in bone that are of particular interest â osteoblasts, osteocytes and osteoclasts, which are respectively responsible for the production, maintenance and resorption of bone. 1  Osteoblasts. 2  Mononucleated âbone-formingâ cells found near the surface of bones. Mononucleated âbone-formingâ cells found near the surface of bones. 2  They are responsible for making osteoid, which consists mainly of collagen. 3  The osteoblasts then secrete alkaline phosphatase to create sites for calcium and phosphate deposition, which allows crystals of bone mineral to grow at these sites.