Demodectic Mange in Dogs. Save to mypetMD. Mange (demodicosis) is an inflammatory disease in dogs caused by various types of the Demodex mite. When the number of mites inhabiting the hair follicles and skin of the dog become exorbitant, it can lead to skin lesions, genetic disorders, problems with the immune system and hair loss (alopecia).
Osteoclasts are found on top of or next to existing bone tissue, sometimes in close proximity to osteoblasts. There is on-going race between the two cell types; osteoblasts make bone tissue while osteoclasts reabsorb it.
Bone is remodeled and modeled by the concerted activities of 3 cell typesâosteoblasts, osteocytes, and osteoclasts. Osteoblasts are the cells that produce bone extracellular matrix and are responsible for its mineralization.Osteoblasts also have endocrine activity through secretion of osteocalcin, which regulates fat and energy metabolism. These cells also control the differentiation and activity of osteoclasts.Osteocytes are osteoblasts that have been incorporated into bone matrix and are cells with extensive dendritic processes through which the cells communicate with other osteocytes and with osteoblasts.n parallel, osteoblasts degrade the unmineralized bone matrix, which is present between the cells and the mineralized bone, and then retract from the area giving the latent osteoclasts a possibility to migrate into the area and attach to mineralized bone through the sealing zone.