TOPROL-XL administered once a day, and immediate-release metoprolol administered once to four times a day, provided comparable total beta 1 -blockade over 24 hours (area under the beta 1 -blockade versus time curve) in the dose range 100-400 mg.
Antimicrobial: A drug used to treat a microbial infection. Antimicrobial is a general term that refers to a group of drugs that includes antibiotics, antifungals, antiprotozoals, and antivirals.
Antimicrobial (Drug) Resistance. Microbes, collectively, include bacteria, viruses, fungi, and parasites. For the past 70 years, antimicrobial drugs, such as antibiotics, have been successfully used to treat patients with bacterial and infectious diseases. Over time, many infectious organisms have adapted to the drugs designed to kill them, making the products less effective.