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The Free Dictionary describes a complexation reaction as a chemical reaction between a ligand and a metal ion. A ligand is an ionic entity with at least one atom that contains an unshared pair of electrons. Keep Learning.
4 people found this useful. An enzyme-substrate complex is formed when a subtrate molecule binds with the active site of an enzyme that is of similar shape and size.nswer by Ataylor12193. Confidence votes 115. An enzyme-substrate complex uses the reactants(substrates) and the enzyme. The enzyme is like a catalyst that reduces the required activation energy and speeds up the chemical reaction.