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The Mann-Whitney U-test is used to test whether two independent samples of observations are drawn from the same or identical distributions. An advantage with this test is that the two samples under consideration do not necessarily need to have the same number of observations or instances.
Concurrent detection of anti-mannan antibodies increased the performance of the test to a sensitivity of 83% specificity of 86% and DOR of 58. In neutropenic patients, at least one positive mannan or anti-mannan test is positive, and so interpretation is improved by repeat testing and requiring 2 positives for a true positive.