1. something that is to happen or has happened to a particular person or thing; lot or fortune. 2. the predetermined, usu. inevitable, course of events. 3. the power or agency that determines the course of events.
Alternating between ibuprofen and acetaminophen every 2 hours because you have to wait 4 hours for each of them to take a second dose of the same thing. So instead you take a dose of Acetaminophen now, then Ibuprofen in 2 hours and back to Acetaminophen 2 hours later as needed.
The risk of adverse events associated with multiple-dose use of non-prescription ibuprofen has been evaluated in a meta-analysis of eight placebo-controlled studies in (Kellstein et al, 1999). The doses ranged from 800 to 1200 mg/day; the duration of use ranged from 1 to 10 days.