1 One form of Stickler syndrome is due to mutation in the COL2A1 gene on chromosome 12 in region 12q13.11-q13.2. It is termed Stickler syndrome, type I and symbolized STL1.  A second form of Stickler syndrome is caused by mutation in the COL11A1 gene on chromosome 1 in region 1p21.
Recent technical advances in this field will give rise to conceptual advances and there is every reason to believe that a new field of cancer genetics is emerging, named here Oncogenetics: a branch of genetics describing the cause of effects of genes causing neoplasia.
Proto-oncogenes are genes whose products promote cell growth and division. They do this by encoding transcription factors that stimulate the expression of other genes, signal transduction molecules that stimulate cell division, or cell cycle regulators that move the ell through the cell cycle.n these cases, the proto-oncogene product is continually in an on state, which may constantly stimulate the cell to divide. When a proto-oncogene is mutated or aberrantly expressed, and contributes to the development of cancer, it is known as an oncogene.