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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Back to Top Causes. Right-sided heart failure occurs in about 1 in 20 people. Coronary artery disease is the most common cause of heart failure in the United States, but it can be a complication of other conditions. Heart failure may affect the right side of the heart (right ventricle), the left side (left ventricle), or both sides. In right-sided heart failure, the right ventricle loses its pumping function, and blood may back up into other areas of the body, producing congestion. Congestion affects the liver, the gastrointestinal tract, and the limbs.