In the early 2000s, the concept of injecting the prostate transperineally with a combination of steroids (betamethasone) and antibiotics (to prevent the steroid-induced local immunosuppression leading to abscess) gained currency through the efforts of European practitioners, and especially Dr Federico Guercini of Rome, Italy.
Fifty-six delegates to the Second Continental Congress in Philadelphia signed the United States Declaration of Independence, a statement announcing that the thirteen American colonies then at war with Great Britain were now independent states, and thus no longer a part of the British Empire.lthough the wording of the Declaration was approved by Congress on July 4, 1776, the date of its signing has been disputed.
In 1877 the Declaration of Independence had a major effect on the  U.S because it declared the United States free from britain rule  and it united the North and the South at â¦ the time America was  divided in North and South and both sides were at war(American  Civil War).