1 One form of Stickler syndrome is due to mutation in the COL2A1 gene on chromosome 12 in region 12q13.11-q13.2. It is termed Stickler syndrome, type I and symbolized STL1.  A second form of Stickler syndrome is caused by mutation in the COL11A1 gene on chromosome 1 in region 1p21.
Recent technical advances in this field will give rise to conceptual advances and there is every reason to believe that a new field of cancer genetics is emerging, named here Oncogenetics: a branch of genetics describing the cause of effects of genes causing neoplasia.
Proto-oncogene: A normal gene which, when altered by mutation, becomes an oncogene that can contribute to cancer. Proto-oncogenes may have many different functions in the cell.Some proto-oncogenes provide signals that lead to cell division. Other proto-oncogenes regulate programmed cell death (apoptosis).The defective versions of proto-oncogenes, known as oncogenes, can cause a cell to divide in an unregulated manner.roto-oncogenes may have many different functions in the cell. Some proto-oncogenes provide signals that lead to cell division. Other proto-oncogenes regulate programmed cell death (apoptosis). The defective versions of proto-oncogenes, known as oncogenes, can cause a cell to divide in an unregulated manner.