This Is Why Kourtney Kardashian Dumps Justin Bieber. Lorde Performs Tracks From Her Upcoming Album During Surprise Concert. Simon Cowell Is Planning 'The X Factor' Spin Off. Selena Gomez and The Weeknd Show Off PDA at Coachella. Report: Young Thug and Lil Uzi Vert Are Gay Lovers.
Glucose on the sugar side chains of proteins keeps unfolded proteins in the ER. Mannoses on sugar side chains act as a timer for protein folding. Unfolded proteins in the ER are threaded through a retrotranslocon into the cytosol where they are ubiquitylated and digested. IRE1, ATF6 and PERK sense the amount of unfolded protein and generates several responses to reduce the effects and amount of unfolded protein.
The giant protein titin (connectin) extends from the Z-line of the sarcomere, where it binds to the thick filament (myosin) system, to the M-band, where it is thought to interact with the thick filaments. Titin (and its splice isoforms) is the biggest single highly elasticated protein found in nature.