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Imipramine (Tofranil) is the medication for panic disorder that has been most thoroughly studied, with at least 10 double-blind, placebo-controlled studies supporting its efficacy in the acute treatment of panic disorder.6 Clomipramine (Anafranil) has shown similar results in several double-blind trials as well.
The drug is prescribed for the treatment of panic disorder and various types of epileptic seizures. Specifically, it is used to treat absence seizures, myoclonic seizures, akinetic seizures, and seizures associated with Lennox-Gastaut syndrome (a severe form of epilepsy).t is sometimes prescribed off-label for the treatment of restless legs syndrome (RLS), insomnia, alcohol withdrawal, or other types of anxiety (other than panic disorder).