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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Cardiac Health. Q: A: Common causes of mild left atrial enlargement can be divided into both congenital causes, like ventricular septal defect, or VSD, and patent ductus arteriosus, or PDA, and acquired causes, like mitral stenosis, mitral regurgitation, left ventricular failure and left atrial myxoma, as reported by Radiopaedia.