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If lactate is significantly elevated, it may be ordered at intervals to monitor the condition. CSF and blood lactate levels may be ordered when a person has signs and symptoms of meningitis, such as severe headaches, fever, delirium, and loss of consciousness.
Lactate measured in blood therefore reflects the balance between release from exercising muscles and uptake (by the liver, cardiac muscle and any skeletal muscle fibres which are not themselves under anaerobic stress).