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The Mann-Whitney U-test is used to test whether two independent samples of observations are drawn from the same or identical distributions. An advantage with this test is that the two samples under consideration do not necessarily need to have the same number of observations or instances.
Screening of newborns for PKU entails a simple heel-stick blood sampling test called the guthrie test, which is routinely performed in the United States, Canada, and many other countries. The test should be done within two weeks of birth, preferably soon after the infant has been fed.