Nextdoor is the private social network for your neighborhood. On Nextdoor, neighbors create private groups for their neighborhoods where they can ask questions, get to know one another, and exchange local advice and recommendations.
Up-regulation is a process that occurs within a cell triggered by a signal (originating internal or external to the cell), which results in increased expression of one or more genes and as a result the protein(s) encoded by those genes.
Altered regulation of expression of at least one cyclin as well as mutation of several proteins that negatively regulate passage through the restriction point can be oncogenic (Figure 24-19). Figure 24-19Restriction point controlOverexpression or loss of the cell-cycle control proteins shown in pink commonly occurs in human cancers.