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But denosumab is a first-in-class drug: It's a biologic, which means it will likely be much more expensive than its competitor drugs, some of which are available as cheaper generics. The drug also boasts an extremely convenient dosing regimen -- subcutaneous injection every six months.
Two years after its approval, Amgen issued warnings that Prolia could cause serious risks like hypocalcemia, serious infections, suppression of bone turnover, including osteonecrosis of the jawâ as well as âatypical femoral fractureâ and âdermatologic adverse events..