Berberine is best taken at doses between 900mg to 2200mg per day taken in 3-4 divided doses. High single doses of Berberine can cause some intestinal update, which is why the dose is split.
Mayan Civilization Rise & Decline (Theories) The Mayan civilization, centered in the tropical lowlands of what is now Guatemala, reached the peak of its power and influence around the sixth century BCE (BC). The Maya excelled at agriculture, pottery, hieroglyph writing, calendar-making and mathematics, and left behind an astonishing amount of impressive architecture and symbolic artwork.
The arc of the Mayan rise and fall is well known: The civilization first took hold in 1,800 BC, in the Central American region that now includes and surrounds Guatemala. It grew slowly until about 250 A.D.