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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Usually right-side heart failure occurs in response to left-side failure. The backup of blood in the lungs caused by left-side heart failure makes the right ventricle work harder. This overload of work can cause the right side of the heart to fail. Right-side heart failure can also accompany other conditions, such as lung disease.