Drugs that cause hyponatremia include: Diuretics: Thiazides, bumetanide, indapamide, ethacrynic acid, furosemide. Diuretics affect the balance between sodium and water and are among the most common drugs implicated in the development of hyponatremia. Antidepressants: Selective serotonin reuptake inhibitors, tricyclic antidepressants (amitriptyline, protriptyline, desipramine), monoamine oxidase inhibitors, venlafaxine.
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