But in the 1920s, a huge discovery in South Asia proved that Egypt and Mesopotamia were not the only early civilizations.. In the vast Indus River plains (located in what is today Pakistan and western India), under layers of land and mounds of dirt, archaeologists discovered the remains of a 4,600 year-old city.
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The HE4 EIA is an enzyme immunometric assay for the quantitative determination of HE4 in human serum. The assay is to be used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer.eparately, an analysis of serum obtained from patients with benign ovarian tumors demonstrated that HE4 had a sensitivity of 67% and a specificity of 96%. In this study, various tumor markers were evaluated, and HE4 had the highest sensitivity as a single marker.