Prednisone is intended for oral administration only. Adults: The initial dose is 5mg to 80mg daily depending on the condition being. treated, as a single dose after breakfast, as divided doses, or as a double dose on. alternate days. The maintenance dose is usually 5mg to 20mg daily. The dose should. be individualised according to the severity of the disease and the patients response. rather than by age or body weight. For adrenogenital syndrome: 5 to 10mg a day as a single dose. The usual adult prescribing limit is up to 250mg day.
View/Edit Mouse. Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels.
Thrombolysis is the breakdown (lysis) of blood clots by pharmacological means, and commonly called clot busting. It works by stimulating secondary fibrinolysis by plasmin through infusion of analogs of tissue plasminogen activator (tPA), the protein that normally activates plasmin. recent multicenter randomized trial (DUET) compared standard catheter-directed thrombolysis (CDT) versus ultrasound-accelerated thrombolysis (USAT, EKOS Corporation) for the treatment of acute peripheral arterial thrombotic occlusions.