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Pulmonary hypertension is high blood pressure within the artery that connects the lungs and heart. It forces the heart to work harder to transfer blood between the heart and lungs, which may lead to an enlargement of the right side. Thyroid problems, whether they involve an underactive or overactive thyroid, can cause a heart to enlarge.
Sometimes, the heart develops on the opposite side of the body because other anatomical problems exist. Defects in the lungs, abdomen, or chest can cause the heart to develop on the right side of the body. You are more likely to have other heart defects and problems with other vital organs in this case.