Hypotheses which have been suggested as the cause of the disaster include unsafe speed, an insurance scam, an ice-pack rather than an iceberg, and even a curse on the ship by the Unlucky Mummy.
Sorting type: |. Confirmed Beta Level Mutants. A character can only be added to this category if they have a reference for when they were 'outed' as a Beta.
AZD9291 is an oral, irreversible, third-generation, selective inhibitor of both EGFR-activating mutations and resistance (T790M) mutations. âAstraZeneca chemists designed a compound that overcomes the limitations of earlier therapies. We developed a novel scaffold that could overcome the double-mutant kinase,â she said.Assuming that human tumors and biomarkers behave in a similar way to those in mouse xenografts, these simulations suggest that a dose of 7 to 17 mg of AZD9291 once a day would be efficacious in patients with advanced NSCLC harboring the EGFR-activating and T790M (resistant) mutations,â Dr. Galbraith said.