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Mannitol Injection USP is one of the nonelectrolyte, obligatory, osmotic diuretics. It is freely filterable at the renal glomerulus, only poorly reabsorbed by the renal tubule, not secreted by the tubule, and is pharmacologically inert.
DOSING: 1  Prevention of acute renal railure (oliguria): 50 to100 g of mannitol given as 5%, 10%, or 15% solution depending on the patient's fluid requirements. 2  Treatment of oliguria: 100 g administered as a 15 or 20% solution. 3  Reduction of intracranial pressure and brain mass: 0.25 g/kg given every 6 to 8 hours.