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Estradiol levels also give important information on the functioning of the ovaries. This can help doctors evaluate menstrual problems, including abnormal bleeding or missing periods. The test may also be used in boys or girls to check for damage or disease of the testes, ovaries, or adrenal glands.
The three major naturally occurring estrogens in women are estrone (E1), estradiol (E2), and estriol (E3). Estradiol is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity.strogen may also refer to any substance, natural or synthetic that mimics the effects of the natural hormone. The steroid 17Î²-estradiol is the most potent and prevalent endogenous estrogen, but several metabolites of estradiol also have estrogenic hormonal activity.