C. difficile diarrhea is largely a nosocomial disease and is the most frequent cause of diarrhea in hospitalized patients. Its occurrence in the outpatient setting, other than in patients confined to nursing homes, is much less common.
Darwin had arrived at a complete theory of evolution by 1839, but it was to be another 20 years before he published his ideas of evolution through natural selection in his epochal book On the Origin of Species by Means of Natural Selection.
The history of evolutionary biology really begins in 1859, with the publication of Charles Darwinâs On the Origin of Species (Ridley, 1996). Darwin challenged the views of early evolutionary biologists that believed in species fixity and transformism.