Groups are determined by PRECIPITIN test, serologic test to measure a specific reaction between antigen (C carbohydrate, located in the cell wall) and antibody which results in a visible precipitate. Group A Streptococci (Streptococcus pyogenes) is among the most important human pathogens.
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PWS is recognized as the most common genetic cause of life-threatening childhood obesity. PWS was first described by Swiss doctors Andrea Prader, Alexis Labhart, and Heinrich Willi in 1956 based on the clinical characteristics of nine children they examined.WS is caused by a lack of active genetic material in a particular region of chromosome 15 (15q11-q13). Normally, individuals inherit one copy of chromosome 15 from their mother and one from their father.