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In clinical studies, Cialis began to work in as little as 30 minutes. For most people, though, it begins working within one hour. There are a number of factors that can increase or decrease how long Cialis lasts.
While Viagra's half-life is 4 hours, Cialis' is 17, which means, as GlobalChange.com calculates, 25% of a Cialis dose is still in the body after 35 hours and 12.5% after over 50 hours. This clearly leads, if the drug is taken regularly, to accumulation of it in the body, making sex at any time a practical possibility.