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1 Blood test. 2  This blood test measures the levels of pregnancy-associated plasma protein-A (PAPP-A) and the pregnancy hormone known as human chorionic gonadotropin (HCG). 3  Abnormal levels of PAPP-A and HCG may indicate a problem with the baby.f your screening test results are positive or worrisome, or you're at high risk of having a baby with Down syndrome, you might consider more testing to confirm the diagnosis. Your health care provider can help you weigh the pros and cons of these tests.
Abnormal Pap Test While Pregnant. Abnormal Pap Test While Pregnant. Pregnancy does not seem to increase the progression of abnormal cervical cell changes. The presence of abnormal cervical cell changes or HPV does not affect the outcome of the pregnancy. Close monitoring is needed so that you and your health professional can make the best treatment decisions at each stage of the pregnancy. An abnormal Pap test may be evaluated further with colposcopy. Colposcopy is a safe test during pregnancy. If colposcopy shows normal tissue, then a repeat Pap test or colposcopy may be done later. Having a second test depends on the type of abnormalities reported on the first Pap test.