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Addisonâs disease affects your bodyâs adrenal glands. The adrenal glands are part of the endocrine system. The endocrine system is a group of glands all over your body that produce hormones to regulate your bodyâs processes, including your moods, growth, metabolism, and tissue function.The adrenal glands are located just above your kidneys. They produce hormones that affect how your body responds to stress.In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.Addisonâs disease is most common among people 30 to 50 years of age, but it can occur at any age and affects men and women equally.hey produce hormones that affect how your body responds to stress. In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.
A single organ or multiple organs and tissues may be affected. There are many autoimmune diseases with symptoms that range from mild rashes to life-threatening conditions that attack major organ systems. Though each disease is different, immune-system malfunction is present in all of them.rgans and tissues frequently affected include the endocrine gland, such as thyroid, pancreas, and adrenal glands; components of the blood, such as red blood cells; and the connective tissues, skin, muscles, and joints. In organ-specific disorders, the autoimmune process is directed mostly against one organ.