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1 Blood test. 2  This blood test measures the levels of pregnancy-associated plasma protein-A (PAPP-A) and the pregnancy hormone known as human chorionic gonadotropin (HCG). 3  Abnormal levels of PAPP-A and HCG may indicate a problem with the baby.f your screening test results are positive or worrisome, or you're at high risk of having a baby with Down syndrome, you might consider more testing to confirm the diagnosis. Your health care provider can help you weigh the pros and cons of these tests.
Firstly, itâs important to understand how a pregnancy test works, so you can get the most accurate result from the test. From the very beginning of your pregnancy, the fetus produces a hormone called hCG, or, human Chorionic Gondotrophin. This hormone can be detected in your urine if you are pregnant. The levels of hCG increase as your pregnancy progresses, peaking at around 8-11 weeks, before dropping to a lower level at 12 and 16 weeks. Some pregnancy test kits can detect hCG levels as low as 10 or 25mIU/ml.