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If the cells are larger than normal, the histogram curve will be more to right, as in megaloblastic anemia, if the. cells are smaller than normal, the curve will be more to the left as in untreated iron deficiency anemia. After.
1 Heart failure. 2  When the heart is unable to maintain adequate blood flow throughout the circulatory system, the excess fluid pressure within the blood vessels can cause shifts into the interstitial spaces. 3  Left-sided heart failure can cause pulmonary edema, as fluid shifts into the lungs.