In the same way that the removal of a single domino in the row would interrupt the sequence of toppling, Heinrich suggested that removal of one of the factors would prevent the accident and resultant injury; with the key domino to be removed from the sequence being number 3.
6The Impact of the Opioid Crisis on the Healthcare System. An analysis of the increase in per-patient charges from 2013 to 2015 shows that the rise in charges from. $50,490 to $63,356 for individuals with an opioid abuse or dependence diagnosis exceeds the per-.
By 2000 that number would balloon to $1.1 billion, an increase of well over 2,000 percent in a span of just four years. Ten years later, the profits would inflate still further, to $3.1 billion. By then the potent opioid accounted for about 30 percent of the painkiller market.