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The U.S. Food and Drug Administration yesterday approved a new oral medication for rheumatoid arthritis, or RA. Tofacitinib, brand name Xeljanz (ZEL'jans) , is for patients with moderate to severe rheumatoid arthritis who do not respond well to methotrexate, a disease-modifying antirheumatic drug, or DMARD.
Methotrexate is among the most commonly prescribed drugs used to treat rheumatoid arthritis. In some cases, it is taken alone. In other cases, methotrexate is prescribed as part of combination therapy, where it is taken along with another DMARD or biologic drug.