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Webster Dictionary (0.00 / 0 votes) Rate this definition: Amphi- a prefix in words of Greek origin, signifying both, of both kinds, on both sides, about, around
The word amphibian comes from the Greek word for âdouble-life,â referring to the fact that amphibians start life in water breathing through gills before maturing into lung-breathing land animals, although most never stray too far from water.