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Addisonâs disease affects your bodyâs adrenal glands. The adrenal glands are part of the endocrine system. The endocrine system is a group of glands all over your body that produce hormones to regulate your bodyâs processes, including your moods, growth, metabolism, and tissue function.The adrenal glands are located just above your kidneys. They produce hormones that affect how your body responds to stress.In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.Addisonâs disease is most common among people 30 to 50 years of age, but it can occur at any age and affects men and women equally.hey produce hormones that affect how your body responds to stress. In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.
Addison's disease. Addisonâs disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss.