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Clinical Significance. Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo-and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.
Define ACTH: a protein hormone of the anterior lobe of the pituitary gland that stimulates the adrenal cortex âcalled also adrenocorticotropicâ¦ a protein hormone of the anterior lobe of the pituitary gland that stimulates the adrenal cortex âcalled also adrenocorticotropic hormoneâ¦