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It dealt with slavery and the issue of including them into the  population of Southern states.   The Three-Fifths Compromise settled the issue of how slaves would  be counted in terms of congressional representation and how the  state would be taxed.
The first issue that called for compromise during the Constitutional Convention was the issue of representation in Congress. There was debate on whether each state should still only have one vote (much like it was under the Articles) or should representation be determined proportionally on things like population.