This occurs when a substance passes from the fluid in the tubular lumen through the apical membrane, across the cytosol , and then into the interstitial fluid.
Yes, it's potent stuff. Cat receive it either as an injection or orally. It takes effect in roughly half an hour, lasting about 8 hours before another administration is necessary. Cats usually react negatively to opiates, but buprenorphine is an exception. That's one reason vets use it if they can receive the necessary special certification.
It is also finding increased use in adult cats taken in for spaying and neutering surgeries as a pre- and post-operative means of pain control in the first place and relief in the second. I say âincreasedâ use, but this does not mean it is commonplace. Buprenorphine is a very powerful medication.