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Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, primarily the mitochondria in cells of the liver.mmunofluorescence staining pattern of AMA shown on stomach (top left), liver (top right), kidney (bottom left) and hep-20-10 cells (bottom right). Primary biliary cirrhosis is seen primarily in middle-aged women, and in those afflicted with other autoimmune diseases.
AIF also causes chromosome condensation and DNA fragmentation independent of caspases. Indeed, the mitochondria are central regulators of apoptosis. Outer mitochondrial membrane proteins Bcl-2, the BH3-only proteins and Bax are involved: Bax can form a pore in the membrane to allow cytochrome c, normally located in the intermembrane space, out into the cytosol.