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A ganglion is a fluid-filled swelling of the lining of a joint or tendon. Although ganglions can form on any part of the foot, they most often appear on the ankle or top of the foot. Ganglions tend to change size and usually grow slowly.
Ankle ganglion cysts at a glance. 1  Ganglion cysts are fluid-filled, benign tumors (cysts) that develop on the outside of a foot joint or tendon, as well as other parts of the body like the hands or knees. 2  The cause of ganglion cysts is unknown. 3  Ganglion cysts tend to appear suddenly, but can also develop over time.