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Addisonâs disease affects your bodyâs adrenal glands. The adrenal glands are part of the endocrine system. The endocrine system is a group of glands all over your body that produce hormones to regulate your bodyâs processes, including your moods, growth, metabolism, and tissue function.The adrenal glands are located just above your kidneys. They produce hormones that affect how your body responds to stress.In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.Addisonâs disease is most common among people 30 to 50 years of age, but it can occur at any age and affects men and women equally.hey produce hormones that affect how your body responds to stress. In people who have Addisonâs disease, the adrenal glands do not produce enough corticosteroid hormones, such as cortisol and aldosterone.
Reduction of all three classes of adrenal steroids (glucocorticoids, mineralocorticioids, androgens) --- reduction occurs because of hypofunction of the adrenal cortex--- this is the most common cause of Addison's disease in the U.S. and is an autoimmune response in which more than 90% of adrenal tissue is destroyed r/t to circulating antibodies that attack adrenal tissue--- destruction of the gland may also be idiopathic (no known cause)