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The signs and symptoms of lupus that you experience will depend on which body systems are affected by the disease. The most common signs and symptoms include: 1  Fatigue and fever. 2  Joint pain, stiffness and swelling. 3  Butterfly-shaped rash on the face that covers the cheeks and bridge of the nose.
Certainly additional pulmonary problems in lupus include infection in the lung, especially in those who take medications that lower the immune system. In this case the clinical signs of infection usually include cough, fever, and shortness of breath or fatigue.