This occurs when a substance passes from the fluid in the tubular lumen through the apical membrane, across the cytosol , and then into the interstitial fluid.
Yes, it's potent stuff. Cat receive it either as an injection or orally. It takes effect in roughly half an hour, lasting about 8 hours before another administration is necessary. Cats usually react negatively to opiates, but buprenorphine is an exception. That's one reason vets use it if they can receive the necessary special certification.
Hi, it takes 3 days for the buprenorphine to build up in your system, so it is then that you should feel the mot pain relief. I'm like you, been on this for about a week and my pain levels are inconsistent. I'm okay in the morning but my pain is greater in afternoon/evenings despite being on the patch for 6 days now.