The symptoms of peripheral artery disease depend upon the location and extent of the blocked arteries. The most common symptom of peripheral artery disease is intermittent claudication, manifested by pain (usually in the calf) that occurs while walking and dissipates at rest.
John Winthrop (1588-1649) was governor of the Massachusetts Bay Colony-a group of entrepreneurs who left Europe in search of trade opportunities in the New World. Like most members of the Colony, Winthrop was a Puritan. This group claimed that the Church of England was corrupted by selfish leaders and petty squabbles.
Winthrop was four times married. His first wife, to whom he was united on the 16th of April 1605, was Mary Forth, daughter of John Forth, of Great Stambridge, Essex. She bore him six children, of whom the eldest was John Winthrop, Jr. She was buried in Groton on the 26th of June 1615.