Symptoms of Pyelonephritis. At least half of women have experienced the discomfort with urination caused by a urinary tract infection: painful, urgent, or frequent urination. Pyelonephritis may start with similar symptoms. However, once the infection has spread to the kidney, signs of more severe illness usually result.They include: 1  Back pain or flank pain. 2  Fever (usually present) or chills. 3  Feeling sick (malaise). 4  Nausea and vomiting. 5  Confusion (especially in the elderly).acteria enter the body from the skin around the urethra. They then travel up the urethra to the bladder. Sometimes, bacteria escape the bladder and urethra, traveling up the ureters to one or both kidneys. Pyelonephritis is a potentially serious kidney infection that can spread to the blood, causing severe illness.
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