In the same way that the removal of a single domino in the row would interrupt the sequence of toppling, Heinrich suggested that removal of one of the factors would prevent the accident and resultant injury; with the key domino to be removed from the sequence being number 3.
6The Impact of the Opioid Crisis on the Healthcare System. An analysis of the increase in per-patient charges from 2013 to 2015 shows that the rise in charges from. $50,490 to $63,356 for individuals with an opioid abuse or dependence diagnosis exceeds the per-.
But the story of the painkiller epidemic can really be reduced to the story of one powerful, highly addictive drug and its small but ruthlessly enterprising manufacturer. On December 12, 1995, the Food and Drug Administration approved the opioid analgesic OxyContin. It hit the market in 1996. In its first year, OxyContin accounted for $45 million in sales for its manufacturer, Stamford, Connecticut-based pharmaceutical company Purdue Pharma.