Depression affects different people in different ways, but most of them experience some combination of the following symptoms: 1  Prolonged sadness or feelings of emptiness. 2  Feelings of helplessness or hopelessness. 3  Feelings of guilt or worthlessness.  Anger and 1  irritability. Restlessness.  Difficulty 1  concentrating. Fatigue.  Changes in sleep patterns.
Diphenhydramine (Benadryl Â® , Sominex Â® , and many other brand names) is an antihistamine that is used for a variety of different purposes. The approved uses may vary, depending on the particular product, and there are also a number of  off-label  uses for diphenhydramine.
In addition to its use as a sleep aid, diphenhydramine is often administered to relieve allergies or treat allergic reactions, and can be helpful in preventing motion sickness. It is also used to alleviate extrapyramidal symptoms, which may occur as a side effect of other medications.