For more information on becoming a referee and referee courses you can download our information sheet (see âDocumentsâ at the end of this web page). Also, you can contact John Monk (Email: john.monk@amateur-fa.com Tel: 0208 733 2613) who will be pleased to answer any questions you may have about the course.
Genes are made up of DNA. Each chromosome contains many genes. A gene is the basic physical and functional unit of heredity. Genes, which are made up of DNA, act as instructions to make molecules called proteins. In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases.
As a subfamily of Argonaute proteins, Piwi is poorly understood compared with Ago subfamily until recent discovery of Piwi protein interacting with piRNA. We did a large scale screening of insect genomes to identify piwi-like genes.Full or partial cDNA sequences were obtained by EST elongation and GENSCAN.IWI domain is of 300 aa in the C-terminal region and structurally similar to RNaseH catalytic domain, which performs a crucial role in slicer activity [6] , [7] and [8] . In animals, Argonaute protein family can be divided into two classes: Ago subfamily and Piwi subfamily.