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Webster Dictionary (0.00 / 0 votes) Rate this definition: Amphi- a prefix in words of Greek origin, signifying both, of both kinds, on both sides, about, around
medical Definition of amphiphilic : of, relating to, consisting of, or being one or more molecules (as of a glycolipid or sphingolipid) in a biological membrane having a polar water-soluble terminal group attached to a water-insoluble hydrocarbon chain