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If a nerve root is compressed in the spinal column it can send pain signals throughout the nerve, causing symptoms to radiate to other parts of the body. Common sources of upper back problems and shoulder pain include: 1  Degenerative disc disease (DDD) or other intervertebral disc problems. 2  Facet disease. 3  Osteoarthritis. 4  Stenosis. 5  Bone spurs.
It also causes shoulder pain that extends to the arms. Other cancers that may cause acute or severe pain in this area are liver cancer, mesothelioma, esophageal cancer, and lymphomas. Cancers that spread to the bones in the neck region may result in pain between shoulder blades. 9. Gallbladder Disease