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Webster Dictionary (0.00 / 0 votes) Rate this definition: Amphi- a prefix in words of Greek origin, signifying both, of both kinds, on both sides, about, around
E.encyclopedia NATURE. Frogs, toads, salamanders, newts, and the strange, wormlike caecilians are all amphibiansâa group of small, generally moist-skinned vertebrates. The word amphibian, meaning âliving two lives,â refers to the fact that most amphibians spend part of their lives in water and part on land.