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If a nerve root is compressed in the spinal column it can send pain signals throughout the nerve, causing symptoms to radiate to other parts of the body. Common sources of upper back problems and shoulder pain include: 1  Degenerative disc disease (DDD) or other intervertebral disc problems. 2  Facet disease. 3  Osteoarthritis. 4  Stenosis. 5  Bone spurs.
Fracture of the bones of the shoulder (such as from biking falls) can cause intense shoulder pain. Pain can also occur in the shoulder from diseases or conditions that involve the shoulder joint (including arthritis such as osteoarthritis or degenerative arthritis with bone spurs), the soft tissues and bones surrounding the shoulder, or the nerves that supply sensation to the shoulder area.