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For the language families subsumed under Khoisan, see Khoisan languages.  Khoisan  (/ËkÉÉªsÉËn/ ; also spelled Khoesaan, Khoesan or KhoeâSan) is a unifying name for two groups of peoples of Southern Africa, who share physical and putative linguistic characteristics distinct from the Bantu majority of the region.arious Y-chromosome studies since confirmed that the Khoisan carry some of the most divergent (oldest) Y-chromosome haplogroups. These haplogroups are specific sub-groups of haplogroups A and B, the two earliest branches on the human Y-chromosome tree.
The Khoikhoi and the San are two groups of people who we can first place archaeologically in South Africa about 25,000 BC. Like everyone else in the world at that time, they were hunters and gatherers.