The symptoms of peripheral artery disease depend upon the location and extent of the blocked arteries. The most common symptom of peripheral artery disease is intermittent claudication, manifested by pain (usually in the calf) that occurs while walking and dissipates at rest.
John Winthrop (1588-1649) was governor of the Massachusetts Bay Colony-a group of entrepreneurs who left Europe in search of trade opportunities in the New World. Like most members of the Colony, Winthrop was a Puritan. This group claimed that the Church of England was corrupted by selfish leaders and petty squabbles.
New England Puritans & Pilgrims. Cite This Source. John Winthrop in New England Puritans & Pilgrims. John Winthrop (c. 1587-1649) was a devoutly religious Puritan elder who led a large migration of Puritans from England to America in 1629 and became the first governor of Massachusetts Bay Colony one year later. He was probably the most powerful figure in New England in the first half of the seventeenth century.