Richard Gere as Edward Lewis in Pretty Woman: 'You and I are both similar creatures, Vivian. We both screw people for money.'. Why they spark: Gere's distinguished looks and hard-line attitude blends with Roberts' light hearted, witty style.
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are about 150-200 Âµm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 Âµm in diameter occur. These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate.
Osteoblasts synthesize the organic component of the bone matrix (osteoid) Osteoid consists of type I collagen, glycosaminoglycans and proteoglycans. When fully active, osteoblasts are cuboidal or polygonal cells. They have basophilic cytoplasm, which reflects the abundance of rough endoplasmic reticulum in their cytoplasm, resulting from their role as active protein-synthesizing and -secreting cells.