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The Prokaryotic Cell. Prokaryotes are unicellular organisms that lack organelles or other internal membrane-bound structures . Therefore, they do not have a nucleus, but, instead, generally have a single chromosome: a piece of circular, double-stranded DNA located in an area of the cell called the nucleoid. Most prokaryotes have a cell wall outside the plasma membrane.
They are simpler and smaller than eukaryotic cells, and lack membrane-bound organelles such as the nucleus. Prokaryotes include two of the domains of life, bacteria and archaea. The DNA of a prokaryotic cell consists of a single chromosome that is in direct contact with the cytoplasm. The eukaryotic DNA is organized in one or more linear molecules, called chromosomes, which are associated with histone proteins. 2  All chromosomal DNA is stored in the cell nucleus, separated from the cytoplasm by a membrane. 3  Some eukaryotic organelles such as mitochondria also contain some DNA.