More directly relevant is the level of kidney function. In patients with poor kidney function or those on dialysis, the drug can accumulate to levels above the theraputic range. There are several reports of abnormal movements (myoclonus) when this occurs. Common practice is to start at a lower dose in these patients.
Bleach (Nirvana album) Bleach is the debut studio album by American rock band Nirvana, released on June 15, 1989 by Sub Pop. The main recording sessions took place at Reciprocal Recording in Seattle, Washington between December 1988 and January 1989.
For the surname, see Cobain (surname). Kurt Donald Cobain (February 20, 1967 â April 5, 1994) was an American musician, artist, songwriter, guitarist and poet. Born in Aberdeen, Washington, Cobain formed the band Nirvana with Krist Novoselic in 1987 and established it as part of the Seattle music scene and grunge genre. Nirvana's debut album Bleach was released on the independent record label Sub Pop in 1989.