More directly relevant is the level of kidney function. In patients with poor kidney function or those on dialysis, the drug can accumulate to levels above the theraputic range. There are several reports of abnormal movements (myoclonus) when this occurs. Common practice is to start at a lower dose in these patients.
Bleach (Nirvana album) Bleach is the debut studio album by American rock band Nirvana, released on June 15, 1989 by Sub Pop. The main recording sessions took place at Reciprocal Recording in Seattle, Washington between December 1988 and January 1989.
At the time that Grohl joined Nirvana, the band had already recorded several demos for the follow-up to their debut album Bleach, having spent time recording with producer Butch Vig in Wisconsin. Initially, the plan was to release the album on Sub Pop, but the band received a great deal of interest based on the demos.