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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
The #1 Pharmacist Recommended OTC Sleep-Aid Brand*. Millions of people turn to Unisom for a safe and restful nightâs sleep. Unisom offers a variety of convenient and effective products to help you fall asleep and wake refreshed.