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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
Abstract. The bloodâbrain barrier consists of endothelial cells lining brain capillaries. It serves to restrict and control the movement of substances between the general circulation and brain extracellular fluid.igure 1. The bloodâbrain barrier consists of endothelial cells lining brain capillaries. These cells are connected by tight junctions, which separate the plasmalemma into luminal (bloodâfacing) and abluminal (brainâfacing) plasma membrane domains.