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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
However, administration of pregabalin with food has no clinically significant effect on the extent of pregabalin absorption. Distribution In preclinical studies, pregabalin has been shown to cross the blood brain barrier in mice, rats, and monkeys.