Muscle, nerve, and joint weakness, and deterioration result. It is not uncommon to see the patient with severe, uncontrolled pain progressively deteriorate due to muscle atrophy and contractures and go from cane to walker to wheelchair. An unappreciated complication of deconditioning and immobility is obesity.
Opsins are a group of light-sensitive proteins found in photoreceptor cells of the retina. Five classical groups of opsins are involved in vision, mediating the conversion of a photon of light into an electrochemical signal, the first step in the visual transduction cascade. Another opsin found in the mammalian retina, melanopsin, is involved in circadian rhythms and pupillary reflex but not in image-forming.
statin - a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase lipid-lowering medication, lipid-lowering medicine, statin drug atorvastatin, Lipitor - an oral drug (trade name Lipitor) that is effective in lowering triglycerides; potent in reducing LDL cholesterol because higher doses can be given