These systems won't slow down from being turned on for long periods of time.. the only thing that isn't hardware related that you NEED to reboot Linux for is if you install a new kernel, you have to reboot in order to load the new kernel..
Masoub or Malakia is a banana and honey wholewheat bread pudding if you will. It is popular in Yemen, Saudi Arabia and the UAE. It is usually served for breakfast or dessert after a meal. The recipe is rather simple and it is a great example of how an outcome can be much greater than the sum of its parts.
What is Cotellic? Cotellic (cobimetinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cotellic is used to treat a certain type of metastatic melanoma (skin cancer) that has spread to other parts of the body and cannot be removed with surgery. Cotellic is usually given together with another medicine called vemurafenib (Zelboraf).