Splenic-flexure syndrome is a chronic disorder that may be caused by gas trapped at bends (flexures) in the colon. Crohn's disease, colon cancer, or any disease that causes intestinal obstruction, may also cause abdominal bloating. Internal hernias or adhesions (scar tissue) from surgery may cause bloating or pain.
For many years it was thought that the maximum number of folds that could be achieved was just seven! This was the case until when in 2002 American teenager Britney Gallivan demonstrated that a sheet of paper can be folded 12 times, provided that it is long enough and thin enough.
So A3 sheets of paper can be folded to create A4-size booklets. Another interesting consequence is that it becomes easy to calculate the weight of single sheets. Standard photocopy paper is usually 80gsm (grams per square metre), thus an A0 sheet, being 1 square metre, weighs 80g.