In a 2009 paper, Ceballos and Ãlvarez showed that the extent of inbreeding increased over the reign of the Habsburgs, so that Charles II was more inbred than is typical of a child of a brother and sister.
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For Patients. Orencia (abatacept) is a recombinant DNA generated fusion protein used to treat the symptoms of rheumatoid arthritis and to prevent joint damage caused by these conditions. Orencia is also used to treat arthritis in children who are at least 6 years old.