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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
The blood-brain barrier, or BBB, consists of the endothelial cells lining the blood vessels in the brain. These fortress cells are glued together very tightly and, in contrast to other organs and tissues, there are no chinks between them for blood-borne materials to leak into brain tissue.