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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Over-the-counter sleep aids help when sleep does not come easily and can be used for up to two weeks to help get the recommended amount of sleep, which is 6 to 10 hours each night. Unisom makes sleep aids for adults, and has three types, each with one active ingredient.