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Immune system disorders cause abnormally low activity or over activity of the immune system. In cases of immune system over activity, the body attacks and damages its own tissues (autoimmune diseases). Immune deficiency diseases decrease the body's ability to fight invaders, causing vulnerability to infections.
Normally, the immune system (the body's defence against invaders) protects the body from infection and foreign substances such as bacteria and viruses. In autoimmune diseases, such as SjÃ¶gren's syndrome, the immune system triggers an inflammatory response when there are no foreign substances to fight off. This inflammatory response causes the body's white blood cells to attack and destroy certain moisture-producing glands. The exact cause for the abnormal immune response in SjÃ¶gren's syndrome is unknown. Some theories suggest that a virus or bacteria may alter the immune system, causing it to attack the glands. Some people may have a genetic or inherited factor that makes them more likely to develop Sjogren's syndrome.