In a 2009 paper, Ceballos and Ãlvarez showed that the extent of inbreeding increased over the reign of the Habsburgs, so that Charles II was more inbred than is typical of a child of a brother and sister.
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Two important final notes: (1) about the similarity of all kinds of entropy change â whether âheatâ transfer to a system from surroundings (or the converse) or the volume expansion of a system or the mixing of fluids or solid and solvent; and (2) the meaning of âunavailable energyâ and âentropy as waste heatâ.