Hypothetically, if the threshold is normally -60mV, but now we have too much calcium on board, our threshold is now -50mv. That is a difference of 40mV that the cell has to account for in order to depolarize. In skeletal muscle, this can cause weakness, fatigue, etc. Too little calcium will cause the threshold to become more negative (gets closer to the resting membrane potential).
OK, this is probably going to come with you laughing at me... Once in a while I wake up with the back of my head sweating, and it`s more common when I take a nap during the day.
Night sweats may indicate hidden infection in the body, an autoimmune digestive disease such as Chron's, or the presence of malignant tumors or leukemia. More commonly, night sweats are a result of hormonal imbalance or the side effects of medications.