Splenic-flexure syndrome is a chronic disorder that may be caused by gas trapped at bends (flexures) in the colon. Crohn's disease, colon cancer, or any disease that causes intestinal obstruction, may also cause abdominal bloating. Internal hernias or adhesions (scar tissue) from surgery may cause bloating or pain.
For many years it was thought that the maximum number of folds that could be achieved was just seven! This was the case until when in 2002 American teenager Britney Gallivan demonstrated that a sheet of paper can be folded 12 times, provided that it is long enough and thin enough.
Brochures are also known as pamphlets and are more expensive to print. A brochure is generally a standard-size sheet of paper that has been folded lengthwise two times to create four panels (bi-fold) or folded three times to create six panels (tri-fold). Brochures are more complicated to print because each panel has its own margins, its own photos and its own headlines.