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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
Tamoxifen is a drug that is given to women who have estrogen-sensitive breast cancer. What does this tell you about the relationship between tamoxifen and the tumor cells in this case? The tumor cells must have receptors for estrogen, and tamoxifen is an agonist of estrogen receptors. The tumor cells have receptors for tamoxifen only.