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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Types of insomnia meds include: 1  Prescription sleeping pills â like Ambien, Lunesta and Rozerem. 2  Non-prescription or over-the-counter sleep aids â like Unisom and Sominex. 3  OTC antihistamines â like Benadryl that contains diphenhydramine. Prescription sleeping pills â like Ambien, Lunesta and Rozerem. 2  Non-prescription or over-the-counter sleep aids â like Unisom and Sominex. 3  OTC antihistamines â like Benadryl that contains diphenhydramine. 4  Anti-depressants â like amitriptyline and trazodone that do better jobs of inducing sleep.