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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
For example, certain cold treatment medications, nasal decongestants, and antiallergy medications can affect your urination. Anticholinergics, which are used to treat stomach cramps, muscle spasms, and incontinence, can also cause urinary retention and hesitancy. Antidepressants may also affect your urinary habits.