Splenic-flexure syndrome is a chronic disorder that may be caused by gas trapped at bends (flexures) in the colon. Crohn's disease, colon cancer, or any disease that causes intestinal obstruction, may also cause abdominal bloating. Internal hernias or adhesions (scar tissue) from surgery may cause bloating or pain.
For many years it was thought that the maximum number of folds that could be achieved was just seven! This was the case until when in 2002 American teenager Britney Gallivan demonstrated that a sheet of paper can be folded 12 times, provided that it is long enough and thin enough.
For example, the Miura map fold is a rigid fold that has been used to deploy large solar panel arrays for space satellites. The napkin folding problem is the problem of whether a square or rectangle of paper can be folded so the perimeter of the flat figure is greater than that of the original square. Curved origami also poses a (very different) set of mathematical challenges. Curved origami allows the paper to form developable surfaces that are not flat.