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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
blood-brain barrier, n barrier formed by epithelial cells in the capillaries that supply the brain and central nervous system. This barrier selectively allows entry of substances such as glucose, some ions, and oxygen, while blocking entry of other substances.lood-brain barrier, n barrier formed by epithelial cells in the capillaries that supply the brain and central nervous system. This barrier selectively allows entry of substances such as glucose, some ions, and oxygen, while blocking entry of other substances.