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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
Keywords: Phenytoin, MRI, Multiple drug resistance, Drug delivery, Drug design, Pharmacokinetics. The bloodâbrain barrier (BBB) protects the brain from harmful substances in the bloodstream, while supplying the brain with the nutrients required for proper function.The endothelial cell cerebrovasculature lining also regulates brain penetration of drugs.ack of significant effect of bloodâbrain barrier disruption (BBBD) on brain water content and modest effect of parenchymal edema on drug uptake. (A) Calibration curve for the determination of water content and determination of water brain content ...