Joe Pesci plays Vinny Gambini, a New York attorney newbie who has to go to Alabama to defend his wrongly accused cousin and friend in a murder trial. Hilarity and profanity ensue. Marisa Tomei plays his argumentative fianc e with a highly-exaggerated New York accent that got her a Best Supporting Actress Oscar.
Parkinson's disease (PD) is a long term disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Thinking and behavioral problems may also occur. Dementia becomes common in the advanced stages of the disease. Depression and anxiety are also common occurring in more than a third of people with PD.
Late-stage Parkinson disease. Summary of Late-stage Parkinson disease.. The cardinal symptoms of Parkinson disease (PD) are asymmetrical bradykinesia, rigidity, resting tremor and postural instability. However, the presence and spectrum of, and disability caused by, nonmotor symptoms (NMS) are being increasingly recognized.