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Benadryl (diphenhydramine) vs. Claritin (loratadine). The main difference between these two medications is that Claritin is a slower acting more long term solution, whereas Benadryl is great for more severe and sudden allergic reactions.
Â· just now. Report Abuse. Claritin (Loratadine) is a 2nd generation anti-histamine and is, in all regards, exactly the same as benadryl. It does not, however, cross into the brain as readily and cause the sedative effects people are very familiar with in anti-histamines.That said, every person has a specific does-response relationship. just now. Report Abuse. Claritin (Loratadine) is a 2nd generation anti-histamine and is, in all regards, exactly the same as benadryl. It does not, however, cross into the brain as readily and cause the sedative effects people are very familiar with in anti-histamines.