Small nerves might comprise a single funiculus, but in case of large nerves, the funiculi join to form large bundles of nerve fibers called fasciculi. These are kept together by membranous sheaths or layers of connective tissue called endoneurium, perineurium, and epineurium. The epineurium is a sense layer of connective tissue that envelops the entire nerve trunk. It surrounds the fascicles and the blood vessels that supply the nerve.
1 The latent period between infection with a cancer-causing HPV virus and demonstration of Pap smear abnormalities can be measured in years. 2  Once dysplastic changes are initiated, the degree of dysplasia typically slowly worsens as the cellular changes progress toward cancer.
The primary immune responses can be divisible into four phases (lag phase, exponential phase, steady state phase, and declining phase) (Fig. 7.1). a. The lag (latent) phase is the period from the initial exposure of immunogen to the time of detection of antibodies (In humans the average time of lag phase is about one week).