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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
If youâre going to try Kirkland Sleep Aid, itâs best to do so when youâre anticipating a long nightâs sleep and not having to get up super early in the morning. This drug can affect your system for many hours, so youâll want to allow plenty of time before you have to be active and certainly before you have to drive.. Unisom OTC sleep aids are some of the best known products on the market. Like the Kirkland sleep aid, they are an anti-histamine sleeping pill, but the active ingredient is different.