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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
1. Kirkland Sleep Aid. This product, which can be found here, is perhaps the strongest OTC sleep aid available. It is an anti-histamine sleep aid, which is a common category of sleep aid.It works against the histamine produced by the bodyâs central nervous system, making it possible for the user to feel drowsy. Many people who have used this product report feeling both physically and mentally drowsy shortly after ingestion.. Unisom OTC sleep aids are some of the best known products on the market. Like the Kirkland sleep aid, they are an anti-histamine sleeping pill, but the active ingredient is different.