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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
A: The estrogen receptor status strongly predicts the response to hormonal treatment in patients with breast cancer, both in the adjuvant ( absolute risk reduction of 10-15% with regard to breast cancer mortality) and metastatic setting (approximately 50-60% response in first line treatment).