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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
Pregnancy causes a high estrogen level in the new mother. Estrogen is any substance, natural or artificial, which induces estrogenic activity. Estradiol is the most potent form of estrogen produced by the body. Derived from cholesterol, it is produced by fat cells, arterial walls, adrenal glands, brain tissue and the ovaries. A blood estradiol test can generally assesses the function of the ovaries.