â¢ AUTOIMMUNE DISEASE (noun). The noun AUTOIMMUNE DISEASE has 1 sense: 1. any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues.
The initiation of cell transformation is generally associated with genetic alterations in normal cells that lead to the loss of intercellular-and/or extracellular-matrix- (ECM-) mediated cell adhesion.ancer afflicts an organ or a tissue by inducing abnormal and uncontrolled division of cells that either constitute it or migrate to it. At the cellular level, this is caused by genetic alterations in networks that regulate cell division and cell death.
While epigenetic changes are required for normal development and health, they can also be responsible for some disease states. Disrupting any of the three systems that contribute to epigenetic alterations can cause abnormal activation or silencing of genes.or example, methylation of a particular lysine (K9) on a specific histone (H3) that marks silent DNA is widely distributed throughout heterochromatin. This is the type of epigenetic change that is responsible for the inactivated X chromosome of females.