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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Updated May 30, 2016. The over-the-counter medication diphenhydramine is found in many sleeping pills intended for insomnia treatment. It is the sleep-inducing element in medications used as sleep aids such as Simply Sleep, Unisom, Tylenol PM, Advil PM, Aleve PM, and Benadryl. Its use does not require a prescription, so it may be a good initial option for the treatment of acute insomnia to help initiate and maintain sleep.