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Gadolinium contrast medium is generally very safe. Side effects or reactions are uncommon, but can occur. In patients with normal kidney function, most of the gadolinium contrast medium injected (over 90%) is passed out in the urine within 24 hours.
Because gadolinium is a large molecule, it normally cannot pass through the blood-brain barrier (a cell layer around blood vessels in the brain and spinal cord that prevents substances from passing from the blood stream into the central nervous system).