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Epigenetics Around the Web is a weekly roundup of the latest studies and news in the field of epigenetics presented by GLP sister site the Epigenetics Literacy Project. This week features a video by scientists from the Garvan Institute of Medical Research on how epigenetic changes lead to cancer and scientists devise a way to edit the epigenome. How epigenetic changes cause cancer. There is a classical view of cancer in which the disease arises via genetic mutations. These mutations cause changes in genes that can make the protein non-functional or over active. But as I pointed out in the December 2 Epigenetics Around the Web post, epigenetic changes can also cause similar changes in a cell. Hypermethylation of a gene important for DNA repair could inhibit the proteinâs activity.
Epigenetics is an emerging science focused on how and when particular genes are turned on or off. Diet and exposure to chemicals in the environment, among other factors, can alter a cell's DNA in ways that affect the activity of genes. That can make people more or less susceptible to developing a disease.n other diseases, a genetic variant may occur. A single gene can have many variants. Sometimes, this difference in a gene can cause a disease directly. More often, a variant plays a role in increasing or decreasing a person's risk of developing a disease or condition.