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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Disorders such as sleep apnea and other associated sleep disorders can also cause excessive urination at night. For a period of time keep an up to date diary of how often you need to urinate. Keep a record of the levels you urinate. Also keep a record of how much fluid you are drinking throughout the day and evening.