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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.oagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host.
A wound stops bleeding due to the process of clot formation called coagulation. Coagulation is from the Latin coagulatus meaning to cause to curdle. Blood contains an enzyme called Protease 34 kD or thrombin for short. Thrombin is made in the liver. The only time thrombin seems to become active in the body is when there is an open wound. Blood is circulating tissue composed of a fluid portion (plasma) with suspended formed elements (platelets, red blood cells, and white blood cells). Arterial blood is the means by which oxygen and nutrients are transported to body tissues.