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Epigenetics Around the Web is a weekly roundup of the latest studies and news in the field of epigenetics presented by GLP sister site the Epigenetics Literacy Project. This week features a video by scientists from the Garvan Institute of Medical Research on how epigenetic changes lead to cancer and scientists devise a way to edit the epigenome. How epigenetic changes cause cancer. There is a classical view of cancer in which the disease arises via genetic mutations. These mutations cause changes in genes that can make the protein non-functional or over active. But as I pointed out in the December 2 Epigenetics Around the Web post, epigenetic changes can also cause similar changes in a cell. Hypermethylation of a gene important for DNA repair could inhibit the proteinâs activity.
What is Epigenetics? âEpigeneticsâ refers to covalent modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences.