About Zollinger-Ellison Syndrome. Zollinger-Ellison syndrome is a rare disorder that occurs when one or more tumors form in the pancreas and duodenum.The tumors, called gastrinomas, release large amounts of gastrin that cause the stomach to produce large amounts of acid.ollinger-Ellison Syndrome. A group of symptoms that occur when a tumor called a gastrinoma forms. The tumor, which can be cancerous, releases large amounts of the hormone called gastrin. The gastrin causes too much acid in the duodenum, resulting in ulcers, bleeding, and perforation. PubMed Health Glossary.
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