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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
It should be safe especially when Unisom can be taken during the day time for morning sickness and at night for difficulty sleeping. I too have taken 1 1/2 tablet last night and still found myself waking up in the middle of the night like at 2am and have a hard time going back to sleep.