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Whatâs more, aside from increased level of ammonia in the blood, other symptoms also can be induced such as muscle weakness, fatigue, lethargy and so on. In addition, if left untreated, elevated blood ammonia can affect brain tissue, leading to symptoms such as confusion and delirium.
Quick Answer. A high blood ammonia level occurs due to the failure of the liver to convert the ammonia in the blood to urea, as stated by WebMD. This may be caused by different conditions, such as severe hepatitis and cirrhosis. This can also be associated with hepatic encephalopathy, an infection that occurs when the liver fails to perform its functions.