When an arrhythmia causes the heart to beat too fast, the heart doesn't pump effectively. Specifically, there may not be enough time between heartbeats for the heart to fill with blood, causing blood to back up into the lungs.
The new non-steroidal and steroidal aromatase inhibitors are at least as effective as megestrol acetate (MA) as second-line hormonal agents in postmenopausal women with breast cancer.However, they are superior to MA in terms of tolerability and adverse effects.he Type I inhibitors have a steroidal structure similar to androgens and inactivate the enzyme irreversibly by blocking the substrate-binding site, and are therefore known as aromatase inactivators. Examples of such drugs include formestane and exemestane (Aromasin).
Freebase(0.00 / 0 votes)Rate this definition: Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis.