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Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. The combination of dextromethorphan and promethazine used to treat cough, itching, runny nose, sneezing, and itchy or watery eyes caused by colds or allergies.
Cough medicine containing dextromethorphan in gel cap form. Dextromethorphan (DXM) , a common active ingredient found in many over-the-counter cough suppressant cold medicines, is used as a recreational drug and entheogen for its dissociative effects.It has almost no psychoactive effects at medically recommended doses.t high doses, dextromethorphan is classified as a dissociative general anesthetic and hallucinogen, similar to the controlled substances ketamine and phencyclidine (PCP). Also like those drugs, dextromethorphan is an NMDA receptor antagonist.