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Whatâs more, aside from increased level of ammonia in the blood, other symptoms also can be induced such as muscle weakness, fatigue, lethargy and so on. In addition, if left untreated, elevated blood ammonia can affect brain tissue, leading to symptoms such as confusion and delirium.
Normally, the urea is removed from the body through the urine. In urea cycle disorders, nitrogen builds up in the blood in the form of ammonia, a highly toxic substance, resulting in hyperammonemia (elevated blood ammonia). Ammonia then reaches the brain through the blood, where it can cause irreversible brain damage, coma and/or death.