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GABA is made in brain cells from glutamate and works by blocking nerve impulses. Glutamate fires the nerve impulses and GABA does the opposite by telling the nerves not to fire. In the case of GABA deficiency, nerve cells fire too often and too easily.hat is where GABA comes in. Gamma-Amino Butyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system.
Amino acid neurotransmitters are all products of intermediary metabolism with the exception of GABA. Unlike all the other amino acid neurotransmitters, GABA is not used in protein synthesis and is produced by an enzyme (glutamic acid decarboxylase; GAD) uniquely located in neurons.Antibodies to GAD can be used to identify neurons that release GABA.xcitatory transmission (the production of EPSPs) is mediated largely by the acidic amino acid glutamate. Inhibitory neurotransmission (IPSPs) is mediated primarily by glycine in the spinal cord, and a metabolite of glutamate called gamma-aminobutyric acid (GABA) in the brain.