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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Unisom does come in 2 different forms, one containing doxylamine, one containing diphenhydramine. From You vage discription one can't really tell what he could have been taking. Nausea is not a strange side effect if taking a overdose of ANY drug. It is most probable that he had been taking diphenhydramine, as he has been taking it before quite often and he probably knows what he buys.