More directly relevant is the level of kidney function. In patients with poor kidney function or those on dialysis, the drug can accumulate to levels above the theraputic range. There are several reports of abnormal movements (myoclonus) when this occurs. Common practice is to start at a lower dose in these patients.
Bleach (Nirvana album) Bleach is the debut studio album by American rock band Nirvana, released on June 15, 1989 by Sub Pop. The main recording sessions took place at Reciprocal Recording in Seattle, Washington between December 1988 and January 1989.
I don't know if this source for TV anime series viewership rating is reliable or not, but viewership for Bleach started out at around 5%, gradually dropped but still managed to get 2-3% up to the point of Aizen's defeat, but it reduced further and sustained at 1-2% till the point it was cancelled.