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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
blood-brain barrier (BBB). Etymology: AS, blod + bragen + ME, barrere. an anatomic-physiologic feature of the brain thought to consist of walls of capillaries in the central nervous system and surrounding astrocytic glial membranes. The barrier separates the parenchyma of the central nervous system from blood.The blood-brain barrier prevents or slows the passage of some drugs and other chemical compounds, radioactive ions, and disease-causing organisms such as viruses from the blood into the central nervous system.he blood-brain barrier prevents or slows the passage of some drugs and other chemical compounds, radioactive ions, and disease-causing organisms such as viruses from the blood into the central nervous system.