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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
C: The estrogen receptor belongs to the nuclear hormone receptor family, is located at the nuclear membrane in the cytosol of the cell ( not on the outer membrane) D: ER positive breast cancers are more likely to cause apparent metastatic disease in bones, genital tract and soft tissue than ER negative tumours.