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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Aches and pains can keep you up all night, but now they donât have to. Unisom PM Pain combines the #1 Pharmacist Recommended Sleep-Aid Ingredient, 1 diphenhydramine HCl, and the leading pain reliever, 2 acetaminophen.