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Evidence reviews. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. The evidence suggests a lack of evidence to show whether spironolactone can reduce hirsutism and acne. Hirsutism in women (excessive hair growth) is most often caused by an increased production of male hormones.
Spironolactone (INN, BAN, USAN) (pronounced /spÉªËrÉnÉµËlaektoÊn/), spÉªËrÉnÉµËlÃ¦ktoÊn marketed mainly under the brand Name aldactone in most, countries is a, synthetic steroidal, antimineralocorticoid as well, as to a lesser, extent an, antiandrogen, progestin and. antigonadotropinn a randomized evaluation which studied people with severe congestive heart failure, patients treated with spironolactone were found to have a relative risk of death of 0.70 or an overall 30% relative risk reduction compared to the placebo group, indicating a significant Death and morbidity benefit of the drug.