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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
I am incredibly sensitive to artificial hormones. I tried several others, all of which caused me to experience severe depression, before switching to a new doctor who realized that it was not the estrogen that was causing my problems but the progestin. She had me try Kariva since it is low-progestin. It made a world of difference.