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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
2-deoxyglucose is an analog of glucose and is transported across the blood-brain barrier by the glucose carrier system. Inside brain cells, 2-deoxyglucose is phosphorylated by hexokinase to deoxyglucose-6-phosphate (DG-6-P) and cannot be further degraded into CO2 and H2O.lucose is the primary energy substrate of the brain. Glucose transport protein (GLUT-1) is highly enriched in brain capillary endothelial cells. These transporters carry glucose molecules through the blood brain barrier.