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To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor positive (ER positive), estrogen sensitive, or estrogen responsive.
Estrogens are hormones that are important for sexual and reproductive development, mainly in women. They are also referred to as female sex hormones. The term estrogen refers to all of the chemically similar hormones in this group, which are estrone, estradiol (primary in women of reproductive age) and estriol.strogen's function. In women, estrogen is produced mainly in the ovaries, but it is also produced by fat cells and the adrenal gland. Estrogen is involved in the onset of puberty, playing a role in the development of so-called secondary sex characteristics, such as breasts, and pubic and armpit hair.