Small nerves might comprise a single funiculus, but in case of large nerves, the funiculi join to form large bundles of nerve fibers called fasciculi. These are kept together by membranous sheaths or layers of connective tissue called endoneurium, perineurium, and epineurium. The epineurium is a sense layer of connective tissue that envelops the entire nerve trunk. It surrounds the fascicles and the blood vessels that supply the nerve.
1 The latent period between infection with a cancer-causing HPV virus and demonstration of Pap smear abnormalities can be measured in years. 2  Once dysplastic changes are initiated, the degree of dysplasia typically slowly worsens as the cellular changes progress toward cancer.
Recombinant human papillomavirus (HPV) nonavalent vaccine is approved to prevent some conditions caused by certain types of HPV. The vaccine protects against nine different types of HPV. It is used in females aged 9 to 26 years and males aged 9 to 15 years to prevent the following: 1  Anal cancer. 2  Cervical cancer.