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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
plays a role in the blood brain barrier, acting as an efflux pump to prevent the entry of. specific drugs into the nervous system [6]. Ivermectin is highly lipophilic and thus. usually has very poor penetration of the blood brain barrier, due to the action of the drug. efflux transporters. Deficiency or disruption of this gene leads to enhanced absorption. and exposure of the brain to a number of drugs, including ivermectin. Treatment has also.