Tensor tympani- The tensor tympani is the larger of the two muscles of the auditory canal, the other being stapedius. The muscle functions to dampen down sounds such as chewing. It arises from the cartilaginous portion of the eustachian tube as well as the adjacent section of the greater wing of the sphenoid bone.
A nonsense mutation in the leptin gene that results in a stop codon and lack of leptin production was first observed in mice in 1950. In the mouse gene, arginine-105 is encoded by CGA and only requires one nucleotide change to create the stop codon TGA.
After receiving injections of leptin, obese mice dropped their fat and returned to a normal body weight. That clinical result led to supplement companies manufacturing leptin and promoting it for weight loss. There was just one little problem. Obese people didn't have a deficiency. The amount of leptin in your body is directly proportional to the amount of fat. As fat cells become enlarged in obesity, they release more leptin.