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The documented causes of hair-shaft discoloration include certain disease states, medications, and exogenous chemicals. The predominant cause of yellow hair, or xanthotrichia, has been determined to be exogenous chemicals. Some of the compounds implicated in yellow hair discoloration include selenium sulfide 2.5% (anti-dandruff) shampoo and dihydroxyacetone (found in self-tanners).
When teeth are forming (during the second half of pregnancy through eight years of age), doxycycline can cause permanent tooth discoloration. The discoloration usually starts off as bright yellow, but fades to a yellow/gray/brown color. Some cases of inadequate tooth enamel have also been reported.