Small nerves might comprise a single funiculus, but in case of large nerves, the funiculi join to form large bundles of nerve fibers called fasciculi. These are kept together by membranous sheaths or layers of connective tissue called endoneurium, perineurium, and epineurium. The epineurium is a sense layer of connective tissue that envelops the entire nerve trunk. It surrounds the fascicles and the blood vessels that supply the nerve.
1 The latent period between infection with a cancer-causing HPV virus and demonstration of Pap smear abnormalities can be measured in years. 2  Once dysplastic changes are initiated, the degree of dysplasia typically slowly worsens as the cellular changes progress toward cancer.
HIV infection goes into its second stage, which can be a long period without symptoms, called the asymptomatic (or latent) period. This is when people may not know they are infected and can pass HIV on to others. This period can last 10 or more years. During this period without symptoms, HIV is slowly killing the CD4 T-cells and destroying the immune system. Blood tests during this time can reveal the number of these CD4 T-cells. Normally, a person has a CD4 T-cell count between 450 and 1,400 cells per microliter.