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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Diphenhydramine HCl is the main active ingredient in Unisom's SleepGels. Diphenhydramine HCl is an antihistamine with sedative effects and is used for many things other than for allergies. Diphenhydramine, depending on the dosage and combination with other drugs, is used for motion sickness and as a sleep aid.