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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
The bloodâbrain barrier is formed by brain endothelial cells, which are connected by tight junctions with an extremely high electrical resistivity of at least 0.1 Ïâm.t is believed that latent HIV can cross the bloodâbrain barrier inside circulating monocytes in the bloodstream ( Trojan horse theory) within the first 14 days of infection. Once inside, these monocytes become activated and are transformed into macrophages.