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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Discover the potential roles of diabetes, obstructive sleep apnea, and prostate or bladder problems in waking to urinate at night. Nocturia is defined as the excessive need to get up and urinate during the night. You may find yourself using the bathroom several times per night and this can be disruptive to your sleep.