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Gadolinium contrast medium is generally very safe. Side effects or reactions are uncommon, but can occur. In patients with normal kidney function, most of the gadolinium contrast medium injected (over 90%) is passed out in the urine within 24 hours.
Story at-a-glance 1  -. The use of gadolinium-based contrast agents for enhanced MRIs has been linked to hypersensitivity in certain brain regions, with unknown consequences. 2  The use of gadolinium-based contrast agents is linked to the development of Nephrogenic Systemic Fibrosis (NSF) in patients with severe kidney disease.