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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.oagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host.
Steps of Coagulation (Blood Clotting): 1  When the lining of a blood vessel is damaged (by an injury/lesion/wound/cut), the blood vessels get contracted to stop bleeding. 2  Small blood cells (called platelets) immediately form a plug at the site of the injury to prevent blood from bleeding out of the injured blood vessel.