â¢ AUTOIMMUNE DISEASE (noun). The noun AUTOIMMUNE DISEASE has 1 sense: 1. any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues.
The initiation of cell transformation is generally associated with genetic alterations in normal cells that lead to the loss of intercellular-and/or extracellular-matrix- (ECM-) mediated cell adhesion.ancer afflicts an organ or a tissue by inducing abnormal and uncontrolled division of cells that either constitute it or migrate to it. At the cellular level, this is caused by genetic alterations in networks that regulate cell division and cell death.
Jordanna Joaquina, MS, CGC. Most cases of polycythemia vera appeared to be caused by sporadic, somatic mutations as opposed to inherited mutations. Most cells in our body divide to make new cells. The DNA in those cells needs to be replicated for each new cell. Sporadic DNA changes can occur during cell division or DNA replication as well as with environment damage. Cancer is a multifactorial condition, which means that it involves a combination of genetic and non-genetic factors. Some types of cancer have a stronger genetic component than others.