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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
The bloodâbrain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function.he BBB is distinct from the quite similar bloodâcerebrospinal-fluid barrier, which is a function of the choroidal cells of the choroid plexus, and from the bloodâretinal barrier, which can be considered a part of the whole realm of such barriers. Several areas of the human brain are not on the brain side of the BBB.