Tensor tympani- The tensor tympani is the larger of the two muscles of the auditory canal, the other being stapedius. The muscle functions to dampen down sounds such as chewing. It arises from the cartilaginous portion of the eustachian tube as well as the adjacent section of the greater wing of the sphenoid bone.
A nonsense mutation in the leptin gene that results in a stop codon and lack of leptin production was first observed in mice in 1950. In the mouse gene, arginine-105 is encoded by CGA and only requires one nucleotide change to create the stop codon TGA.
In this open-label pilot study in HIV-infected men with lipoatrophy and hypoleptinemia, administration of recombinant human leptin for 6 months was associated with a robust decrease in visceral fat, an increase in hepatic insulin sensitivity, and marked improvement of dyslipidemia.