For a single return trip from Paris to Brussels, a point to point ticket is the best value for money and the cheapest train ticket. Best prices are available when buying the train ticket well in advance. For extensive train travel, a rail pass for France and Belgium is a better choice.
creÂ·tinÂ·ism. n. A congenital condition caused by a deficiency of thyroid hormone during prenatal development and characterized in childhood by dwarfed stature, mental retardation, dystrophy of the bones, and a low basal metabolism. Also called congenital myxedema. (ËkrÉtÉªËnÉªzÉm).
Thyroid disorders caused by overproduction of thyroid hormones are called hyperthyroidism, and underproduction of these hormones is known as hypothyroidism. The cause of secondary hypothyroidism is failure of the pituitary gland to secrete thyroid stimulating hormone (TSH). This is usually caused by a tumor in the region of the pituitary. Rarely the cause is an infiltration of the pituitary by inflammatory cells from the immune system or foreign substances (such as iron in hemochromotosis).