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Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. The combination of dextromethorphan and promethazine used to treat cough, itching, runny nose, sneezing, and itchy or watery eyes caused by colds or allergies.
Dextromethorphan (DXM or DM) is an active ingredient in several over-the-counter cough medicines, including generic labels and store brands (TheraFlu, Delsym, Coricidin, Vicks, Dimetapp, Robitussin, Benylin, NyQuil).