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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
However, magnetic resonance imaging has shown that when a person is undergoing an MS attack, the bloodâbrain barrier has broken down in a section of the brain or spinal cord, allowing white blood cells called T lymphocytes to cross over and attack the myelin.t is believed that latent HIV can cross the bloodâbrain barrier inside circulating monocytes in the bloodstream ( Trojan horse theory) within the first 14 days of infection. Once inside, these monocytes become activated and are transformed into macrophages.