In the Garden (1912 song) For the Van Morrison song, see In the Garden (Van Morrison song). In the Garden (sometimes rendered by its first line I Come to the Garden Alone) is a gospel song written by American songwriter C. Austin Miles (1868â1946), a former pharmacist who served as editor and manager at Hall-Mack publishers for 37 years.
The price of sofosbuvir, quoted in various media sources as $84,000 to $168,000 for a course of treatment in the U.S., Â£35,000 in the UK for 12 weeks has engendered considerable controversy.
Class and Mechanism. Sofosbuvir (Sovaldi) is a nucleotide analog inhibitor of hepatitis C virus NS5B polymeraseâthe key enzyme mediating HCV RNA replication. Sofosbuvir is a prodrug and after ingestion it is rapidly converted to GS-331007, the predominant circulating drug that accounts for greater than 90% of the systemically active drug.