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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
The methylcobalamin B12 is the only one that crosses the blood brain barrier. I think the 5000 mcg is the highest dosage made in one sublingual.I just had a huge relapse of my Chronic Fatigue Syndrome. I searched for something that might help my debilitating brain fog.I got this out of desperation.he methylcobalamin B12 is the only one that crosses the blood brain barrier. I think the 5000 mcg is the highest dosage made in one sublingual.I just had a huge relapse of my Chronic Fatigue Syndrome. I searched for something that might help my debilitating brain fog. I got this out of desperation.