Tensor tympani- The tensor tympani is the larger of the two muscles of the auditory canal, the other being stapedius. The muscle functions to dampen down sounds such as chewing. It arises from the cartilaginous portion of the eustachian tube as well as the adjacent section of the greater wing of the sphenoid bone.
A nonsense mutation in the leptin gene that results in a stop codon and lack of leptin production was first observed in mice in 1950. In the mouse gene, arginine-105 is encoded by CGA and only requires one nucleotide change to create the stop codon TGA.
The most common cause of secondary imatinib resistance is point mutations in BCR-ABL that prevent effective binding of imatinib but may retain kinase activity. Over 100 point mutations coding for single amino acid substitutions in the BCR-ABL kinase domain have been isolated from imatinib resistant CML patients.he exchange of the amino acids threonine and isoleucine at position 315 (T315I) of the BCR-ABL protein was the first mutation detected in imatinib resistant chronic myeloid leukemia (CML) patients. Sequencing of cloning products revealed the T315I mutation in 6 of 9 resistant patients.