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Vibrato is a musical effect consisting of a regular, pulsating change of pitch. It is used to add expression to vocal and instrumental music. Vibrato is typically characterised in terms of two factors: the amount of pitch variation (extent of vibrato) and the speed with which the pitch is varied (rate of vibrato).ibrato is typically characterised in terms of two factors: the amount of pitch variation (extent of vibrato) and the speed with which the pitch is varied (rate of vibrato).
Valsartan/sacubitril (brand name Entresto) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotension receptor blocker in people with heart failure with reduced ejection fraction.