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The documented causes of hair-shaft discoloration include certain disease states, medications, and exogenous chemicals. The predominant cause of yellow hair, or xanthotrichia, has been determined to be exogenous chemicals. Some of the compounds implicated in yellow hair discoloration include selenium sulfide 2.5% (anti-dandruff) shampoo and dihydroxyacetone (found in self-tanners).
Anemia. Anemia is one of the common causes of lip discoloration particularly in women during the reproductive years. It is often related to iron-deficiency anemia but any type of anemia can be responsible. Anemia is a lower than normal concentration of the oxygen-carrying compound known as hemoglobin.