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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
What are the active ingredients in Unisom products? SleepGels: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose). SleepTabs: SleepTabs contain doxylamine succinate (25 mg/dose). SleepMinis: The active sleep-aid ingredient is Diphenhydramine HCl (50 mg/dose). Unisom Liquid: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose or 30mL/dose). SleepMelts: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose). PM Pain: The active sleep-aid ingredient is diphenhydramine HCl (50 mg/dose).