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Whatâs more, aside from increased level of ammonia in the blood, other symptoms also can be induced such as muscle weakness, fatigue, lethargy and so on. In addition, if left untreated, elevated blood ammonia can affect brain tissue, leading to symptoms such as confusion and delirium.
Early-onset hyperammonemia presents in the neonatal period. The baby is usually well for the first day or two. As the ammonia level rises, the baby becomes symptomatic. The family gives a history of lethargy, irritability, poor feeding, and vomiting. These symptoms correlate with an ammonia level of 100-150 Âµmol/L, which is 2-3 times the reference range.