GERD may lead to Barrett's esophagus, a type of intestinal metaplasia, which is in turn a precursor condition for esophageal cancer. The risk of progression from Barrett's to dysplasia is uncertain, but is estimated at about 20% of cases.
The Newell Manufacturing Company was founded in Ogdensburg, New York in 1903 as a manufacturer of metal curtain rods.
After a long period attempting to develop a process to upgrade rubber qualities (such as including nitric acid) that almost ruined him, in 1840 Goodyear discovered vulcanization, quite by accident. An interesting fact: in 1815, a humble sawyer-Hancock-became one of the leading manufacturers in the UK.