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Based on site visits to a number of mixed waste MRFs in California, equipment retrofits completed in the last three years cost $14.7 million and $26 million for 1,500 and 2,000 TPD mixed waste MRFs, respectively.
The estimated US prevalence of MF in the US is ~18,000, most of whom are symptomatic to some extent. Annual cost of Jakafi is ~$92k. Assuming 9,000 receive treatment with a JAK inhibitor at an annual cost of $70k (patients may have treatment holidays), the addressable market is $630M. PV is much more prevalent (90,000 patients in the US) but it is typically milder and the unmet need is lower.