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TPD. 16 The average O&M cost for the smallest MRFs (less than 6 TPD throughput) was $201.78 per ton. This decreased to about $46.09 per ton for facilities processing 121 to 218 TPD, and then rose slightly to $55.87 per ton for MRFs processing more than 218 tons per day.
The estimated US prevalence of MF in the US is ~18,000, most of whom are symptomatic to some extent. Annual cost of Jakafi is ~$92k. Assuming 9,000 receive treatment with a JAK inhibitor at an annual cost of $70k (patients may have treatment holidays), the addressable market is $630M. PV is much more prevalent (90,000 patients in the US) but it is typically milder and the unmet need is lower.