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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Unisom comes in several types, and the effects differ on which was taken. For diphenhydramine (benedryl), the maximum amount that you should take in any 24-hour period is 300 mg. However, for Doxylamine Succinate (unisom sleeptabs) The lethal dose for most people is estimated to be 50â500 mg/kg in humans.