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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Brand names: Compoz Nighttime Sleep Aid, Nytol, Simply Sleep, Sominex, Unisom SleepGels, Unisom SleepMelts, ZzzQuil, Nytol QuickCaps, Sleepinal, Tranquil Nighttime Sleep Aid, Twilite, Z-Sleep â¦ Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents