When an arrhythmia causes the heart to beat too fast, the heart doesn't pump effectively. Specifically, there may not be enough time between heartbeats for the heart to fill with blood, causing blood to back up into the lungs.
The new non-steroidal and steroidal aromatase inhibitors are at least as effective as megestrol acetate (MA) as second-line hormonal agents in postmenopausal women with breast cancer.However, they are superior to MA in terms of tolerability and adverse effects.he Type I inhibitors have a steroidal structure similar to androgens and inactivate the enzyme irreversibly by blocking the substrate-binding site, and are therefore known as aromatase inactivators. Examples of such drugs include formestane and exemestane (Aromasin).
Aromatase inhibitors are only used to treat postmenopausal women. Premenopausal women should not take aromatase inhibitors. And, women with certain heart problems should not take the aromatase inhibitor anastrozole. Compared to chemotherapy, aromatase inhibitors have few side effects.For example, they do not cause nausea.p to 36 percent of women in clinical trials of aromatase inhibitors have reported joint pain and up to 15 percent have reported muscle pain (other studies have found even higher rates of these side effects) [ 73-75 ].