Veni Vidi Veci. Death. Julius Caesar was assassinated as the result of a conspiracy by many Roman senators who called themselves Liberators. It was led by Gaius Cassius Longinus and Marcus Junius Brutus, who stabbed Caesar to death near the Theatre of Pompey on March 15, 44 BC.
Transgenic Mice. One of the simplest ways to study gene function in a mouse is exogenous expression of a protein in some or all tissues. For this type of genetic modification, a new piece of DNA is introduced into the mouse genome.ne of the simplest ways to study gene function in a mouse is exogenous expression of a protein in some or all tissues. For this type of genetic modification, a new piece of DNA is introduced into the mouse genome.
Excess BAFF also leads to overproduction of anti-dsDNA antibodies and a lupus-like syndrome in mice. In the present study, we use mice transgenic for the R4A-CÎ¼ (IgM) heavy chain of an anti-dsDNA antibody, to study the effects of BAFF overexpression on anti-dsDNA B-cell regulation.he number of R4A-CÎ¼, Tg anti-dsDNA B cells is increased in the MZ and FO of R4A-CÎ¼/BAFF +/+ mice. Splenic B cells from R4A-CÎ¼ and R4A-CÎ¼/BAFF +/+ mice were immunostained with antibodies to B220, CD21, and CD23 and sorted to obtain MZ (B220 + CD21 hi CD23 lo) and FO (B220 + CD21 int CD23 hi) B cells.