Bump keys are keys cut to a special design that will allow them to be used for picking pin-tumbler locks. Pin-tumbler locks are the world's most popular lock, and these include exterior door entry locks for homes. The process of gaining entry using a bump key is called âbumping,â and it can be very effective.
1 An oncogene may cause a cell to secrete growth factors even though it does not normally do so. 2  It will thereby induce its own uncontrolled proliferation (autocrine loop), and proliferation of neighboring cells. 3  It may also cause production of growth hormones in other parts of the body.
Pathogenesis of the Increased Osteoclast Activity in Myeloma The adherence of abnormal myeloma cells in the bone marrow stromal cells (BMSCs), through the binding of VCAM-1 on stromal cells and Î±4Î²1 integrin on MM cells, leads to the upregulation of a broad spectrum of factors that stimulate osteoclast formation, differentiation and activity, as well as suppression of negative regulators of osteoclastogenesis.