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Abstract. Here we hypothesized that the water-soluble lysosomal enzymes may cross the bloodâbrain-barrier and reach the brain using the mechanism of unspecific fluid-phase endocytosis.n fact, there has been increasing evidence that when high serum levels of lysosomal enzymes are achieved, either by GT or ERT, a small fraction of the enzyme is able to cross the BBB by mechanisms not clearly understood [6] , [7] and [8] . Table 1.
From there, certain forms of metals can cross the blood brain barrier. DMSA is commonly prescribed as an oral administration. This makes it more convenient for the patient, less profitable for the doctor. Oral administration is generally safer, because a patient can start with a low dose to test tolerance levels.