Metallosis often causes the following symptoms: Cardiomyopathy (heart problems), including heart failure. Depression, anxiety and other mental problems. Visual impairment that may lead to blindness. Cognitive impairment. Nerve problems. Thyroid problems. Auditory impairment that may lead to deafness.
Coordination refers to the coordinate covalent bonds (dipolar bonds) between the ligands and the central atom. Originally, a complex implied a reversible association of molecules, atoms, or ions through such weak chemical bonds. As applied to coordination chemistry, this meaning has evolved.
Vertical coordination: The process of ensuring that each successive stage in the production, processing, and marketing of a product is appropriately managed and interrelated to the next, so that decisions about what to produce, and how much, are communicated as efficiently as possible from the consumer to the producer.