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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.oagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host.
Coagulation - procoagulants. The third step, coagulation or blood clotting, reinforces the platelet plug with fibrin threads that act as a molecular glue for the aggregated platelets. The resulting blood clot (fibrin mesh) is quite effective in sealing larger breaks in a blood vessel. Blood is transformed from a liquid to a gel in a multistep process that involves a series of substances called clotting factors, or procoagulants.