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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Contagious and incubation period. 1  You can pass the Epstein-Barr virus (EBV) to others for several weeks or months during and after the time you are first infected with EBV.2  There is a small risk of spreading EBV through blood products. 3  It takes 4 to 6 weeks for symptoms to develop after you come in contact with EBV. If you know you have mono, you should not donate blood. 2  It takes 4 to 6 weeks for symptoms to develop after you come in contact with EBV. 3  This is called the incubation period.