For example, positive anti-thyroid peroxidase and/or anti-thyroglobulin antibodies in a patient with hypothyroidism make a diagnosis of Hashimotoâs thyroiditis. If the thyroid antibodies are positive in a hyperthyroid patient, the most likely diagnosis is autoimmune thyroid disease.wo common thyroid antibodies that cause thyroid problems are directed against thyroid cell proteins: thyroid peroxidase and thyroglobulin. Measuring levels of thyroid antibodies may help diagnose the cause of the thyroid problems.
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