Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Another famous highway, Route 66, was one of the original federal routes, established on November 11, 1926. It ran 2,347 miles from Chicago through Missouri, Kansas, Oklahoma, Texas, New Mexico, and Arizona before ending at the beach in Santa Monica, California.