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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Smooth muscle, found in the walls of the hollow internal organs such as. blood vessels, the gastrointestinal tract, bladder, and uterus, is under. control of the autonomic nervous system.