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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Several of the B vitamins (B3, B5, B6, B9, and B12) and other vitamins may help achieve a good night's sleep, but they do not alleviate insomnia for all individuals. B3 has been shown to increase REM sleep, help with depression in some cases and decrease nighttime awakenings. 2  B6 is essential in the production of serotonin, the âcalmingâ hormone that helps calm the body before falling asleep. 3  Folic acid: A deficiency in folic acid deficient can be found in those with insomnia.