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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
Formally speaking, cloture is the Senate voting to cut off debate. But the Senate has a tradition of unlimited debate that goes back to the 19th century. (If I recall correctly, early in the 1800s, the Senate reorganized its rules and inadvertently allowed unlimited debate, and Senators quickly embraced it).