Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
U.S. Highway 61 (U.S. 61) is a highway in southeast and east-central Minnesota, which runs from the River Bridge over the Mississippi River at La Crescent and continues north to its northern terminus at its junction with Interstate 35 at the city of Wyoming. U.S. 61 in Minnesota is 165 miles (266 km) in length. The route connects the cities of La Crescent, Winona, Wabasha, Lake City, Red Wing, Hastings, Cottage Grove, Saint Paul, Forest Lake, and Wyoming.