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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Hypertrophy of smooth muscle cells seems to be a major cause for the growth of the urinary bladder wall in response to urinary outflow obstruction (214), although measurements of DNA content suggest some contribution of smooth muscle hyperplasia (680).