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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Instead, smooth muscles are controlled by involuntary responses in the brain and body. One example of smooth muscle is the digestive system, where muscles in the esophagus contract to move food down to the stomach and tighten when you have an illness that causes you to vomit.