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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Histamine also causes constriction of smooth muscle. If you have asthma, histamine is partially to blame. When irritants are inhaled into the lungs, histamine is released to that area, and the smooth muscles around the bronchi of the lungs contract. This makes breathing difficult and can produce an asthma attack.