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One common cause of muscle aches and pain is fibromyalgia, a condition that causes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.
Muscle pain, tenderness, and spasm are characteristics of myofascial pain syndrome. Myofascial pain syndrome typically affects muscle in asymmetric areas of the body. The precise cause of myofascial pain syndrome is not known. Myofascial pain syndrome leads to localized pain in the muscle tissue.