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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
In 1 â¦ 617 the Pilgrims began  looking to leave Holland and settle in the New World. In 1620, the  Pilgrims landed at Plymouth Rock and established the second  successful English settlement in the New World (Jamestown in  Virginia being the first, having been established in 1607).