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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Neuropathy, the most common disorder of the peripheral nervous system, is characterized by symptoms such as weakness, numbness, and changes in skin color or texture. Amyotrophic lateral sclerosis (also called ALS or Lou Gehrigâs Disease) is a progressive motor neuron disease involving the painless deterioration of muscle function. Symptoms include muscle weakness and atrophy, and possibly difficulty with swallowing and speaking. Myopathy is a muscle disorder causing weakness that is usually most severe in the upper arms and thighs. Causes may include infection and injury. Muscular dystrophy is a group of progressive muscle disorders caused by genetic defects. Symptoms may start with weakening of the muscles closest to the trunk, muscle enlargement, and clumsiness, and progress to severe muscle deterioration and muscle contraction..