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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
1 Snooze Foods and Pick-Me-Ups Certain foods contain an amino acid called tryptophan that causes sleepiness. 2  Carbohydrates make tryptophan more available to the brain, which is why carbohydrate-heavy meals can make you drowsy. It is made in the brain by converting tryptophan first to serotonin and then to melatonin, which is secreted at night by the pineal gland in the brain to induce and maintain sleep. 2  Scientific evidence shows little or no benefit of melatonin in improving sleep.