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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
But in the Senate, 60 is the most important number. It takes 60 votes in the Senate to block a filibuster, or an unlimited debate. Senate rules allow any member or group of senators to speak as long as necessary on an issue. The only way to end the debate is to evoke  cloture , or win a vote of 60 members. Without the 60 votes needed, the filibuster can go on forever.