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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
The third stage is called the acute stage (you ARE sick), which usually lasts from 7-20 days. Now you have the symptoms of mono like sore throat, fever, swollen glands, etc. The final stage, the convalescent period, can last from 2-6 weeks to up to 3 months. During this time you'll feel much better, but are still weak and tired.