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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
1 You can only donate blood every 56 days. If you have donated blood more recently than that, then you are not eligible again.  Do not give blood if you have had simple dental work done within 24 hours or major dental work in the past month. Dental work in general can place one at risk for dislodging bacteria.