In summary, we have shown the inhibitory effects of Bcl-2 family on the ceramide-mediated apoptotic pathway in glioma cells. Bcl-2 is considered to act not only downstream of ceramide to inhibit cytochrome c release followed by caspase activation, but also upstream of or at SMase to prevent ceramide generation.igure 3 Effects of Bcl-2 or Bax overexpression on ceramide formation and neutral sphingomyelinase activation in etoposide-treated C6 cells. C6/Neo (), C6/Bcl-2 (), and C6/Bax () cells were treated with 40 M etoposide for indicated periods.
Hawaii, which has the highest-paid waiters and waitresses in the country (mean wage: $13.91/hour) has a minimum wage of $7.00 for tipped employees.
A high school diploma is often required for employment in this professional field. A Waiter or Waitress can expect a pay level of somewhere between 16000 and 24000 based on experience. Waiters and Waitresses usually get an average pay level of Twenty Thousand Eight Hundred dollars per year. Waiters and Waitresses are paid most highly in Washington, where they get wages of about $28590.