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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Like many antibiotics, clindamycin can cause gastrointestinal upset. Common side effects of clindamycin include diarrhea, nausea, vomiting, abdominal pain or constipation. Some people complain of a metallic taste in their mouth when on the drug. Colitis, an inflammation of the colon, can occur.lindamycin is used to prevent or treat bacterial infection. Clindamycin is also applied topically to the skin as an ointment to treat or prevent acne. Like any medication, clindamycin can have side effects, and some can be severe. Most people will not experience all the possible common side effects.