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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Symptoms. The virus has a long incubation period and sometimes won't show symptoms until 30 to 60 days after infection. Most often symptoms appear two weeks to 60 days after you've been infected.The most common symptom is constant fatigue, a constant state of feeling tired.verview. Mononucleosis is a respiratory virus that affects the blood cells and salivary glands (glands responsible for producing saliva). Even though anyone can get mononucleosis, most people who get the illness are between the ages of 15 and 25. Mono can keep you out of work or school for several weeks or months.