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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Diseases Causing Muscle Spasms: 1. Parkinsonâs Disease: Parkinsonâs disease is a disorder that is characterized by the degeneration of the central nervous system. Degeneration of neurons causes movement disorders characterized by trembling of legs, hands, head, arms, muscular rigidity of the trunk or legs and postural instability.