Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Johann Gutenberg (1398-1468), inventor of the printing press. The printing press was invented in 1448 by German goldsmith Johann Gutenberg. Because it allowed books to be mass-produced and made available to the general population, the invention changed the course of history in many ways. Gutenberg was a goldsmith, metallurgist and stone cutter living in Germany.