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blastula. the usually spherical body produced by cleavage of a fertilized ovum (zygote), consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele); it follows the morula stage. (blas'tÅ«-lÄ),lastula. the usually spherical body produced by cleavage of a fertilized ovum, consisting of a single layer of cells (blastoderm) surrounding a fluid-filled cavity (blastocoele); it follows the morula stage.