When methionine is in excess, Hcy is directed to the transulphuration pathway, where it is irreversibly sulfoconjugated to cysteine by cystathionine B-synthase with vitamin B 6 as a cofactor. Hcy is also remethylated in a methionine-conserving pathway. This process requires methionine synthase, vitamin B 12 as a cofactor, and methyltetrahydrofolate as a cosubstrate. The methionine-conserving pathway requires folic acid and methyltetrahydrofolate reductase (MTHFR).
Wire-transferred funds typically appear within 24 to 48 hours. A wire transfer is a bank-to-bank transaction in which a sender goes to his bank and has money transferred from his account to another person's account at the same bank or in a different bank. Typically, an interbank transfer occurs in the same-day.
Since the 8 to 59 hour elimination half-life encompasses the others mentioned, we shall use it to estimate possible average clearance times of methadone. Assuming 50% of the methadone is cleared from your system in 8 to 59 hours, it will likely take between 1.83 days and 13.52 days for complete systemic clearance. It is important to realize that this clearance range is just an average estimate.