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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
The muscle inflammation, however, is not isolated only to the skeletal muscles of the limbs and can affect even smooth muscles and cardiac muscle. There are several other clinical manifestations that may affect many other parts of the body other than the muscles or skin.