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Ulcerative colitis causes swelling in the large intestine and can lead to cramping, diarrhea, and more. Celiac disease Celiac disease, which is an intestinal reaction to gluten, can cause gas, diarrhea, bloating, and weight loss.
Other medications used for digestive conditions may make it more difficult to lose weight or cause someone to gain weight. These include the SSRIs and the tricyclic antidepressant medications (amitriptyline, nortriptyline, desipramine) used in irritable bowel syndrome or hormones used for endometriosis.igestive conditions such as Crohn's disease or ulcerative colitis are often treated with steroids; steroid use can cause weight gain. Also, patients with GERD (gastroesophageal reflux disease) or PUD (peptic ulcer disease) often feel better when there is food in their stomach to soak up excess acid.