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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Melatonin is the chemical your brain releases to make you sleepy, and itâs available over the counter, but itâs not regulated by the FDA and isnât right for everyone. However, one study found that a dose of 5mg of melatonin in the early evening helped participants to adjust to new time zones faster.