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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
View full size image. Jamestown, founded in 1607, was the first successful permanent English settlement in what would become the United States. It was located on Jamestown Island, in Virginia, about 30 miles (47 kilometers) up the James River from the Atlantic coast.amestown was not the first successful permanent European settlement in what would become the United States; that distinction belongs to St. Augustine, in Florida, which was founded by the Spanish in 1565.