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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Skeletal muscle spasms and cramps are usually caused by overuse of the muscle, either from exercise or a repetitive motion. Spasms can also occur if a muscle is overstretched or held in the same position for too long.The muscle essentially becomes hyperexcitable and fails to relax.lthough we often think of skeletal muscle spasms or cramps, other kinds of muscle, such as smooth muscle, can spasm or cramp. Smooth muscles are found in the walls of hollow organs in your body, such as your stomach, bladder, and blood vessels, and play an important role in normal organ function.