In addition, thiazolidinediones have several other potential side effects, which make them less appealing as initial or second step therapy. (See 'Cardiovascular effects' below and 'Safety' below.). The pharmacology and use of thiazolidinediones will be reviewed here.
Alcohol impairs brain areas such as the cerebellumâthe control site for your balance and coordinationâand your cerebral cortex, which is responsible for thinking, memory, and learning, says Kimberly S. Walitzer, Ph.D., deputy director of the University at Buffaloâs Research Institute on Addictions.
Areas of the brain that may be particularly vulnerable to alcohol's effects. For example, the hippocampus, which lies deep within the cerebral hemispheres, plays an important role in learning and memory formation. Heavy drinking during adolescence can lead to reduced hippocampal volume.lthough it is clear that heavy alcohol use can lead to changes in brain structure which can affect brain functioning, the reverse processâthat an abnormality existing prior to alcohol exposure may predispose a person to alcohol use and the development of an AUDâalso is plausible.