Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Melville Bissell developed an early carpet sweeping machine to aid in cleaning the crockery shop he and his wife Anna owned and operated. The device was patented as the Bissell Carpet Sweeper in 1876. In 1883 Bissell built the company's first manufacturing plant in Grand Rapids. By the 1890s the company had an international presence and was producing 1000 sweepers per day. Melville Bissell died in 1889, and his wife Anna took over as leader of the company.