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This type of pain is usually localized, affecting just a few muscles or a small part of your body. Systemic muscle pain â pain throughout your whole body â is more often the result of an infection, an illness or a side effect of a medication. Common causes of muscle pain include: Chronic exertional compartment syndrome. Chronic fatigue syndrome.
Muscle pain, tenderness, and spasm are characteristics of myofascial pain syndrome. Myofascial pain syndrome typically affects muscle in asymmetric areas of the body. The precise cause of myofascial pain syndrome is not known. Myofascial pain syndrome leads to localized pain in the muscle tissue.