Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Courtesy of Callisburg Community Club. Early settlers in the area include Jim K. Hogan who was one of the freighters operating out of Sherman. Levi Harrison built three adjoining stores, a dry-goods store, grocery store, and a drug store run by Dan Stover. Sam Hargis built the first cotton gin and grist mill. The little community began to flourish and at one time had as many as eight businesses, houses, three saloons, a wagon yard, grist mill and cotton gin. There were as many as three grist mills in the area and three more cotton gins were built over the years.