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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Muscular dystrophies are a group of diseases that make muscles weaker and less flexible over time. Duchenne muscular dystrophy (DMD) is the most common type. Itâs caused by flaws in the gene that controls how the body keeps muscles healthy. The disease almost always affects boys, and symptoms usually begin early in childhood. Children with DMD have a hard time standing up, walking, and climbing stairs.