Fever can support the immune system's attempt to gain advantage over infectious agents, such as viruses and bacteria, and it makes the body less favorable as a host for replicating viruses and bacteria, which are temperature sensitive. Infectious agents are not the only causes of fever, however.
Your sister's grandson is your great nephew. You are his great aunt (if you are a woman) or his great uncle (if you are a man).
Son and daughter of your siblings and siblings-in-law. As with uncle and aunt, they're not your nieces and nephews by marriage, they're your nieces and nephews, plain and simple, even if they're your spouse's siblings' kids and don't have a single drop of blood in common with you.