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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Mononucleosis is technically called infectious mononucleosis or glandular fever, but is generally referred to as mono for short. It occurs primarily between the ages of 10 and 35 years old. When younger children are infected, it causes little or no illness. Such exposure does, however, create an immunity to the disease.