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Scientists know that lead exposure during childhood harms the developing brain and nervous system, but it is not clear if childhood lead exposure has long-lasting effects on adult brain function. Changes in adult intelligence quotients â IQs â is a way to measure effects of lead and other neurotoxic substances.
Lead poisoning is most often a chronic disorder and may not cause acute symptoms. With or without acute symptoms, poisoning eventually has irreversible effects (eg, cognitive deficits, peripheral neuropathy, progressive renal dysfunction). Symptoms of lead poisoning are roughly proportional to lead levels, but there are no safe levels of lead. Risk of cognitive deficits increases when the whole blood lead level (PbB) is â¥ 10 Î¼g/dL (â¥ 0.48 mmol/L) for an extended period, although the cutoff may be even lower.