Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Interstate 65 (I-65) meanders across 367 miles (591 km) of the Alabama countryside linking six of the state's ten largest cities. The highway links together many important roadways that make commerce inside and outside of the state's boundaries possible. It starts at Interstate 10 near Mobile.