In addition, thiazolidinediones have several other potential side effects, which make them less appealing as initial or second step therapy. (See 'Cardiovascular effects' below and 'Safety' below.). The pharmacology and use of thiazolidinediones will be reviewed here.
Alcohol impairs brain areas such as the cerebellumâthe control site for your balance and coordinationâand your cerebral cortex, which is responsible for thinking, memory, and learning, says Kimberly S. Walitzer, Ph.D., deputy director of the University at Buffaloâs Research Institute on Addictions.
Alcohol is permeable to many areas of the brain.   However, the main areas affected are:  1) the neocortex - alcohol inhibits activity in the neocortex,  responsible forâ¦ higher-level thinking and execution;   2) the hippocampus - by inhibiting NMDA receptors and increasing  GABA-A receptor activity in this region, memory impairment results.