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Oral flunixin meglumine should be given with food. Flunixine meglumine is quickly absorbed into the blood stream; pain relief and fever reduction usually starts within one to two hours. Drugs to protect the digestive tract, such as omeprazole, cimetidine, or sucralfate, are frequently used with flunixin. Wash your hands after giving your horse this medication. Side Effects. Be sure to discuss any side effects with your veterinarian immediately. The most common side effects are ulcers of the stomach and large colon.