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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Melatonin Isâ¦. A hormone produced by the pineal gland that regulates the sleep/wake cycle, and promotes deep sleep. Also known as as N-acetyl-5-methoxytryptamin, melatonin is a potent antioxidant that is able to cross the blood/brain barrier. Melatonin prepares the body for sleep by causing drowsiness and lowering body temperature. Melatonin May Work in Chronic Fatigue Syndrome (ME/CFS) Because..