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Standing is a natural human posture and by itself poses no particular health hazard. However, working in a standing position on a regular basis can cause sore feet, swelling of the legs, varicose veins, general muscular fatigue, low back pain, stiffness in the neck and shoulders, and other health problems.
So anyway - the answer to your question then is, first, nobody knows if humans can survive zero g for more than two years. And worst case scenario is that you die from the combined effects of all those changes in your body long term. But we might be able to solve all those problems with artificial gravity.