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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using clindamycin vaginal and call your doctor at once if you have diarrhea that is watery or bloody. Keep using clindamycin vaginal and talk to your doctor if you have any of these less serious side effects: 1  mild nausea or stomach pain; 2  constipation, gas; 3  vaginal itching, discharge, or pain; or. 4  changes in your menstrual periods; or. 5  mild skin rash or...