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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Much of the reason Plymouth did better than Jamestown was because the Pilgrims put their trust in God and were there to establish His Kingdom among themselves in a sacrificial, unselfish manner, while at Jamestown, the mindset was quite selfish.