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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Best Answer: Permission to found the first permanent English colonies in America was given in 1607 in a Royal Charter by James I-hence the name Jamestown. It was sponsored and fully financed by The Virginia Company of London one half of an English joint stock company, The Virginia Company (the other half being . The Virginia Company of Plymouth).