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One common cause of muscle aches and pain is fibromyalgia, a condition that causes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.
Musculoskeletal Pain. Causes. Musculoskeletal pain can be caused by damage to bones, joints, muscles, tendons, ligaments, bursae, or nerves. Injuries are the most common cause. If no injury has occurred or if pain persists for more than a few days, then another cause is often responsible.Bone pain is usually deep, penetrating, or dull.ain with muscle spasm suggests that pain is caused by a muscle disorder. The site of swelling or the location of tenderness when the doctor palpates the area (for example, a joint, ligament, or bursa) often indicates the source of pain. However, often these characteristics of pain do not indicate its origin or cause.