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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
In fact, as late as 1600, Spain's power over what is now the southeastern United States was unquestioned. When English settlers came to America, they established their first colonies well to the Northâat Jamestown (in the present state of Virginia) in 1607 and Plymouth (in the present state of Massachusetts) in 1620.