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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
The longest uninterrupted filibuster on record belongs to South Carolina Senator Strom Thurmond, who stopped a vote on a 1957 civil rights bill for 24 hours and 18 minutes. A filibuster is often an effort of several Senators, but can also be done by a single Senator. The only way to stop one is by invoking cloture  which forces a vote to take place. Cloture, adopted in 1917, used to require two-thirds of the Senate to agree to stop the talking.