Substance use disorder occurs when a person needs alcohol or another substance (drug) to function normally. Abruptly stopping the substance leads to withdrawal symptoms. Addiction means that a person has a strong urge to use the substance and cannot stop, even if they want to.
So it is important to maintain positive nitrogen balance in the body while sleeping. When you do and conditions are right so that your rate of protein synthesis exceeds your rate of degradation, and you maintain a positive nitrogen balance, you can grow while you sleep.
At night, your mouth is much less active, which allows bacteria more time to grow without being mechanicalyl sloughed off. Many years ago my orthodontist told me that it was most important to brush your teeth before going to sleep (I guess either for the night, or for a nap). Saliva production is down, and if you happen to sleep with your mouth gaping open, your teeth dry out and don't have that protective layer of saliva.