Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Major highways are often named and numbered by the governments that typically develop and maintain them. Australia's Highway 1 is the longest national highway in the world at over 14,500 km or 9,000 mi and runs almost the entire way around the continent. China has the world's largest network of highways followed closely by the United States of America.