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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
If you have a fever or an active infection, wait until the infection has resolved completely before donating blood. You cannot donate blood if you are taking antibiotics for an infection. You must wait 10 days after the last antibiotic injection before donating blood. Guidelines on eligibility to give blood change from time to time.