Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Old English heahweg main road from one town to another; see high (adj.) in sense of main + way. High street (Old English heahstrÃ¦te) was the word before 17c. applied to highways and main roads, whether in the country or town, especially one of the Roman roads. In more recent usage, it generally is the proper name of the street of a town which is built upon a highway and was the principal street of the place.