Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
A route (or road) number is an identifying numeric (or alphanumeric) designation assigned by a highway authority to a particular stretch of roadway to distinguish it from other routes and, in many cases, also to indicate its classification (e.g. motorway, primary route, regional road, etc.), general geographical location (in zonal numbering systems ...