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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Clindamycin is the generic name of the prescription drug Cleocin, which is an antibiotic used to treat certain serious bacterial infections. Clindamycin belongs to a group of medicines known as lincosamide or lincomycin antibiotics. It works by stopping bacteria from producing the protein they need to reproduce and spread infection in your body.