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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Raynaud's phenomenon is a disorder characterized by blood vessel abnormality caused by overactivity of smooth muscle in the wall of arteries, leading to spasms (vasospasms with narrowing) of the small vessels that supply blood to the arms, legs, hands, feet, and sometimes the ears and nose.