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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Overview. Degenerative muscle diseases cause progressive damage and loss of muscle cells with associated weakness. There are many types of degenerative muscle diseases, and they act in different ways to cause loss of functional muscle mass.egenerative muscle diseases that affect the muscles of the mouth and throat typically cause speech, chewing and swallowing difficulties. The Myasthenia Gravis Foundation of America notes that these symptoms are common with myasthenia gravis.