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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Take medication. If you have severe smooth muscle spasms, your doctor may be able to prescribe you medicine. For example, medications such as anticholinergic agents can help intestinal spasms that do not respond to diet and lifestyle changes.alk to your doctor if any medicine you take causes muscle spasms. 1  Flexeril (cyclobenzaprine) is a commonly prescribed medication for moderate to severe muscle spasms that works on your central nervous system to relax your muscles. 2  Some muscle relaxers are highly addictive.