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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Clusters of sleep-promoting neurons in many parts of the brain become more active as we get ready for bed. Nerve-signaling chemicals called neurotransmitters can âswitch offâ or dampen the activity of cells that signal arousal or relaxation. GABA is associated with sleep, muscle relaxation, and sedation.