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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
1 Your dose will be between 25â100 mg per day. Youâll take losartan by mouth once or twice per day.  You shouldnât take this drug if youâre pregnant or plan to become pregnant. Losartan can harm or be fatal to your unborn baby.