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1 How long does unopened sour cream last after the sell-by date? 2  Sour cream will generally keep for one to two weeks after the sell-by date on the package, assuming it has been continuously refrigerated; be sure that the temperature of your refrigerator remains at or below 40Â° Fahrenheit at all times.
The Shelf Life of Sour Cream. According to the USDA, sour cream (opened or unopened) is good for up to three weeks after the sell-by date, as long as it's been stored in the refrigerator. Inspect your sour cream to make sure it hasn't developed mold, an off color or an off smell, and if nothing seems amiss, consider it safe to use.