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Kohlerâs disease is a rare condition in which the tarsal navicular bone (a bone in the arch of the foot) becomes inflamed. This bone disease is named after the German radiologist who described the condition in the early twentieth century. Kohlerâs disease usually affects children between the ages of three and five. It occurs more commonly in boys than in girls, and is often unilateral, affecting one foot. It is described as an avascular necrosis, or osteonecrosis, in which bone tissue deteriorates due to an interruption of blood supply.
What is Wernicke-Korsakoff syndrome (WKS)? Wernicke-Korsakoff syndrome (WKS) is a type of brain disorder caused by a lack of vitamin B-1, or thiamine. The syndrome is actually two separate conditions that can occur at the same time, Wernickeâs disease (WD) and Korsakoff syndrome. Usually, people get the symptoms of WD first. WD is also known as Wernickeâs encephalopathy. Symptoms of WKS may include confusion, changes to the eyes and vision, or exaggerated storytelling, among others. Alcoholism, or chronic alcohol misuse, is the most common cause of WKS.