in the x direction, the water wants to flow in that direction) For a given hydraulic. conductivity, the vertical flow rate depends on the sum of the gravitational potential energy. gradient per unit weight of water (dz/dz =1) and the vertical gradient in soil water pressure.
Origin and spread of the 1278insTATC mutation causing TayâSachs disease in Ashkenazi Jews: Genetic drift as a robust and parsimonious hypothesis. Human Genetics 114 (4): 366â376. pmid 14727180.
Tay-Sachs disease. Tay-Sachs disease occurs due to mutations disrupting the function of an enzyme needed to break down specific lipids which then accumulate in tissues, particularly neurons that use this type of lipid for membranes and synapses.utosomal recessive inherited, Tay-Sachs disease is most common in families of Eastern European Jewish origin, where as many as 1 in 45 are carriers of the mutant gene compared to the general incidence of 1 in 300. This disease has actually been described in the Ashkenazi Jewish population as early as the 15 century.