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How does an ACE Inhibitor work? ACE inhibitors prevent an enzyme in your body from producing angiotensin II, a substance that affects your cardiovascular system by narrowing your blood vessels and releasing hormones that can raise your blood pressure. This narrowing can cause high blood pressure and force your heart to work harder. ACE inhibitors also increase blood flow, which helps to decrease the amount of work your heart has to do and can help protect your kidneys from the effects of hypertension (high blood pressure).
Font Size. A. A. A. Angiotensin converting enzyme (ACE) inhibitors are heart medications that widen or dilate your blood vessels to improve the amount of blood your heart pumps and lower blood pressure. ACE inhibitors also increase blood flow, which helps to decrease the amount of work your heart has to do. Examples of ACE inhibitors include: 1  Accupril (quinapril). 2  Aceon (perindopril). 3  Altace (ramipril). 4  Capoten (captopril). 5  Lotensin (benazepril). 6  Mavik (trandolapril). 7  Monopril (fosinopril).