Model assumptions: Metapopulation models â¢â¯Homogenous patches â¢â¯No spatial structure â¢â¯No time lags â¢â¯Large number of patches. Metapopulations The development of metapopulation models has lead to research on: â¢â¯How to estimate factors that influence patch colonization and extinction.
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Osteomyelitis is a secondary complication in 1â3% of patients with pulmonary tuberculosis. In this case, the bacteria, in general, spread to the bone through the circulatory system, first infecting the synovium (due to its higher oxygen concentration) before spreading to the adjacent bone.