Figure 3: Vasodilation produced by the direct effects of caffeine on the VSMC. Caffeine inhibits the voltage-dependent Ca2+ channels and the entrance of calcium to the cytoplasm. In addition, it inhibits the IP3 receptor and increases the ânon-contractile Ca2+.
Instructions. 1. Fill the bottom of the pan with a layer of water. 2. Add the vinegar. 3. Bring the pan to the boil. It should be looking a bit cleaner already. 4. Remove the pan from the heat and add the baking soda. Expect fizz! 5.Empty the pan and scour as normal; if necessary add an extra bit of dry baking soda.6. If there are any super stubborn marks that don't come off with scouring, make a paste of baking soda and a couple of drops of water.. Remove the pan from the heat and add the baking soda. Expect fizz! 5. Empty the pan and scour as normal; if necessary add an extra bit of dry baking soda. 6. If there are any super stubborn marks that don't come off with scouring, make a paste of baking soda and a couple of drops of water.
Pour some dish detergent in the pan and fill it with hot water. Leave the pan overnight so the solution loosens the stain. In the morning wipe the pan with a sponge and try to remove the burnt sugar. Third recipe is if the first two recipes fail to clean the stain. Put some water in another pan and bring to a boil. Add two or three tablespoons of baking soda and pour the solution in the burned pan. Leave it for a couple of minutes to cool off. After that try to remove the sugar stain with a sponge or a soft bristled brush. These tips should be sufficient for removing the stubborn stain.