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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
1 If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. 2  The full name of this medicine is Losartan potassium/Hydrochlorothiazide 50/12.5mg and 100/25mg Tablets but within the leaflet it will be referred to as Losartan HCT tablets.he usual dose of Losartan HCT tablets for most patients with high blood pressure is 1 Losartan HCT 50/12.5mg tablet once daily to control blood pressure over the 24-hour period. This can be increased to 2 Losartan HCT 50/12.5mg tablets once daily or 1 Losartan HCT 100/25mg tablet (a stronger strength) once daily.