MALIGNANCY. Low back pain at night that is not relieved by lying down may be caused by a tumor in the cauda equina (the roots of the spinal nerves controlling sensation in and movement of the legs), or a cancer that has spread to the spine from the prostate, breasts, or lungs. The pain is caused by irritation of a nerve root. 2  Sciatica is an example of radicular pain. 3  Referred. 4  The pain is perceived in the lower back but is caused by inflammation elsewhereâoften in the kidneys or lower abdomen.
While most moles donât turn into melanoma, researchers are unsure why some do. Like basal and squamous cell skin cancer, melanoma can be caused by UV rays. However, some melanomas can appear in body parts not exposed to sunlight. Both types of skin cancer occur when your skin cellsâ DNA has errors (or mutations). According to the Mayo Clinic, these errors cause skin cells to grow uncontrollably and form a mass of cancer cells.
Skin cancers are of three major types: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. 1  The vast majority of skin cancers are BCCs or SCCs. While malignant, these are unlikely to spread to other parts of the body. 2  A small but significant number of skin cancers are malignant melanomas.