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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
Trifexis Flea Heartworm Chewable For Dogs. Trifexis is an exciting new flea and heartworm control chewable. It combines two popular ingredients - spinosad, a flea control ingredient also found in the comfortis flea pill, and milbemycin oxime, the heartworm preventative found in sentinel. Trifexis for dogs also controls adult hookworm, roundworm and whipworm infections - but it does not control ticks. Trifexis requires a prescription because it contains a heartworm preventative, which like all heartworm medication requires an annual check up and prescription from your veterinarian.