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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
In patients with mild-to-moderate hepatic impairment the recommended starting dose of Losartan potassium tablets USP is 25 mg once daily. Losartan potassium tablets USP has not been studied in patients with severe hepatic impairment [see Use in Special Populations ( 8.8) and Clinical Pharmacology ( 12.3)].