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The Ohio River ends at the confluence with the Mississippi River at Cairo, Illinois. This confluence borders Kentucky, Illinois and Missouri. Even though the Ohio River is much wider and carries more water than the Mississippi where they meet, the Ohio is considered the tributary to the Mississippi.
It begins in Pittsburgh, Pa., where it is joined with the Allegheny and the Monongahela rivers. From there, the river flows along the southern borders of Ohio, Indiana and Illinois before emptying into the Mississippi River in Cairo, Ill. Several major cities are located in the Ohio Valley. As of 2014, Pittsburgh is the largest metropolitan area located on the river. Louisville, Ky., is located on the Ohio River's widest and deepest point. The first city to construct a bridge across the Ohio River was Wheeling, W.Va.