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endogenous definition: The definition of endogenous is coming from the inside. (adjective) An example of something endogenous is a tumor that is caused by conditions inside the body not by externally-introduced conditions such as smoking. ...
The term endogenous simply refers to the ACTH that is produced by the animal itself (as opposed to synthetic ACTH, which is used for diagnostic testing purposes). ACTH regulates the production of cortisol (a stress hormone) by the adrenal glands and its concentration can be measured in the blood.