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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
The usual initial dose of Losartan Potassium in patients with heart failure is 12.5 mg once daily. The dose should generally be titrated at weekly intervals (i.e. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily) as tolerated by the patient. The usual starting dose is 50 mg of Losartan Potassium once daily. A low dose of hydrochlorothiazide should be added and/ or the dose of Losartan Potassium should be increased to 100 mg once daily based on blood pressure response.