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1 When to take: Depending on the severity of the sleep problem, take time-released melatonin 1 to 3 hours prior to the time you usually fall asleep. 2  Since time release melatonin only lasts for 3 â 4 hours, any need to shift sleep schedules more than 3 hours may require taking another pill in 3 or 4 hours.
11 Feb 2011. The plasma half-life of Melatonin is short, around 20 to 50 minutes. This means that there is probably no advantage of taking a higher dose before bed. You may be better off looking at taking the long acting tablet instead - but then you do run the risk of waking up being groggy.