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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
DOSING: The usual starting dose is 12.5/50 mg of Hyzaar once daily for patients not controlled on losartan or HCTZ treatment alone. The dose may be increased after 3 weeks to 2 tablets of 12.5/50 mg or one tablet of 25/100 mg daily.Patients who have not been controlled on losartan 100 mg alone should be switched to Hyzaar 12.5/100 mg.DRUG INTERACTIONS: Losartan may increase levels of blood potassium which can lead to serious heart problems (arrhythmias).atients who have not been controlled on losartan 100 mg alone should be switched to Hyzaar 12.5/100 mg. DRUG INTERACTIONS: Losartan may increase levels of blood potassium which can lead to serious heart problems (arrhythmias).