The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Native American names for the flute include: 1  Cheyenne: tÃ¢hpeno. 2  Chippewa: bÄ­bÄ­'gwÃ»n. 3  Dakota: ÄotaÅke. 4  Kiowa: do'mba'. 5  Lakota: Å iyÃ³tÈaÅka. 6  Ãpata: bÃ­cusirina (Teguima language) 7  Unami: achipiquon (Lenape) 8  Zuni: TchÃ¡-he-he-lon-ne, lit. 'sacred warbling flute'.