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Kohlerâs disease is a rare condition in which the tarsal navicular bone (a bone in the arch of the foot) becomes inflamed. This bone disease is named after the German radiologist who described the condition in the early twentieth century. Kohlerâs disease usually affects children between the ages of three and five. It occurs more commonly in boys than in girls, and is often unilateral, affecting one foot. It is described as an avascular necrosis, or osteonecrosis, in which bone tissue deteriorates due to an interruption of blood supply.
Wernicke-Korsakoff syndrome (WKS) is a type of brain disorder caused by a lack of vitamin B1. The syndrome is actually two separate conditions that can occur at the same time.Usually youâll experience symptoms of Wernickeâs encephalopathy first.igns of Korsakoff psychosis tend to follow as the Wernickeâs symptoms wane. If Wernickeâs disease is treated quickly and effectively, Korsakoff syndrome may not develop (Mayo Clinic). Korsakoff psychosis is the result of chronic brain damage. Korsakoff syndrome affects the areas of your brain that control memory.