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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
It may have had aspirin in it.â Or, âOh, I do take a baby aspirin.â Voila. I have my answer. Iâll just have to apply pressure for ten minutes instead of five, Or twenty minutes instead of ten. Aspirin doesnât stay in the system that long, but its effect on bleeding does.Hereâs how. If a blood vessel is injured, platelets are the first line of defense to stop bleeding. Almost immediately they start gathering at the injured site. And the bleeding triggers them to become stickier. They form a plug at the site.f youâre taking aspirin daily to prevent a heart attack, and the bleeding is not internal, this is a tricky question best answered by your doctor. 1  Remember the aspirin already has a permanent effect on the platelets in your system.