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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Aspirin, acetylsalicylic acid has a half life of 0. 25 hours. It's main metabolite however is salicylic acid, which has a half life of from 2-6 hours. Larger doses have a longer half life. Would you like to video or text chat with me?