The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
NATIVE AMERICAN LEGENDS Pueblo Indians-Oldest Culture in the U.S. The Pueblo Indians, situated in the Southwestern United States, are one of the oldest cultures in the nation. Their name is Spanish for stone masonry village dweller.he Pueblo Indians, situated in the Southwestern United States, are one of the oldest cultures in the nation. Their name is Spanish for stone masonry village dweller.