Post differentials. (a). A post differential may be granted on the basis of conditions of environment which differ substantially from conditions of environment in the continental United States and warrant additional pay as a recruitment and retention incentive.
We will also see that in order for a neuron to generate an action potential, the membrane potential has to depolarize from the resting value of around â70 mV to the threshold value of around â50 mV. A similar situation is also at play in muscle cells (skeletal, cardiac, and smooth).
Hypothetically, if the threshold is normally -60mV, but now we have too much calcium on board, our threshold is now -50mv. That is a difference of 40mV that the cell has to account for in order to depolarize. In skeletal muscle, this can cause weakness, fatigue, etc. Too little calcium will cause the threshold to become more negative (gets closer to the resting membrane potential).