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When someone gets HIV, the body's immune system makes antibodies to try to fight the infection. Most HIV tests available today test for HIV antibodies. If HIV antibodies are present, it means that a person is infected with HIV. One type of HIV test detects the virus itself. This is called an RNA test. RNA testing is more expensive and much less common than antibody tests.
There are three main types of HIV tests: antibody tests, RNA tests, and a combination test that detects both antibodies and viral protein called p24. All tests are designed to detect HIV-1, which is overwhelmingly the most common type of HIV in the United States.