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White blood cells known as lymphocytes arise from by mitosis of stem cells in the bone marrow. Some lymphocytes migrate to the thymus and become T cells that circulate in the blood and are associated with the lymph nodes and spleen.
Most, but not all large granular lymphocytes are more commonly known as the natural killer cells (NK cells). The small lymphocytes are the T cells and B cells. Lymphocytes play an important and integral role in the body's defenses. The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. T cells belong to a group of white blood cells known as lymphocytes and play a central role in cell-mediated immunity.