The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Also See: Ancient & Modern Pueblos-Oldest Cites in the U.S. Ancient Cities of Native Americans Ancient Puebloans of the Southwest Pueblo and Reservation Etiquette The Pueblo Indians were eventually subdued by the Spanish Conquistadors.ueblo Indians-Oldest Culture in the U.S. The Pueblo Indians, situated in the Southwestern United States, are one of the oldest cultures in the nation.