renin-angiotensin-aldosterone system the regulation of sodium balance, fluid volume, and blood pressure by secretion of renin in response to reduced perfusion of the kidney.
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The result is a thinning of the bone with an accompanying loss in bone strength and a greater risk of fracture. A thinning bone results in a lower bone density or bone mass. There are two major types of bone. Cancellous bone (also known as trabecular bone) is the inner, softer portion of the bone, and cortical bone is the outer, harder layer of bone. Cancellous bone undergoes turnover at a faster rate than cortical bone.