The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Tribes or ethnic groups along the North American Pacific coast with some sort of longhouse building traditions include the Haida, Tsimshian, Tlingit, Makah, Clatsop, Coast Salish and Multnomah (tribe) .onghouses were a style of residential dwelling built by Native American tribes and First Nation band governments in various parts of North America.