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White blood cells known as lymphocytes arise from by mitosis of stem cells in the bone marrow. Some lymphocytes migrate to the thymus and become T cells that circulate in the blood and are associated with the lymph nodes and spleen.
Lymphocytes are the white blood cells responsible for acquired (specific) immunity, including producing antibodies (by B cells), distinguishing self from nonself (by T cells), and killing infected cells and cancer cells (by killer T cells). Macrophages are large cells that develop from white blood cells called monocytes.