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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Diseases Diseases. Cardiovascular system diseases are the conditions that affect the heart and the blood vessels, which are the main components of the system. These diseases are often linked with a wrong or unhealthy lifestyle. People that are obese are more likely to have these diseases.