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Manganese is a part of many enzyme systems, including the enzymes involved in blood sugar control, energy metabolism, and thyroid hormone function. Manganese also participates in the antioxidant enzyme, superoxide dismutase, or SOD.
In biology, manganese(II) ions function as cofactors for a large variety of enzymes with many functions. Manganese enzymes are particularly essential in detoxification of superoxide free radicals in organisms that must deal with elemental oxygen. Manganese also functions in the oxygen-evolving complex of photosynthetic plants. The element is a required trace mineral for all known living organisms but is a neurotoxin.