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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
If blood pressure remains uncontrolled after about 3 weeks of therapy, the dose may be increased to two tablets of HYZAAR 50/12.5 once daily or one tablet of HYZAAR 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily.nother study investigated the doseresponse relationship of various doses of -. hydrochlorothiazide (6.25, 12.5 and 25 mg) or placebo on a background of losartan (50 mg). in patients not adequately controlled (sitting diastolic blood pressure [SiDBP] 93-120 mmHg). on losartan (50 mg) alone.