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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
The researchers reported that by taking 75 mg of aspirin (similar to the amount in a âbabyâ aspirin, also referred to as âlow-doseâ) for 5 or more years: 1  The risk of developing colon cancer decreased by up to 70% and, 2  The risk of developing rectal cancer decreased by 40%.