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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
Trifexis starts killing fleas within 30 minutes before they can lay eggs. It is given once a month to your dog and acts as their flea and tick medication also protecting them from heartworm! Key Benefits of Trifexis for Dogs. Kills fleas, prevents heartworm, and treats and controls intestinal parasites.