The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
âIndian moundâ is the common name for a variety of solid structures erected by some of the indigenous peoples of the United States. Most Native American tribes did not build mounds. The majority were constructed in the Lower Southeast, Ohio River Valley, Tennessee River Valley and the Mississippi River Valley. Some types of shell mounds can be found along the entire length of the United Statesâ Atlantic Coast.