The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
As of the early twenty-first century, the states with the largest populations of Native Americans are Oklahoma, California, Arizona, and New Mexico. Sometimes called American Indians, the Native Americans lived in dozens of tribal groupsâfrom Abenaki to Zuniâscattered across North America. 2 history and food Before Europeans settled North America, Native American tribes lived in five major parts of the United States: the Northeast, the South, the Great Plains, the Pacific Coast, and the deserts of the Southwest.