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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Re: Low dose aspirin (81 mg.). Echoing what Connie said, the time of day doesn't matter at all. When aspirin attaches to a platelet it makes that platelet semi-immune to clumping and the effect lasts for the life of the platelet...about 7-10 days.e: Low dose aspirin (81 mg.). If you are taking niacin, taking an aspirin with or 1/2 hour before you take the niacin may help reduce flushing. Otherwise, I don't think it matters when you take the aspirin.