Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Settled in 1776, the town's first mill, a grist mill, was built on the Salmon Falls River in 1779 by Joseph Parsons. Prior to incorporation it was the western part of the plantation of Hubbardstown; in 1789 it became the eastern part of the town of Shapleigh.