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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
There is, currently, only one case report of clindamycin interacting with warfarin and, in that instance, in addition to the prophylactic dose, it had been used as a 7-day therapeutic dose for local infection. There is no evidence to suggest that single dose clindamycin interacts with warfarin.In the cases described, the increases in INR occurred a few days post-operatively and in one patient was not associated with signs of bleeding. Evidence can be contradictory as to the effect of certain antibiotics on the action of warfarin. 2  A review is presented here outlining important effects that commonly prescribed antibiotics have on the action of warfarin.