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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Muscular dystrophy is a group of progressive muscle disorders caused by genetic defects. Symptoms may start with weakening of the muscles closest to the trunk, muscle enlargement, and clumsiness, and progress to severe muscle deterioration and muscle contraction.. Myasthenia gravis is an autoimmune disorder that blocks the signals from the nerves to the muscles, rendering the muscle unable to move.