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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Myasthenia gravis is an autoimmune disease that causes muscle weakness. The symptoms are caused by the immune system interfering with the transmission of messages from the nervous system to the muscles. There is no cure, but the symptoms can be managed.