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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
The main neurotransmitters involved with smooth muscle is Acetylcholine which causes an exited effect in smooth tissue and Adrenalin which causes an inhibitory effect. Adrenalâ¦in is produced by the adrenal gland when animals are in high stress or phsically elated situations.