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Phenylbutazone (âbuteâ) is arguably the most commonly prescribed drug for horses on the planet. My guess is that whether by injection, paste, pill, or powder, more bute is given to horses than all other medications combined. Itâs a non-steroidal anti-inflammatory drug, used for treatment of just about anything thatâs painful, including muscles, tendons, and joints, as well as for conditions such as laminitis.