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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Incubation Period. When a person becomes infected with the virus that causes mononucleosis, the virus begins to multiply within the body. After four to eight weeks, mono symptoms can begin. The period between becoming infected and the start of symptoms is called the mononucleosis incubation period.ncubation Period. When a person becomes infected with the virus that causes mononucleosis, the virus begins to multiply within the body. After four to eight weeks, mono symptoms can begin. The period between becoming infected and the start of symptoms is called the mononucleosis incubation period.