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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Muscle problems can result from several causes: 1  Myasthenia gravis is an autoimmune illness that blocks the stimulation of muscles by nerves inside the head. 2  The earliest signs are often double vision and drooping eyelids, or ptosis. 3  Graves' disease is a thyroid condition that affects the muscles of the eyes.