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Standing is a natural human posture and by itself poses no particular health hazard. However, working in a standing position on a regular basis can cause sore feet, swelling of the legs, varicose veins, general muscular fatigue, low back pain, stiffness in the neck and shoulders, and other health problems.
When you sit at your desk for long periods of time, the iliopsoas muscles are in a constant, flexed position. In this position, the muscles are shorter, which can pull on your spine more when you are standing, contributing to back pain and difficulty straightening your leg muscles after long periods of sitting.