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Amlodipine/benazepril. Amlodipine/benazepril, marketed in the U.S. as Lotrel by Novartis and manufactured as a generic drug by Teva and Sandoz, is an antihypertensive medication which combines a calcium channel blocker (amlodipine besilate) with an angiotensin converting enzyme inhibitor (benazepril).
DRUG CLASS AND MECHANISM: Lotrel is a combination drug, containing benazepril (Lotensin) and amlodipine (Norvasc) and is used for treating high blood pressure. Benazepril is an angiotensin converting enzyme (ACE) inhibitor. ACE is an enzyme in the body that is important for the formation of angiotensin II. Angiotensin II causes constriction of the muscles surrounding arteries in the body, thereby narrowing the arteries and elevating blood pressure. ACE inhibitors such as benazepril lower blood pressure by inhibiting the formation of angiotensin II, thus relaxing the muscles and dilating the arteries.