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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
REM sleep is produced by the excretion of the chemical acetylcholine in the pons which is part of the brainstem. Other neurotransmitters (noradrenaline and serotonin) produced by other cells in the pons switch off the REM sleep. (This is known as the reciprocal interaction/activation-synthesis model).