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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
Therefore, supporters of a nominee may have to use the cloture process to reach a vote on the nominee. For nominees to the U.S. Supreme Court, invoking cloture requires the support of three-fifths of the Senate; for other nominees, the cloture vote is subject to a simple majority threshold. Regardless of the relevant vote threshold, using cloture to reach a vote on a pending nomination may take significant floor time.