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After donating, eat and drink this. When you're done, itâs important to drink water again to replenish your system, and to rest for a bit. Most blood donation centers will not allow you to get up right away anyway, so use the time to drink, drink, drink â and send an email or two.
1 A good meal and plenty of fluids are recommended prior to donation. 2  Your body replenishes the plasma or liquid portion of each pint of donated blood in 12 to 36 hours. 3  The red cells are replaced by the body in four to six weeks.