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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
Cloture requires 60 votes (three-fifths of the Senate) to be successful, and is followed by an up or down vote on the issue being debated. If the other party is engaged in a filibuster (rather than simple debate), a two-thirds majority vote is required to end the filibuster.