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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Slow waves cause no smooth muscle contraction.When the amplitude of slow waves in smooth muscle cells reaches a certain thresholdâthe slow-wave threshold âa particular membrane ion channel, L-type Ca 2+ channels, are activated, resulting in calcium influx and initiation of motility.