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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
PHYSILOGY AND PATHOLOGY. Definition. Bile acids or, better, bile salts are the metabolites of cholesterol. Cholesterol metabolism occurs in the liver. Formation from cholesterol. Bile acids are formed by removal of the last three carbon atoms of the terminal aliphatic side chain of cholesterol.ile salts increase the elimination of water, cholesterol, lecithin and conjugated bilirubin in the bile. In liver disease bile acid synthesis and turnover are decreased, therefore micelle formation and emulsification of fats is impaired, favoring the development of gall stones and steatorrhea.