Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Median strip. The median strip or central reservation is the reserved area that separates opposing lanes of traffic on divided roadways, such as divided highways, dual carriageways, freeways, and motorways. The term also applies to divided roadways other than highways, such as some major streets in urban or suburban areas. The reserved area may simply be paved, but commonly it is adapted to other functions; for example, it may accommodate decorative landscaping, trees, a median barrier or railway, light rail