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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Myasthenia gravis is an autoimmune disease that affects nerve function and results in muscle weakness. Muscle weakness can be the result of a muscular diseases, disorders or conditions, which affect the ability of the muscles to move.