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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Jamestown. Plymouth. 1  ISABELLA was a small town that Columbus ordered his men to build on the northeastern shore of Hispaniola (in present-day Dominican Republic) during his second voyage to the New World in 1493. 2  Hunger and disease soon led to mutiny, punishment, disillusion, and more hunger and disease.