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Malnutrition is the most common cause of low alkaline phosphatase. In particular, inadequate consumption of vitamin B6, folic acid, vitamin C, zinc, and magnesium are the most common nutritional causes, along with excess consumption of vitamin D.
When AP is elevated in mature pets, most causes are associated with a primary or secondary liver problem that prevents the normal flow of bile. In cats, the two most common causes of elevated alkaline phosphatase are cholangiohepatitis and hepatic lipidosis (HL). In HL, blood bilirubin levels are usually quite high as well. Bile duct obstruction (gallstones) â particularly when GGT enzyme is elevated equally or greater - is sometimes the cause.