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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
These neurotransmitters are the feel good chemical messengers in the brain, and both depend on adequate sleep; a decrease in serotonin and dopamine is associated with poor sleep or sleep problems. One reason for waking with migraines is that REM sleep is most powerful just before awakening.