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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Systemic dosing: note, clindamycin capules should be taken with a full glass of water to avoid esophageal irritation. Soft tissue infections: 300-450 mg PO q6h or 600 mg IV q8h x 7-14 d with reassessment. Pelvic inflammatory disease: 900 mg IV q8h (in combination with gentamicin), initial regimen in hospital.