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Pyrilamine maleate and tripelennamine are used to treat allergic reactions in horses. Injectable antihistamines, such as pyrilamine maleate and tripelennamine, act rapidly and are often used for allergic reactions such as tongue or facial swelling due to bee sting, insect bite, or contact with an irritating plant.ntihistamines are used to counteract histamines that lower blood pressure and cause the inflammation and itching of allergic reactions.