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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Brain Changes = Sleep Problems. When researchers compared the 13 patients' results with 27 healthy people, they found very different patterns. The 13 sleep-problem patients had far fewer brain cells -- neurons -- that produce the chemicals dopamine and acetylcholine.And those with fewer such neurons had the worst sleep problems. Patients who had the lowest dopamine levels talked and thrashed while they slept.hen researchers compared the 13 patients' results with 27 healthy people, they found very different patterns. The 13 sleep-problem patients had far fewer brain cells -- neurons -- that produce the chemicals dopamine and acetylcholine. And those with fewer such neurons had the worst sleep problems.