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Difference Between Physiological & Pathological Jaundice. Physiological and pathological jaundice both result in a yellow tint to the skin, whites of the eyes and mucous membranes but are caused by different conditions. Physiological Jaundice. When jaundice occurs in a healthy baby, it is considered physiological jaundice.
Jaundice (Definition) 1  Jaundice is the accumulation in the body of bilirubin. Normally it is excreted by the liver, via the bile. 2  Jaundice is a yellow color in the skin, mucus membranes, or eyes. The yellow pigment is from bilirubin, a byproduct of the breakdown of old red blood cells.