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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Causes of muscle disorders include. 1  Injury or overuse, such as sprains or strains, cramps or tendinitis. 2  A genetic disorder, such as muscular dystrophy. 3  Some cancers. 4  Inflammation, such as myositis. 5  Diseases of nerves that affect muscles. 6  Infections. 7  Certain medicines.