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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Serotonin and melatonin are both neurotransmitters derived from the essential amino acid tryptophan, found in protein. These brain messengers are important for regulating our sleep cycles and our moods.ryptophan is a precursor for 5-HTP, which is subsequently a precursor serotonin and melatonin. Therefore, tryptophan or 5-HTP may be consumed or supplemented to increase levels of both serotonin and melatonin in the body.