Giant axonal neuropathy is caused by mutations in the GAN gene, which provides instructions for making a protein called gigaxonin. Some GAN gene mutations change the shape of the protein, affecting how it binds to other proteins to form a functional complex.iant axonal neuropathy generally appears in infancy or early childhood. It progresses slowly as neuronal injury becomes more severe. Signs of giant axonal neuropathy usually begin in the peripheral nervous system, which governs movement and sensation in the arms, legs, and other parts of the body.
The Handmaid's Tale will enter production later this year, and premiere on Hulu in 2017. I am thrilled that MGM and Hulu are developing The Handmaid's Tale as a series, and extra thrilled that the very talented Elizabeth Moss will be playing the central character, Atwood said.
Mild spoilers for The Handmaid's Tale book and TV show below! One of the more interesting aspects of Margaret Atwood's 1985 book, The Handmaid's Tale, is that she leaves a number of key plot points up for interpretation. By the end of the dystopian feminist novel, everything from the fates of big characters to the real name of the protagonist, Offred, remains unclear. Luckily, Hulu's adaptation of The Handmaid's Tale has finally confirmed the latter. In Atwood's story, the moniker of Offred literally means of Fred, ie she's the child-bearing property of her Commander, whose name happens to be Fred (we also encounter other Handmaids with names like Ofglen, Ofwarren, and so on).