If one is talking about interstate business, a company that is in one state provides its products and services to a customer in another state or several states. Intrastate. Intrastate refers to anything that pertains to a single state and does not require crossing over the boundaries of a single state.
H. pylori was first discovered in the stomachs of patients with gastritis and ulcers in 1982 by Drs. Barry Marshall and Robin Warren of Perth, Australia. At the time, the conventional thinking was that no bacterium could live in the acid environment of the human stomach.
Helicobacter pylori (see the image below) is a ubiquitous organism that is present in about 50% of the global population. Chronic infection with H pylori causes atrophic and even metaplastic changes in the stomach, and it has a known association with peptic ulcer disease. The most common route of H pylori infection is either oral-to-oral or fecal-to-oral contact.