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GENERAL DESCRIPTION: This drug is an antibiotic that fights bacterial infections. This combination antibiotic contains trimethoprim and a sulfonamide, either sulfadiazine or sulfamethoxazole. These two medications work synergistically together which increases their effectiveness against bacteria.This medication is available as an oral paste and an injectable solution.otify your veterinarian if your horseâs condition does not improve or worsens despite this treatment. This product should not be used in horses intended for human consumption. Check with the appropriate regulatory body regarding the use in competition horses.