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Most of the time, no apparent cause for night leg cramps can be identified. In general, night leg cramps are likely to be related to muscle fatigue and nerve problems. The risk of having night leg cramps increases with age. Pregnant women also have a higher likelihood of having night leg cramps. Several conditions, such as kidney failure and diabetic nerve damage, are known to cause night leg cramps. But if you have one of these, you're most likely aware of it and have symptoms other than night leg cramps.
Quick Answer. Ankle and leg cramps at night often occur for unknown reasons, but structural disorders, such as spinal stenosis; medications for blood pressure and cholesterol; or conditions such as dehydration and diarrhea can cause the discomfort, according to Mayo Clinic. Pregnancy and muscle fatigue also cause ankle cramps.