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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
The incubation period of the virus is the time between when you contract the infection and when you start to have symptoms. It lasts four to six weeks. The signs and symptoms of mono typically last for one to two months. Occasionally, your spleen or liver may also swell, but mononucleosis is rarely ever fatal.