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While the effects of Vicodin last around 4 hours, traces of the drug can remain in your system for up to 72 hours. In some adults you can still find traces of the drug in your system after 5 days.
Some may need higher doses of Vicodin for the analgesic effect to work in the same amount of time. Vicodin peaks about an hour to an hour and half after Vicodin it starts working on the body system, with strongest effects at this time. Vicodin will continue to work for about another two hours before it begins to wear off and you have to take another dose. Further, stronger concentrations of Vicodin will work for longer amounts of time. Extended release Vicodin can last up to about 6 hours of pain management before it begins to wear off.