Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
exists and is an alternate of . Someone here has said Woodward Ave. in Detroit, and that is elsewhere cited as the first mile-plus concrete highway in the early 20th century. However, city streets were commonly paved with brick-like blocks (Belgian blocks) in the 19th century, and with cobblestone and other masonry well before that.