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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
Drink plenty of fluids, and have some snacks. Call the blood bank or clinic if you feel sick within 24 hours after giving blood. Your body will replace the lost fluid in 24 hours. (It takes a few weeks to replace red blood cells.) You will have to wait 56 days before you can give whole blood again.