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Difference Between Physiological & Pathological Jaundice. Physiological and pathological jaundice both result in a yellow tint to the skin, whites of the eyes and mucous membranes but are caused by different conditions. Physiological Jaundice. When jaundice occurs in a healthy baby, it is considered physiological jaundice.
During pregnancy, the mother's liver eliminates bilirubin for her baby. After birth, it takes a while for the baby's liver to start doing the job. The result: Pigment builds up in the baby's blood and his skin takes on the yellowish cast of jaundice. This type of jaundice, called physiologic jaundice, usually appears on a baby's second or third day of life and disappears on its own within two weeks. (In premature babies, it peaks at 5 to 7 days and may take up to two months to go away.)