Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Highways in the United States are split into at least four different types of systems, Interstate Highways, U.S. Highways, state highways, and county highways. Highways are generally organized by a route number or letter. These designations are generally displayed along the route by means of a highway shield.