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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
You may not be able to donate blood if: 1  you have had a serious illness or major surgery in the past. 2  you have had complicated dental work (it is safe to donate blood 24 hours after having a filling or seven days after a simple extraction).3  you have recently come into contact with an infectious disease.f you are over 70, you need to have given blood in the last two years to continue donating. Your blood volume may need to be estimated first if you are a women and you: 1  are under 20 years old. 2  weigh under 65kg (10st 3lb).