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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
More research is required to figure this all out, but given the close association between appetite and sleep regulation, it would not be surprising if MCH plays a part in sleep. Arousal and Sedation. Acetylcholine, dopamine, glutamate, histamine, norepinephrine, orexin, and serotonin are all active in promoting wakefulness. Some neurons (brain cells) specialize in releasing certain neurotransmitters and scientists have found the firing rates of those neurons can vary with wakefulness and sleep.