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The Mother's Experience. The nausea and fatigue characteristic of the first trimester begin to fade for most women as they move into their second trimester. The second trimester is also marked by the development of outward symptoms of pregnancy. Many women first really begin to feel pregnant, and to show physical signs of pregnancy during the second trimester. Your abdomen will begin to expand as your growing fetus gets bigger.
Estrogen levels increase steadily during pregnancy and reach their peak in the third trimester. The rapid increase in estrogen levels during the first trimester may cause some of the nausea associated with pregnancy. During the second trimester, it plays a major role in the milk duct development that enlarges the breasts. Progesterone levels also are extraordinarily high during pregnancy. The changes in progesterone cause a laxity or loosening of ligaments and joints throughout the body. In addition, high levels of progesterone cause internal structures to increase in size, such as the ureters. The ureters connect the kidneys with the maternal bladder.