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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
In the Senate, cloture is invoked by a vote of 60 Senators. In the House, constituency is much narrower than in the Senate. In the House, the constituency is limited to each House District. In the Senate, the constituency is larger and involves an entire state. In communicating with members of Congress, keep in mind that representatives are less reliant on staff. On the other hand, Senators are often more reliant on staff.