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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
Times Topic: Personal Health. Bile is not acid. Itâs an alkaline fluid consisting of bile salts, bile pigments, cholesterol and lecithin. It is produced by the liver, stored in the gallbladder and released intermittently into the duodenum, the upper part of the small intestine, when needed to digest fat. (Bile continues to be produced as a digestive aid even after the gallbladder is removed.). Misdiagnosis of bile reflux and failure to control it can result in serious, sometimes life-threatening problems â stomach ulcers that bleed and Barrettâs esophagus, a possible precursor to esophageal cancer.