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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Smooth muscle is an involuntary non-striated muscle. It is divided into two subgroups; the single-unit and multiunit smooth muscle. Within single-unit cells, the whole bundle or sheet contracts as a syncytium. It occurs in the walls of hollow organs, including the stomach, intestines, urinary bladder and uterus, and is found in the walls of passageways, such as the arteries and veins of the circulatory system, and the tracts of the respiratory, urinary, and reproductive systems. Furthermore, it