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Most of the time, no apparent cause for night leg cramps can be identified. In general, night leg cramps are likely to be related to muscle fatigue and nerve problems. The risk of having night leg cramps increases with age. Pregnant women also have a higher likelihood of having night leg cramps. Several conditions, such as kidney failure and diabetic nerve damage, are known to cause night leg cramps. But if you have one of these, you're most likely aware of it and have symptoms other than night leg cramps.
Quick Answer. Some causes of a burning leg pain or cramp at night may be some types of medications and different medical conditions, such as diabetes, neuropathy, hypothyroidism and dehydration. In some cases, activities during the day time can contribute to this type of leg pain, including standing on a hard surface for a prolonged period of time or overexertion of the leg muscles, states Cleveland Clinic.