Project managed by RPC Oevel who provide the single point of contact for the customer, RPC Oevel are supplying 300 and 675ml bottles from their standard range, while RPC Kutenholz are producing two custom-moulded designs.
Production of Thrombopoietin. The liver is the major producer of Thrombopoietin in the human body. It has special cells that handle the production of several hormones including Thrombopoietin. Both the parenchymal cells and sinusoidal cells of the liver play a major role in the production of this hormone.
The cell ceases its growth at 4N, 8N or 16N, becomes granular, and begins to produce platelets. Thrombopoietin plays a role in inducing the megakaryocyte to form small proto-platelet processes. Platelets are held within these internal membranes within the cytoplasm of megakaryocytes. There are two proposed mechanisms for platelet release. In one scenario, these proto-platelet processes break up explosively to become platelets. Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via pseudopodia and they are able to continuously emit platelets into circulation. In either scenario, each of these proto-platelet processes can give rise to 2000â5000 new platelets upon breakup. Overall, 2/3 of these newly produced platelets will remain in circulation while 1/3 will be sequestered by the spleen.