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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
The production of smooth muscle or actin antibodies is strongly associated with autoimmune hepatitis. It may also sometimes be seen in other forms of liver disease, such as primary biliary cirrhosis (PBC), but usually at lower antibody titers.