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While the effects of Vicodin last around 4 hours, traces of the drug can remain in your system for up to 72 hours. In some adults you can still find traces of the drug in your system after 5 days.
26 Apr 2012. Vicodins metabolites can be detected in the urine for about 3-7 days on average depending on how long you have used them and how many you take per day and how fast your metabolism is. If you have a test coming up and you need to show negative, to be safe, give it at least seven days, if not more. roughly 24-72 hours.