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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Founded by a group of separatists who later came to be known as the Pilgrims, Plymouth Colony was, along with Jamestown, Virginia, one of the earliest colonies to be founded by the English in North America and the first sizable permanent English settlement in the New England region.