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Difference Between Physiological & Pathological Jaundice. Physiological and pathological jaundice both result in a yellow tint to the skin, whites of the eyes and mucous membranes but are caused by different conditions. Physiological Jaundice. When jaundice occurs in a healthy baby, it is considered physiological jaundice.
Jaundice is a common, temporary. and usually harmless condition in newborn infants. It affects both full-term and premature babies, usually appearing during the first week of the baby's life. Jaundice occurs when there is a build-up of a naturally occurring substance in the blood called bilirubin. Bilirubin is an orange/red pigment in the blood. Bilirubin is produced by the normal breakdown of red blood cells. It is normal for everyone to have low levels of bilirubin in their blood.