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This type of pain is usually localized, affecting just a few muscles or a small part of your body. Systemic muscle pain â pain throughout your whole body â is more often the result of an infection, an illness or a side effect of a medication. Common causes of muscle pain include: Chronic exertional compartment syndrome. Chronic fatigue syndrome.
Chronic fatigue can also cause widespread muscle aches. This is because your body is not getting the rest it needs so daily activities put an excessive amount of stress on the body. You may notice pain in the joints and muscles as well as tender lymph nodes, sore throat or headaches.