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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Symptoms and Signs. In most young children, primary EBV infection is asymptomatic. Symptoms of infectious mononucleosis develop most often in older children and adults. The incubation period is about 30 to 50 days.The triad of fever, pharyngitis, and adenopathy is present in most patients. Fatigue can last months but is usually maximal during the first 2 to 3 wk.ymptoms and Signs. In most young children, primary EBV infection is asymptomatic. Symptoms of infectious mononucleosis develop most often in older children and adults. The incubation period is about 30 to 50 days.