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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Sometimes antibodies are mistakenly produced against the bodyâs own healthy cells. These are called autoantibodies. If the body starts attacking itself, it causes an autoimmune disorder. ASMA testing looks for one type of autoantibodyâthe type that attacks smooth muscle. Autoimmune diseases that attack smooth muscle include the liver diseases cirrhosis and hepatitis. An ASMA test is often performed in patients who have chronic liver disease. It can confirm a diagnosis of chronic, active autoimmune hepatitis.