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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
Some things to remember when donating blood: 1  Drink plenty of fluids, both before and after to help your body recover and rebuild your blood supply. 2  Donât skip meals the day you donate blood. 3  Refrain from having a cigarette for at least one hour after giving blood.