In summary, we have shown the inhibitory effects of Bcl-2 family on the ceramide-mediated apoptotic pathway in glioma cells. Bcl-2 is considered to act not only downstream of ceramide to inhibit cytochrome c release followed by caspase activation, but also upstream of or at SMase to prevent ceramide generation.igure 3 Effects of Bcl-2 or Bax overexpression on ceramide formation and neutral sphingomyelinase activation in etoposide-treated C6 cells. C6/Neo (), C6/Bcl-2 (), and C6/Bax () cells were treated with 40 M etoposide for indicated periods.
Hawaii, which has the highest-paid waiters and waitresses in the country (mean wage: $13.91/hour) has a minimum wage of $7.00 for tipped employees.
WAGES, HOURS, AND FRINGE BENEFITS Although some very few are paid as much as $12.25 per hour, Waiters and Waitresses are usually paid minimum wage, plus tips. The amount of money you earn depends on the type of restaurant where you work. The bigger the restaurant the more tips you get; the more expensive the restaurant the bigger the tips you get. Waiters and Waitresses generally work a 40-hour, five-day workweek. The employer usually provides one or two free meals per shift, depending on the length of the shift.