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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
1 in the cardiovascular system, is released by the endothelial cells into the vicinity of the smooth muscle cells. 2  Binds to a cell surface receptor (IP) that leads to the production of cAMP.  Like the cGMP made by NO, cAMP tends to cause relaxation of smooth muscle (we'll talk about how later).