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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Degenerative changes cause the normally smooth cartilage to become rough due to a loss of chondrocytes (the cells that make cartilage, fluid and connective tissues for the joint). When this happens, they do not produce normal synovial fluid or connective tissue, and pain becomes a symptom.