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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
As of early 2003, three transfusion recipients were known to have become HIV seropositive in donated blood from two different donors (among 25 million donations). Again in 2008 donated blood from a single individual, who had made donations in June and again in November, was found to have seroconverted for HIV. Of the three people who received transfused blood, a single transplant patient was confirmed as having HIV that came from the donor.