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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Excess cortisol: Cushing's disease is excessive cortisol in the body from a pituitary tumor that leads to its secretion.Cushing's syndrome refers to the stigmata with excessive cortisol.This can be from the pituitary or administered by drs. Symptoms include hypertension, obesity, heart problems, sensitivity to infection.