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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Cushing's syndrome is a group of symptoms caused by too much of the hormone cortisol in the blood and is a well-documented side effect of steroid therapy.(36,41) Symptoms include weight gain (especially around the stomach and face), insulin resistance, acanthosis nigricans (see below) . . . and eczema.