Scleritis (inflammation of sclera) is a strong indication of the underlying medical problem. It can be due to fungal, viral or parasitic infection, trauma, exposure to chemicals, poisonous gases or due to post-surgical complications.
Mast cells are granulated cells typically found in connective tissue. These cells mediate immune responses to foreign particles. In particular, they release large amounts of histamine and enzymes in response to antigen recognition.
Storage and release. Histamine is found in almost all bodily tissues, mainly stored inside the granules of mast cells, where it is bound to compounds such as heparin. Mast cells are abundant in tissues that are prone to injury such as the extremities and blood vessels.Blood cells called basophils also contain some granules that have histamine inside them. The plasma concentration of histamine is less than 1 mg/L, although it may be higher in patients who have asthma.he increased permeability of blood vessels allows immune cells and substances to migrate from the bloodstream, through the vessels and into the site where injury or infection has occurred. Leukocytes and blood plasma proteins can then begin the process of fighting infection and healing the tissue.