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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
High altitude may increase pressure in the pulmonary capillaries and forces fluid into the alveoli. Pulmonary embolisms, nervous system dysfunctions, reactions to toxic substances, adverse drug reactions, severe smoke inhalation and near drowning also cause fluid in the lungs, explains Mayo Clinic.