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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
The German biologist Theodor Schwann (1810-1882) is considered a founder of the cell theory. He also discovered pepsin, the first digestive enzyme prepared from animal tissue, and experimented to disprove spontaneous generation. Theodor Schwann was born at Neuss near DÃ¼sseldorf on Dec. 7, 1810.