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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
Both UA and NSTEMI, as well as ST elevation MI, are associated with unstable coronary lesions and plaque rupture. (See The role of the vulnerable plaque in acute coronary syndromes.) DEFINITIONS.