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A nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants. nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants.
Nucleated Red Blood Cells. The presence of circulating NRBCs, outside of the neonatal period or occasionally during pregnancy, generally indicates either increased red blood cell production or bone marrow infiltration by malignant cells, fibrosis, granulomas, etc. When bone marrow infiltration occurs, granulocytic precursors are usually concurrently seen in circulation.