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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
Fluid accumulation in the lungs occurs due to two reasons: 1  Cardiogenic reasons where the heart fails to pump the blood to the systemic circulation, leading to build up of blood in the pulmonary circulation, which eventually leads to increased hydrostatic pressure and causes the fluids to leak from the capillaries into the lung itself.