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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
An associated increase in the amount of fluid in the blood vessels of the lungs causes shortness of breath because the excess fluid from the lungs' blood vessels leaks into the airspaces (alveoli) and interstitium in the lungs. This accumulation of fluid in the lung is called pulmonary edema.