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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Symptoms of cortisol imbalance in men are similar to those typified by other hormonal imbalances such as andropause (the male menopause) and often include the following: 1  Fatigue.2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking. 6  Anxiety. 7  Irritability.ortisol is a hormone secreted by the adrenal glands as a biological response to stress, which is why many refer to it as the stress hormone.. In addition to helping the body cope with stress, cortisol also assists with glucose metabolism, helping the body convert sugars into energy. Stress isn't always a bad thing.