1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Cramps are the involuntary tightening of a muscle that won't relax, occurring most often in the calf and thighs. The cause of muscle cramps is not exactly known, but is thought to be caused by many things such as overuse, injury, staying in one place to long, strain and of course from being dehydrated.