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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Low cortisol levels may cause 1  : Hypoglycemia â low blood glucose levels. 2  Muscle weakness. 3  Fatigue. Weight loss.  Muscle aches and joint 1  pains. Nausea, vomiting and diarrhea.  Irritability and 1  depression. Lack of appetite.