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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
The non-ST elevation acute coronary syndromes (ACS; unstable angina [UA] and non-ST elevation [non-Q wave] myocardial infarction [NSTEMI]) occur in a variety of clinical settings. The definitions of and classification systems for UA and NSTEMI and their use to assess risk will be reviewed here.