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They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.
Schwann cells - cells of ectodermal (neural crest) origin that compose a continuous envelope around each nerve fiber of peripheral nerves. Schwann white substance - the lipid material present in the myelin sheath of nerve fibers; the medulla of bones and other organs. schwannoma - Synonym(s): neurilemoma; neuroschwannoma. sheath of Schwann - a cell that enfolds one or more axons of the peripheral nervous system. Synonym(s): neurilemma. see Schwann cell.