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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
3. Mood swings and irritability. These can become anxiety and even depression. People who have an imbalance in cortisol, testosterone, or estrogen can all have mood swings and irritability. Neurotransmitters that are out of balance can also cause this symptom. 4. Skin changes.