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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
Non-ST-segment Elevation Myocardial Infarction (NSTEMI): there is no ST-segment change but there is myocardial necrosis for release of a biomarker such as the troponins or CK-MB. ST-segment Elevation Myocardial Infarction (STEMI): there is ST-segment elevation and myocardial necrosis with release of a biomarker such as the troponins or CK-MB.