1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
Litters of 5 or 6 young are born 19 to 21 days after mating, although females that conceive while still nursing may have a slightly longer gestation period. Mice are born hairless and with their eyes closed. They grow rapidly, and after 2 weeks they are covered with hair and their eyes and ears are open.