1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
SIMIAN CREASE: Normal palmar crease. SIMIAN CREASE: Simian crease. simian crease. A crease on the palm of the hand, so called because of its similarity to the transverse flexion crease found in some monkeys. Normally the palm of the hand at birth contains several flexion creases, two of which are separate and approx. transverse. When these two appear to fuse and form a single transverse crease, a simian crease is present.