At the state level, Vandergrift is within Pennsylvania's 55th House of Representatives District, represented by Joseph A. Petrarca, Jr. (D), elected 1995. Vandergrift is also within Pennsylvania's 38th Senatorial District, represented by Jim Ferlo (D), elected 2003.
Marfan syndrome also can damage the heart valves. Marfan syndrome affects approximately 200,000 people in the United States. Causes of Marfan syndrome. Marfan syndrome is caused by a genetic mutation. The disorder is usually inherited, but spontaneous cases occur. Having a parent with Marfan syndrome is the greatest risk factor. Symptoms of Marfan syndrome. Many patients with Marfan syndrome have no symptoms.
Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue.It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.he syndrome is caused by the misfolding of fibrillin-1, a glycoprotein which forms elastic fibers in connective tissue and contributes to cell signaling activity by binding to and sequestering transforming growth factor beta (TGF-Î²).