1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
transverse. When these two appear to fuse and form a single transverse crease, a simian crease is present. The crease may be present in a variety of developmental abnormalities, including Down syndrome, rubella syndrome, Turner syndrome, Klinefelter syndrome, pseudohypoparathyroidism, and gonadal dysgenesis.