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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
Causes of Fluid Build Up in the Lungs. The human body produces a small amount of pleura liquid in order to lubricate the surfaces of the pleura. Pleura refers to the thin tissue that surrounds the lungs and lines the chest cavity. When an abnormal or excessive collection of this fluid occurs, it leads to pleural effusion.