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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Lysine. One of the best vitamins for cold sores is lysine, which helps to prevent outbreaks and lessen their growth if they do appear. Lysine suppresses argenine, an element that helps viral cells reproduce.