1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
Causes of Simian crease that are rare The offical US government definition of a rare disease is one that affects 200,000 people or less. The following causes of Simian crease appear in the population at a rate of less than 200,000 people per year in the USA: Coffin-Lowry syndrome - simian crease.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.