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A nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants. nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants.
Because of nucleated red cells on the peripheral smear, the patient had bilateral bone marrow aspiration and biopsies, which revealed extensive plasmacytic cell infiltrate comprising 70% of marrow cellularity, with the presence of homogenous eosinophilic material consistent with amyloid (Fig 1).