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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
Non-ST Segment Elevation Myocardial Infarction (NSTEMI) is one of the three types of Acute Coronary Syndrome (ACS), and like all ACS, NSTEMI should be considered a medical emergency. All three types of ACS are produced when a plaque ruptures in a coronary artery.