Scleritis (inflammation of sclera) is a strong indication of the underlying medical problem. It can be due to fungal, viral or parasitic infection, trauma, exposure to chemicals, poisonous gases or due to post-surgical complications.
Mast cells are granulated cells typically found in connective tissue. These cells mediate immune responses to foreign particles. In particular, they release large amounts of histamine and enzymes in response to antigen recognition.
It is destroyed by the enzyme diamine oxidase (histiminase), which is also involved in the metabolism of other bioactive amines. Histamine is synthesized in all tissues, but is particularly abundant in skin, lung and gastrointestinal tract. Mast cells, which are present in many tissues, are a prominent source of histamine, but histamine is also secreted by a number of other immune cells.