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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
There are multiple causes of fluid in the lungs and many of them relate to the heart, notes Mayo Clinic. When the left ventricle is unable to efficiently pump out the blood it receives from the pulmonary circulation, pressure occurs in the left atrium, the veins and eventually the capillaries in the lungs.