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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
In these cases, while cell death occurs, some of the heart muscle supplied by the artery survives. In these âpartialâ heart attacks, the ST segment on the ECG does not become elevated. So this type of ACS is referred to as a ânon-ST-segment elevation myocardial infarction,â or NSTEMI.