1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Simian crease: is a single line that runs across the palm of of the vhand instead of the 3 creases that are normaly seen appears in 1 out of 30 people more seen in males is often normal may be linked with some other symptoms that define a syndrome like Downs syndrome or fetal alcohol syndrome ...Read more.