Energy intensity is a measure of a nation's energy efficiency represented through energy use per unit of GDP (Gross Domestic Product). Sorry, thatâs incorrect. Energy intensity is a measure of a nation's energy efficiency represented through energy use per unit of GDP (Gross Domestic Product).
Goodpasture syndrome (GPS; also known as Goodpastureâs disease, antiglomerular basement antibody disease, or anti-GBM disease) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.PS causes the abnormal production of anti-GBM antibodies, by the plasma cells of the blood. The anti-GBM antibodies attack the alveoli and glomeruli basement membranes. These antibodies bind their reactive epitopes to the basement membranes and activate the complement cascade, leading to the death of tagged cells.
Recently, ipilimumab was approved by the US Food and Drug Administration for the treatment of metastatic melanoma. We review the literature on managing the adverse effects and kinetics of tumor regression with ipilimumab and provide guidelines on their management.During treatment with these antibodies, a unique set of adverse effects may occur, called immune-related adverse events (irAEs).bstract. Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152)âipilimumab and tremelimumabâhave been investigated in metastatic melanoma and other cancers and have shown promising results.