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Lactoferrin is related to another stool test, calprotectin. Both are substances that are released by WBCs in the stool and are associated with intestinal inflammation. The clinical use of these tests is still relatively new.n endoscopy (colonoscopy or sigmoidoscopy) may be indicated as a follow-up test. Increases in lactoferrin are seen with IBD but also with other inflammatory conditions, with intestinal bacterial infections, some parasitic infections, and with colon cancer.
What does the test result mean? An elevated lactoferrin indicates that inflammation is likely present and active in the gastrointestinal tract but does not indicate either its location or cause. In general, the degree of elevation is associated with the severity of the inflammation.