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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
1901 - Karl Landsteiner, an Austrian physician, and the most important individual in the field of Blood transfusion, documented the first three human Blood groups (based on substances present on the red Blood cells), A, B and O. 1902 - A fourth main Blood type, AB was found by A. Decastrello and A. Sturli. 1907 - Hektoen suggested that the safety of transfusion might be improved by cross-matching Blood between donors and patients to exclude incompatible mixtures.