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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Many sufferers experience a crisis-like event due to the cortisol deficiency. The symptoms of the crisis often include severe vomiting, diarrhea, dehydration, low blood pressure, loss of consciousness, and intense low back, abdomen or leg pain, notes the Pituitary Network Association.