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Expectorant: A medication that helps bring up mucus and other material from the lungs, bronchi, and trachea. An example of an expectorant is guaifenesin, which promotes drainage of mucus from the lungs by thinning the mucus, and also lubricates the irritated respiratory tract. Search MedTerms:
Definition. 1  Expectorants are drugs that loosen and clear mucus and phlegm from the respiratory tract. 2  The drug described here, guaifenesin, is a common ingredient in cough medicines. It is classified as an expectorant, a medicine that helps clear mucus and other secretions from the respiratory tract. However, some debate exists about how effectively guaifenesin does this. In addition, some cough medicines contain other ingredients that may cancel out guaifenesin's effects.