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Expectorant: A medication that helps bring up mucus and other material from the lungs, bronchi, and trachea. An example of an expectorant is guaifenesin, which promotes drainage of mucus from the lungs by thinning the mucus, and also lubricates the irritated respiratory tract. Search MedTerms:
Expectorants and Mucolytic Drugs. Expectorants and mucolytic drugs are used to increase the output of bronchial secretions, enhance the clearance of bronchial exudate, and promote a productive cough.Saline expectorants are promoted to stimulate bronchial mucous secretions via a vagally mediated reflex action on the gastric mucosa.ts mucolytic effect is the result of the exposed sulfhydryl groups on the compound, which interact with disulfide bonds on mucoprotein. Acetylcysteine helps to break down respiratory mucus and enhance clearance. It may also increase the levels of glutathione, which is a scavenger of oxygen-free radicals.