1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
A lesion in this area would cause paralysis of the contralateral side of the body, including facial palsy, arm or leg monoparesis, and hemiparesis. Area 5 â Somatosensory association cortex â Brodmann area 5 is part of the parietal cortex.