1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
In Palmistry and Hand Analysis these are called the Heart Line and the Head Line. When the Heart Line and Head Line are fused together, only one major line is present, and it extends all the way across the hand from edge to edge. In Palmistry and Hand Analysis this is called a Simian Line. Medical references call it the Proximal Transverse Palmar Crease or Single Palmar Crease.