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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
Here, ST-segment elevation appears in ECG due to full thickness damage of cardiac muscle. Therefore, STEMI is more severe type of myocardial infarction compared to NSTEMI (non-ST segment elevation myocardial infarction) in which partial thickness damage of heart muscle develops.