GeneCards Summary for CHAT Gene. CHAT (Choline O-Acetyltransferase) is a Protein Coding gene. Diseases associated with CHAT include Myasthenic Syndrome, Congenital, 6, Presynaptic and Congenital Myasthenic Syndrome With Episodic Apnea. Among its related pathways are Metabolism and Transmission across Chemical Synapses.
FREE subscriptions for doctors and students... click hereYou have 3 open access pages. Ludwig's angina is an acute cellulitis in the region of the submandibular gland. It is most commonly due to sepsis in the throat or mouth which migrates to the submandibular space.Occasionally, it may be the result of suppuration in the submandibular gland itself.1  it is necessary to consider the anatomy of the submandibular space in order to understand the pathophysiology of Ludwig's angina.t is most commonly due to sepsis in the throat or mouth which migrates to the submandibular space. Occasionally, it may be the result of suppuration in the submandibular gland itself. 1  it is necessary to consider the anatomy of the submandibular space in order to understand the pathophysiology of Ludwig's angina.
As the submandibular space is expanded by cellulitis or abscess formation, the floor of the mouth becomes indurated and the tongue is forced upward and backward, causing airway obstruction. Ludwig's angina does not necessarily mature to form an abscess, it is more likely to produce a cellulitis or a phlegmon.It is typically bilateral and presents with drooling, trismus, pain, dysphagia, submandibular swelling airway obstruction caused by displacement of the tongue.s the submandibular space is expanded by cellulitis or abscess formation, the floor of the mouth becomes indurated and the tongue is forced upward and backward, causing airway obstruction. Ludwig's angina does not necessarily mature to form an abscess, it is more likely to produce a cellulitis or a phlegmon.