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The opposite is hypothyroidism, when the thyroid gland does not make enough thyroid hormone. Graves' disease is the cause of about 50% to 80% of case of hyperthyroidism in the United States. Other causes include multinodular goiter, toxic adenoma, inflammation of the thyroid, eating too much iodine, and too much synthetic thyroid hormone. A less common cause is a pituitary adenoma.
Hyperthyroidism is also a cause of goiter - from an overactive thyroid gland, which produces too much thyroid hormone. This usually happens as a result of Graves' disease, also an autoimmune disorder in which the body's immunity turns on itself and attacks the thyroid gland, causing it to swell.3.