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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
1. See if you have symptoms of cortisol deficiency. Many people worry about having too much cortisol, since elevated levels of cortisol can lead to weight gain, fatigue, and more serious symptoms. But having too little cortisol can be just as harmful to your health.