A written agreement which explicitly states a fixed duration that the contract will be in effect. The signing parties are obligated to adhere to the terms and conditions within the contract until the expiration, or end date, of the contract. http://www.businessdictionary.com/definition/term-contract.html.
The most common symptoms of Lou Gehrig's Disease are: 1  twitching. 2  cramping, or stiffness of muscles. 3  muscle weakness affecting an arm or a leg.  slurred and nasal 1  speech. or difficulty chewing or swallowing.
The progressive accumulation of this substance damages cells, leading to the varied signs and symptoms of Fabry disease. GLA gene mutations that result in an absence of alpha-galactosidase A activity lead to the classic, severe form of Fabry disease.Mutations that decrease but do not eliminate the enzyme's activity usually cause the milder, late-onset forms of Fabry disease that affect only the heart or kidneys.he progressive accumulation of this substance damages cells, leading to the varied signs and symptoms of Fabry disease. GLA gene mutations that result in an absence of alpha-galactosidase A activity lead to the classic, severe form of Fabry disease.