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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
When you factor in the hormonal changes women face as they age, the combination can really get the cortisol pumping. Symptoms of cortisol imbalance in women are similar to those typified by other hormonal imbalances such as perimenopause and menopause and often include the following: 1  Fatigue. 2  Depression. 3  Weight gain.4  Bone and muscle loss. 5  Foggy thinking. 6  Anxiety.hen you factor in the hormonal changes women face as they age, the combination can really get the cortisol pumping. Symptoms of cortisol imbalance in women are similar to those typified by other hormonal imbalances such as perimenopause and menopause and often include the following: 1  Fatigue. 2  Depression. 3  Weight gain.