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Denis transfused the blood from a sheep to a 15-year old boy and later to a labourer, both of whom survived the transfusions. In 1818, British obstetrician James Blundell successfully transfused human blood to a patient who had hemorrhaged during childbirth. In 1901, Karl Landsteiner, an Austrian physician discovered the first human blood groups, which helped transfusion to become a safer practice.
The study looked at 48,986 non-Witnesses who had blood transfusions and 322 Witnesses who refused to have blood transfusions who all underwent cardiac surgery between 1983 to 2011. After matching the patients up by similar cases, researchers found both groups had similar risks for dying at the hospital.