For example, your standard fixed overhead cost is $3 per unit. If your actual fixed overhead cost is $4 per unit, you have an unfavorable variance of $1. You spent $1 more per unit than you had originally budgeted.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and playing a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA).
Double-stranded DNA loops around 8 histones twice, forming the nucleosome, which is the building block of chromatin packaging. DNA can be further packaged by forming coils of nucleosomes, called chromatin fibers. These fibers are condensed into chromosomes during mitosis, or the process of cell division. However, packaging of chromatin into chromosomes that we are most familiar with occurs only during a few stages of mitosis.