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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Cortisol is a powerful anti-inflammatory and helps the body deal with stress and infections. This defect, in turn, causes a domino-effect producing too much estrogen and not enough thyroid hormones. When the endocrine (hormonal) system is out of balance the end result is low antibodies and a poor immune system.e uncovered a hidden adrenal gland defect that caused an endocrine-immune system imbalance. His research showed this endocrine-immune system dysfunction was caused primarily by poor genetics and over-breeding with a poor nutritional diet of dry kibbles, environmental pollutants, stress and age being secondary factors.