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Schwann cells are the supporting cells of the PNS. Like oligodendrocytes schwann cells wrap themselves around nerve axons, but the difference is that a single schwann cell makes up a single segment of an axon's myelin sheath.
They also carry out important functions in both the CNS and PNS. Schwann cells express the ERM proteins and merlin, but the absence of merlin alone results in NF2-related schwannomas, indicating that merlin has a distinct function in these cells. In neurons, the ERM proteins regulate key aspects of actin-dependent growth-cone motility.