1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
There is no universal cause for angular cheilitis, and the cracks can develop for a number of different reasons, including: yeast, staph, or strep infections. dry lips and skin (particularly during dry winter weather!) B-vitamin deficiencies, including B2 (riboflavin), B6, and B12.