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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
1 Vitamin E, and echinacea are said to help treat cold sores. 2  Don't squeeze or touch the sore, it will probably just get more infected. 3  Aftershave will dry up the cold sore and speed up the healing. 4  When eating, try to take smaller bites to limit the stretching action of the lips during healing.