For example, your standard fixed overhead cost is $3 per unit. If your actual fixed overhead cost is $4 per unit, you have an unfavorable variance of $1. You spent $1 more per unit than you had originally budgeted.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and playing a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA).
One of the main functions of chromatin is to reduce the size of DNA so it can fit in the cell. It does this by wrapping a DNA molecule tightly around proteins called histones. The histones are there to maintain the structure of the chromosome. Other functions of chromatin include reinforcing DNA molecules for mitosis, preventing DNA damage, and helping to control DNA replication.