1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
Mice are capable of producing six to eight babies in each litter, sometimes as many as ten. The biggest problem with mice is that they have multiple litters each year. One male and female mouse can produce up to 40 babies in one year. Multiply that by the fact that each litter will start producing babies as well within the year and you can see how quickly a couple of mice can get out of control. In just that first year those original mice can product up to 139.