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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Diclofenac is an anti-inflammatory, sort of a souped-up Ibuprofen. So if you're looking for control of the pain of the cold-sore, it may help. But it's not going to help you with shortening the duration of the cold sore or the area that it spreads to.or that you need a prescription anti-viral, Zovirax (acyclovir), because cold sores are caused by the Herpes virus (HSV-1). Alternatively, you could get Abreva which is a non-prescription ointment that will also shorten the cold sore's lifespan.