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A nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants. nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants.
Amphibian Red Blood Cells. Most mammalian red blood cells are highly evolved and have lost their nucleus. The nucleated red blood cells illustrated in the phase contrast optical micrograph below were derived from a frog, but are common to all amphibians.