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Pathophysiology of NSTEMI vs STEMI: Pathophysiologically, NSTEMI is somewhat different from STEMI. NSTEMI occurs by developing a complete occlusion of a minor coronary artery or a partial occlusion of a major coronary artery previously affected by atherosclerosis. This causes a partial thickness damage of heart muscle.
An ECG will show the following characteristics for an NSTEMI: depressed ST wave or T-wave inversion; no progression to Q wave; partial blockage of the coronary artery; A STEMI will show: elevated ST wave; progression to Q wave; full blockage of the coronary artery