1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
Mice have 20 chromosomes in their haploid genome (thus 40 chromosomes in all). The haploid genome is about 3 picograms, similar to humans. The gene order of the genomes of mice and humans are conserved (synteny) although there are rearrangements, several per chromosome.