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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
The most common secondary skin lesions include: 1  crust: a crust, or a scab, is created when dried blood forms over a scratched and irritated skin lesion. 2  ulcer: typically caused by a bacterial infection or physical trauma. 3  scale: patches of skin cells that build up and then fall off the skin.wo types of skin lesions exist: primary and secondary. Primary skin lesions are abnormal skin conditions present at birth or acquired over oneâs lifetime. Birthmarks are primary skin lesions. Other types include: 1  blisters: also called vesicles; these are small lesions filled with a clear fluid.