1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Alkylating agents such as ethylene oxide and Benzo[ a ]pyrene in cigarette smoke or coal tar. Modification of guanine by Benzo[ a ]pyrene would result in a distortion of the DNA helical structure. Upon replication, the DNA product would contain an insertion.