Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
The difference between the two is that density-dependent limiting factors rely on population size; the larger a population, the bigger impact a density-dependent limiting factor will have.Density-independent limiting factors do NOT rely on population size, instead they affect all populations equally.f the population density in the ecosystem were to increase, competition over these cacti would increase, making this a density-dependent limiting factor. Only a certain density of Cactus Wren can be supported in an ecosystem. Another example of a density-dependent limiting factor is disease.