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A Sharecare Ad Target User , Administration, answered. An outbreak of oral herpes, or cold sores, should go away on its own in about one or two weeks. Antiviral medications can help them heal faster if taken early. Talk to your doctor if your cold sores do not go away after two weeks. Helpful? 1 person found this helpful.
Any topical treatment for cold sores from the pharmacy will help it go away faster. Also, you should take L-lysine tablets (available at health food stores) as soon as you feel one coming on. Since I've discovered this, I have not had any more fever blisters and this was about 3 years ago.