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A nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants. nucleated red blood cell, or NRBC, is a red blood cell (RBC) that retains nucleus. Normally, NRBCs are only found in the circulation of fetuses and newborn infants.
Because nucleated red blood cells (NRBC) have a size and a nucleus similar to that of lymphocytes, many haematology analysers misclassify NRBC and produce a wrong total leukocyte and lymphocyte count.