1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
Although transplant-associated renal dysfunction is often multifactorial, calcineurin inhibitor (CNI) nephrotoxicity is thought to be a major contributor. Chronic allograft nephropathy is the most common cause of late renal allograft loss, due in large part to CNI toxicity.Similarly, heart, liver, and lung transplant patients experience native CKD at rates as high as 20% within five years (N Engl J Med. 2003;349:931-940) in the setting of chronic CNI exposure.iven the lack of major advances in effective âkidney-friendlyâ immunosuppression, progressive CKD is nearly inevitable in the current era of solid organ transplantation. Thus, we and other researchers are seeking to identify novel factors that could help clinicians better stratify a patient's risk of CNI-induced CKD.