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The opposite is hypothyroidism, when the thyroid gland does not make enough thyroid hormone. Graves' disease is the cause of about 50% to 80% of case of hyperthyroidism in the United States. Other causes include multinodular goiter, toxic adenoma, inflammation of the thyroid, eating too much iodine, and too much synthetic thyroid hormone. A less common cause is a pituitary adenoma.
Causes of high levels of thyroid-stimulating hormone include hypothyroidism, a tumor in the pituitary gland, or a need to increase the amount of thyroid hormone medicine, according to WebMD. The pituitary gland produces TSH, which then stimulates the thyroid to produce other hormones to regulate metabolism. Continue Reading.