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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Causes and Treatment of Feline Skin Lesions. Feline skin lesions have many possible causes including allergy, infections and parasites. Diagnosis of skin problems in cats can be a challenge since cats have a tendency to lick or use their teeth on itchy areas. Licking can cause lesions to become infected and hair loss. The leading cause of skin lesions in cats are fleas, which are often the problem despite the owners ability to locate a flea on the cats body. For example, a human could carry fleas into a house, which in turns causes a cat skin reaction.