Anti-HMGCR antibody titers ranged from 2,800 to 80,000 (mean 12,606) and were similar in patients with and without statin exposure (table). Serum CK was high in 83% of our patients (mean 4,232 IU/L; range 26 to 27,000). Fifty percent of patients with normal strength had high serum CK (mean 447 IU/L; range 48â1,846).atients with HMGCR antibodyâassociated myopathies present with weakness and muscle discomfort and often have damage to both perimysial connective tissue and muscle fibers, with necrosis and myonuclear pathology.
Density dependence occurs when the population growth rate, or constituent gain rates (e.g. birth and immigration) or loss rates (death and emigration), vary causally with population size or density (N). When these parameters do not vary with N, they are densityâindependent.
Definition of Density-Independent Factors. Both living and non-living things can influence the size of a population of organisms. Some things that happen to populations, such as disease and parasites, depend on the size of the population to be successful at causing destruction. Things and events that limit the size of a population regardless of the density of the population are called density-independent factors. The density of a population can be described as the number of organisms living in a specific area at a certain time.