They make up the cardiac pacemaker, that is, the natural pacemaker of the heart. In most humans, the concentration of pacemaker cells in the sinoatrial (SA) node is the natural pacemaker, and the resultant rhythm is a sinus rhythm. Sometimes an ectopic pacemaker sets the pace, if the SA node is damaged or if the electrical conduction system of the heart has problems.
Lobo is an extensible all-Java web browser and RIA platform. It supports HTML 4, Javascript (AJAX) and CSS 2 plus direct JavaFX and Java (Swing/AWT) rendering. Cobra is the web browser's renderer API; also a Javascript-aware HTML parser.
Java applications are offered though web browsers as either a web start application (which do not interact with the browser once they are launched) or as a Java applet (which might interact with the browser). This change does not affect Web Start applications, it only impacts applets.