1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
4. Single Palmar Crease. People will tell you the single palmar crease or simian crease is the hallmark physical characteristic of a child born with Down syndrome. Itâs a single crease across the palm of the hand. Despite the theory that this is so common, only 45% of children have a simian crease.