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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
Majority of the cases of Pulmonary Edema are caused by cardiac conditions but there may be other conditions which can cause fluid buildup in the lungs as well which includes conditions like pneumonia, certain classes of medications, or chronic exposure to certain toxins.