1 The processing time does not apply to services where prior approval has to be obtained from authorities in India or elsewhere. For such cases, the processing time is a minimum of thirty (30) business days.  The Consular Officer can at any time call an applicant for a personal interview.
The simian crease is one of the listed signs in Down Syndrome which would imply there's some genetic factor at play. My eldest daughter has a simian crease on one hand and the other hand is 'normal'.
One study in 2006 found that earlobe creases were strong predictors of coronary artery disease (the primary cause of heart attacks) in men and women and of sudden cardiac death in men. Risk was most pronounced in people who were under 40 years of age.