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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Low cortisol occurs when the body just can't take that stress anymore and it totally burns out. Symptoms are more fatigue related and include low energy, sadness/depression, light-headedness, salt cravings, heart palpitations, joint stiffness, weakness, and lack of concentration.