For example, your standard fixed overhead cost is $3 per unit. If your actual fixed overhead cost is $4 per unit, you have an unfavorable variance of $1. You spent $1 more per unit than you had originally budgeted.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and playing a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to 1 in human DNA).
Histones are the major proteins involved in this packaging. 1  The binding of the chromosomal DNA to histones is the first level of packaging. 2  The DNA-histone protein complex is called the chromatin. 3  There are 5 types of histones namely, H1, H2A, H2B, H3 and H4. The DNA-histone protein complex is called the chromatin. 2  There are 5 types of histones namely, H1, H2A, H2B, H3 and H4. 3  These are basic proteins (25% of basic amino acids lysine and arginine) and negatively charged DNA (due to the presence of phosphate group) can easily bind to these positively charged proteins.