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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Common symptoms of both high and low cortisol levels include anxiety, insomnia, irritability, memory problems, confusion, depression, cravings for sugar, and body temperature regulation problems such as chills, hot flashes, and night sweats.ortisol imbalances often come along with other symptoms of stress and fatigue and energy problems. Depressive symptoms and anxiety are common, no wonder because it is depressing and anxiety-inducing when you feel you canât function normally.