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The organ system in which the blood is pumped through the heart and circulates throughout the body through the blood vessels. Supplement. The cardiovascular system is a closed circulatory system seen in humans and other vertebrates. Its components include the heart, blood vessels, and blood.
Heart disease, or cardiovascular disease, is a general name for a wide variety of diseases, disorders and conditions that affect the heart and blood vessels. Heart disease is the number one cause of death in the United States, according to the Centers for Disease Control and Prevention (Source: CDC).