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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
A cortisol test may be ordered when a person has symptoms that suggest a high level of cortisol and Cushing syndrome, such as. 1  High blood pressure (hypertension) 2  High blood sugar (glucose)  Obesity, especially in the trunk.