Top Ten Tips for Graduate Students Who Want to Conduct a Meta-analysis. All you need to conduct a meta-analysis is use of one or more comprehensive literature search engines (e.g., Web of Science, PsycINFO, PubMed), access to a basic statistics program such as SPSS or SAS at your disposal, and a good idea for a meta-analysis topic.
Signs and symptoms vary depending on what parts of your body are affected by Wilson's disease. They may include: 1  Fatigue, lack of appetite or abdominal pain.  Jaundice, a yellowing of the skin and the whites of the eye.
With Wilson disease, the copper builds up in your liver, and it releases the copper directly into your bloodstream. This can cause damage to your brain, kidneys, and eyes. Wilson disease is present at birth, but symptoms usually start between ages 5 and 35. It first attacks the liver, the central nervous system or both. The most characteristic sign is a rusty brown ring around the cornea of the eye. A physical exam and laboratory tests can diagnose it. Treatment is with drugs to remove the extra copper from your body.