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The opposite is hypothyroidism, when the thyroid gland does not make enough thyroid hormone. Graves' disease is the cause of about 50% to 80% of case of hyperthyroidism in the United States. Other causes include multinodular goiter, toxic adenoma, inflammation of the thyroid, eating too much iodine, and too much synthetic thyroid hormone. A less common cause is a pituitary adenoma.
TSH (thyroid stimulating hormone) is part of a feedback loop controlling levels of thyroid hormone. TSH levels are high when parts of this feedback loop do not function properly. The commonest cause is a problem in the thyroid resulting in hypothyroidism, treated with thyroid hormone.A tumor in the pituitary gland or the hypothalamus can also cause high TSH levels and hyperthyroidism. thyroid scan and thyroid tests identify the cause. Thyroid stimulating hormone (TSH) is a protein hormone released from the pituitary gland in the brain that stimulates the thyroid to produce thyroid hormone, which regulates body metabolism.