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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
Some other symptoms of adrenal cancer that produce excess cortisol and aldosterone in adults can include: 1  high blood pressure. 2  high blood sugar. 3  weight gain.  irregular 1  periods. easy bruising. 2  depression. frequent urination.  muscle cramps.