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Pulmonary edema facts. 1  Pulmonary edema is typically caused by filling of alveoli in the lungs by fluid leaking out of the blood. 2  Pulmonary edema may be caused by a number of cardiac or non-cardiac conditions.  Breathing difficulty is the main manifestation of pulmonary edema.
Autoimmune diseases like sarcoidosis may cause fluid in the lungs due to the inflammation of the lung tissue. Shortage of oxygen due to high altitudes, COPD (chronic obstructive pulmonary disease) and suffocation may result in pulmonary edema. Fluid Outside the Lungs. Pleural effusion is when fluid accumulates around the lung, in the pleural space.