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The organ system in which the blood is pumped through the heart and circulates throughout the body through the blood vessels. Supplement. The cardiovascular system is a closed circulatory system seen in humans and other vertebrates. Its components include the heart, blood vessels, and blood.
Cardiovascular disease is a general name for a wide variety of diseases, disorders and conditions that affect the heart and sometimes the blood vessels as well. Cardiovascular disease is the number one killer of women and men in the United States, according to the National Heart, Lung, and Blood institute.