Coal forms from the accumulation of plant debris, usually in a swamp environment. When plant debris dies and falls into the swamp the standing water of the swamp protects it from decay. Swamp waters are usually deficient in oxygen, which would react with the plant debris and cause it to decay.
Porokeratosis is generally considered to be a benign condition though malignant transformation has been seen in all but the punctate variety, necessitating regular followup of patients with porokeratosis (Maubec et al., 2005; Sasson & Krain, 1996).
In human submandibular gland (HSG) cells as well as in human epidermal keratinocytes (HaCaT) we demonstrate that over-expression of TRPC1 augmented cell proliferation whereas, silencing of TRPC1 by siRNA (small interfering RNA) or expression of the channels' pore-mutant significantly inhibited proliferation.