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Symptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.6  Anxiety.7  Irritability. 8  Tired but wired feeling.ymptoms of cortisol imbalance are similar to other hormone deficiencies. 1  Fatigue, sluggish. 2  Depression. 3  Weight gain. 4  Bone and muscle loss. 5  Foggy thinking.
group of symptoms attributed to the excessive production of cortisol by the adrenal cortices. This syndrome may be the result of a pituitary tumor or a primary adrenal gland dysfunction. Symptoms include abnormally pigmented skin, moon face, pads of fat on the chest and abdomen, buffalo hump and wasting away. diabetes insipidus (DI)