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Lactoferrin is related to another stool test, calprotectin. Both are substances that are released by WBCs in the stool and are associated with intestinal inflammation. The clinical use of these tests is still relatively new.n endoscopy (colonoscopy or sigmoidoscopy) may be indicated as a follow-up test. Increases in lactoferrin are seen with IBD but also with other inflammatory conditions, with intestinal bacterial infections, some parasitic infections, and with colon cancer.
A doctor may order a lactoferrin test to help investigate the cause of a person's persistent watery or bloody diarrhea. The test may be ordered along with other stool tests, such as a stool culture to detect a bacterial infection, a stool white blood cell test, and/or a fecal occult blood test.