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Lactoferrin is related to another stool test, calprotectin. Both are substances that are released by WBCs in the stool and are associated with intestinal inflammation. The clinical use of these tests is still relatively new.n endoscopy (colonoscopy or sigmoidoscopy) may be indicated as a follow-up test. Increases in lactoferrin are seen with IBD but also with other inflammatory conditions, with intestinal bacterial infections, some parasitic infections, and with colon cancer.
The Lactoferrin Screen, Stool is more specific and beneficial than the orderable Fecal Leukocyte (WBC) Test as it detects an increased presence of lactoferrin. The screen does not rely upon the staining of intact leukocytes, which in some cases may not be present due to collection, age of specimen, and cell lysis. The Lactoferrin Quantitative, Stool assay offers a safe nonâinvasive, accurate method of differentiating inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS), once infectious causes of inflammation and colorectal cancer are ruled out.