1 Coadministration with moderate CYP3A4 and/or PgP inhibitors: Reduce dose by 50%; administer every other day if dose reduction is required for patients receiving the lowest available strength and maintain trough concentrations of 5 to 15 ng/mL.
A pregnant mouse can give birth to six to 12 babies in one litter. A female mouse can become pregnant several times a year. One mouse couple can produce 40 or more babies in one year.
Depending on the line, a female shouldn't be bred much past 8 months either. As stated before, having babies isn't easy for a mouse. By the time that they are 8 months old they are actually getting elderly! Breeding age will vary from line to line.