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Skin lesions have a wide variety of causes. The most common causes of skin lesions are injury, aging, infectious diseases, allergies, and small infections of the skin or hair follicles.Chronic diseases such as diabetes or autoimmune disorders can cause skin lesions.Skin cancer or precancerous changes also appear as skin lesions.ommon causes of skin lesions. Changes in the appearance of the skin can result from common conditions such as: 1  Acne. 2  Boils and carbuncles. 3  Folliculitis. 4  Freckles. 5  Nevi (moles) and other benign skin growths.
Skin cancer and precancerous changes in the skin are more serious causes of skin lesions. These lesions most commonly appear on areas of your body that have been exposed to sun, including your face, arms and hands. skin lesion is any change in the normal character of your skin. A skin lesion may occur on any part of your body and cover a tiny or large area.