You never know when set notation is going to pop up. Usually, you'll see it when you learn about solving inequalities, because for some reason saying x < 3 isn't good enough, so instead they'll want you to phrase the answer as the solution set is { x | x is a real number and x < 3 }.
If the skin really looks like the color of ash, a deeper more persistent gray or gray-blue color, this could potentially be due to a side effect of certain medications, with or without interaction from sunlight.
The majority of melanomas are black or brown, but they can also be skin-colored, pink, red, purple, blue or white. Melanoma is caused mainly by intense, occasional UV exposure (frequently leading to sunburn), especially in those who are genetically predisposed to the disease.