Statistical significance considers the first and third of these concerns. The middle one, bias, cannot be detected by mathematical deductive logic: it needs detailed information on the way the sample was chosen. This is dealt with in the notes on bias.
A HEIC file is a raster image saved in the High Efficiency Image Format (HEIF), a lossy compressed format. It may contain still images, image collections, image bursts, or image sequences, along with metadata that describes each image. HEIC files may also appear as .HEIF files.
Reading HEIC image file on Mac is straightforward unlike in the case of Windows users, however, if your Mac operating system is old, you may not be able to read the file. Since Apple is introducing it in iOS 11, there is no support for old Mac OS to read the HEIC image format.