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So, how long does mono last? Hopefully you see that it really depends on when it is detected and knowing those warning signs are the best way to get help. Once you are undergoing the necessary treatments mono usually lasts for about a month but has been known to last up to 6 months in some rare cases.
One of the complications of mono is a ruptured spleen, which is a life-threatening situation. A ruptured spleen will usually occur between four and 21 days after you begin to have symptoms. If your spleen ruptures, you will need emergency surgery to remove it.