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In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days. In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days.  In brief: Naproxen.
Some general considerations for when and how to take naproxen include the following: 1  The medication comes in tablet, caplet (capsule-shaped tablet), or liquid form. 2  It is usually taken by mouth no more than twice daily or every 12 hours as needed (or as directed by your healthcare provider) for pain relief. For naproxen to work properly, you have to take it as prescribed. 2  The medication will not work if you stop taking it. 3  It is important to take the lowest effective dose for the least amount of time in order to treat your condition.