Strain-specifictransgene methylation occurs early in mouse developmentand can be recapitulated in embryonic stem cells. Develop-ment 121: 2853â2859.Wigler, M., Levy, D., and Perucho, M. 1981. The somatic repli-cation of DNA methylation. Cell 24: 33â40.Wolffe, A.P., Jones, P.L., and Wade, P.A. 1999.
1 Toronto remains a mosaic of many languages. In 2006, forty-seven percent of the population had a mother tongue in a language other than English or French. 2  The top 5 mother tongue languages in 2006 were:  Chinese (420,000);
Canada has two official languages: English and French. English is the most commonly spoken language in most provinces and territories. French is the main language spoken in Quebec and in some areas of Ontario, New Brunswick and Manitoba. In addition, there are francophone communities in all provinces and territories across Canada. Quebec also has a large minority of English-speaking residents.