Treatment is indicated in patients with Pagetâs disease of bone with elevations in serum alkaline phosphatase of two times or higher than the upper limit of the age-specific normal reference range, or those who are symptomatic, or those at risk for complications from their disease [see Clinical Studies (14.5)].
experimenter bias - (psychology) bias introduced by an experimenter whose expectations about the outcome of the experiment can be subtly communicated to the participants in the experiment. number of conclusions drawn from the reviewed studies were unfounded because the experimenters inferred causation from correlation, lacked standardized measures, had poor sampling procedures, failed to control for threats to validity, had very limited assessment of anxiety, had.
8.2.1 âBiasâ and ârisk of biasâ. A bias is a systematic error, or deviation from the truth, in results or inferences. Biases can operate in either direction: different biases can lead to underestimation or overestimation of the true intervention effect.ecause the results of a study may in fact be unbiased despite a methodological flaw, it is more appropriate to consider risk of bias. Differences in risks of bias can help explain variation in the results of the studies included in a systematic review (i.e. can explain heterogeneity of results).