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In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days. In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days.  In brief: Naproxen.
Here are general guidelines for naproxen dosages: 1  Extended-release tablets may be taken once a day. 2  Enteric coated tablets may be taken twice a day. 3  Tablets may be taken every 8 hours for gout or pain. 4  OTC naproxen is usually taken every 8 to 12 hours.