Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
One bone marrow disease, bone cancer, may be the result of a malignant tumor of the bone or cancer that has spread, or metastasized, from another area of the body to the bone. Bone cancer can destroy bone marrow tissue and the bodyâs ability to manufacture red blood cells, thereby causing anemia. With this type of anemia, the body does not make enough red and white blood cells and platelets. 2  In severe cases of aplastic anemia, the body totally stops production of these cells. 3  Paroxysmal nocturnal hemoglobinuria (PNH). 4  In PNH, abnormal stem cells in the bone marrow produce defective red blood cells.