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As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as renal failure, hypoalbuminemia, congestive heart-failure, protein-losing nephropathy, pulmonary hypertension, obesity, pregnancy and drug-induced edema.
Lymphedema occurs when there is inadequate lymph drainage from the body, usually from a blockage in a lymph channel. Lymphatic fluid builds up underneath the skin and causes swelling. Most commonly lymphedema affects the arms or legs.