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Abdominal cancer occurs when old or damaged cells divide and multiply uncontrollably. The underlying cause of this varies depending on the specific form of cancer. For example: Colorectal cancer commonly develops from adenomatous intestinal polyps in the colon that are not removed while still benign.
1 Stomach cancer can cause a mass in the left-upper abdomen in the stomach area (epigastric) if the cancer is large. 2  Uterine leiomyoma (fibroids) can cause a round, lumpy mass above the pelvis in the lower abdomen (sometimes can be felt if the fibroids are large).