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So, how long does mono last? Hopefully you see that it really depends on when it is detected and knowing those warning signs are the best way to get help. Once you are undergoing the necessary treatments mono usually lasts for about a month but has been known to last up to 6 months in some rare cases.
Sometimes, a swollen spleen or liver involvement may develop. These symptoms usually last for more than two days and may appear slowly. Heart problems or involvement of the central nervous system occurs only rarely, and mono is almost never fatal.