Reg. 259 (Jan. 4, 2011). 4 See definition of applicable clinical trial at 42 U.S.C. 282(j)(1)(A). The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.
We identified a risk haplotype in SLC18A2 and found a consistent result in the Detroit Neighborhood Health Study (DNHS) (N=748), an epidemiologic sample of primarily African-American adults residing in urban Detroit (Goldmann et al, 2011).
What the physician (and the carrier of an âat riskâ genotype) want to know is not the magnitude of the increased risk conferred by this particular genotype with respect to the most frequent genotype in the population but the actual probability to develop the disease according to age and sex.