Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
American Society of Hematology. Leukemia. Leukemia is a type of cancer found in your blood and bone marrow and is caused by the rapid production of abnormal white blood cells. These abnormal white blood cells are not able to fight infection and impair the ability of the bone marrow to produce red blood cells and platelets. Leukemia can be either acute or chronic.