Suggested Resources (0.00 / 0 votes) Rate this definition: ROCA. What does ROCA stand for?-- Explore the various meanings for the ROCA acronym on the Abbreviations.com website.
Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue.eutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue.
Neutrophil elastase ([NE] also called elastase-2 [ELA-2]) is a powerful serine protease stored in the primary granule of neutrophils.This enzyme is synthesized primarily at the promyelocyte stage of neutrophil development in the bone marrow.The human gene for NE is located at 19 p 13.3, and mutations in NE are regarded as the primary cause of cyclic neutropenia and some, but not all, cases of severe congenital neutropenia.n the other hand, patients whose clinical phenotype and mutational analysis are consistent with the diagnosis of severe congenital neutropenia are at risk for evolution to leukemia. In this report, 4 of 54 patients with congenital neutropenia developed AML.