Reg. 259 (Jan. 4, 2011). 4 See definition of applicable clinical trial at 42 U.S.C. 282(j)(1)(A). The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.
We identified a risk haplotype in SLC18A2 and found a consistent result in the Detroit Neighborhood Health Study (DNHS) (N=748), an epidemiologic sample of primarily African-American adults residing in urban Detroit (Goldmann et al, 2011).
Human major histocompatibility complex (MHC) alleles can be used as markers for a wide variety of autoimmune and other disorders.The interpretation of and possible bases for these associations should be considered in relation to conserved extended MHC haplotypes (CEHs). The genomic architecture of the MHC, strongly influenced by the presence of conserved extended haplotypes (CEHs), which are 1â5 megabase essentially identical by descent common population MHC haplotypes, should be considered when analysing MHC disease markers.