Suggested Resources (0.00 / 0 votes) Rate this definition: ROCA. What does ROCA stand for?-- Explore the various meanings for the ROCA acronym on the Abbreviations.com website.
Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue.eutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue.
The ELANE gene provides instructions for making a protein called neutrophil elastase. This protein is found in neutrophils, a type of white blood cell that plays a role in inflammation and in fighting infection.When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase.ore than 15 mutations in the ELANE gene have been found to cause cyclic neutropenia, a condition characterized by episodes of neutrophil shortages (neutropenia) and increased risk of infection. ELANE gene mutations that cause cyclic neutropenia change single protein building blocks (amino acids) in neutrophil elastase.