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Lithium may cause arrhythmias, or irregular heartbeat, throughout the course of therapy. If the patient experiences heart palpitations or uneven heart beat, he should seek medical care right away.
The most common reasons are due to an imbalance (usually deficiency) of: 1  Calcium-a lack of calcium may cause abnormal heart rhythm. 2  Magnesium-a lack of magnesium can cause abnormal heart rhythm. 3  Vitamin B1 - a lack of vitamin B1 (thiamin) can cause abnormal heart rhythm.ertain prescription medications can also cause arrhythmia as a side effect. The most common medications to cause this type of side effect are: 1  Allergy and sinus medications that contain pseudoephedrine. 2  Appetite suppressants. 3  Beta-blockers. 4  Psychotropics (anti-depressants). 5  Thyroid medications.