Recent reports have identified EPCAM deletions in patients with Lynch syndrome. As the data about EPCAM and LS is rapidly changing, consider consulting with a genetics specialist. â¢ If no mutation is found, follow up with MSH6 genetic testing. If only MSH6 is absent â¢ If only MSH6 is absent, the patient may have LS.
Progesterone is one of the dominant sex hormones in females, and it helps maintain a pregnancy by preventing the contraction of the uterus or womb. Progesterone can lead to constipation by slowing the passage of digested food through the intestines.
Spironolactone fits (blocks) your testosterone receptor, which is why itâs used, but unfortunately, it also disrupts ovulation, estrogen metabolism and adrenal function. The drug causes loss of libido, menstrual irregularity, and breast pain. It has been linked with breast cysts, and possibly breast cancer. By interfering with your hypothalamic-pituitary-adrenal (HPA) axis, spironolactone causes low blood pressure, headaches, fatigue, and depression. It increases the risk for blood clots. I know you want a fast, effective solution for your hair loss, but spironolactone is not it.