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In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days. In brief: Naproxen. In a patient with normal kidney and liver function, Naproxen would normally be completely out of the body within 5 - 7 days.  In brief: Naproxen.
If you are taking naproxen on a regular basis, you should take it at the same time(s) every day. Nonprescription naproxen comes as tablet and a gelatin coated tablet to take by mouth. It is usually taken with a full glass of water every 8 to 12 hours as needed.