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Knee pain facts. 1  Knee pain is a common problem with many causes, from acute injuries to medical conditions. 2  Knee pain can be localized or diffuse throughout the knee. 3  Knee pain is often accompanied by physical restriction. 4  A thorough physical examination will usually establish the diagnosis of knee pain.
Patellofemoral syndrome ( PFS ) : The commonest cause of chronic knee pain , PFS characteristically causes vague discomfort of the inner knee area , aggravated by activity ( running , jumping , climbing or descending stairs ) or by prolonged sitting with knees in a moderately bent position ( the so-called  theater sign  of pain upon arising from a ...