Morning stiffness is often an early sign of arthritis. Stiffness that lasts for a few minutes is usually a symptom of a degenerative form of arthritis. Stiffness that lasts for several hours is generally a symptom of inflammatory arthritis and is typical of RA.
Early cities developed in a number of regions, from Mesopotamia to Asia to the Americas. The very first cities were founded in Mesopotamia after the Neolithic Revolution, around 7500 BCE. Mesopotamian cities included Eridu, Uruk, and Ur. Early cities also arose in the Indus Valley and ancient China.
In the thirty thousand years since then the region had usually been at the forefront of human cultural progression, By the fourth millennium BC, the first city states had appeared in Sumer and Akkad in southern Mesopotamia, and by the third they were flourishing with creative ideas and large populations.