Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
Secondary Polycythemia Secondary polycythemia - also called reactive polycythemia - is characterized by excessive production of circulating red blood cells (RBCs) due to hypoxia, tumor, or disease. It occurs in about 2 out of every 100,000 persons who live at or near sea level; incidence increases among people who live at high altitudes.