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Primary Cause of Amebiasis. The primary cause of Amebiasis is the result: 1  of transmission of an infectious agent by another person by one or more of the following: saliva, air, cough, fecal-oral route, surfaces, blood, needles, blood transfusions, sexual contact, mother to fetus, etc.
In rare instances the amoeba can attach to one of the nerves that takes smell signals to the brain. There, the amoeba reproduces and the brain swelling and infection that follows is almost always deadly. The amoeba can cause an infection of the brain called primary amebic meningoencephalitis, the CDC said. It is rare: The CDC said only 138 cases have been reported from 1962 to 2015. Only three people survived. Texas and Florida lead in reported cases of primary amebic meningoencephalitis during that time frame.