Statistical significance considers the first and third of these concerns. The middle one, bias, cannot be detected by mathematical deductive logic: it needs detailed information on the way the sample was chosen. This is dealt with in the notes on bias.
A HEIC file is a raster image saved in the High Efficiency Image Format (HEIF), a lossy compressed format. It may contain still images, image collections, image bursts, or image sequences, along with metadata that describes each image. HEIC files may also appear as .HEIF files.
When you want to transfer photos in HEIC format over to your computer, you will have a file that is bigger than the original image. Another disadvantage of the HEIC image format is that on a non-compatible device, you cannot edit nor view them without the help of third party software. How to Read HEIC on Mac and Windows Computer 1 On Mac