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Lithium may cause arrhythmias, or irregular heartbeat, throughout the course of therapy. If the patient experiences heart palpitations or uneven heart beat, he should seek medical care right away.
Many NSAIDs, but particularly indomethacin, cause lithium retention by reducing its excretion by the kidneys. Thus indomethacin users have an elevated risk of lithium toxicity. For patients taking lithium (e.g. for treatment of depression or bipolar disorder), less toxic NSAIDs such as sulindac or aspirin are preferred.