Let's look at the details: 1  An enzyme called DNA gyrase makes a nick in the double helix and each side separates. 2  An enzyme called helicase unwinds the double-stranded DNA.  Several small proteins called single strand binding proteins (SSB) temporarily bind to each side and keep them separated.
prurigo miÂ´tis prurigo of a mild type. prurigo nodulaÂ´ris a form of neurodermatitis, usually occurring on the extremities in middle-aged women, marked by discrete, firm, rough-surfaced, dark brownish-gray, intensely itchy nodules. prurigo simÂ´plex papular urticaria.
Clinical features of prurigo pigmentosa include: 1  A pruritic (itchy) rash, which may recur. 2  Inflamed, red raised spots (papules) that merge to form a reticulate (network-like) pattern.  A symmetrical distribution on trunk with a preference for the upper back, sacrum (natal cleft), abdomen and chest.