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The type of nephrotic syndrome that is most common in children is called idiopathic nephrotic syndrome. It accounts for about 90 percent of children with nephrotic syndrome. Idiopathic means that a disease occurs with no known cause.The most common type of idiopathic nephrotic syndrome is called minimal-change nephrotic syndrome (MCNS). Idiopathic nephrotic syndrome is more common in boys than girls.With MCNS, the child usually has relapses of the illness, but the disease can usually be managed and prognosis is good.ephrotic syndrome is characterized by the following symptoms that result from changes that occur to the small, functional structures in the kidneys, such as: Very high levels of protein in the urine. Low levels of protein in the blood due to its loss in the urine.
The nephrotic syndrome is characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show nonspecific histologic changes such as minimal change, focal segmental glomerulosclerosis (FSGS), and diffuse mesangial proliferation.