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The prefrontal cortex, which is part of the brain's frontal lobe, is the region responsible for short-term memory. The Canadian Institutes of Health Research states that the human prefrontal cortex is highly developed, resulting in the complex functions and manipulation of memory. The prefrontal cortex is referred to as the coordinator in short-term memory, as it is involved in the ways in which memories are used. Brain imaging shows that activation occurs in the prefrontal cortex during rehearsal, an essential step in transforming short-term memories into long-term memories.
The temporal lobe contains the hippocampus, which is the memory center of the brain. The hippocampus plays a key role in the formation of emotion-laden, long-term memories based on emotional input from the amygdala. The left temporal lobe holds the primary auditory cortex, which is important for processing the semantics of speech.