Morning stiffness is often an early sign of arthritis. Stiffness that lasts for a few minutes is usually a symptom of a degenerative form of arthritis. Stiffness that lasts for several hours is generally a symptom of inflammatory arthritis and is typical of RA.
Early cities developed in a number of regions, from Mesopotamia to Asia to the Americas. The very first cities were founded in Mesopotamia after the Neolithic Revolution, around 7500 BCE. Mesopotamian cities included Eridu, Uruk, and Ur. Early cities also arose in the Indus Valley and ancient China.
During the same sliver of cosmic time, cities, states, and civilizations emerged independently in several places around the world. The first agrarian civilizations developed in about 3200 BCE. These early farming societies started in three areas: Mesopotamia; in Egypt and Nubia (now northern Sudan); and in the Indus Valley.