In our patient, suffering from a rebound radiculopa- thy due to clearly demonstrable scar tissue around the L5 root, in whom re-exploration was not a feasible option, hyaluronidase applied locally succeeded in pro- ducing periods with drastic reduction of pain where regular pharmaceutical means had failed.
About this book. Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics.
Mitochondrial disorders are a clinically heterogeneous group of conditions that are typically the result of mitochondrial respiratory chain dysfunction, which is essential for aerobic metabolism. Mitochondrial disorders can be caused by mutations of mitochondrial DNA or nuclear DNA. Each human cell contains thousands of copies of mitochondrial DNA and usually, all copies are identical genetically, which is referred to as homoplasmy. Individuals with mitochondrial disorders may have a mixture of mutant and normal mitochondrial DNA within each cell, also known as heteroplasmy.