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As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as renal failure, hypoalbuminemia, congestive heart-failure, protein-losing nephropathy, pulmonary hypertension, obesity, pregnancy and drug-induced edema.
Causes of Unilateral oedema of the lower extremity: The following medical conditions are some of the possible causes of Unilateral oedema of the lower extremity. There are likely to be other possible causes, so ask your doctor about your symptoms. Rupture of a Baker's cyst.