Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
Aplastic Anemia. Aplastic anemia (AA) is a disease in which the bone marrow fails to produce sufficient numbers of blood cells. Typically, patients have low blood counts across all three types of blood cells â red cells, white cells, and platelets.our bone marrow produces the blood cells that circulate in your body. If you have a bone marrow failure disease, your bone marrow stops functioning or begins producing abnormal blood cells.