Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
Leukemia is cancer of the blood cells. Blood cells and platelets are produced in the bone marrow. In leukemia, white bloods cells fail to mature properly. These immature cells continue to reproduce at a rapid rate, crowding out healthy cells and producing a host of symptoms.nemia. Red blood cells help to distribute oxygen throughout the body. Overcrowding makes it difficult to produce enough red blood cells. This is a condition called anemia. Symptoms include fatigue, pale skin, and rapid breathing. Some children also report feeling weak or lightheaded.