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As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as renal failure, hypoalbuminemia, congestive heart-failure, protein-losing nephropathy, pulmonary hypertension, obesity, pregnancy and drug-induced edema.
Lower extremity edema involves swelling of the feet and legs, which typically occurs due to an abnormal accumulation of fluid. This fluid buildup can be caused by a wide variety of factors, ranging from something relatively simple, such as standing too long, to something more serious, such as kidney disease.