Recent reports have identified EPCAM deletions in patients with Lynch syndrome. As the data about EPCAM and LS is rapidly changing, consider consulting with a genetics specialist. â¢ If no mutation is found, follow up with MSH6 genetic testing. If only MSH6 is absent â¢ If only MSH6 is absent, the patient may have LS.
Progesterone is one of the dominant sex hormones in females, and it helps maintain a pregnancy by preventing the contraction of the uterus or womb. Progesterone can lead to constipation by slowing the passage of digested food through the intestines.
Progestogen-only contraceptives such as an IUD are not believed to affect milk supply or infant growth. However, a study in the Mirena application for FDA approval found a lower continuation of breastfeeding at 75 days in hormonal IUD users (44%) versus copper IUD users (79%). When using Mirena, about 0.1% of the maternal dose of levonorgestrel can be transferred via milk to the nursed infant.