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As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as renal failure, hypoalbuminemia, congestive heart-failure, protein-losing nephropathy, pulmonary hypertension, obesity, pregnancy and drug-induced edema.
An infection involving the lymphatic vessels â An infection that involves the lymphatic vessels can be severe enough to cause lymphedema. In areas of the tropics and subtropics, such as South American, the Caribbean, Africa, Asia and the South Pacific, parasites are a common cause of lymphedema.