Statistical significance considers the first and third of these concerns. The middle one, bias, cannot be detected by mathematical deductive logic: it needs detailed information on the way the sample was chosen. This is dealt with in the notes on bias.
A HEIC file is a raster image saved in the High Efficiency Image Format (HEIF), a lossy compressed format. It may contain still images, image collections, image bursts, or image sequences, along with metadata that describes each image. HEIC files may also appear as .HEIF files.
You can view HEIC files in Windows using the desktop or web version of Dropbox. You can also install CopyTrans HEIC for Windows, which allows programs, such as Windows Explorer and Windows Photo Viewer to open HEIC files. iMazing HEIC Converter can be used to convert HEIC files to JPG or PNG files. The program is available for Windows or macOS.