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Lithium may cause arrhythmias, or irregular heartbeat, throughout the course of therapy. If the patient experiences heart palpitations or uneven heart beat, he should seek medical care right away.
Other manifestations of lithium toxicity on the kidney include renal tubular acidosis, chronic tubulointerstitial nephritis, and nephrotic syndrome. The most common endocrine disorder secondary to chronic toxicity is hypothyroidism.yxedema coma has been reported as a complication of toxicity. Acute exposure to lithium can cause leukocytosis, whereas chronic exposure can produce aplastic anemia. Patients who are on long-term lithium therapy can develop localized edema, dermatitis, and skin ulcers.