Treatment for hemoglobin E disease is typically not needed. Folic acid supplements may be prescribed to help the body produce normal red blood cells if mild anemia causes symptoms. Most people do not have any symptoms. People with hemoglobin E disease can expect to lead a normal life.
Blood groups are inherited from both parents. The ABO blood type is controlled by a single gene (the ABO gene) with three types of alleles inferred from classical genetics: i, IA, and IB. The gene encodes a glycosyltransferase âthat is, an enzyme that modifies the carbohydrate content of the red blood cell antigens.he ABO blood group system is widely credited to have been discovered by the Austrian scientist Karl Landsteiner, who identified the O, A, and B blood types in 1900. Landsteiner originally described the O blood type as type C, and in parts of Europe it is rendered as 0 (zero), signifying the lack of A or B antigen.
Figure 1: The ABO system of blood types results from the presence of different sugars on the extracellular end of a ceramide molecule embedded in the membrane of the RBC. The presence and identity of the added sugar is determined by the type of enzyme produced in the red blood cell.