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As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as renal failure, hypoalbuminemia, congestive heart-failure, protein-losing nephropathy, pulmonary hypertension, obesity, pregnancy and drug-induced edema.
Some immune system disorders are prone to causing lower extremity edema. This swelling is not related to an accumulation of fluid, but instead is a result of inflammatory disease. Some potential causes of this type of edema include gout, broken bones, and certain types of arthritis.