The 50 most significant moments of Internet history. The Internet has revolutionised the way we live, over almost 50 years of development. In this feature, we detail the 50 defining moments we feel are most significant to the Web. Up Next No faking it, Facebook rakes it in.
Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.
Once at the ER, IP 3 is able to bind to the Ins3P receptor (Ins3PR) on a ligand-gated Ca 2+ channel that is found on the surface of the ER. The binding of IP3 (the ligand in this case) to InsP3R triggers the opening of the Ca 2+ channel, and thus release of Ca 2+ into the cytoplasm.n the nervous system, IP 3 serves as a second messenger, with the cerebellum containing the highest concentration of IP 3 receptors. There is evidence that IP 3 receptors play an important role in the induction of plasticity in cerebellar Purkinje cells.