Primase is an enzyme that synthesizes short RNA sequences called primers. These primers serve as a starting point for DNA synthesis.Since primase produces RNA molecules, the enzyme is a type of RNA polymerase.Primase functions by synthesizing short RNA sequences that are complementary to a single-stranded piece of DNA, which serves as its template.It is critical that primers are synthesized by primase before DNA replication can occur.rimase functions by synthesizing short RNA sequences that are complementary to a single-stranded piece of DNA, which serves as its template. It is critical that primers are synthesized by primase before DNA replication can occur.
A research protocol is a document that describes the background, rationale, objectives, design, methodology, statistical considerations, and organization of a clinical research project.According to the ICH Good Clinical Practice guidelines, a protocol should include the following topics:he NIH provides many resources for protocol development to assist investigators in writing and developing clinical research protocols that are in compliance with regulatory/GCP requirements.
A Clinical Research Associate (CRA), also called a clinical monitor or trial monitor, is a health-care professional who performs many activities related to medical research, particularly clinical trials. Clinical Research Associate ensures compliance with the clinical trial protocol, checks clinical site activities, makes on-site visits, reviews Case Report Forms (CRFs), and communicates with clinical research coordinators.