Morning stiffness is often an early sign of arthritis. Stiffness that lasts for a few minutes is usually a symptom of a degenerative form of arthritis. Stiffness that lasts for several hours is generally a symptom of inflammatory arthritis and is typical of RA.
Early cities developed in a number of regions, from Mesopotamia to Asia to the Americas. The very first cities were founded in Mesopotamia after the Neolithic Revolution, around 7500 BCE. Mesopotamian cities included Eridu, Uruk, and Ur. Early cities also arose in the Indus Valley and ancient China.
The Process of Urbanization. The startling fact revealed by big history about states and civilization is that they emerged independently in many placesâat least sevenâaround the world at about the same time, when viewed on a large time scale. The first city/state probably emerged in Mesopotamia about 3200 bce.