Let's look at the details: 1  An enzyme called DNA gyrase makes a nick in the double helix and each side separates. 2  An enzyme called helicase unwinds the double-stranded DNA.  Several small proteins called single strand binding proteins (SSB) temporarily bind to each side and keep them separated.
prurigo miÂ´tis prurigo of a mild type. prurigo nodulaÂ´ris a form of neurodermatitis, usually occurring on the extremities in middle-aged women, marked by discrete, firm, rough-surfaced, dark brownish-gray, intensely itchy nodules. prurigo simÂ´plex papular urticaria.
nodule. noun. 1  A small knotlike protuberance. 2  Medicine A small, abnormal but usually benign mass of tissue, as on the thyroid gland, in the lung, or under the skin. 3  Botany A small knoblike outgrowth, especially one on the roots of a leguminous plant that contains bacteria that fix nitrogen.