Morning stiffness is often an early sign of arthritis. Stiffness that lasts for a few minutes is usually a symptom of a degenerative form of arthritis. Stiffness that lasts for several hours is generally a symptom of inflammatory arthritis and is typical of RA.
Early cities developed in a number of regions, from Mesopotamia to Asia to the Americas. The very first cities were founded in Mesopotamia after the Neolithic Revolution, around 7500 BCE. Mesopotamian cities included Eridu, Uruk, and Ur. Early cities also arose in the Indus Valley and ancient China.
Across the length and breadth of Europe and beyond, the Roman Empire built and developed great cities. Founded in 89 AD, Aquincum in Hungary, now known as Budapest, is such an example; another is Bonna founded in 18 AD, now called Bonn.