Common symptoms of clubbing: 1  The nail beds soften. The nails may seem to float instead of being firmly attached. 2  The nails forms a sharper angle with the cuticle. 3  The last part of the finger may appear large or bulging. It may also be warm and red.  The nail curves downward so it looks like the round part of an upside-down spoon.
Failure of blood cell production due to absence of formation of cells in the bone marrow? What is a bone marrow disorder characterized by the insufficient production of one or more types of blood cells? Myelodysplasias (myelodsplastic syndrome) are bone marrow disorders  that impact blood cell production.
Because leukemia is cancer of the blood-forming tissue called the bone marrow, the initial symptoms are often related to irregular bone marrow function. The bone marrow is responsible for producing most of the body's blood cells, including the red blood cells, white blood cells, and platelets.hronic myelogenous leukemia (CML). Chronic myelogenous leukemia (CML) is uncommon in children. Chronic myelogenous leukemia is cancer of the blood in which too many granulocytes, a type of white blood cell, are produced in the marrow. The granulocytes normally fight infection.