Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
It is the first installment in a three-part film adaptation based on the 1937 novel The Hobbit by J. R. R. Tolkien. It is followed by The Desolation of Smaug (2013) and The Battle of the Five Armies (2014), and together they act as a prequel to Jackson's The Lord of the Rings film trilogy.