NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
independent variable in a mathematical equation or relationship between two or more variables, any variable whose value determines that of others; it represents the treatment or experimental variable that is manipulated by the researcher to create an effect on the dependent variable.1) Any attribute, phenomenon or event that can have different qualitative or quantitative values. Typically, a form of metadata goes with the variable, there is a variable definition that describes what is varying and there is a value for the variable.