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Regions of the brain that may be affected by depression include the hypothalamus, hippocampus, anterior cingulate gyrus, amygdala, and all parts of the limbic system (which is involved with emotion formation as well as processing, learning, and memory). Certain parts of the brain associated with emotion, memory, and learning, particularly the prefrontal cortex and the hippocampus, can shrink in size. 2  This might explain some of the emotional changes observed in people with depression.
The wide range of potential causes has lead to the development of numerous depression treatments. Biological Cause of Major Depressive Disorder. A change in brain activity is almost always associated with major depressive disorder. There is decreased activity in the left frontal lobe during depression and a rise in activity following stabilization of mood. These discrepancies between over-active and under-active regions of the brain are at the biological cause of major depressive disorder. Neurotransmitters Could Cause Depression The release and reuptake of neurotransmitters (serotonin, norepinephrine, and dopamine) in the brain is linked to a personâs mood.