Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
Smaug (/smaÊÉ¡/) is a fictional character and the primary antagonist in J. R. R. Tolkien's 1937 novel The Hobbit. He is a powerful, fearsome dragon who invaded the Dwarf kingdom of Erebor 150 years prior to the events described in the novel.