Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
via io9 : The Hobbit: The Desolation of Smaug. There it is. The title of Peter Jackson's second Hobbit film. There's been some speculation about the titling of the films ever since Jackson announced he'd be stretching the adaptation of JRR Tolkien's The Hobbit from two to three movies. Warner Bros. and MGM have also announced the release dates, so here's everything, in a neat and tidy list: