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Choline (2-hydroxy-N,N,N-trimethyl-ethanaminium) is a water soluble nutrient that is closely related to the B complex of Vitamins. While your body naturally makes a small amount of this compound, we require external sources from our diet and supplements in order to meet our daily needs.
Diagram showing the role of acetyl-CoA from glucose metabolism and choline from the high affinity uptake in ACh biosynthesis. Choline acetyltransferase (CAT) : As shown in Figure 11.5, ACh is synthesized by a single step reaction catalyzed by the biosynthetic enzyme choline acetyltransferase. As is the case for all nerve terminal proteins, CAT is produced in the cholinergic cell body and transported down the axon to the nerve endings.