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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
You may have an early ultrasound at your practitioner's office at 6 to 10 weeks to confirm and date the pregnancy. Or you may not have one until the standard midpregnancy ultrasound between 16 and 20 weeks.ltrasound exam. At a mid-pregnancy ultrasound, usually done between 16 and 20 weeks, your baby will be carefully examined. Quad screen (second-trimester prenatal screening). Find out what the multiple marker screening test can tell you.