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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
All pregnant women should be offered the quad screen, but it is recommended for women who: 1  Have a family history of birth defects. 2  Are 35 years or older. 3  Used possible harmful medications or drugs during pregnancy.  Have diabetes and use 1  insulin. Had a viral infection during pregnancy.  Have been exposed to high levels of radiation.