Webster Dictionary(0.00 / 0 votes)Rate this definition: 1  Hypo-. a prefix signifying a less quantity, or a low state or degree, of that denoted by the word with which it is joined, or position under or beneath. 2  Hypo-.
Confidence votes 25. St Patrick's Cathedral in New York City. ***Actually, the Basilica of the National Shrine of the Immaculate Conception in DC is larger than St. Patrick's in NYC. The National Shrine is the largest Roman Catholic church in the U.S., and one of the 10 largest Roman Catholic churches in the world.
Saint Peter's Basilica in the Vatican City is the largest church in the world, as it can hold up to 60,000 people and it is 22,000 square meters. Saint Peter is considered to be the first pope, and after he died as a martyr in 64 AD, it was believed that he was buried where Saint Peterâs Basilica stands today (E.