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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Driving distance from Knoxville, TN to Kansas City, MO. The total driving distance from Knoxville, TN to Kansas City, MO is 734 miles or 1 181 kilometers. Your trip begins in Knoxville, Tennessee. It ends in Kansas City, Missouri.