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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
If you're found to be fewer than 11 weeks pregnant at your dating scan, you'll be able to rebook your combined screening. If you're more than 14 weeks pregnant, your doctor will offer you the quadruple test for Down's Syndrome instead. This can be carried out between 14 weeks plus two days and 20 weeks of pregnancy.