She had five of them during the next 4 months before her heart doctors were able to figure out the problem: She had a genetic mutation that causes clotting. The chest pains were emergency flares, letting Gregory know something was wrong. It can be tricky to know when your pain is normal and when you should worry.
1 Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. Pour the cooking liquid over the meat. 2  Cover the pan with foil.  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.
Low and slow smoking or roasting a big piece of meat to 190 to 200Â°F like brisket or pork shoulder. Usually cooked at 225Â°F these meats can take 8 to 12 hours and starting at room temp saves only about 20 to 30 minutes. The reverse sear theory is not a factor because it is cooked so long that the temp is uniform from top to bottom. Thick cuts cooked to 130 to 165Â°F.