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Quick Answer. Early symptoms of Lou Gehrig's disease, also known as ALS, include muscle weakness in the hands, arms or legs, twitching of the muscles and difficulty projecting the voice, describes the ALS Association. In more advanced stages, patients have trouble swallowing and breathing, and often feel short of breath.
Lou Gehrig's Disease (ALS)âFear, Symptoms, and Statistics. The motor neuron disease, Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig's disease, is a devastating illness. ALS is one of the major neurodegenerative diseases alongside Parkinson's disease and Alzheimer's disease.