Potential Side Effects More Common. Delayed epithelial healing is more typical of flapless procedures, such as PRK, LASEK and Epi-LASIK because they disturb a large area of epithelium, as opposed to flap procedures, which leave the epithelium intact. Normally, the epithelium heals 3 to 5 days after a flapless procedure.
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In a study of 352 healthy subjects assessing the effect of multiple daily doses of 50 mg, 100 mg, and 200 mg of MYRBETRIQÂ® for 10 days on the QTc interval, the maximum mean increase in supine SBP/DBP at the maximum recommended dose of 50 mg was approximately 4.0/1.6 mm Hg greater than placebo.