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Beta thalassemia is a blood disorder that reduces the production of hemoglobin. Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body. Affected individuals also have a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, and more serious complications.
You need both alpha-and beta-globin to make hemoglobin. Beta thalassemia occurs when one or both of the two genes that make beta-globin don't work or only partly work as they should. 1  If you have one damaged gene, you may have mild anemia and probably won't need treatment.2  This is called beta thalassemia minor or beta thalassemia trait. You may have moderate or severe anemia. 2  If you have moderate anemia (beta thalassemia intermedia), you may need blood transfusions. 3  People with severe anemia (called beta thalassemia major or Cooley's anemia) need blood transfusions throughout life. 4  Symptoms of anemia usually begin within a few months after birth.