She had five of them during the next 4 months before her heart doctors were able to figure out the problem: She had a genetic mutation that causes clotting. The chest pains were emergency flares, letting Gregory know something was wrong. It can be tricky to know when your pain is normal and when you should worry.
1 Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. Pour the cooking liquid over the meat. 2  Cover the pan with foil.  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.
Wrap brisket in foil, place on a baking sheet, and cook in a 250Â°F oven until meat reaches the same 195-205Â°F internal temperature, 4-6 hours longer. What's important is getting that smoky flavor into the meat, and 5-6 hours on the grill should do it. After that point, you're simply getting the meat cooked through.