Webster Dictionary(0.00 / 0 votes)Rate this definition: 1  Hypo-. a prefix signifying a less quantity, or a low state or degree, of that denoted by the word with which it is joined, or position under or beneath. 2  Hypo-.
Confidence votes 25. St Patrick's Cathedral in New York City. ***Actually, the Basilica of the National Shrine of the Immaculate Conception in DC is larger than St. Patrick's in NYC. The National Shrine is the largest Roman Catholic church in the U.S., and one of the 10 largest Roman Catholic churches in the world.
The current number of parishes is about equal to the number that existed in 1965, even as the number of self-identified U.S. Catholics has risen in the past half-century, from 48.5 million to 76.7 million between 1965 and 2014, according to CARAâs data.