Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
The Hobbit: The Desolation of Smaug is a 2013 high fantasy adventure film directed by Peter Jackson. It was produced by WingNut Films in collaboration with New Line Cinema and Metro-Goldwyn-Mayer.