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Quick Answer. Injury to the phrenic nerve can paralyze the diaphragm and have a serious impact on the regulation of breathing, such as difficulty during inhalation, according to the UCLA Division of Plastic & Reconstructive Surgery. The phrenic nerve is responsible for the function of the diaphragm. Continue Reading.
The phrenic nerve originates mainly from the 4th cervical nerve, but also receives contributions from the 5th and 3rd cervical nerves (C3-C5) in humans. The right phrenic nerve passes over the brachiocephalic artery, posterior to the subclavian vein, and then crosses the root of the right lung anteriorly and then leaves the thorax by passing through the vena cava hiatus opening in the diaphragm at the level of T8. 2  The right phrenic nerve passes over the right atrium.