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Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories).astrointestinal diseases that may cause macrocytosis include celiac disease (severe sensitivity to gluten from wheat and other grains that causes intestinal damage) and Crohnâs disease (inflammatory bowel disease that can affect any part of the gastrointestinal tract).
Expert: Dr. R. Bora replied 6 years ago. Hello, welcome to just answer and thank you for your question. Anisocytosis means that blood cells are of unequal size. This can be seen in condition like anemia, thalassemia, vitamin B12 deficiency and so on. Macrocytosis means red blood cells which are larger than normal in size.This is normal during chemotherapy or other systemic therapies since the body is under the pressure to produce increased blood cells. 1+ is minimal degrees of these two conditions.