In a direct Coombs' test a special antibody is added to a sample of blood. This test checks whether there are antibodies already bound to the surface of the red blood cell. If the test is positive the antibodies that are added bind to the antibodies on the surface of the cell.
The River Hull is a navigable river in the East Riding of Yorkshire in the north of England. It rises from a series of springs to the west of Driffield, and enters the Humber estuary at Kingston upon Hull.
Medieval Hull was located west of the River Hull and on the north side of the Humber. It was bordered on its western flank by a moat served to protect this important war base from attack. This area of town is known as the Old Town. Here many of the streets and narrow alleys have medieval origins.