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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
If you're having the quad screen as part of an integrated or sequential screening, the results will be combined with those from the tests you took in your first trimester for a more comprehensive risk assessment and a higher detection rate.