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Quick Answer. Early symptoms of Lou Gehrig's disease, also known as ALS, include muscle weakness in the hands, arms or legs, twitching of the muscles and difficulty projecting the voice, describes the ALS Association. In more advanced stages, patients have trouble swallowing and breathing, and often feel short of breath.
You may have heard about Lou Gehrig disease and know it's a scary diagnosis. But exactly what is Lou Gehrig disease? Also known as ALS, or amyotrophic lateral sclerosis (ALS), Lou Gehrig disease is a progressive neurodegenerative condition that affects nerve cells (neurons). According to the ALS Society, the progressive degeneration of motor neurons that connect the brain, spinal cord and muscles eventually leads to their death.