For those who want to know what all the hubbub about the drama is about, The Americans follows Phil (Matthew Rhys) and Elizabeth Jennings (Keri Russell), two Soviet spies sent to live undercover in America as husband and wife during the Cold War.
Like most antidepressants, MAOIs work by changing the levels of one or more of these naturally occurring brain chemicals. An enzyme called monoamine oxidase is involved in removing the neurotransmitters norepinephrine, serotonin and dopamine from the brain.MAOIs prevent this from happening, which makes more of these brain chemicals available.his is thought to boost mood by improving brain cell communication. MAOIs also affect other neurotransmitters in the brain and digestive system, causing side effects. MAOIs are sometimes used to treat conditions other than depression, such as Parkinson's disease.
Perhaps importantly, monoamine oxidase B (MAO-B) is located in the mitochondrial wall and plays a significant role in dopamine degradation in PD. This can explain the symptomatic actions of MAO-B inhibitors, such as selegiline and rasagiline on motor symptoms of PD.n this brief review, the role played by mitochondria is examined and in turn, how monoamine oxidase B (MAO-B) located in the inner mitochondrial wall might be a target for modifying cell death in PD through the use of selective MAO-B inhibitors.