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How long is the drive from Charlotte, NC to Murrells Inlet, SC? The total driving time is 3 hours, 32 minutes.Your trip begins in Charlotte, North Carolina. It ends in Murrells Inlet, South Carolina. If you're planning a road trip, you might be interested in seeing the total driving distance from Charlotte, NC to Murrells Inlet, SC.ou can also calculate the cost to drive from Charlotte, NC to Murrells Inlet, SC based on current local gas prices and an estimate of your car's best gas mileage.
Continue on SC-576 and go southeast for 3.1 miles. Continue on US-501-BR and go southeast for 0.9 miles. If you're headed south of 501, you might want to take 544 which brings you out on Route 17 south of Myrtle Beach airport.This is the way to go if you're headed for Surfside, Garden City, Murrells Inlet, Pawleys Island or Georgetown.It's approximately 30 miles all the way down to Georgetown!If you're headed north you can take new route 22 in Conway to North Myrtle Beach.(the Barefoot Landing, Kinston Plantation area).ontinue on SC-576 and go southeast for 3.1 miles. Continue on US-501-BR and go southeast for 0.9 miles. If you're headed south of 501, you might want to take 544 which brings you out on Route 17 south of Myrtle Beach airport.