Pope Julius II asked Michelangelo to paint the ceiling of the Sistine (sins-teen) chapel in 1508. The chapel was Built by Pope Sixtus IV in 1481. Which happened to be in the Vatican, is known to be the pope's headquarters in Rome.
Cardiac Output. Cardiac output is the amount of blood your heart pumps out in one minute. It is regulated by the amount of blood your heart pumps out in one contraction, or stroke volume, and the number of times your heart beats in one minute, or your heart rate.Cardiac output increases as a short-term and a long-term effect of regular aerobic exercise.Initially, cardiac output increases due to an increase in your heart rate. Then, as your aerobic fitness improves, cardiac output increases due to an increase in stroke volume and a decrease in heart rate.ardiac output increases as a short-term and a long-term effect of regular aerobic exercise. Initially, cardiac output increases due to an increase in your heart rate.
Cardiac output is primarily controlled by the oxygen requirement of tissues in the body. In contrast to other pump systems, the heart is a demand pump that does not regulate its own output. When the body has a high metabolic oxygen demand, the metabolically controlled flow through the tissues is increased, leading to a greater flow of blood back to the heart, leading to higher cardiac output.