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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
What is the driving time between Knoxville TN and Nashville TN? The driving distance between Knoxville, TN and Nashville, TN is approximately 180 miles.   MapQuest gives the estimated driving time as 6 hours and 52 minutes. From the 1st Sun. of Nov. until the 2nd Sun. of March, Nashville is 4 hrs. ahead of Hawaii.