If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
The words effacement, being effaced and effacing are terms that you will hear often as you approach your last trimester. These terms are used to describe the process that the cervix prepares itself for delivery and it is measured by percentage.
Usually the cervix is firm and can feel like the end of your nose. When effacement begins, the cervix begins to feel softer and feels like a dimple. The position of your cervix during pregnancy is usually posterior â which means it is pointing toward your back â or in the mid position, which is easier to reach. As the cervix begins to efface and prepare for labour, it will move forward (anterior).