Domain: 1  The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide. 2  The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4. 3  The HIT domain is required for enzymatic activity. 4  The C2H2-type zinc finger mediates DNA-binding.
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