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Anemia is a condition where a person has a lower than normal level of red blood cells. Anemia is related to a low supply of oxygen reaching cells and tissues throughout the body. Anemia symptoms include: feeling like youâre always tired despite how much you sleep.
1 Chronic Fatigue Syndrome-a condition that causes unexplained exhaustion and fatigue. 2  Depression-constant tiredness is a major indicator of depression or emotional stress. 3  Diabetes-sudden and extreme tiredness is one of the main symptoms of diabetes mellitus.