NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
The concept of independence extends to dealing with collections of more than two events or random variables, in which case the events are pairwise independent if each pair are independent of each other, and the events are mutually independent if each event is independent of each other combination of events.