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Quick Answer. Early symptoms of Lou Gehrig's disease, also known as ALS, include muscle weakness in the hands, arms or legs, twitching of the muscles and difficulty projecting the voice, describes the ALS Association. In more advanced stages, patients have trouble swallowing and breathing, and often feel short of breath.
Lou Gehrig's disease is a fatal, progressive disease that affects the nerves that control a personâs voluntary muscle movement. Individuals afflicted with the disorder lose the capacity to control and initiate voluntary movements.