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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Birmingham is only 95 miles southeast via I-65; Memphis is approximately 125 miles to the west via U. S. Hwy 72; Nashville is 100 miles to the north via the Natchez Trace Parkway; and Atlanta is only 200 miles to the east. View Map.