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Testicular cancer can also cause other symptoms, including a: 1  dull ache or sharp pain in your testicles or scrotum, which may come and go. 2  feeling of heaviness in your scrotum. 3  change in the texture or increase in firmness of a testicle.  difference between one testicle and the other.
Testicular cancer. Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system. Not all lumps on the testicles are tumors, and not all tumors are cancer. There are many other conditions, such as testicular microlithiasis, epididymal cysts, and appendix testis (hydatid of Morgagni), which may be painful but are non-cancerous.