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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
The distance between Kansas City and Knoxville in a straight line is 173 miles or 278.36 Kilometers. Driving Directions & Drive Times from Kansas City to Knoxville can be found further down the page. Driving distances, maps and journey times are currently provided by Google mapping systems.