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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Driving distance from Kansas City, MO to Knoxville, TN. The total driving distance from Kansas City, MO to Knoxville, TN is 734 miles or 1 181 kilometers. Your trip begins in Kansas City, Missouri. It ends in Knoxville, Tennessee.