Other mutations in the COL4A3 gene severely decrease or prevent the production of alpha3(IV) chains. As a result, there is a serious deficiency of the type IV collagen alpha3-4-5 network in the basement membranes of the kidney, inner ear, and eye.hese networks make up a large portion of basement membranes, which are thin sheet-like structures that separate and support cells in many tissues. Type IV collagen alpha3-4-5 networks play an especially important role in the basement membranes of the kidney, inner ear, and eye.
Net Financial Debt. View Financial Glossary Index. Financial debt of a company after its ending cash balance has been subtracted. If a company has 50 million in financial debt, but 30 million in cash, the net financial debt is 20 million in financial debt.
If there is any debt we look at the companies capability to repay it, and whether the level has increased over the past 5 years. 1  The level of debt (134%) compared to net worth is high (greater 40%). 2  The level of debt compared to net worth has increased over the past 5 years (89% vs 134% today). Total debt is well covered by annual operating cash flow (greater than 20% of total debt). Interest on debt is well covered by earnings (13.4x coverage).