Other mutations in the COL4A3 gene severely decrease or prevent the production of alpha3(IV) chains. As a result, there is a serious deficiency of the type IV collagen alpha3-4-5 network in the basement membranes of the kidney, inner ear, and eye.hese networks make up a large portion of basement membranes, which are thin sheet-like structures that separate and support cells in many tissues. Type IV collagen alpha3-4-5 networks play an especially important role in the basement membranes of the kidney, inner ear, and eye.
Net Financial Debt. View Financial Glossary Index. Financial debt of a company after its ending cash balance has been subtracted. If a company has 50 million in financial debt, but 30 million in cash, the net financial debt is 20 million in financial debt.
Calculating Total Debt. In the context of the debt-to-tangible-net-worth calculation, debt includes all company liabilities. This means that short-term liabilities -- like wages payable, accounts payable, and short-term loans and notes -- along with long-term notes, bonds and loans are all included in total debt.bout the Ratio. Debt to tangible net worth is a derivative of the debt-to-equity ratio. The debt-to-equity ratio is used by potential investors and creditors as a way to gauge the proportion of debt to available company assets. Normally, equity represents both tangible and intangible assets.