Webster Dictionary(0.00 / 0 votes)Rate this definition: 1  Hypo-. a prefix signifying a less quantity, or a low state or degree, of that denoted by the word with which it is joined, or position under or beneath. 2  Hypo-.
Confidence votes 25. St Patrick's Cathedral in New York City. ***Actually, the Basilica of the National Shrine of the Immaculate Conception in DC is larger than St. Patrick's in NYC. The National Shrine is the largest Roman Catholic church in the U.S., and one of the 10 largest Roman Catholic churches in the world.
In terms of membership, of all US Orthodox Christian Churches, the Greek Orthodox Archdiocese of America (GOA) is by far the largest one. According to 2010 US Orthodox Census, GOA has nearly 477,000 members. Put differently, 46% of all Orthodox Church members in the USA belong to GOA.