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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
birmingham nashville and chattanooga are all options for getting to huntsville birmingham is about 1 1 2 hours away chattanooga about 2 hours and nashville about 2 1 4 hours the drive from b ham is the easiest with a short stint on i 20w then straight up i 65n to i 565e to huntsville