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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
You can also calculate the cost to drive from Knoxville, TN to Birmingham, AL based on current local gas prices and an estimate of your car's best gas mileage. If you're meeting a friend, you might be interested in finding the city that is halfway between Knoxville, TN and Birmingham, AL.