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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
The Quad Screen. The quad screen is perhaps one of the most misunderstood of the prenatal tests. The triple screen (also known by several other names including the multiple marker screening and maternal serum screening) is a blood test administered between 15 to 20 weeks gestational age.