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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
How many driving miles from Birmingham Alabama to Memphis Tennessee? The driving distance between Birmingham, AL and Memphis, TN is approximately 240 miles. The driving time would be approximately 4 hours if you were to travel non-stop in good â¦driving conditions.