Reference Range. Ionized calcium binds to negatively charged sites on protein molecules, competing with hydrogen ions for the same binding sites on albumin and other calcium-binding proteins. This binding is pH dependent and alters the level of ionized calcium in the blood.An increase in pH, alkalosis, promotes increased protein binding, which decreases free calcium levels.onized calcium is interpreted in conjunction with the total serum calcium measurement. An ionized calcium value within the reference range implies adequate calcium homeostasis, as this is a direct measure of calcium in its active form.
Acute hepatic necrosis. Drug induced liver injury can resemble an acute ischemic or toxic injury to the liver with rapid onset of hepatocellular injury and marked elevations in serum ALT and just as rapid decline once the agent is stopped.rug induced liver injury can resemble acute viral hepatitis with prominence of hepatocellular injury and marked elevations in serum ALT. Symptoms may also be identical those of viral hepatitis, with a prodomal period of fatigue, nausea and poor appetite followed by abdominal discomfort, dark urine and jaundice.
Hepatocellular Carcinoma-Abbreviated as HCC, is a primary cancer of the liver, most commonly caused by one of the above diseases going untreated. Jaundice: Can be a common sign of liver problems is Jaundice, unfortunately is is a possible herbalife side effect.Jaundice is the main symptom of Liver disease. It is known that the persistence of jaundice indicates that there is something very wrong with your gall bladder or liver.epatocellular Carcinoma-Abbreviated as HCC, is a primary cancer of the liver, most commonly caused by one of the above diseases going untreated. Jaundice: Can be a common sign of liver problems is Jaundice, unfortunately is is a possible herbalife side effect.