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Byetta (exenatide) is an injectable diabetes medicine that helps control blood sugar levels. Exenatide is used to treat type 2 (non-insulin dependent) diabetes.Side effects of Byetta include nausea, vomiting, upset stomach, diarrhea, constipation, weight loss, loss of appetite, heartburn, dizziness, or headache.yetta (exenatide) is an injectable diabetes medicine that helps control blood sugar levels. Exenatide is used to treat type 2 (non-insulin dependent) diabetes.
1 Exenatide (Byetta, Bydureon). 2  The most common side effect of exenatide is mild to moderate nausea, which improves with time in most people. 3  Several cases of kidney problems, including kidney failure, have been reported in people who have taken exenatide.