They are at least a thousand times larger than the 1980 eruption of Mount St. Helens, which produced only 1 km3 (0.2 cu mi) of material, and at least six times larger than the 1815 eruption of Mount Tambora, the largest eruption in recent history, which produced 160 km3 (38 cu mi) of volcanic deposits.
Listen. 1  This severe homocystinuria is caused by rare MTHFR gene mutations (sometimes in combination with a second common MTHFR gene mutation). In severe MTHFR deficiency, signs and symptoms become apparent in infancy, however the condition can be milder, presenting in later childhood or adulthood.
1 Many children and adults with mitochondrial disease complain of erratic symptoms that don't make sense, such as heat intolerance, erratic blood pressure, dizziness, nausea, intermittent gut dysfunction, and more.he first slide demonstrates the pedigree or matrilineal inheritance of many functional disorders in one particular family. The elephant slide also shows the many related functional mitochondrial disorders, such as cyclic vomiting syndrome (CVS) and migraines can be related to dysautonomia.