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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
How far is Knoxville Tennessee from Greenville Tennessee? 70 miles taking this route: Take U.S. 11E SOUTH, from Greeneville, to I-81 SOUTH to KNOXVILLE.Take I-81 SOUTH to I-40 WEST to KNOXVILLE at EXIT 0B.Take I-40 WEST to KNOXVILLE.