Abstract. Barbiturates and the related depressant drugs, etazolate and etomidate, inhibited both the binding of [ 3 H]bicuculline methochloride (BMC) to Î³-aminobutyric acid (GABA) receptor sites and the binding of [ 3 H]Î²-carboline-3-carboxylic acid methyl ester (Î²CCM) to benzodiazepine receptor sites in mammalian brain.he barbiturate inhibition of [ 3 H]BMC binding involved a decrease in affinity which at high concentrations of barbiturates results in an effective complete loss of detectable binding. The maximal inhibition of [ 3 H]Î²CCM binding involved a more modest decrease in affinity (increase in K D from 1.35 to 1.85 nM).
Oona /oona/ [2 sylls.] as a girls' name is pronounced OO-nah. It is of Scottish, Irish and Gaelic origin. Variant of Una (Latin) one. Playwright Eugene O'Neill gave this name to his daughter.ona /oona/ [2 sylls.] as a girls' name is pronounced OO-nah. It is of Scottish, Irish and Gaelic origin. Variant of Una (Latin) one. Playwright Eugene O'Neill gave this name to his daughter.
Rose O'Neill. Rose Cecil O'Neill (June 25, 1874 â April 6, 1944) was an American cartoonist, illustrator, artist, and writer. She rose to fame for her creation of the popular comic strip characters, Kewpies, in 1909, and was also the first published female cartoonist in the United States. The daughter of a book salesman and homemaker, O'Neill was raised in rural Nebraska.