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The quad screen is usually done between 15 and 20 weeks of pregnancy. You'll have a blood sample taken and sent to a lab for analysis. Results are usually available in about a week. The test measures the levels of four substances in your blood: 1  alpha-fetoprotein (AFP), a protein made by the baby.
The quad screen test is a maternal blood screening test that looks for four specific substances: AFP, hCG, Estriol, and Inhibin-A. AFP: alpha-fetoprotein is a protein that is produced by the fetus. hCG: human chorionic gonadotropin is a hormone produced within the placenta. Estriol: estriol is an estrogen produced by both the fetus and the placenta. Inhibin-A: inhibin-A is a protein produced by the placenta and ovaries.