Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
In The Hobbit, Bilbo Baggins, a hobbit in comfortable middle age at 50 years old, was hired despite his objections as a burglar by the wizard Gandalf and 13 Dwarves led by their king Thorin Oakenshield on a quest to reclaim the Lonely Mountain and its treasure from the dragon Smaug.