Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
The Hobbit recounts the tale of a party of dwarves (consisting of a few of the original residents of the Lonely Mountain and their descendants), the hobbit Bilbo Baggins, and their quest to recapture the mountain and kill the dragon. In the book, the dragon is sometimes called Smaug the Golden or Smaug the Magnificent.