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Regions of the brain that may be affected by depression include the hypothalamus, hippocampus, anterior cingulate gyrus, amygdala, and all parts of the limbic system (which is involved with emotion formation as well as processing, learning, and memory). Certain parts of the brain associated with emotion, memory, and learning, particularly the prefrontal cortex and the hippocampus, can shrink in size. 2  This might explain some of the emotional changes observed in people with depression.
The foundation of this theory is that brain inflammation is the root cause of depression. Cytokines are immune system messengers that regulate inflammation. Inflammatory cytokines have been linked to depression, anxiety, memory loss, brain fog, inability to focus, schizophrenia, bipolar disorder, stroke and Alzheimerâs. Related article â