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Quick Answer. Early symptoms of Lou Gehrig's disease, also known as ALS, include muscle weakness in the hands, arms or legs, twitching of the muscles and difficulty projecting the voice, describes the ALS Association. In more advanced stages, patients have trouble swallowing and breathing, and often feel short of breath.
Amyotrophic lateral sclerosis (ALS) is also known as Lou Gehrig's disease, after the famous baseball player who had it. It is a progressive neurodegenerative disorder (affects the nerves and gets worse over time). In healthy people, cells in the spinal cord and brain called motor neurons control the voluntary muscles (muscles you can control).