Etiology. The etiology of hypertensive heart disease is a complex interplay of various hemodynamic, structural, neuroendocrine, cellular, and molecular factors. These factors play integral roles in the development of hypertension and its complications; however, elevated BP itself can modulate these factors.tiology. The etiology of hypertensive heart disease is a complex interplay of various hemodynamic, structural, neuroendocrine, cellular, and molecular factors. These factors play integral roles in the development of hypertension and its complications; however, elevated BP itself can modulate these factors.
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