Diseases and Conditions. Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones.
In addition to the previous cast from The Hobbit: An Unexpected Journey, Lee Pace, Orlando Bloom, Evangeline Lilly, Luke Evans and Mikael Persbrandt join the cast. The Hobbit: The Desolation of Smaug is a film, the second part of The Hobbit film series. It was released on December 13, 2013. It grossed over $960 million worldwide.
The Hobbit's Gandalf almost proved a greenscreen too far for Ian McKellen. Isolated and 'pretty miserable' during Peter Jackson's gruelling New Zealand shoot, actor thought about quitting acting. â¢ The Hobbit: The Desolation of Smaug trailer. â¢ Ben Child: Peter Jackson's Hobbit philosophy - more is better.