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From Old French malicios, from Latin malitiosus, from malitia (âmaliceâ), from malus (âbadâ). malicious (comparative more malicious, superlative most malicious) Of, pertaining to, or as a result of malice or spite. spiteful and deliberately harmful He was sent off for a malicious tackle on Jones.
Noun. 1. malignancy - (medicine) a malignant state; progressive and resistant to treatment and tending to cause death. malignance. cancer cell-a cell that is part of a malignant tumor. medical specialty, medicine-the branches of medical science that deal with nonsurgical techniques.