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Your immune system may become sensitive to the antibiotic the first time you take it. You may have an allergic reaction the next time. The antibiotics most likely to cause an allergic reaction are penicillins and cephalosporins. Mild symptoms include red, itchy, flaky, or swollen skin. You may have a flat, red area on your skin that is covered with small bumps.
The most common symptoms of allergic reactions to drugs are: The most common drug that can cause problems is penicillin. Antibiotics, sulfa drugs, barbiturates, and insulin also can cause adverse drug reactions. Some medicines trigger a response from the immune system in people with drug hypersensitivity. The body's immune system perceives the substance as attacking the body, so it attacks the system.