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Venice and Florence, two of Italy's big three art cities, are joined by a fast and efficient rail service, as well as a fast toll road called the Autostrada. The distance between Venice and Florence is about 258 kilometers, or about 160 miles. See also: Four-Day Tour of Venice, Florence and Pisa. Popular Stops en Route
Travel considerations for a journey between Rome and Florence. By Road: If you were in a road vehicle maintaining an average speed of 40mph (64 kmh), it would take you approximately 4.42 hours to travel from Rome to Florence for an estimated driving distance of 176.9 miles (284.64 kms) . (see map below for precise driving times, directions and distance).