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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
Mild to moderate allergic reactions to penicillin are common, and symptoms may include any of the following: 1  Hives (raised, extremely itchy spots that come and go over a period of hours) 2  Tissue swelling under the skin, typically around the face (also known as angioedema) 3  Throat tightness. 4  Wheezing. 5  Coughing. 6  Trouble breathing.