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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
1 The FeLV virus has been shown to cause lymphoma and the FIV virus can predispose infected animals to develop lymphoma. 2  Second hand smoke is also known to cause gastrointestinal lymphoma in cats--the carcinogens from the smoke are thought to settle on cat's fur, and when the cat grooms itself, get ingested. Because lymphoma is a systemic disease, chemotherapy is the preferred treatment modality. 2  In selected cases, prior to the administration of chemotherapy, radiation therapy or surgery may be used to treat lymphoma localized to a defined site. 3  It is important to understand that lymphoma is not curable.