Fluid exchange between capillaries and the interstitial fluid. takes place between the blood and interstitial fluid across the thin endothelial walls of the capillaries. blood pressure drives fluid out of the capillaries, blood proteins pull fluid back in the capillaries by osmotic pressure. Difference in osmotic pressure and blood pressure drives fluids out of capillaries at the arteriole end and into capillaries at the venule end.
Premarket approval (PMA) is the FDA process of scientific and regulatory review to evaluate the safety and effectiveness of Class III medical devices.remarket approval (PMA) is the FDA process of scientific and regulatory review to evaluate the safety and effectiveness of Class III medical devices.
The Food and Drug Administrationâs 510(k) premarket program allows manufacturers to release knee implants without testing as long as they are similar to products already on the market. 1  Complications from faulty knee implants may result in the need for a second operation to fix or replace the problematic device.