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Treatment of Insomnia and Sleep Disorders. Although not approved by the Food and Drug Administration for this purpose, trazodone is frequently prescribed âoff-labelâ as a sleep drug. When used as a sleep aid, the usual trazodone dosage is 25 to 50 mg taken at bedtime.
All of the low-dose sedating antidepressants have half-lives greater than the usual sleep period. Even trazodone, the shortest-acting of these drugs and the least sedating, at a dose of 50 mg is associated with reports of daytime somnolence in 23% of patients compared with 8% for placebo. The prevalence of daytime somnolence is higher at higher doses, in elderly patients, and for tricyclic antidepressants.