Owners or operators of places of business (also called establishments or facilities) that are involved in the production and distribution of medical devices intended for use in the United States (U.S.) are required to register annually with the FDA. This process is known as establishment registration (Title 21 CFR Part 807).
1 1400sâ1800s (The Renaissance) â Copper, iron, steel, and wood were the most common materials used for prosthetics during this period.  1863 â During the American Civil War, the U.S. started to see advancements in the field of prosthetics.
Typically, a prosthetic arm or leg is made from a strong and durable but lightweight material such as carbon fiber, covered with foam padding (for comfort) or flesh-colored plastic. The weight of prosthetic limbs is a very important factor. We don't notice how much our limbs weigh because they feel so natural and seem to move themselves.