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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
The Causes of Asthma. Asthma is a chronic disease affecting the air passages in the lungs. Actual causes of asthma are not known. However, asthma experts believe that a combination of genetic and environmental factors can cause asthma or at least make a person sensitive to asthma triggers. Family history, childhood viral infections, and early allergen exposure may be factors.