2. Cholera exotoxin (choleragen), produced by Vibrio cholerae (inf). This exotoxin catalyzes the ADP-ribosylation of a host cell protein called Gs that turns the synthesis of a metabolic regulator molecule callec cyclic AMP (cAMP) on and off. In this case, synthesis stays turned on.
Question: What is end-stage glaucoma, and how serious is it? Answer: End-stage glaucoma is generally the term we apply when there is very advanced disease. It is a very serious situation because that means there's not very much healthy tissue left. In other words, there has been a lot of visual damage.
Glaucoma is a complicated eye disease where damage to the optic nerve results in vision loss. Typically the condition is classified as either primary open angle glaucoma where no symptoms occur until significant vision loss has occurred, or angle closure glaucoma where certain noticeable symptoms occur followed by very rapid vision impairment. If untreated, glaucoma will eventually cause complete loss of vision.