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Definition. Protein characteristic of the postsynaptic membrane. In a chemical synapse, the postsynaptic membrane is the membrane that receives a signal (binds neurotransmitter) from the presynaptic cell and responds via depolarisation or hyperpolarisation. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft.
1 The postsynaptic membrane is the third part of the synapse. 2  This portion of the outer membrane of the receiving neuron is functionally specialized.. 3  The structure of a synapse is clearly illustrated in Figure 5.2, which shows a special type of synapse between the endfoot of a neuron and a muscle fiber.xocytosis. 1  The process by which vesicles inside the cell fuse with the cell membrane and release their contents into the synaptic cleft is called exocytosis. 2  The cycle of exocytosis is as follows: First a vesicle approaches the membrane, on its way to an activate site.