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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
Because of the important role of D2 autoreceptors in regulating dopamine synthesis, they aimed to examine whether subjects with the A1 allele have altered presynaptic dopamine function in the brain. There is evidence of enhanced sensitivity of D2 autoreceptors to alterations by lead (Zuch et al.