1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Definition of pK a and K a. The definition of K a is: [H + ] . [B] / [HB], where B is the conjugate base of the acid HB. The pK a value is defined from K a, and can be calculated from the K a value from the equation pKa = -Log 10 (K a).