1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Population PK/PD analysis allows for more efficient use of clinical trial results for decision making in several ways: 1) it can provide better insights as to how patients tolerate and respond to a new drug; 2) it can shorten development time via the conduct of informative trials; and 3) it can help identify drug candidates that are unlikely to meet target clinical therapeutic goals early in development.