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The channel has a large diameter of 0.8x1.1nm, and is non-selective for small ions. However, it has an upper exclusion size limit corresponding to molecular weights of about 600 Dalton of permeants. Because most metabolites have molecular weights lower than 600 Da and have been shown to pass through porin channels, porins are called general diffusion pores.
A.There are a lot of factors that combine to make the swim hard. The English Channel is approximately -19 nautical miles (38000 yards) or 35 kilometres (35000 mtrs) - wide at its narrowest point (actually 18.2 nm from Shakespeare Beach, Dover to Cap Gris Nez, France). Most swims are a little longer to the landing on either side.