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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
Symptoms of an allergic reaction which may require medical intervention include: 1  Swelling or angioedema of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs. 2  Hoarseness. 3  Difficulty breathing or swallowing. 4  Rash or hives. 5  Abdominal pain.