Problem solving is the act of defining a problem; determining the cause of the problem; identifying, prioritizing and selecting alternatives for a solution; and implementing a solution.
Ipilimumab costs $120,000 for four treatments, and nivolumab is priced at $12,500 a month, the Wall Street Journal reported. Serious Side Effects. However, the ipilimumab with nivolumab combination comes with serious side effects, such as colitis (swelling of the colon), diarrhea and problems with the endocrine glands (which produce hormones).
Nivolumab (OPDIVOÂ®, Bristol Myers Squibb, New Jersey, USA) is a human programmed death receptor-1 (PD-1)âblocking antibody, approved in Japan and the USA for treatment of advanced melanoma. In December 2014, the US Food and Drug Administration (FDA) approved the use of nivolumab: 1  in patients with unresectable or metastatic melanoma and disease progression after treatment with ipilimumab (YervoyÂ®)