2. Cholera exotoxin (choleragen), produced by Vibrio cholerae (inf). This exotoxin catalyzes the ADP-ribosylation of a host cell protein called Gs that turns the synthesis of a metabolic regulator molecule callec cyclic AMP (cAMP) on and off. In this case, synthesis stays turned on.
Question: What is end-stage glaucoma, and how serious is it? Answer: End-stage glaucoma is generally the term we apply when there is very advanced disease. It is a very serious situation because that means there's not very much healthy tissue left. In other words, there has been a lot of visual damage.
P: Dr. Werner, how do you define the stages of glaucoma? Dr. Elliot Werner: Glaucoma staging is not an exact science. In clinical terms, most of us use âearly,â âmoderate,â âadvanced,â and âend stage.â These are usually defined by the amount of cupping and field loss present. For research purposes, more precise definitions are used.