The women were randomly assigned to receive either 100 mg of aspirin a day or no aspirin. Over five years of follow-up, aspirin use was found to lower heart attack risk by 47 percent, and mini-stroke (transient ischemic attack) risk by 43 percent. Aspirin did not reduce the risk of larger or persistent strokes from clots or brain bleeds.
Platelet ADP release (Table 3 Table 3 Platelet Size, Nucleotides and ADP Release. ). The patients' platelets released less ADP when incubated with kaolin or when stirred with connective tissue than normal platelets did.
Drug-induced Thrombocytopenia. When drugs are the cause of low platelets, the disease is called drug-induced thrombocytopenia (DITP). In some cases, as in chemotherapy drugs, the drop in platelet count is due to changes in the bone marrow. In other cases antibodies can develop to both the drug and platelets at the same time, causing the platelets to drop. Sometimes drugs cause a combination of both bone marrow and immune problems.42.