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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
Predisposition seems to play a role in addiction, as does the dopamine system's rapid and robust reduction in D2 receptor availability in response to cocaine, says Dr. Nader. The team's findings and those of others suggest that therapies that elevate D2 receptor availability may help prevent and treat cocaine abuse.