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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
Although the cause of asthma is unknown, a number of things that can increase your chances of developing the condition have been identified. These include: 1  a family history of asthma or other related allergic conditions (known as atopic conditions) such as eczema, food allergy or hay fever.2  having another atopic condition.t's not clear exactly what causes asthma, although it is likely to be a combination of factors. Some of these may be genetic. However, a number of environmental factors are thought to play a role in the development of asthma.