The women were randomly assigned to receive either 100 mg of aspirin a day or no aspirin. Over five years of follow-up, aspirin use was found to lower heart attack risk by 47 percent, and mini-stroke (transient ischemic attack) risk by 43 percent. Aspirin did not reduce the risk of larger or persistent strokes from clots or brain bleeds.
Platelet ADP release (Table 3 Table 3 Platelet Size, Nucleotides and ADP Release. ). The patients' platelets released less ADP when incubated with kaolin or when stirred with connective tissue than normal platelets did.
Effect of a fibrinogen receptor antagonist on ADP-induced generation of thromboxane A 2. Washed human platelets were activated with ADP (10 Î¼M) plus fibrinogen at 37Â°C with stirring in the presence or absence of varying doses of SC49992, a fibrinogen receptor antagonist.