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Most pituitary tumors can be removed transsphenoidally. The approach is through the sphenoid sinus, one of the facial air spaces behind the nose. Rarely, a craniotomy is required, where the skull is opened to reach the tumor. There are three basic approaches to the sella, which is the bony cavity in the skull base where the pituitary gland is located. Many neurosurgeons now use a direct transnasal approach, where an incision is made in the back wall of the nose and the sphenoid sinus is entered directly.
Pituitary adenomas are benign (noncancerous) tumors of the pituitary gland-a small structure located behind the eyes, beneath the brain. Most pituitary tumors are benign, meaning that they do not spread to distant locations in the body. Cancerous pituitary tumors are extremely rare. The pituitary gland is a principal part of the endocrine system (the set of glands and organs that produce hormones).