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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
Genetic mutations occur when DNA changes, altering the genetic instructions. This may result in a genetic disorder or a change in characteristics. Mutations can be caused by exposure to specific chemicals or radiation. For example, cigarette smoke is full of chemicals that attack and damage DNA.This causes mutations in lung cell genes, including the ones that control growth.he chromosomes contain the genes you inherit from your parents. There may be different forms of the same gene â called alleles. For example, for the gene that determines eye colour, you may inherit a brown allele from your mother and a blue allele from your father.