The hallmark of increased platelet destruction is increased marrow megakaryocytes or, when available, high reticulated platelet count. 1  Platelet destruction results from various immune conditions, including the following: 2  Immune thrombocytopenic purpura (ITP) 3  Thrombotic microangiopathies. 4  Post-transfusion purpura (PTP)
DRUG CLASS AND MECHANISM: Methadone is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control.RUG CLASS AND MECHANISM: Methadone is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control.
Pharmacodynamics: Methadone is a long acting m opioid receptor agonist with potent central analgesic, sedative, and antitussive actions. Methadone inhibits ascending pain pathways, alters perception of and response to pain (dissociative effect), and produces generalized CNS depression.