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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Lung, breast, or gastrointestinal carcinoma; melanoma; leukemia; and Hodgkinâs or non-Hodgkinâs lymphoma may involve the pericardium and are the most frequent causes of massive pericardial effusion. 5 Lung carcinoma with pleural and pericardial involvement would already have been in an advanced stage, but the patient had no symptoms or signs of this disease.