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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
Dopamine is released from the axon extension of the presynaptic neuron for binding on the postsynaptic neuron at two types of receptors: the dopamine 1 (D1) family, comprising D1 and D5 receptors, and the D2 family that includes D2, D3, and D4.