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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
T790M Mutation in the EGFR Gene. â¢ T790M is a mutation on a portion of. the gene for the epidermal growth. factor receptor (EGFR) that drives a. minority of lung cancers. â¢ Specifically, the T790M mutation, which is on a portion of the gene. called exon 20, is associated with. resistance to oral tyrosine kinase.