Owners or operators of places of business (also called establishments or facilities) that are involved in the production and distribution of medical devices intended for use in the United States (U.S.) are required to register annually with the FDA. This process is known as establishment registration (Title 21 CFR Part 807).
1 1400sâ1800s (The Renaissance) â Copper, iron, steel, and wood were the most common materials used for prosthetics during this period.  1863 â During the American Civil War, the U.S. started to see advancements in the field of prosthetics.
Interface between the residual limb and prosthesis. The prosthesis attaches to the body at the interface. The interface consists of a socket and a rigid frame. The socket, which is made of plastic or laminated material, is where the working parts of the prosthesis (the components) attach to the person. The frame, which is made of graphite or similar materials, provides structural support for the socket and the components.