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Your immune system may become sensitive to the antibiotic the first time you take it. You may have an allergic reaction the next time. The antibiotics most likely to cause an allergic reaction are penicillins and cephalosporins. Mild symptoms include red, itchy, flaky, or swollen skin. You may have a flat, red area on your skin that is covered with small bumps.
Mild to moderate allergic reactions to penicillin are common, and symptoms may include any of the following: 1  Hives (raised, extremely itchy spots that come and go over a period of hours) 2  Tissue swelling under the skin, typically around the face (also known as angioedema) 3  Throat tightness. 4  Wheezing. 5  Coughing. 6  Trouble breathing.