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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
Asthma in Children. Asthma in Children. The cause of asthma is unknown. Health experts believe that inherited, environmental, and immune system factors combine to cause inflammation of the bronchial tubes , which carry air to the lungs. This can lead to asthma symptoms and asthma attacks. Family history. Asthma may run in families (inherited).