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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
These fragments are then cleared by the kidneys. 1  The parathyroid hormone acts directly on bones to increase bone resorption and mobilize Ca++. 2  It increases the reabsorption of Ca++ in the distal tubules.  It increases the formation of 1,25-dihydroxycholecalciferol, and this increases Ca++ absorption from the intestines.