1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Population PK analysis Population PK modeling was performed using NONMEM v. 7.3.0 (ICON Development Solutions, Ellicott City, MD) and Monolix (v. 4.3.2, LIXOFT, Orsay, France) software. Graphical analyses were conducted using SAS 9.2 (SAS Institute, Cary, NC).