Morphine was the first single-substance drug to be derived from a plant, in this case from the resin of the opium poppy (Papaver somniferum) by a German pharmacist named Setru â¦ rner, in 1803-1805. It was first sold commercially by Heinrich Merck in the 1820's.
1 To find percentiles outside of this range, use the PERCENTILE.INC function. The syntax on this function is exactly the same as for the PERCENTILE.EXC function.  If you will need this worksheet to run on versions of Excel prior to 2007, use PERCENTILE instead of PERCENTILE.EXC or PERCENTILE.INC.
However there are efficient ways of figuring out just the 25% and 75% percentiles using a the quick select algorithm, which is typically $O(n)$. If you know these end points, you can quickly loop over the data again, and replace values less than 25% with the 25% value and more than 75% with 75% and average.