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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
Asthma is a complex disease that causes wheezing, coughing, and shortness of breath. Researchers say many factors, including genetics and environmental factors, play a role in the cause of asthma. Until now, only one gene has been associated with childhood asthma, but many genes are thought to be involved.