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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Rare diseases related to environmental factors include uncommon types of anemia caused by vitamin-deficient diets or certain medications. A rare cancer caused by environmental factors is mesothelioma (See: General Information About Malignant Mesothelioma [cancer.gov]), which affects the cells lining the chest cavity.