2. Cholera exotoxin (choleragen), produced by Vibrio cholerae (inf). This exotoxin catalyzes the ADP-ribosylation of a host cell protein called Gs that turns the synthesis of a metabolic regulator molecule callec cyclic AMP (cAMP) on and off. In this case, synthesis stays turned on.
Question: What is end-stage glaucoma, and how serious is it? Answer: End-stage glaucoma is generally the term we apply when there is very advanced disease. It is a very serious situation because that means there's not very much healthy tissue left. In other words, there has been a lot of visual damage.
There are two main types of glaucoma, open angle and closed angle (angle closure) glaucoma. The fluid in the eye flows through an area between the iris and cornea, where it escapes via the trabecular meshwork - angle refers to this area. The trabecular meshwork is made of sponky tissue lined by trabeculocytes.