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Your immune system may become sensitive to the antibiotic the first time you take it. You may have an allergic reaction the next time. The antibiotics most likely to cause an allergic reaction are penicillins and cephalosporins. Mild symptoms include red, itchy, flaky, or swollen skin. You may have a flat, red area on your skin that is covered with small bumps.
Can vary: Allergic reactions from taking antibiotics can be an immediate event or can take days to develop. When they take a longer period of time, we call them delayed hypersensitivity reactions. If there is a concern about an allergy to a medication, it is best to speak with the prescribing physician about what to do next.