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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Causes include: 1  Surgery. Removal of or injury to lymph nodes and lymph vessels may result in lymphedema. 2  Radiation treatment for cancer. Radiation can cause scarring and inflammation of your lymph nodes or lymph vessels. 3  Cancer. If cancer cells block lymphatic vessels, lymphedema may result.  Infection.