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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
The type of lymphoma will influence the types of symptoms that are most common. For example, gastric MALT lymphomas may present as an upset stomach; or a change in bowel movement could be caused by an enlarged lesion in the GI tract. Systemic symptoms (or b-symptoms) such as unexplained fever and chills are most likely to appear in advanced stages of lymphoma or when there is steady progression.