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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Hodgkin lymphoma - Causes. Causes of Hodgkin lymphoma. Hodgkin lymphoma is caused by a change (mutation) in the DNA of a type of white blood cell called B lymphocytes, although the exact reason why this happens isn't known. The DNA gives the cells a basic set of instructions, such as when to grow and reproduce.