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Alka-Seltzer Plus Cold and Cough is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
All Alka Seltzer Plus preparations contain aspirin to reduce fever. Aspirin may cause a number of side effects, including heartburn, stomach pain, nausea or vomiting. These symptoms are common, according to MedlinePlus, and a patient should consult a doctor if they do not subside after stopping the medicine.