6. Copper cookware. Copper leaches into food when heated, prompting the FDA to caution against using unlined copper for general use. Accordingly, the cooking surfaces are usually lined with tin, nickel or stainless steel. Coated copper cookware can lose its protective layer if damaged or scoured.
Liver disorders that causes Hepatosplenomegaly. The major liver disorders that cause hepatosplenomegaly are; Hepatitis Câ Hepatitis C is a viral liver disease that is transmitted through blood. There are many symptoms for Hepatitis C, most of which directly affect the liver and spleen.
Mechanism of Injury. The cause of amiodarone hepatotoxicity appears to be direct damage to lipid bilayers and disturbance of lysosomal and/or mitochondrial function. Amiodarone appears to be potent inhibitor of phospholipase A accounting for the accumulation of lipid-rich material in lysosomes.