In addition to the purchase price of a property in France, and the various expenses, commissions, and taxes that that purchase entails, there is a further series of outlays that will arise out of your purchase.
When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the activation energy of the reaction and promotes its rapid progression by providing certain ions or chemical groups that actually form covalent bonds with molecules as a necessary step of the reaction process.
Lock-and-key is the model such that active site of enzyme is good fit for substrate that does not require change of structure of enzyme after enzyme binds substrate The induced-fit model involves the changing of the conformation of the active site to fit the substrate after binding.