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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
It is a cancer of the lymphocytes (a type of blood cell) and lymphoid tissues. Lymphoid tissue is normally present in many places in the body including lymph nodes, spleen, liver, gastrointestinal tract and bone marrow. The feline leukemia virus (FeLV) has been shown to cause lymphoma in some cats.ther organs, such as the liver, spleen and bone marrow can be involved as well. Diagnosis/Initial evaluation A complete evaluation of a dog suspected of having lymphoma involves obtaining a biopsy or needle aspirate of the affected tissues and a search for lymphoma in other locations (this is what we call staging).