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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
Symptoms of a severe allergic reaction: 1  hives. 2  trouble breathing or swallowing. 3  wwelling of the lips, tongue, face.  throat tightness, 1  hoarseness. rapid heartbeat. 2  faint.  rash.