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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Specific causes of primary lymphedema include: 1  Milroy's disease (congenital lymphedema). This disorder begins in infancy and causes lymph nodes to form abnormally. 2  Meige's disease (lymphedema praecox). This disorder often causes lymphedema around puberty or during pregnancy, though it can occur later, until age 35.