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When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the activation energy of the reaction and promotes its rapid progression by providing certain ions or chemical groups that actually form covalent bonds with molecules as a necessary step of the reaction process.
A Dictionary of Biology | 2004 | 438 words. Â© A Dictionary of Biology 2004, originally published by Oxford University Press 2004. enzymeâsubstrate complex The intermediate formed when a substrate molecule interacts with the active site of an enzyme.Following the formation of an enzymeâsubstrate complex, the substrate molecule undergoes a chemical reaction and is converted into a new product.Various mechanisms for the formation of enzymeâsubstrate complexes have been suggested, including the induced-fit model and the lock-and-key mechanism. Cite this article. Dictionary of Biology | 2004 | 438 words. Â© A Dictionary of Biology 2004, originally published by Oxford University Press 2004. enzymeâsubstrate complex The intermediate formed when a substrate molecule interacts with the active site of an enzyme.