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A: According to MedicineNet, a low granulocyte count can be caused by bacterial or viral infections, certain cancers, chemotherapy drugs, radiation treatment or certain autoimmune disorders. A low granulocyte count can also occur in healthy people without any known cause. Granulocytes are immune cells that are filled with toxic granules.
Three kinds of granulocyteâmast cells, basophils. and eosinophilsâare distinguished from neu-. trophils by the differential staining characteristics. of their granules. In mast cells and basophils this is. caused by the presence of an acidic proteoglycan; in eosinophils the characteristic granules contain. several basic proteins. The basophil is a circulating. cell whereas the mast cell is sessile and present. throughout the body but chieï¬y in perivascular. connective tissue, epithelia and lymph nodes. There is heterogeneity within the mast cell popula-. tion and dye binding is considerably affected by.