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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
When you have an allergic reaction there may be a combination of the following allergy symptoms: 1  sneezing. 2  wheezing. 3  nasal congestion. 4  coughing. itchy, watery eyes.  runny 1  nose. itchy throat. 2  stomach ache. itchy 3  skin. hives. 4  fatigue. irritability.