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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
Parathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma.xpression of parathyroid hormone-related protein and its receptor in bone metastases from prostate cancer. J Pathol 2000; 191: 170-174. Article MEDLINE. 27 Lee C et al. Expression of parathyroid hormone-like protein in prostate cancer and prostatic intraepithelial neoplasia. J Urol 1997; 157: (Suppl 4) 225.