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Largest study to date of rare genetic variants and asthma risk finds few associations. Despite a strong suspected link between genetics and asthma, commonly found genetic mutations account for only a small part of the risk for developing the disease -- a problem known as missing heritability.
Among the five remaining regions most associated with asthma (Table 1), only for chromosome 5q31 there was an obvious candidate gene under the association peak, the chemokine CXC motif ligand 14 (CXCL14) gene, which is thought to be a potent chemoattractant and activator of dendritic cells.