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The cause of CFS if unknown. A large portion of cases are triggered by an infection and some by trauma. Stress is also present at the onset in almost all cases. Some people believe that CFS is caused by an agent entering the body, while others think it is due to the body's response, possibly to various agents.
Different people may have different degrees of symptoms. CF is an autosomal recessive disorder. It is caused by the presence of mutations in both copies of the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). Those with a single working copy are carriers and otherwise mostly normal.