Owners or operators of places of business (also called establishments or facilities) that are involved in the production and distribution of medical devices intended for use in the United States (U.S.) are required to register annually with the FDA. This process is known as establishment registration (Title 21 CFR Part 807).
1 1400sâ1800s (The Renaissance) â Copper, iron, steel, and wood were the most common materials used for prosthetics during this period.  1863 â During the American Civil War, the U.S. started to see advancements in the field of prosthetics.
Above Knee Prosthetics A Closer Look At Above Knee Prosthetics One of the most common type of prosthesis is the lower extremity prosthesis, designed to replicate one or both legs. Lower extremity prosthetic devices are typically broken down into two categories â above knee and below knee.