2. Cholera exotoxin (choleragen), produced by Vibrio cholerae (inf). This exotoxin catalyzes the ADP-ribosylation of a host cell protein called Gs that turns the synthesis of a metabolic regulator molecule callec cyclic AMP (cAMP) on and off. In this case, synthesis stays turned on.
Question: What is end-stage glaucoma, and how serious is it? Answer: End-stage glaucoma is generally the term we apply when there is very advanced disease. It is a very serious situation because that means there's not very much healthy tissue left. In other words, there has been a lot of visual damage.
Final Stages of ALS Photo Credit Jupiterimages/Polka Dot/Getty Images. ALS, or Amyotrophic Lateral Sclerosis, is a disease of progressive muscle weakness which occurs due to the destruction of motor neuron cells in the nervous system. Without these neurons, the brain is unable to send information to muscles. End-stage ALS occurs when muscles weaken to the point where vital systems are paralyzed and cannot function. Montgomery Hospice in Maryland lists the ability to breathe and swallow as crucial factors in end-of-life ALS.