Problem solving is the act of defining a problem; determining the cause of the problem; identifying, prioritizing and selecting alternatives for a solution; and implementing a solution.
Ipilimumab costs $120,000 for four treatments, and nivolumab is priced at $12,500 a month, the Wall Street Journal reported. Serious Side Effects. However, the ipilimumab with nivolumab combination comes with serious side effects, such as colitis (swelling of the colon), diarrhea and problems with the endocrine glands (which produce hormones).
Availability of Nivolumab and Use. Nivolumab is typically combined with Yervoy (ipilimumab) and has been shown to lead to deep tumor regression in a third of patients who have advanced melanoma. The response is shown to be quicker when the combination is used versus a single drug.