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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
During an allergic reaction additional symptoms may include: 1  Watery eyes. 2  Red bloodshot eyes. 3  Swollen eyelid.  Difficulty seeing or blurred 1  vision. Inability to open eye due to swelling.  Congestion; difficulty breathing; 1  wheezing. Sneezing or runny  nose.