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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
In most studies, however, lung carcinoma has been the most common neoplasm, accounting for approximately one-third of all malignant effusions. Breast carcinoma is the second most common. Lymphomas, including both Hodgkin's disease and non-Hodgkin's lymphoma, are also an important cause of malignant pleural effusions.pproximately 10% of malignant pleural effusions are due to lymphoma. According to reports in the early 1940s, in Hodgkin's disease, pleural effusions develop in 16% of patients, pleural thickening in 7%; the figures were, respectively, 15 and 11% in non-Hodgkin's lymphoma and 2 and 4% in leukemia (11).