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Causes of Muscle weakness (Weak muscles): See detailed list of causes below. Muscle weakness (medical symptom): Weakness of the muscles or loss of tone. The list of medical condition causes of Muscle weakness (Weak muscles) includes: Muscle overuse.
Weak leg muscles may be from an electrolyte imbalance. Photo Credit Goodshoot/Goodshoot/Getty Images. If you are experiencing weak leg muscles, contact your doctor to determine the cause. Weak leg muscles can be from over-activity, serious illness, pain or vitamin deficiency. Muscles require nutrients such as vitamins, minerals, carbohydrates, protein and adequate fluids to function properly and at optimum levels.