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A: According to MedicineNet, a low granulocyte count can be caused by bacterial or viral infections, certain cancers, chemotherapy drugs, radiation treatment or certain autoimmune disorders. A low granulocyte count can also occur in healthy people without any known cause. Granulocytes are immune cells that are filled with toxic granules.
The term agranulocytosis derives from the Greek: a, meaning without; granulocyte, a particular kind of white blood cell (containing granules in its cytoplasm); and osis, meaning condition [esp. disorder].