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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
How do the dopamine receptor agonists differ from one another? At least five subtypes of dopamine receptors (D1-D5) have been identified in the brain. It appears that the D1, D2 and D3 receptors are located in the striatum, a major target of dopamine neurons projecting from the substantia nigra.