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A: According to MedicineNet, a low granulocyte count can be caused by bacterial or viral infections, certain cancers, chemotherapy drugs, radiation treatment or certain autoimmune disorders. A low granulocyte count can also occur in healthy people without any known cause. Granulocytes are immune cells that are filled with toxic granules.
Agranulocytosis: A marked decrease in the number of granulocytes. Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms. Granulocytes are part of the innate, somewhat non specific infection-fighting immune system. They do not respond exclusively to specific antigens, as do B-cells and T-cells.