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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Back to TopCauses. The cause of primary brain lymphoma is not known. Patients who have a weakened immune system are at high risk of primary lymphoma of the brain. Common causes of a weakened immune system include HIV and organ transplants (especially heart transplants).