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Nerve cells called motor neurons control the skeletal muscles. Each motor neuron controls several muscle cells in a group known as a motor unit. When a motor neuron receives a signal from the brain, it stimulates all of the muscles cells in its motor unit at the same time.
The synaptic knob contains vesicles filled with neurotransmitters.  Therefore, Acetylcholine is the neurotransmitter that stimulates  skeletal muscle to contract. It is rele â¦ ased into the synaptic  clefts between motor neuron axons and motor end plates.