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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
The most common symptoms of allergic reactions to drugs are: The most common drug that can cause problems is penicillin. Antibiotics, sulfa drugs, barbiturates, and insulin also can cause adverse drug reactions. Some medicines trigger a response from the immune system in people with drug hypersensitivity. The body's immune system perceives the substance as attacking the body, so it attacks the system.