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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
So, findings on D2 receptor availability may be relevant to a wide range of addictions and conditions. To measure monkeys' D2 receptor availability before cocaine exposure, Dr. Nader and colleagues injected each animal with a radiotracer that binds to the receptors. The radiotracer competes with dopamine for the receptor and provides a measure of D2 function.