The Small Business Liability Relief and Brownfields Revitalization Act, an amendment to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), defines a brownfield site as real property, the expansion, redevelopment or reuse of which may be complicated by the presence of a hazardous substance, pollutant, or contaminant ...
Chronic pain management always require higher dose of hydrocodone due tolerance. The maximum recommended dose for the hydrocodone is 60mg/day which is equivalent to 12 tablets of (5/325). As you go up, the risk of side effects and toxicity increases. Combining one and more product has synergistic effect. You can read more about it from here.
Example conversion from a single opioid to HYSINGLA ER: For example, a total daily dose of oxycodone 50 mg would be converted to hydrocodone 50 mg based on the table above, and then multiplied by 0.75 (ie, take a 25 % reduction) resulting in a dose of 37.5 mg hydrocodone. Round this down to the nearest dose strength available, HYSINGLA ER 30 mg, to initiate therapy.