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Antibiotic allergic reactions. Around 1 in 15 people have an allergic reaction to antibiotics, especially penicillin and cephalosporins. In most cases, the allergic reaction is mild to moderate and can take the form of: a raised, itchy skin rash (urticaria, or hives)
The common symptoms of an allergic reaction are as follows: 1  Itching, redness, rash, hives or blistering on the skin. 2  Coughing, wheezing, chest tightness and breathing difficulty. 3  Swelling of the eyes, throat, face, lips. 4  Runny nose, sneezing, nasal congestion. 5  Redness in the eyes. 6  Nausea, vomiting, abdominal pain and diarrhea.