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By inhibiting the dopamine transporter, a dopamine reuptake inhibitor increases the body's extracellular concentrations of dopamine, which in turn increases dopaminergic neurotransmission and creates feelings of pleasure or even euphoria. A dopamine reuptake inhibitor has a number of medical applications.
At presynaptic terminals D2-receptors regulate the release, uptake and synthesis of dopamine. (1) Autoreceptors inhibit the probability of dopamine vesicle release by activating K v 1.2 channels and also potentially secondarily by inhibiting calcium entry through voltage-gated calcium channels (VGCC).2-autoreceptors also regulate dopamine transmission by increasing the activity of DAT (Cass and Gerhardt, 1994, Dickinson et al., 1999, Mayfield and Zahniser, 2001, Schmitz et al., 2002, Wu et al., 2002 and Benoit-Marand et al., 2011).