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Prevalance of Scleroderma: Estimates for the number of people in the United States with systemic sclerosis range from 40,000 to 165,000. By contrast, a survey that included all scleroderma-related disorders, including Raynaud's phenomenon, suggested a number between 250,000 and 992,500.bout prevalence and incidence statistics: The term 'prevalence' of Scleroderma usually refers to the estimated population of people who are managing Scleroderma at any given time.
Definition and etiology. Scleroderma, or systemic sclerosis (SSc), is a chronic multisystem autoimmune disease characterized by a vasculopathy, diffuse fibrosis of skin and various internal organs, and immune abnormalities.ystemic scleroderma always leads to some internal organ involvement. It is further divided into two subsets of disease, limited or diffuse (see Box 1). According to LeRoy and colleagues, limited or diffuse disease is based on the extent of skin tightening.