He then asked news organizations to tally up the number of Americans killed through terrorist attacks in the last decade and compare it with the number of Americans who have died in gun violence.
In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons.
(No, theoretically this mRNA can code for something.) Since you don't know where the gene starts, you have to consider all three frames of the sequence. You realize that you don't know how your sister got this sequence, so you really have to consider all six frames.