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Your immune system may become sensitive to the antibiotic the first time you take it. You may have an allergic reaction the next time. The antibiotics most likely to cause an allergic reaction are penicillins and cephalosporins. Mild symptoms include red, itchy, flaky, or swollen skin. You may have a flat, red area on your skin that is covered with small bumps.
Aspirin and penicillin could also cause anaphylactic reaction in some people. Common symptoms include facial swelling, shortness of breath, wheezing, rash, itchy skin, stomach ache, slurred speech, confusion, anxiety, and coughing. (Read: Anaphylactic attack â when an allergy can kill you)