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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
Only target cells have receptors inside cytoplazm (for steroid  hormones) or on cell membrane (for protein hormones) that make the  hormone active.irstly, steroid hormones (For example cortisol) or a fat-soluble hormone PASSES THROUGH THE PLASMA MEMBRANE to cause changes in its target cell. Once it's through the membrane and it's nuclear envelope, this is where the protein comes in. It binds to a receptor protein which is inside the nucleus.