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Causes of Muscle weakness (Weak muscles): See detailed list of causes below. Muscle weakness (medical symptom): Weakness of the muscles or loss of tone. The list of medical condition causes of Muscle weakness (Weak muscles) includes: Muscle overuse.
1 Calcium and vitamin D intake. 2  A diet low in calcium and vitamin D makes you more prone to bone loss. 3  Medication use. 4  Some medicines increase the risk of osteoporosis. 5  Activity level. 6  Lack of exercise or long-term bed rest can cause weak bones.