The hallmark of increased platelet destruction is increased marrow megakaryocytes or, when available, high reticulated platelet count. 1  Platelet destruction results from various immune conditions, including the following: 2  Immune thrombocytopenic purpura (ITP) 3  Thrombotic microangiopathies. 4  Post-transfusion purpura (PTP)
DRUG CLASS AND MECHANISM: Methadone is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control.RUG CLASS AND MECHANISM: Methadone is a strong, synthetic (man-made) narcotic that acts on the central nervous system (brain) in a manner similar to other narcotics. It is used in the management of narcotic addiction and for pain control.
How It Works. Methadone works on parts of the brain and spinal cord to block the high caused by using opiates (such as heroin). It also helps reduce cravings and withdrawal symptoms caused by opiate use. The action of methadone is similar to other synthetic (man-made) medicines in the morphine category (opioids). Substances that are derived directly from the opium plant (such as heroin, morphine, and codeine) are known as opiates.