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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
One of the most severe potential side effects of L-arginine is anaphylaxis [source: Mayo Clinic]. That's a very severe allergic reaction that can result in shock and potentially even death. In an anaphylactic reaction, you may experience sudden chills, sweating, tremors, hives, vomiting, and diarrhea, shortness of breath and light-headedness or fainting -- all at once.