Bearing in mind that HIF-1 is essential for heat acclimation, we tested whether this pathway contributes to the cross-tolerance phenomenon as well. Our findings from this investigation confirmed that heat acclimation induces cross-tolerance to heavy metals (cadmium) and chemical hypoxia in the wild-type C. elegans.
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Michigan /ËmÉªÊáµ»É¡Én/ is a state located in the Great Lakes and Midwestern regions of the United States. The name Michigan is the French form of the Ojibwa word mishigamaa, meaning large water or large lake. Michigan is the tenth most populous of the 50 United States, with the 11th most extensive total area (the largest state by total area east of the Mississippi River). Its capital is Lansing, and its largest city is Detroit.