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Tramadol levels in the blood peak 2 hours after taking a 100 mg oral dose. In clinical studies, the onset of pain relief was faster with a combination formula of tramadol hydrochloride and acetaminophen (brand name Ultracet) than Tramadol alone. Onset of analgesia (pain relief) occurred in less than one hour. However, it takes 2 days to reach steady-state concentrations of Tramadol in the blood at a dosing rate of four times per day. As stated before Tramadol works differently for every person.
tramadol or ultram is a german invented pain reliever created in the 1970s it is quite different than other prescribed pain relievers like codeine or hydrocodone and generally considered far less addictive though people can become addicted to itramadol is sometimes prescribed off label to treat migraines and drug withdrawal some individuals may experience hives as part of an allergic reaction to tramadol drowsiness is a common side effect of tramadol