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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
Deficiency symptoms include: 1  Brittle and thin fingernails. 2  Hair loss (alopecia) 3  Conjunctivitis. 4  Dermatitis in the form of a scaly, red rash around the eyes, nose, mouth, and genital area. 5  Neurological symptoms in adults, such as depression, lethargy, hallucination, and numbness and tingling of the extremities.