These mutations range from being non-harmful all the way up to causing death. Point Mutations. A point mutation is usually the least harmful of the types of DNA mutations. It is the change of a single nitrogen base in a DNA sequence. Depending on the placement of that nitrogen base in the codon, it can cause no affect to the protein.
1. hoagie-a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States.
[Photographs: Hawk Krall] A common argument among Philadelphians is what sandwich defines us best: the famous cheesesteak or the slightly lesser known roast pork. While I've eaten plenty of both, my vote goes to the Italian hoagie. Not a ham and cheese sub, or some ciabatta-arugula trainwreck, but a real Philadelphia hoagie.