These mutations range from being non-harmful all the way up to causing death. Point Mutations. A point mutation is usually the least harmful of the types of DNA mutations. It is the change of a single nitrogen base in a DNA sequence. Depending on the placement of that nitrogen base in the codon, it can cause no affect to the protein.
1. hoagie-a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States.
The secret to Philadelphia Hoagies and cheese steaks is the roll. If you start with one that you need to scoop out, you are using the wrong roll! Hoagie or Hogie is a shortened version of Hog Island ship yard where they were first sold by a vendor who made them at home to sell to the workers at the shipyard.