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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
Clinical features of vitamin B6 deficiency include peripheral neuropathy presenting as numbness, weakness, and dysesthesias in the limbs, glossitis, cheilitis, pellagra-like symptoms including seborrheic dermatitis and diarrhea, conjunctivitis, sideroblastic anemia, and neurological symptoms such as confusion, depression, insomnia, irritability, chronic fatigue, EEG abnormalities and convulsions, which are often tonic-clonic seizures.