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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Some average dosages are as follows: 1  Individuals with chest pain from angina have taken between 3 and 6 g of L-arginine per day for a period of up to one month. 2  Individuals with angina who need to prevent nitroglycerin tolerance have taken 700 mg (.7 g) of L-arginine four times per day for a total of 2.8 g.