Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
Sorghum is a cereal grain that originated in Africa about 5000 years ago where it continues to be an important food source today. It's sometimes called milo and in India it is known as jowar. Today the United States is the largest producer of sorghum where it's primarily used for animal feed.