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Consequently, the incidence of VTE in the absence of. prophylaxis ranges from 40% to 60% (venographic rates) 7 to 14 days after major orthopedic surgery.1,11 The rate of. DVT during the same period is approximately 50% (Table.
Prophylactic antibiotic administration should be initiated within one hour before the surgical incision, or within two hours if the patient is receiving vancomycin or fluoroquinolones. The goal of antibiotic prophylaxis is to ensure effective serum and tissue levels of the drug for the duration of the surgery.