morphine). Since diffusion across a lipid bilayer requires that a drug be lipid-soluble, the ionized form of a drug cannot cross membranes. Thus, weak acids that are nonprotonated and weak bases that are protonated cannot diffuse across membranes. At a pH that is equal to a drugâs pKa, equal amounts of the protonated and nonprotonated forms are present. Assuming the pH is the same on both sides of a given membrane, the drug will be at equilibrium across the membrane.
Ledyba (Japanese: ã¬ãã£ã Rediba) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledyba is a common Bug type PokÃ©mon that resembles a ladybug. It has six legs, that are all wearing gloves.
Litleo is the new lion cub PokÃ©mon in PokÃ©mon X & Y. It has an interesting Fire/Normal-type combination and is shown using the new move, Noble Roar, in battle, which lowers the foe's Attack and Special Attack. It was officially revealed in English on June 14th, 2013, although was earlier shown in a leak of the July issue of CoroCoro on June 12th, 2013. It was revealed along with Scatterbug, Spewpa, and FlabÃ©bÃ©. Litleo evolves into Pyroar, although the method or level of evolution has yet to be revealed.