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This supports the idea that in embryos from wild-type mothers, dpp H~- mutations cause the transformation of dorsal into ven-tral epidermis. If tissue determined to become dorsal epidermis dies in the dpp rim-null embryos, then one should not see ventral or lateral tissue formed in the double-mutant combination.
In wing imaginal discs of Drosophila melanogaster larvae, dying cells release mitogenic signals (Grusche et al., 2011; Ryoo et al., 2004; Sun and Irvine, 2011). The resulting proliferation of the neighbors compensates for cell loss and helps regenerate the disc.