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Researchers do know from twin studies that genetics plays a role in personality disorders. Environmental factors, such as childhood abuse, neglect and separation from caregivers, as well as brain abnormalities, emotion regulation, impulsivity, aggression and serotonin levels all play a role.ecause many personality domains are heritable, borderline personality disorder may be a result of a genotype interacting with adverse environmental factors. This would in turn lead to the expression of borderline symptoms or other dysfunctional personality traits.
We focus on 15q11-q13 as a model example for the role genomic imprinting plays in human brain development, and discuss the role other imprinted loci may play in brain development. Keywords. genomic imprinting, PraderâWilli syndrome, Angelman syndrome, lncRNA, neurodevelopmental disorders, epigenetics, 15q11-q13