1 Diabetes often causes numbness and other complications in the feet. 2  Determine if your numbness is related to pregnancy. 3  Pregnancy often causes swelling of the feet and toes, which can cause numbness.
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes and mast cells. It is also used by certain lymphocytes such as natural killer cells and cytotoxic T cells, whose main purpose is to destroy invading microorganisms.
Mast cell degranulation, and the subsequent recruitment of infiltrating inflammatory cells, such as eosinophils, into the nasal mucosa has long been considered the most important model to explain allergic rhinitis. Several studies show a decrease in the number of eosinophils and possibly also mast cells during local corticosteroid treatment.