1 Diabetes often causes numbness and other complications in the feet. 2  Determine if your numbness is related to pregnancy. 3  Pregnancy often causes swelling of the feet and toes, which can cause numbness.
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes and mast cells. It is also used by certain lymphocytes such as natural killer cells and cytotoxic T cells, whose main purpose is to destroy invading microorganisms.
Anaphylatoxins are able to trigger degranulation (release of substances) of endothelial cells, mast cells or phagocytes, which produce a local inflammatory response. If the degranulation is widespread, it can cause a shock-like syndrome similar to that of an allergic reaction.