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Frontotemporal dementia (FTD) or frontotemporal degenerations refers to a group of disorders caused by progressive nerve cell loss in the brain's frontal lobes (the areas behind your forehead) or its temporal lobes (the regions behind your ears). About. Types.
Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. It is characterized by pyramidal cell loss in the frontal and temporal lobes and degeneration of motor neurons in the hypoglossal nucleus and spinal motor neurons.istologic Findings. Early in the disease, frontotemporal lobe dementia with motor neuron disease (FTD/MND) preferentially affects frontal and temporal lobes, the hypoglossal nucleus, and the spinal motor neurons. The later and terminal stages reveal histologic evidence of widespread cortical involvement.