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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
They see what's already there in a different way, and most of the time, they're aware that their altered perceptions are caused by the drug. After taking LSD, the effects -- known as a trip -- usually start within an hour and can last up to 12 hours, with a peak about halfway through the experience. Exactly how LSD affects each person varies widely.