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The cause of simple liver cysts isn't known, but they may be the result of a malformation present at birth. Rarely, liver cysts may indicate a serious, underlying condition such as: 1  Polycystic liver disease, an inherited disorder.  Echinococcus infection, a parasitic infection.
(Also Called 'Liver Cysts and Tumors'). Liver cysts occur in approximately 5% of the population. However, only about 5% of these patients ever develop symptoms. In general, cysts are thin-walled structures that contain fluid. Most cysts are single, although some patients may have several.The symptoms associated with liver cysts include upper abdominal fullness, discomfort, or pain. A small number of patients bleed into the cyst, which causes sudden and severe right upper quadrant and shoulder pain.he benign cystic tumor seen most frequently is called a cystadenoma; its malignant counterpart is a cystadenocarcinoma. The symptoms caused by cystic tumors are the same as those seen with simple cysts; fullness, discomfort, and pain. The liver blood tests usually remain normal, unless a cancer has developed.