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Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma.
physostigmine. an alkaloid usually obtained from the dried ripe seed of Physostigma venenosum; used as a topical miotic in the form of the base and of the salicylate and sulfate salts.physostigmine challenge test.hyÂ·soÂ·stigÂ·mine. An alkaloid of physostigma; it is a reversible inhibitor of the cholinesterases and prevents destruction of acetylcholine; used as a cholinergic agent, and experimentally to enhance the action of acetylcholine at any of its sites of liberation. Synonym(s): eserine.