Slemp then bequeathed the house and collection to the Commonwealth of Virginia for a museum. It was officially dedicated as a museum on May 30, 1948. Wax Avenue was named for Don Wax. Don was born April 21, 1927 and grew up in Big Stone Gap.
Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension (PAH). It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer. 1 Medical uses.
The TracleerÂ® (bosentan) REMS (Risk Evaluation. and Mitigation Strategy) Program. A Risk Evaluation and Mitigation Strategy (REMS) is a program required by the Food and Drug Administration (FDA) to manage serious risks associated with a drug product. Because of the risks of hepatotoxicity and teratogenicity, Tracleer is available only through a restricted program called the Tracleer REMS Program. Under the Tracleer REMS, prescribers, patients, pharmacies, and hospitals must enroll in the program.