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1 Gonorrhea and chlamydia are the most common causes of epididymitis in young, sexually active men. 2  Other infections. 3  For boys and men who aren't sexually active, epididymitis can be caused by a nonsexually transmitted bacterial infection.
Epididymitis: A common cause of pain and swelling. Sometimes testicular pain seems to come out of nowhere. Even if you haven't had an injury, one of your testicles may start gradually aching and swelling. This is often the first sign of epididymitis, a bacterial infection in the tubes that store sperm.