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The most common treatment for CLL is the chemotherapy drug fludarabine. This is given intravenously (through an IV) five days a week once a month, for four to six months. Although the schedule for fludarabine is rather inconvenient, it causes only modest side effects, such as fatigue.
At the same time, they take aim at normal cells and can cause side effects. Yet, not everyone experiences side effects and people react differently. Doctors commonly combine two or more chemotherapy drugs to treat CLL. Each drug type works in a different way to kill the cancerous cells. Combining drug types can strengthen their effectiveness. Standard chemotherapy drugs that doctors use to treat CLL as a single agent or in combination include: