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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
The thalassemias are a group of genetic blood diseases that cause a reduction of the production of normal hemoglobin in the red blood cells. Hemoglobin is a protein carried by the red blood cells, which brings oxygen to all the parts of the body.The reduction of hemoglobin in the blood results in anemia.There are two types of thalassemia, alpha thalassemia and beta thalassemia, depending on which protein chain of the hemoglobin molecule is missing in the red blood cells.he thalassemias are especially common in areas where there are high rates of malaria, such as southeast Asia, China, the Mediterranean, and Africa. Women and their partners who want to become pregnant and who come from these areas should undergo testing to determine whether they carry the thalassemia trait.