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Quick Answer. Endometrial hyperplasia is an abnormal thickening of the lining of the uterus, according to the American Congress of Obstetricians and Gynecologists. The condition usually develops during menopause and perimenopause when ovulation is irregular or absent. It can also occur in women affected by polycystic ovary syndrome or obesity.
1 Complex endometrial hyperplasia without atypia â Cells are thicker than simple hyperplasia, but are normal in appearance. 2  Patients have a 10% higher risk of developing cancer. 3  Complex endometrial hyperplasia with atypia â Cells are thicker than simple hyperplasia and have bizarre appearances.earn. A type of endometrial hyperplasia with a higher risk of developing endometrial cancer, complex endometrial hyperplasia affects the uterus. In a normal menstrual cycle, the lining of the uterus, the endometrium, builds up and then sheds. Complex endometrial hyperplasia occurs when the lining doesnât shed.