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The most common treatment for CLL is the chemotherapy drug fludarabine. This is given intravenously (through an IV) five days a week once a month, for four to six months. Although the schedule for fludarabine is rather inconvenient, it causes only modest side effects, such as fatigue.
Clindamycin (10 to 22 mg/kg orally every 24 hours or divided) is a good choice for treatment of oral infections, especially when bone involvement is suspected. Amoxicillin-clavulanate (12.5 to 22 mg/kg orally every 12 hours) is another good choice, especially when a broad spectrum of protection is desired.