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Doxycycline. Doxycycline is an antibiotic used to treat chlamydia infection. It is used mainly as an alternative to the antibiotic azithromycin. Doxycycline is equally as effective as azithromycin, but whereas azithromycin is a single dose treatment, doxycycline treatment needs to be taken twice daily for 7 days.1  Avoid sexual contact whilst taking doxycycline and for 7 days afterwards, until no longer infectious. 2  People with a positive chlamydia test and their sexual partners should be ...lternative antibiotic. The most frequently used antibiotic for the treatment of chlamydia is azithromycin taken as a single dose. Azithromycin is preferred by most doctors and patients because it is a single dose, although it is more expensive than doxycycline.
If you have chlamydia, your doctor will prescribe oral antibiotics, usually azithromycin (Zithromax) or doxycycline. Your doctor will also recommend your partner(s) be treated to prevent reinfection and further spread of the disease. With treatment, the infection should clear up in about a week or two. It is important to finish all of your antibiotics even if you feel better. Women with severe chlamydia infection may require hospitalization, intravenous antibiotics (medicine given through a vein), and pain medicine.