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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
A Dr. Michael T. Murray, ND , Naturopathic Medicine, answered. A deficiency of thiamine (vitamin B1) usually results in fatigue, depression, pins and needles sensations or numbness in the legs, and constipation. Severe thiamine deficiency results in a deficiency syndrome known as beriberi.