Intravenous (IV) antibiotics are used if: Your nervous system is affected by late Lyme disease and you have bad headaches, neck pain, weakness or numbness in the arms or legs, or problems with thinking or memory. Lyme disease bacteria or antibodies against the bacteria have been found in your spinal fluid.
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For something like my expeditions (like Antarctica in my avatar at the left, or the Kilimanjaro or Denali expeditions in some trip reports here on Trailspace), it goes to 6000 calories per day (and yes, that is kilocalories, the standard measure for food energy content) - less than that and I tend to lose weight.