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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
Severe deficiency, called pellagra, can cause symptoms related to the skin, digestive system, and nervous system. They include: 1  thick, scaly pigmented rash on skin exposed to sunlight.2  swollen mouth and bright red tongue. 3  vomiting and diarrhea.4  headache. 5  apathy.6  fatigue. 7  depression.evere deficiency, called pellagra, can cause symptoms related to the skin, digestive system, and nervous system. They include: 1  thick, scaly pigmented rash on skin exposed to sunlight. 2  swollen mouth and bright red tongue. 3  vomiting and diarrhea. 4  headache. 5  apathy. 6  fatigue. 7  depression.