1 Diabetes often causes numbness and other complications in the feet. 2  Determine if your numbness is related to pregnancy. 3  Pregnancy often causes swelling of the feet and toes, which can cause numbness.
Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes and mast cells. It is also used by certain lymphocytes such as natural killer cells and cytotoxic T cells, whose main purpose is to destroy invading microorganisms.
Upon stimulation by an allergen, the mast cells release the contents of their granules (a process called degranulation) into the surrounding tissues. The chemical mediators produce local responses characteristic of an allergic reaction, such as increased permeability of blood vessels (i.e., inflammation and swelling), contraction of smooth muscles (e.g., bronchial muscles), and increased mucus production. 1  Skin mast cells.