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Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma.
physostigmine. a cholinergic alkaloid having anticholinesterase activity, obtained from the dried ripe seed (Calabar bean) of Physostigma venenosum; used topically to produce miosis and to decrease intraocular pressure in glaucoma.hyÂ·soÂ·stigÂ·mine. An alkaloid of physostigma; it is a reversible inhibitor of the cholinesterases and prevents destruction of acetylcholine; used as a cholinergic agent, and experimentally to enhance the action of acetylcholine at any of its sites of liberation. Synonym(s): eserine.