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Madison is located in Southeastern Indiana on the north bank of the Ohio River at mile 557.6, 46 miles upstream from Louisville Ky, and 88 miles downstream from Cincinnati, Ohio. By highway, Madison is 90 miles from Indianapolis the state capitol, 55 miles from Louisville, KY.
As the state's third-largest city and the largest city in Southern Indiana, it is the commercial, medical, and cultural hub of Southwestern Indiana and the Illinois-Indiana-Kentucky tri-state area. Situated on an oxbow in the Ohio River, the city is often referred to as the Crescent Valley or River City.