24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just a more 24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just an inch below index finger.
Apoptosis (from Ancient Greek á¼ÏÏÏÏÏÏÎ¹Ï falling off) is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. Between 50 and 70 billion cells die each day due to apoptosis in the average human adult.
Apoptosis is a highly regulated process in which the nuclear lamina is disassembled in an early stage. In contrast to the phosphorylation-induced disassembly during mitosis, the nuclear lamina is degraded by proteolytic cleavage, and both the lamins and the nuclear lamin-associated membrane proteins are targeted.he nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to maintain nuclear stability, organize chromatin and bind nuclear pore complexes (NPCs) and a steadily growing list of nuclear envelope proteins (purple) and transcription factors (pink).