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The cause of simple liver cysts isn't known, but they may be the result of a malformation present at birth. Rarely, liver cysts may indicate a serious, underlying condition such as: 1  Polycystic liver disease, an inherited disorder.  Echinococcus infection, a parasitic infection.
A Johns Hopkins Medicine answered. People can develop liver cysts for a variety of reasons. In most cases, these cysts do not cause symptoms, and if they do, your doctor can surgically remove them. Cysts can sometimes start in the bile ducts either inside or outside the liver.