Terminal illness is a disease that cannot be cured or adequately treated and that is reasonably expected to result in the death of the patient within a short period of time.he six-month standard is arbitrary, and best available estimates of longevity may be incorrect. Consequently, though a given patient may properly be considered terminal, this is not a guarantee that the patient will die within six months.
1 Stop metformin if the eGFR is below 30 ml/minute/1.73m2.  Prescribe metformin with caution for those at risk of a sudden deterioration in kidney function and those at risk of eGFR falling below 45ml/minute/1.73m2.
Chest Pain. People who suddenly stopped metoprolol may have chest pain. To prevent this effect, the dose of metoprolol should be reduced slowly over a period of one to two weeks while you are monitored by a doctor. These effects may be possible even in people who take metoprolol for something other than angina.