In the United States, Mother's Day is celebrated on the second Sunday of May. In some countries it was changed to dates that were significant to the majority religion, or to historical dates.
Recently, type A or B recommendations are given in favor or against. the use of antiepileptic drugs to treat neuropathic pain on the basis of their scientific quality. Key Words: Neuropathic pain, antiepileptic drugs (AEDs), trigeminal neuralgia, glossopharyngeal neuralgia,
Several antiepileptic drugs have multiple or uncertain mechanisms of action. Next to the voltage-gated sodium channels and components of the GABA system, their targets include GABA A receptors, the GAT-1 GABA transporter, and GABA transaminase. Additional targets include voltage-gated calcium channels, SV2A, and Î±2Î´. By blocking sodium or calcium channels, antiepileptic drugs reduce the release of excitatory glutamate, whose release is considered to be elevated in epilepsy, but also that of GABA.