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Prostaglandin F2-alpha(PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction (tightening) in some blood vessels. As a pharmaceutical, the generic name of PGF-2 alpha is dinoprost.rostaglandin F2-alpha(PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction (tightening) in some blood vessels. As a pharmaceutical, the generic name of PGF-2 alpha is dinoprost.
The discovery of the potent vasodilator PGI2 and the development of RIAs to measure its metabolite, 6-keto-PGF1Î±, renewed interest in measuring circulating levels of prostaglandins in pregnancy. PGI2 is produced in vascular tissue and appears to be important in local vasodilation.