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The serotonin transporter gene (5-HTT) is considered as a candidate gene for BPD as multiple lines of evidence have suggested that it plays an important role in suicide, impulsive behaviour, and emotional liability.ompared with healthy controls, patients with BPD showed higher frequencies of the 10 repeat of the VNTR marker and the S-10 haplotype, and fewer 12 repeat and L A -12 haplotype. These results suggest that the serotonin transporter gene may play a role in the aetiology of BPD.
Genes are also known to play a role in the occurrence of infectious diseases like tuberculosis and AIDS as well as some non communicable diseases like cancer and diabetes. This section includes a brief introduction to the role of genetics in some major diseases that burden the human population globally.1  1.2  2. An example of a single gene disorder is sickle-cell anaemia. 2  Multifactorial disorders: occur as the result of mutations in multiple genes, frequently coupled with environmental causes. 3  An example of a multifactorial disorder is diabetes.