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The most common treatment for CLL is the chemotherapy drug fludarabine. This is given intravenously (through an IV) five days a week once a month, for four to six months. Although the schedule for fludarabine is rather inconvenient, it causes only modest side effects, such as fatigue.
How to use clonidine HCl. Take this medication by mouth with or without food as directed by your doctor, usually twice daily (in the morning and at bedtime). If the doses are not equal, take the larger dose at bedtime to decrease the risk of side effects.