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Doxycycline. Doxycycline is an antibiotic used to treat chlamydia infection. It is used mainly as an alternative to the antibiotic azithromycin. Doxycycline is equally as effective as azithromycin, but whereas azithromycin is a single dose treatment, doxycycline treatment needs to be taken twice daily for 7 days.1  Avoid sexual contact whilst taking doxycycline and for 7 days afterwards, until no longer infectious. 2  People with a positive chlamydia test and their sexual partners should be ...lternative antibiotic. The most frequently used antibiotic for the treatment of chlamydia is azithromycin taken as a single dose. Azithromycin is preferred by most doctors and patients because it is a single dose, although it is more expensive than doxycycline.
OR. Ofloxacin 300 mg orally twice a day for 7 days. A meta-analysis of 12 randomized clinical trials of azithromycin versus doxycycline for the treatment of genital chlamydial infection demonstrated that the treatments were equally efficacious, with microbial cure rates of 97% and 98%, respectively (284).hlamydia treatment should be provided promptly for all persons testing positive for infection; delays in receiving chlamydia treatment have been associated with complications (e.g., PID) in a limited proportion of chlamydia-infected subjects (283).