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Hedgehog signaling pathway. The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma. The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its
Interview with John Incardona, PhD Incardona is a senior fellow at the University of Washington in Seattle. He studies the Sonic Hedgehog gene and its role in development.He also studies how the compound cyclopamine affects the hedgehog signaling pathway.n a normal embryo, the patterning of the nervous system happens on a temporal scale from head to tail basically, and it's almost like a zipper being closed. Hedgehog signaling is coming from the notochord to the overlying neurectoderm pattern: the head, then the trunk, then the tail, and so on.