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The cause of simple liver cysts isn't known, but they may be the result of a malformation present at birth. Rarely, liver cysts may indicate a serious, underlying condition such as: 1  Polycystic liver disease, an inherited disorder.  Echinococcus infection, a parasitic infection.
Patients typically present with a single liver cyst, although multiple cysts sometimes develop. Liver cysts rarely impair the liver's ability to function. Most liver cysts do not cause symptoms. If they do occur, symptoms include: 1  Upper abdominal fullness, discomfort, or pain.2  Sudden and severe right upper quadrant and shoulder pain caused by bleeding into the cyst, but this occurs In only in a small group of patients,ost liver cysts do not cause symptoms. If they do occur, symptoms include: 1  Upper abdominal fullness, discomfort, or pain. 2  Sudden and severe right upper quadrant and shoulder pain caused by bleeding into the cyst, but this occurs In only in a small group of patients,