Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
Economic and Cultural Significance of the Genus Agave. Learn more about this article. Agave, commonly referred to as âCentury Plantâ in North America and âMagueyâ in Central and South America, is a genus of succulents comprised of more than 200 species (Franck 2012; Morales Areli et al.gave plants became widespread outside of their native range in the 19 th century when they became as popular ornamental garden plants in Europe and the United States (Morh 1999). Agave are now cultivated in North America, South America, Africa and Europe for ornamental and commercial reasons.