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1 Gonorrhea and chlamydia are the most common causes of epididymitis in young, sexually active men. 2  Other infections. 3  For boys and men who aren't sexually active, epididymitis can be caused by a nonsexually transmitted bacterial infection.
Epididymitis is inflammation of the long, narrow, tightly coiled tube (epididymis) found behind each testicle. The epididymis carries sperm from the testicle to the spermatic duct. Affected individuals usually have painful swelling of the one epididymis and the associated testicle.