When I was first diagnosed with thyroid cancer, I didn't feel any odd lumps or nodules in my neck, but I was suffering from muscle weakness, tiredness and getting constant colds. After a particularly nasty bug I noticed that my lymph nodes never seemed to go down in size.
SIRS is nonspecific and can be caused by ischemia, inflammation, trauma, infection, or several insults combined. Thus, SIRS is not always related to infection. Venn diagram showing overlap of infection, bacteremia, sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction.
Recommendations were first. published as in Critical Care Medicine, Mar 2004. SIRS (Systemic inflammatory response syndrome): The clinical syndrome that results from a deregulated. inflammatory response or to a noninfectious insult. Sepsis: SIRS that is secondary to infection that has been diagnosed clinically. Positive cultures add to the. validity but are not required for the diagnosis. Severe Sepsis: Sepsis plus at least one sign of hypoperfusion or organ dysfunction (see below), that is new, and.