All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Sonoma is the southwestern county and largest producer of California's Wine Country region, which also includes Napa, Mendocino, and Lake counties. It has 13 approved American Viticultural Areas and over 250 wineries. In 2002, Sonoma County ranked as the 32nd county in the United States in agricultural production.