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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Can Botox for Migraine Affect Eyebrow Movement? MAR 11, 2014. Question: I have been receiving Botox injections for a number of years both for migraine (a severe headache brought on by changes within the brain to blood vessels in the brain) and temporomandibular joint syndrome (a disorder of the jaw muscles).