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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
Lesson Summary. The heart is a very powerful organ in the cardiovascular system. The endocardium is the inner lining of the heart, covering the atrium, ventricles, and heart valves. It's made up of three layers, which contain the vascular endothelium, muscle tissue, and connective tissue.