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A low RDW (below 10.2%) means that the red blood cells vary very little in size. One reason for a low RDW level is macrocytic anemia. Another cause of a low RDW level is microcytic anemia. In these two disorders the red blood cells do not vary much in size because they are either all small or all large.
What is the significance of low RDW (RBC Distribution Width) particularly in the presence of normal blood profiles? Normal and high RDW can be seen in thalassemias, in iron, and in B12 deficiency anaemias, respectively, and usually with low Hb and or low or high MCV, accordingly.