All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Napa is warmer in the summer than Sonoma County, to the west, or Santa Barbara County, a wine-producing county in southern California. Thus, the Napa wineries favor varietals such as Cabernet Sauvignon, while Pinot noir and Chardonnay are more the specialty of Sonoma and Santa Barbara wineries.