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Comparing carvedilol and metoprolol: results of the COMET trial. The Carvedilol or Metoprolol European Trial (COMET) compared overall mortality in patients with heart failure, randomised to receive either carvedilol or metoprolol tartrate.t is important to note that in the COMET trial, carvedilol was compared with metoprolol tartrate. The MERIT-HF trial compared metoprolol succinate to placebo and it was found that metoprolol succinate reduced the mortality rate by 34% in patients with heart failure.
Carvedilol is indicated for the treatment of heart failure in patients with clinically stable NYHA functional class II or III heart failure. Patients taking diuretics, digitalis or ACE inhibitors should be taking stable dosages of these medications before carvedilol therapy is initiated.Carvedilol may also be used in patients unable to tolerate an ACE inhibitor and in those not taking digoxin, hydralazine (Apresoline) or nitrate therapy.arvedilol (Coreg) is the first beta blocker labeled in the United States specifically for the treatment of mild to moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.