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Quick Answer. Endometrial hyperplasia is an abnormal thickening of the lining of the uterus, according to the American Congress of Obstetricians and Gynecologists. The condition usually develops during menopause and perimenopause when ovulation is irregular or absent. It can also occur in women affected by polycystic ovary syndrome or obesity.
If the endometrium is thick, it may mean that endometrial hyperplasia is present. The only way to tell for certain that cancer is present is to take a small sample of tissue from the endometrium and study it under a microscope.This can be done with an endometrial biopsy, dilation and curettage, or hysteroscopy.f the endometrium is thick, it may mean that endometrial hyperplasia is present. The only way to tell for certain that cancer is present is to take a small sample of tissue from the endometrium and study it under a microscope.