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The most common treatment for CLL is the chemotherapy drug fludarabine. This is given intravenously (through an IV) five days a week once a month, for four to six months. Although the schedule for fludarabine is rather inconvenient, it causes only modest side effects, such as fatigue.
Two drugs doctors often use to try and improve blood flow in the leg arteries are naftidrofuryl and cilostazol. Drugs that make the blood less sticky, such as clopidogrel, may also be given. If your legs and feet are very cold and you are unable to walk far without pain, surgery may be a better option.