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The cause of simple liver cysts isn't known, but they may be the result of a malformation present at birth. Rarely, liver cysts may indicate a serious, underlying condition such as: 1  Polycystic liver disease, an inherited disorder.  Echinococcus infection, a parasitic infection.
The symptoms associated with liver cysts include upper abdominal fullness, discomfort, or pain. A small number of patients bleed into the cyst, which causes sudden and severe right upper quadrant and shoulder pain. The bleeding stops on its own, and the pain then improves over the next several days. Liver cysts do not impair the liverâs ability to function. The cyst(s) are usually found by ultrasound (US) or computed tomography (CT scan). Simple liver cysts are always benign. The only patients who require treatment for a liver cyst(s) are those who develop symptoms.