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Comparing carvedilol and metoprolol: results of the COMET trial. The Carvedilol or Metoprolol European Trial (COMET) compared overall mortality in patients with heart failure, randomised to receive either carvedilol or metoprolol tartrate.t is important to note that in the COMET trial, carvedilol was compared with metoprolol tartrate. The MERIT-HF trial compared metoprolol succinate to placebo and it was found that metoprolol succinate reduced the mortality rate by 34% in patients with heart failure.
carvedilol is used alone or together with other medicines to treat high blood pressure hypertension high blood pressure adds to the workload of the heart and arteriesif it continues for a long time the heart and arteries may not function properlyigh blood pressure may also increase the risk of heart attacks these problems may be less likely to occur if blood pressure is controlled carvedilol is also used to prevent further worsening of congestive heart failure it is also used to treat left ventricular dysfunction after a heart attack