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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
If the deficiency worsens, symptoms can include numbness or tingling in the hands and feet, difficulty maintaining balance, yellowing of the skin, memory loss and hallucinations. Severe vitamin B-12 deficiencies may require weekly vitamin B-12 shots or strong doses of supplementation.