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According to the Mayo Clinic, the pathophysiology of a urinary tract infection is that bacteria enter the urinary tract and start to multiply. This causes symptoms including a frequent urge to urinate and burning upon passing urine.
People experiencing an upper urinary tract infection, or pyelonephritis, may experience flank pain, fever, or nausea and vomiting in addition to the classic symptoms of a lower urinary tract infection. Rarely the urine may appear bloody or contain visible pus in the urine.