Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
Borgund Stave Church, Norway. A stave church is a medieval wooden church. This one was built between 1180 and 1250 with some refurbishing done afterwards. Of all the 28 stave churches in Norway, this one at Borgund is the best preserved.