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1 Gonorrhea and chlamydia are the most common causes of epididymitis in young, sexually active men. 2  Other infections. 3  For boys and men who aren't sexually active, epididymitis can be caused by a nonsexually transmitted bacterial infection.
Men's Health. Epididymitis is an infection and inflammation of the tube that connects the testicle with the vas deferens. This tube is called the epididymis. It is most common in men from ages 19 to 35 and is often caused by the spread of bacterial infections such as gonorrhea or chlamydia.