The most common cause of Angelman syndrome is a deletion of the maternal chromosome region 15q11-q13, which includes the UBE3A gene. Importantly, mutations and deletions of the UBE3A gene are sufficient to cause Angelman syndrome, making UBE3A the single gene responsible for the core symptoms of the disorder. Two major deletion classes known as class I and class II deletions in the 15q11-q13 region both cause Angelman syndrome.
1 ER+/PR+: About 65% of estrogen-receptor-positive breast cancers are also progesterone-receptor-positive. 2  This means that the cells have receptors for both hormones, which could be supporting the growth of the breast cancer.
Triple-Negative Breast Cancer. Your pathology report may say that the breast cancer cells tested negative for estrogen receptors (ER-), progesterone receptors (PR-), and HER2 (HER2-). Testing negative for all three means the cancer is triple-negative. These negative results mean that the growth of the cancer is not supported by the hormones estrogen and progesterone, nor by the presence of too many HER2 receptors.