These mutations range from being non-harmful all the way up to causing death. Point Mutations. A point mutation is usually the least harmful of the types of DNA mutations. It is the change of a single nitrogen base in a DNA sequence. Depending on the placement of that nitrogen base in the codon, it can cause no affect to the protein.
1. hoagie-a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States.
It's in the water. The above hoagie roll recipe is, indeed, pretty darned close to a Philly Hoagie roll (esp. if you have similar water to Philly). A hoagie isn't a cheesesteak, but the roll is close enough if you don't have access to Amoroso Bakery. Here's another recipe that comes close to cheesesteak rolls. It's not exact and has no detailed steps since it was passed down to me by my Philadelphian grandmother... but it works pretty well if you have good hard spring water.