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Doxycycline. Doxycycline is an antibiotic used to treat chlamydia infection. It is used mainly as an alternative to the antibiotic azithromycin. Doxycycline is equally as effective as azithromycin, but whereas azithromycin is a single dose treatment, doxycycline treatment needs to be taken twice daily for 7 days.1  Avoid sexual contact whilst taking doxycycline and for 7 days afterwards, until no longer infectious. 2  People with a positive chlamydia test and their sexual partners should be ...lternative antibiotic. The most frequently used antibiotic for the treatment of chlamydia is azithromycin taken as a single dose. Azithromycin is preferred by most doctors and patients because it is a single dose, although it is more expensive than doxycycline.
In a use-effectiveness study at seven public health clinics, doxycycline and azithromycin were equivalent for treating genital chlamydia infection and preventing recurrences. [3] Studies have shown chlamydia cure rates of 98% with 5 days of doxycycline therapy or 8 to 10 of the prescribed 14 doxycycline pills.fficacy. In research studies, doxycycline and azithromycin have been shown to be equivalent for the treatment of genital chlamydia infection. [2] A meta-analysis of randomized clinical trials showed equal efficacy with no difference in adverse events.