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The most common treatment for CLL is the chemotherapy drug fludarabine. This is given intravenously (through an IV) five days a week once a month, for four to six months. Although the schedule for fludarabine is rather inconvenient, it causes only modest side effects, such as fatigue.
However, some medications that are commonly prescribed to treat other opiate withdrawal symptoms can also help to reduce the severity of RLS. Ask your doctor about: 1  Clonidine: Some people find that clonidine reduces RLS severity. 2  Clonidine is a hypertension medication thatâs very commonly prescribed to reduce the anxiety, agitation, muscle aches, sweating, runny nose, and cramping of opiate withdrawal.