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Place the pan in the microwave oven and cook the meatloaf at medium-high temperature for five minutes. Change the heat setting to high after five minutes and continue cooking for 15 minutes. Remove the meatloaf from the microwave oven after 15 minutes, and cover it with a lid or aluminum foil. After five minutes, use a meat thermometer to check the temperature. You can safely serve meatloaf if it is at least 160 degrees F.
A typical two pound meatloaf should be covered in foil. Preheat  oven at 375 degrees and back for 80 minutes. Next remove the foil  and cook at 375 for another 15 minutes.eatloaf should normally be cooked on 350 degrees for 40 minutes per pound. This varies between ovens, ways it is cooked, and how done a person wants the meat.