Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
As the word sowa (or sova), has the same meaning, owl, in Ukrainian, it is found among Ukrainians both in Ukraine, and in the diaspora (especially Canada and United States). There are two spellings: Sowa and Sova. In Ukrainian usage, as in Polish, the w is always pronounced as v. It is unclear if the Ukrainian Sowas are related to the Polish Sowas, or if the surname originated separately. It is noted the name Sova (same meaning, owl) also exists among Czechs and Slovaks.