morphine). Since diffusion across a lipid bilayer requires that a drug be lipid-soluble, the ionized form of a drug cannot cross membranes. Thus, weak acids that are nonprotonated and weak bases that are protonated cannot diffuse across membranes. At a pH that is equal to a drugâs pKa, equal amounts of the protonated and nonprotonated forms are present. Assuming the pH is the same on both sides of a given membrane, the drug will be at equilibrium across the membrane.
Ledyba (Japanese: ã¬ãã£ã Rediba) is a Bug/Flying-type PokÃ©mon introduced in Generation II. Ledyba is a common Bug type PokÃ©mon that resembles a ladybug. It has six legs, that are all wearing gloves.
Litleo (ã·ã·ã³ Shishiko) is a Fire/Normal-type PokÃ©mon introduced in Generation VI. Litleo is a small feline PokÃ©mon that is based on a lion cub. Its fur is mainly deep brown with tan colored paws, ears, tail tip, and muzzle. It has an triangular orange nose and a small orange tuft of fiery fur (which is very hot to the touch) on the top of its head.