Going forward, FDA has indicated a willingness to extend that accommodation further upstream in the process. Roughly 72% of the BTD denials relate at least in part to trial design or analysis problems, which suggests that sponsors must do more to engage with FDA prior to submitting their request.
Soave, from the Veneto in North East Italy, has a reputation for producing rather neutral, boring white wines. Its partly deserved. Pop into your local supermarket and buy their cheapest Soave. It will be a commodity wine, with some fresh acidity but rather neutral flavours.
A stave is the crosspiece between the legs of a chair or a wooden slat forming the side of a barrel. In music, it's the five lines you write notes on. Stave comes from the word staff, as in a walking stick. You're most likely to encounter the word stave if you're learning woodworking. If someone staves in a door, they've broken a hole in it. You also might hear the idiom stave off, which means to hold off for a short time. Definitions of stave.