24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just a more 24 yr old: transected median nerve 48 days ago at wrist level - epineural repair. Tinels sign now positive just an inch below index finger.
Apoptosis (from Ancient Greek á¼ÏÏÏÏÏÏÎ¹Ï falling off) is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. Between 50 and 70 billion cells die each day due to apoptosis in the average human adult.
Tumor cells can acquire resistance to apoptosis by the expression of anti-apoptotic proteins such as Bcl-2 or by the down-regulation or mutation of pro-apoptotic proteins such as Bax. The expression of both Bcl-2 and Bax is regulated by the p53 tumor suppressor gene (Miyashita, 1994).inally, apoptosis is a coordinated and often energy-dependent process that involves the activation of a group of cysteine proteases called âcaspasesâ and a complex cascade of events that link the initiating stimuli to the final demise of the cell.