Bearing in mind that HIF-1 is essential for heat acclimation, we tested whether this pathway contributes to the cross-tolerance phenomenon as well. Our findings from this investigation confirmed that heat acclimation induces cross-tolerance to heavy metals (cadmium) and chemical hypoxia in the wild-type C. elegans.
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Coordinates: 30Â°01â²30â³N 89Â°54â²54â³W / 30.025000Â°N 89.915000Â°W / 30.025000; -89.915000. The Michoud Assembly Facility (MAF) is an 832-acre (3.4-kmÂ²) site owned by NASA in New Orleans East, a district within New Orleans, Louisiana in the United States.