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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
The duration of the block depends on the agent used. Local anesthetics typically provide analgesia lasting up to 12 hours, whereas neurolytic agents such as glycerol or alcohol have effects lasting for up to 6 months. Radiofrequency ablation has a 98% success rate and yields a longer pain-free period.