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Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma.
Physostigmine (also known as eserine from esere, Ã©sÃ©rÃ© The West african name for The calabar) bean is a parasympathomimetic, alkaloid, specifically a reversible cholinesterase. Inhibitor it occurs naturally in The calabar. Bean the chemical was synthesized for the first time in 1935 By Percy Lavon julian And Josef. piklhysostigmine acts by interfering with the metabolism of acetylcholine. It is a covalent (reversible-bond hydrolyzed and released) inhibitor of acetylcholinesterase, the enzyme responsible for the breakdown of acetylcholine in the synaptic cleft of the neuromuscular junction.