These mutations range from being non-harmful all the way up to causing death. Point Mutations. A point mutation is usually the least harmful of the types of DNA mutations. It is the change of a single nitrogen base in a DNA sequence. Depending on the placement of that nitrogen base in the codon, it can cause no affect to the protein.
1. hoagie-a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States.
No matter what the sandwich is called though, they tend to follow the same basic pattern of meat, cheese, lettuce, onion, tomato, and seasonings on a roll no matter where the sandwich is purchased. However, a hoagie is the only proper and acceptable name for Philly's biggest culinary contribution.