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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Temporary bruising is the most common side effect of Botox. Headaches, which end in 24 to 48 hours, can happen, but this is rare. A small percentage of patients may develop eyelid drooping. This usually ends within three weeks.Drooping usually happens when the Botox moves around, so don't rub the treated area for 12 hours after injection or lie down for three to four hours.eadaches, which end in 24 to 48 hours, can happen, but this is rare. A small percentage of patients may develop eyelid drooping. This usually ends within three weeks. Drooping usually happens when the Botox moves around, so don't rub the treated area for 12 hours after injection or lie down for three to four hours.