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The most common form of glycine encephalopathy, called the classical type, appears shortly after birth. Affected infants experience a progressive lack of energy (lethargy), feeding difficulties, weak muscle tone (hypotonia), abnormal jerking movements, and life-threatening problems with breathing.
1 A gross vitamin B1 deficiency leads to eventual beriberi disease, which is rare except in severely ill alcoholics. 2  Gross deficiencies also cause pain or tingling in the arms or legs, decreased reflex activity, fluid accumulation in the arms and legs, enlargement of the heart, constipation, and nausea and vomiting.ymptoms Of A Deficiency Of Vitamin B1. 1  Low vitamin B1 deficiency signs include loss of appetite, fatigue, nausea, gastrointestinal disorders, tender, atrophied muscles and mental problems such as rolling of the eyeballs, depression, memory loss, difficulty concentrating and rapid heartbeat.