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hypokinetic disease meaning, hypokinetic disease definition | English Cobuild dictionary. adj. n. a substance containing a harmless form of the germs that cause a particular disease.
Hypophosphatasia (HPP) is an inborn error of metabolism with highly variable clinical severity caused by loss-of-function mutations in the gene encoding tissue nonspecific alkaline phosphatase (TNSALP). The prevalence of the severe form is estimated to be between 1/100,000 and 1/300,000.