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The cause of simple liver cysts isn't known, but they may be the result of a malformation present at birth. Rarely, liver cysts may indicate a serious, underlying condition such as: 1  Polycystic liver disease, an inherited disorder.  Echinococcus infection, a parasitic infection.
1 Hepatitis causes swelling of the liver and results in pain in the right rib (liver pain in right side). 2  Hepatic abscess. 3  Hydatid cyst is the result of a parasitic tapeworm and its endocysts in the liver. [ 4  10 ] This video illustrates the surgical removal of these cysts.