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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
1 Thus large doses of Warfarin affects both the intrinsic and the extrinsic pathways. 2  It takes 9-16 hours for Warfarin effects to show up in the blood after oral intake (PO) and 36 to 48 hours for complete effectiveness, i.e for therapeutic index levels for the drug to occur.