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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Other side effects may be slower to appear following Botox treatment for migraines, and itâs important you monitor your own health for any changes in how your body responds or feels. The most common and least serious of these side effects include: Muscle weakness where the injections occurred.