These mutations range from being non-harmful all the way up to causing death. Point Mutations. A point mutation is usually the least harmful of the types of DNA mutations. It is the change of a single nitrogen base in a DNA sequence. Depending on the placement of that nitrogen base in the codon, it can cause no affect to the protein.
1. hoagie-a large sandwich made of a long crusty roll split lengthwise and filled with meats and cheese (and tomato and onion and lettuce and condiments); different names are used in different sections of the United States.
A cheesesteak is made up of thinly sliced, sauteed rib eye beef and melted cheese on a long, crusty roll. Common toppings include fried onions, hot or sweet peppers, sauteed mushrooms and ketchup. A cheesesteak hoagie is a combination of a cold hoagie (as subs are called in the Philly area), and the traditional hot cheesesteak. These have lettuce, tomato and mayonnaise. Origin According to Philadelphia's official tourism site, Pat Olivieri invented the cheesesteak in the 1930s.