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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
No, and taking as much as that guy recommends may actually damage your health. L-arginine helps the body get rid of waste and synthesize proteins. Certain conditions such as severe burns, sepsis, jaundice, protein deficiencies and malnutrition can affect your ability to produce L-arginine [source: Drugs.com]. So can dialysis.