22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Origins [edit]. Edwin Hawkinsâ gospel style arrangement of the hymn Oh, Happy Day has a long pedigree: It began as a hymn written in the mid-18th century (O happy day, that fixed my choice) by English clergyman Philip Doddridge (based on Acts 8:35) set to an earlier melody (1704) by J. A. Freylinghausen.