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The methylenetetrahydrofolate reductase (MTHFR) mutation test is used to detect two relatively common mutations in the MTHFR gene that are associated with elevated levels of homocysteine in the blood. It is not routinely ordered.
If you suffer from any of the following symptoms or if there is a family history of any of these health concerns, it may be worth doing the MTHFR test: 1  Depression. 2  Insomnia. 3  Family history of dementia. 4  Alcoholism. 5  Long-term use of birth control pills.