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How to Take PRISTIQ. Most people start with a once-daily 50-mg dose of PRISTIQ (taken with or without food). Your doctor may keep you on your starting dose throughout your treatment.Talk to your doctor about any health conditions you may have, as your dose might be affected.PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.our doctor may keep you on your starting dose throughout your treatment. Talk to your doctor about any health conditions you may have, as your dose might be affected. PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.
I expierenced a lot of irritability with pristiq alone. I have started taking pristiq (50 mg.) 3 weeks ago and hadn't noticed anything but side effects like nausea that have pretty much subsided. I am also on 300 mg. wellbutrin, which I have taken for several years.osted. For the last 2 weeks, I have been taking 50 mg of Pristiq in the morning along with 300 mg of Wellbutrin XL. I had that energized feeling the first few days I started with the Pristiq, but it is gone now.