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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Causes of Piriformis Syndrome. Piriformis syndrome is caused by overuse of the piriformis muscle in the buttocks. Tight adductor muscles on the inside of the thigh exacerbate piriformis muscle inflammation and accompanying bursitis.iriformis Syndrome: Related Medical Conditions. To research the causes of Piriformis Syndrome, consider researching the causes of these these diseases that may be similar, or associated with Piriformis Syndrome: 1  Sciatica. 2  Neuropathy. 3  Overuse injury. 4  NSAIDs. 5  Physical therapy. 6  Osteopathic manipulative medicine.