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Medicines and Drugs that can Destroy Your Teeth. There are some medications, such as the antibiotics tetracycline, that may result in internal staining of the teeth. The production and use of methamphetamines, which is a strong stimulant drug, is an increasing problem in the United States.
There are also some medications such a heart drugs and antidepressants that may reduce the flow of saliva in your mouth. Because saliva protects your gums and teeth from infection, a lack of it increases the risk of gum disease. There are some medications, such as the antibiotics tetracycline, that may result in internal staining of the teeth. Depending on the age of the user, other drugs can also cause staining.