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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
1 Heart attack. 2  Taking L-arginine does not seem to help prevent a heart attack. 3  It also does not seem to be beneficial for treating a heart attack after it has occurred. 4  In fact, there is concern that L-arginine might be harmful for people after a recent heart attack.