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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
A person with piriformis syndrome can have any or all of the following symptoms: 1  Pain, numbness, burning, or tingling in the buttocks, that may radiate down the back of the thigh into the calf and foot regions. 2  Pain and symptoms are aggravated by sitting, particularly sitting with the one leg crossed over the other.