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nodule - (mineralogy) a small rounded lump of mineral substance (usually harder than the surrounding rock or sediment) mineralogy - the branch of geology that studies minerals: their structure and properties and the ways of distinguishing them.
From Wikipedia, the free encyclopedia. A rheumatoid nodule is a local swelling or tissue lump, usually rather firm to touch, like an unripe fruit, which occurs almost exclusively in association with rheumatoid arthritis.Very rarely rheumatoid nodules occur as ' rheumatoid nodulosis ' in the absence of arthritis.They are usually subcutaneous especially over bony prominences such as the tip of the elbow or olecranon or over the finger knuckles. Less commonly they occur in the lining of the lung and other internal organs.odules vary in size from that of a lentil or pea to that of a mandarin orange. Quite often they are associated with synovial pockets or bursae. About 5% of rheumatoid arthritis patients have such nodules within 2 years of disease onset, and the cumulative prevalence is about 25%.