Changes with Age. In most cases, a person's normal respiratory rate will change with age; younger adults, children, and babies will typically have faster respiratory rates, because as people age, their breathing usually slows down.
Modic changes are pathological changes in the bones of the spine, the vertebrae. These changes are situated in both the body of the vertebrae and in the end plate of the neighboring disc.
Minimal clinicall important change (MCIC) is defined as the minimal change in the score that is meaningful for patients [1â12]. Different approaches can be used to determine MCIC. One is to estimate the mean change in score in patients who actually report to have improved (referred to as mean change score, or MCS).