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Sudafed (pseudoephedrine) and other decongestants can cause erectile dysfunction (ED) in some men. If you are having trouble getting or maintaining an erection while taking Sudafed, your doctor or pharmacist can recommend a different medication.
Ephedrine and Pseudoephedrine. Ephedrine and pseudoephedrine are closely related drugs with actions and side effects similar to the hormone epinephrine (adrenaline). Ephedrine, available in prescription and nonprescription strengths, is sometimes used to dilate bronchi, making it easier for people with asthma to breathe.