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But the bottom line is that long-term, heavy cannabis use may impair the dopaminergic system, which could have a variety of negative effects on learning and behavior.. You might also like: Young Marijuana Users Show a Unique Response to Social Rejection, Study Finds.
Marijuana overactivates parts of the brain that contain the highest number of these receptors. This causes the high that users feel. Other effects include: 1  altered senses (for example, seeing brighter colors). 2  altered sense of time.