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Side Effects of L-arginine Hydrochloride For most people, taking L-arginine hydrochloride is thought to be relatively safe. Possible side effects of using L-arginine HCL capsules or powder include bloating, diarrhea, abdominal pain, gout, abnormalities in blood circulation, low blood pressure, inflammation of the lungs and airways, allergies and worsening of asthma symptoms. High-doses of L-arginine may be potentially fatal in children.
1 Heart attack. 2  Taking L-arginine does not seem to help prevent a heart attack. 3  It also does not seem to be beneficial for treating a heart attack after it has occurred. 4  In fact, there is concern that L-arginine might be harmful for people after a recent heart attack.