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Causes. Ischemic cardiomyopathy is weakness in the muscle of the heart due to coronary artery disease. Individuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.ndividuals with ischemic cardiomyopathy typically have a history of myocardial infarction (heart attack). Nonischemic cardiomyopathy is weakness in the muscle of the heart that is not due to coronary artery disease.
Some of the potential signs and symptoms of ischemic cardiomyopathy include: 1  Angina, which is chest pain that occurs as a result of a heart problem. 2  Dyspnea, or shortness of breath or difficulty breathing. 3  Edema, or swelling of the tissues (namely in the legs/feet in this particular case)  Syncope, or fainting.