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How to Take PRISTIQ. Most people start with a once-daily 50-mg dose of PRISTIQ (taken with or without food). Your doctor may keep you on your starting dose throughout your treatment.Talk to your doctor about any health conditions you may have, as your dose might be affected.PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.our doctor may keep you on your starting dose throughout your treatment. Talk to your doctor about any health conditions you may have, as your dose might be affected. PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.
What is PRISTIQ? PRISTIQÂ® (desvenlafaxine) is FDA approved to treat depression. It has been prescribed to 2.5 million patients since 2008.* In clinical studies, PRISTIQ 50 mg also helped improve patientsâ ability to function according to a scaleâ  used to measure how depression disrupts the following areas: Work.