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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
1. : cause, origin; specifically: the cause of a disease or abnormal condition. 2. : a branch of knowledge concerned with causes; specifically: a branch of medical science concerned with the causes and origins of diseases. See etiology defined for kids.