When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Likewise, I also found that my local Target had the best price on the Lantus vial. The expiration date on an open vial or pen is 28 days from initial use. However, when treated carefully (stored in the fridge, not shaken or rolled, no air or Lantus injected back in), it can last considerably longer than that.