When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Approximately 60 days prior to the expiration of your DEA registration, a renewal packet will be sent to you at the address indicated on your current registration. Remember these tips to help your renewal go smoothly: Whenever you move, you must submit a change of address to the DEA.