In 1841 and 1842, the first two years of the Trail's use by emigrant parties, the overland route ended at Fort Walla Walla, at the mouth of the Walla Walla River. From there, emigrants rafted their wagons down the Columbia River to the Willamette River Valley.
I have been an insulin dependent diabetic for 20 years. I had my first ever cortison injection for a worn out knee. For 5 days after the injection my blood sugar levels ran between 450 and 600. No matter how much fast acting insulin I took, it would not go down.
The trigger finger came back after 1 year, and I had another shot. Other than the cramps, the finger has been fine for 2 years now. Each cortisone shot gave me 6 months of dizziness, and permanent leg cramps that were getting more severe and frequent. The dizziness want away but not the leg cramps. When I was in my 40s, these injections for sports injuries did not bother me.