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Signs of physical and emotional exhaustion: 1  Chronic fatigue. 2  Insomnia. 3  Forgetfulness/impaired concentration and attention. 4  Physical symptoms. 5  Increased illness. 6  Loss of appetite. 7  Anxiety. 8  Depression. 9  Anger.
Unrelenting exhaustion may be a sign of a condition or an effect of the drugs or therapies used to treat it, such as: Acute liver failure. Anemia. Anxiety. Cancer. Chronic fatigue syndrome. Chronic infection or inflammation. Chronic kidney disease.