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Overview. 1  Quinine, a bitter tasting powder made from the bark of the cinchona tree, is known mainly for its use in malaria treatment. 2  Tonic water, a bitter liquid sometimes used as a mix for alcoholic drinks, contains only a small amount of quinine compared to quinine medications.
Quinine is only approved for the treatment of malaria. Tonic water contains quinine but it does not have enough quinine to help with leg cramps. Common side effects associated with quinine can include headache, nausea, diarrhea, vomiting, hives, fever, ringing in the ears, vision problems, and bleeding problems.