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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
Making the world better, one answer at a time. The most common cause of melanosis coli is an extended use of laxatives. This condition is basically a disorder in the pigmentation of the wall of the colon.aking the world better, one answer at a time. The most common cause of melanosis coli is an extended use of laxatives. This condition is basically a disorder in the pigmentation of the wall of the colon.