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Sudafed (pseudoephedrine) and other decongestants can cause erectile dysfunction (ED) in some men. If you are having trouble getting or maintaining an erection while taking Sudafed, your doctor or pharmacist can recommend a different medication.
Up to 60 percent of people taking SSRIs may experience ED, according to Medscape. Though itâs unclear how it causes ED, experts suspect it relates to the way the drugs influence function of the neurotransmitters serotonin, norepinephrine, and dopamine, all of which relate to feelings of well-being.