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The mononuclear phagocyte system constitutes macrophage cells spread throughout the human body. The macrophages are long-lived cells that provide a major defense system against hostile elements through phagocytosis and subsequent intracellular destruction of the particle or cell.
Agranulocytes are white blood cells that hove no distinct granules in their cytoplasm. Lymphocytes have large single nuclei that occupy most of the cells. They are an important part of the body's immune system. Monocytes are the largest of the white blood cells. They have large pleomorphic (variously shaped) single nuclei and function mainly as phagocytic (engulfing) cells. They are important in the long-term cleanup of debris in an area of injury.