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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
Disease. A disease is an abnormal state in the human body, psyche or the interpersonal negotiations, which causes greater levels of morbidity and mortality. It is usually associated with symptoms and signs. The disease may be caused by congenital, traumatic, toxic, infectious, inflammatory, neoplastic, metabolic, degenerative, iatrogenic, vascular, etc. One of the most common causes is the infective organisms, which include bacteria, fungi, parasites and viruses. Metabolic causes, give rise to a set of the most common present day diseases, namely diabetes mellitus.