When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
Best Answer: They expire on your birthday, if you look at your renewal slip there is a fee for renewing after your birthday. We use to get to the end of your birth month but about 4 years ago that got changed, it was a way for the state to get a little more money out of us. Source(s): MI resident, just renewed plates.