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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Medline Plus also notes that L-arginine is possibly effective for the chest pain associated with coronary artery disease -- although it does not improve heart disease itself -- erectile dysfunction, cramping in the legs associated with atherosclerosis, heart attack and increased gestational blood pressure.nce in the body, L-arginine is converted into another chemical, known as nitric oxide, which can improve blood flow and stimulate the release of certain hormones, including insulin and growth hormone.