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The mononuclear phagocyte system constitutes macrophage cells spread throughout the human body. The macrophages are long-lived cells that provide a major defense system against hostile elements through phagocytosis and subsequent intracellular destruction of the particle or cell.
Antinuclear antibodies (ANA) are a group of antibodies produced by a person's immune system when it fails to adequately distinguish between self and nonself. These antibodies, known as autoantibodies, attack the body's own healthy cells and cause signs and symptoms such as tissue and organ inflammation, joint and muscle pain, and fatigue. ANA specifically target substances found in the nucleus of a cell, hence the name antinuclear.