When incompatible blood is given, antibodies and complement in the recipient plasma attack the antigens on the donor RBC. Hemolysis ensues The antigen-antibody complex activate the Hageman factor (factor XII), which acts on the kinin system to produce bradykinin
Still it is not advisable to take it after the expiry date written on the bottle. This is just for your information to let you know that you are safe. Anyway Saline Nasal spray is not going to do any harm even if you used an expired one. So forget about it.
In short yes they do expire. The timing varies depending on the manufacturer. If the pack appears yellow in color most likely it will not work to its original standards. It â¦may not get as cold or may not stay cold for as long. The further from white the color is the less it is going to work properly.