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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Piriformis syndrome is an uncommon neuromuscular disorder caused by the compression or irritation of the sciatic nerve by the piriformis muscle. It results in pain in the buttocks and the leg and it is an unusual cause of sciatica.It is often misdiagnosed or unrecognised in patients with lower back pain.ommon causes of piriformis syndrome include: 1  Long-distance walking or running (overuse of the piriformis muscle). 2  Direct compression of the piriformis muscle (repetitive trauma). 3  Direct trauma to the buttocks resulting in sciatic nerve compression.