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The mononuclear phagocyte system constitutes macrophage cells spread throughout the human body. The macrophages are long-lived cells that provide a major defense system against hostile elements through phagocytosis and subsequent intracellular destruction of the particle or cell.
Medical Definition of MONONUCLEAR PHAGOCYTE SYSTEM. : a system of cells comprising all free and fixed phagocytes and especially macrophages together with their ancestral cells including monocytes and their precursors in the bone marrowâcompare reticuloendothelial system.efinition of MONONUCLEAR PHAGOCYTE SYSTEM. : a system of cells comprising all free and fixed phagocytes together with their ancestral cells including monocytes and their precursors in the bone marrow âcalled also reticuloendothelial system. ADVERTISEMENT.