The MDMA metabolite, S-(+)- MDA, elicits more stereotypic behavior and is an even more potent neurotoxin than the parent drug. MDA destroys serotonin-producing neurons which play a direct role in regulating aggression, mood, sexual activity, sleep, and sensitivity to pain.
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As much as possible, encourage the person with dementia to adhere to a regular routine of meals, waking up and going to bed. This will allow for more restful sleep at night. Avoid stimulants and big dinners. Avoid nicotine and alcohol, and restrict sweets and caffeine consumption to the morning hours.