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Signs of physical and emotional exhaustion: 1  Chronic fatigue. 2  Insomnia. 3  Forgetfulness/impaired concentration and attention. 4  Physical symptoms. 5  Increased illness. 6  Loss of appetite. 7  Anxiety. 8  Depression. 9  Anger.
Medical causes â unrelenting exhaustion may be a sign of an underlying illness, such as a thyroid disorder, heart disease or diabetes. Lifestyle-related causes â alcohol or drugs or lack of regular exercise can lead to feelings of fatigue. Workplace-related causes â workplace stress can lead to feelings of fatigue. Emotional concerns and stress â fatigue is a common symptom of mental health problems, such as depression and grief, and may be accompanied by other signs and symptoms, including irritability and lack of motivation.