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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
The Side Effects Of This Amino Acid. There seem to be, for now, no key side effects of L-lysine. However, excessive amounts can trigger the forming of gallstones, as well as an increase of the level of triglycerides and cholesterol. Also, doses above 40 grams per day can produce cramps, nausea, diarrhea and stomach pain.