anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
6 mMol/L which is very significant given that in vivo serum lactic acid levels above 4 mmol/L are associated with 11% survival in ICU patients if persistent for 24 hours, and the potential complications of a hemolytic transfusion reaction superimposed on severe lactic acidosis would most likely ensure death.