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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Other L-arginine benefits include: 1  fighting inflammation. 2  lowering risk for arteriosclerosis and heart attack. 3  repairing blood vessels. 4  fighting congestive heart failure (CHF) and coronary artery disease. 5  helping lower high blood pressure. 6  improving athletic performance. 7  increasing immune function.