Changes with Age. In most cases, a person's normal respiratory rate will change with age; younger adults, children, and babies will typically have faster respiratory rates, because as people age, their breathing usually slows down.
Modic changes are pathological changes in the bones of the spine, the vertebrae. These changes are situated in both the body of the vertebrae and in the end plate of the neighboring disc.
In Modic type 1 there is vascular development in the vertebral body, with findings of inflammation and edema, but no trabecular damage or marrow changes. In Modic type 2 there are changes in bone marrow, with fatty replacement of formerly red, cellular marrow normally seen there.