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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Typical piriformis syndrome symptoms may include: 1  A dull ache in the buttock. 2  Pain down the back of the thigh, calf and foot (sciatica) 3  Pain when walking up stairs or inclines. 4  Increased pain after prolonged sitting. 5  Reduced range of motion of the hip joint.