By Carolyn L. Driedger and William E. Scott, USGS -- Republished from USGS fact sheet 2008-3062. 1  Mount Rainier: The flat floor of the Puyallup River valley near Orting, Washington, is formed by deposits of the 500-year-old Electron lahar, which surged down from Mount Rainier (in background).
Substitution mutation. Definition. A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.Supplement.n transversion, purine is substituted with pyrimidine or a pyrimidine with a purine. See also: point mutation. Please contribute to this project, if you have more information about this term feel free to edit this page. This page was last modified on 16 October 2008, at 00:53.This page has been accessed 109,894 times.
1 For example, sickle cell anemia is caused by a substitution in the beta-hemoglobin gene, which alters a single amino acid in the protein produced. 2  change a codon to one that encodes the same amino acid and causes no change in the protein produced. 3  These are called silent mutations.nowing a few basic types of mutations can help you understand why some mutations have major effects and some may have no effect at all. Substitution. A substitution is a mutation that exchanges one base for another (i.e., a change in a single chemical letter such as switching an A to a G).