22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
In live performances and acoustic versions of the Nick Cave song  Deanna  (1988), portions of Oh Happy Day are included, revealing the inspiration for Cave's song. George Harrison has stated the song was a primary inspiration in the writing of his 1970 international hit single  My Sweet Lord ..