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Signs of physical and emotional exhaustion: 1  Chronic fatigue. 2  Insomnia. 3  Forgetfulness/impaired concentration and attention. 4  Physical symptoms. 5  Increased illness. 6  Loss of appetite. 7  Anxiety. 8  Depression. 9  Anger.
Medical conditions. Unrelenting exhaustion may be a sign of a medical condition or underlying illness, such as: 1  Acute liver failure. 2  Anemia. 3  Cancer. 4  Chronic fatigue syndrome. 5  Chronic kidney disease. 6  COPD. 7  Emphysema. 8  Heart disease.