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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
After completing a thorough lab analysis of your recent colon biopsy, a specialized doctor called a. pathologist reported a diagnosis of melanosis coli, an abnormal discoloration of the lining of the. colon. Melanosis coli is not cancer, and does not appear to increase the risk of developing. colorectal cancer. About the Condition. The colon, or large intestine, is a tube lined with muscles that extracts moisture and nutrients from. food, storing the waste matter until it is expelled from the body.