In both sleep laboratory and outpatient studies, elderly patients with insomnia responded to a 5 mg dose with a reduced sleep latency, and thus 5 mg is the recommended dose in this population. During short-term treatment (14 night studies) of elderly patients with Sonata, no adverse event with a frequency of at least 1% occurred at a significantly higher rate with either 5 mg or 10 mg Sonata than with placebo.
As in all other cells, the resting potential of a pacemaker cell (-60mV to -70mV) is caused by a continuous outflow or leak of potassium ions through ion channel proteins in the membrane that surrounds the cells.hese cells form the atrioventricular node (or AV node), which is an area between the left atrium and the right ventricle within the atrial septum, will take over the pacemaker responsibility. The cells of the AV node normally discharge at about 40-60 beats per minute, and are called the secondary pacemaker.
** You may repeat the animation again if you wish by clicking on the autorhythmic cell again. Page 18. Summaryâ¢ Initiation of action potential in autorhythmic cells:1. Pacemaker Potential due to influx of sodium and reduced efflux of2.