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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
These syndromes, caused by inherited mutations, include xeroderma pigmentosum (XP), Bloom syndrome, Rothmund-Thomson syndrome, Werner syndrome, Muir-Torre syndrome, multiple self-healing squamous epitheliomata (Ferguson-Smith syndrome), dystrophic epidermolysis bullosa, junctional epidermolysis bullosa, epidermodysplasia verruciformis, Fanconi anemia, dyskeratosis congenita (Zinsser-Cole-Engman syndrome) and certain albinism syndromes.