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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Here are the walk away lessons from this piece on piriformis syndrome: 1  Piriformis syndrome is painful and can lead to nerve impingement which is never something to take lightly. 2  Piriformis syndrome is usually the result of some other dysfunction whether itâs a flexibility issue, a muscular imbalance, or a foot dysfunction.