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Biogenic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms. In food and beverages they are formed by the enzymes of raw material or are generated by microbial decarboxylation of amino acids.hey play an important role as source of nitrogen and precursor for the synthesis of hormones, alkaloids, nucleic acids, proteins, amines and food aroma components. However, food containing high amounts of biogenic amines may have toxicological effects.
Hundreds of different neurotransmitters exist in the brain, and they fall in different groups as well based on their chemical structure. The biogenic amines are the most understood group of neurotransmitters and include dopamine, serotonin, and norepinephrine.Each biogenic amine is made within a small region of the brain, but axons from the neurons in those areas of the brain disseminate these neurotransmitters widely throughout the brain. Depletion of serotonin (by other medications such as certain antihypertensives) can precipitate depression. 2  Patients who have successfully committed suicide by violent means have evidence for reduced serotonin levels in the central nervous system based on post-mortem analyses.