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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
L-arginine isn't recommended after a heart attack due to concerns that the supplement might increase the risk of death. L-arginine can worsen allergies or asthma. Use the supplement with caution if you have these conditions. Be careful about taking L-arginine if you've had cold sores or genital herpes.