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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
The pathogenesis of a disease is the mechanism by which an etiological factor causes the disease. The term can also be used to describe the development of the disease, such as acute, chronic and recurrent. The word comes from the Greek pathos, disease, and genesis, creation.