what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Yes you can take 800mg safely - as long as you aren't taking any other pain medications. And I believe it should be every 6-8hr for that amount of ibuprofin. You cannot MIX ibuprofin & Tylenol. This will damage your kidney's. Consult your doctor, and confirm this. It's ok to take 800mg of ibuprofin.