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In terms of cause and effect, a root cause is the cause of symptoms and a symptom stemming from a root cause is the effect of the root cause. There is no entity disease involved in cause and effect.
As can be expected from an organ responsible for getting blood throughout the body, the root of heart disease is when that blood flow is blocked. Heart disease, or cardiovascular disease, encompasses a range of conditions, including blood vessel diseases such as coronary artery disease, problems with heart rhythm (arrhythmias) and congenital heart defects, according to the Mayo Clinic. Coronary artery disease is the most common type of heart disease in the United States, according to the CDC.