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Malignant hypertension is a serious condition caused by very high blood pressure. It can quickly cause serious damage to eyes, kidneys and brain. Some of the changes can be reversed by treatment but some permanent damage may occur. Malignant means bad or evil.
Acute tubular necrosis is a kidney disorder involving damage to the tubule cells of the kidneys, which can lead to acute kidney failure. Causes. Acute tubular necrosis (ATN) is often caused by a lack of blood flow and oxygen to the kidney tissues (ischemia of the kidneys). It may also occur if the kidney cells are damaged by a poison or harmful substance.