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Freebase(0.00 / 0 votes)Rate this definition: Levothyroxine. Levothyroxine, also L-thyroxine or T4, is a synthetic form of the thyroid hormone thyroxine, which is normally secreted by the follicular cells of the thyroid gland. It is also used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer.
Thyroxine (3,5,3',5'-tetraiodothyronine) is produced by follicular cells of the thyroid gland. It is produced as the precursor thyroglobulin (this is not the same as TBG), which is cleaved by enzymes to produce active T 4. The steps in this process are as follows:hyroxine is produced by attaching iodine atoms to the ring structures of tyrosine molecules. Thyroxine (T 4) contains four iodine atoms. Triiodothyronine (T 3) is identical to T 4, but it has one less iodine atom per molecule.