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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
What are multi-drug resistant organisms? Multi-drug resistant organisms (MDRO) are common bacteria (germs) that have developed resistance to multiple types of antibiotics. These bacteria are present on the bodies of many people, including on the skin, in the nose or other moist areas of the body, and in secretions.