The plasma protein binding of diazepam and lidocaine was measured in patients with renal disease (those with uremia, nephrotic syndrome, or who had received a transplant) and in age-and sex-matched control subjects.hus, the binding of basic drugs may be increased or decreased in patients with renal disease, depending on the relative contribution of the individual plasma to the total binding and the type of disease. [PubMed-indexed for MEDLINE].
English Wikipedia - The Free Encyclopedia. Microglia are a type of glial cell that are the resident macrophages of the brain and spinal cord, and thus act as the first and main form of active immune defense in the central nervous system (CNS).
The embryonic origin of microglia is distinct from other types of neuroglia. Whereas other neuroglia are derived from an embryonic layer of tissue known as neuroectoderm, which gives rise to nervous tissue, microglia are derived from embryonic mesoderm, which gives rise to cells of the blood and immune system.