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The most common causes behind an inflamed pancreas are prolonged alcohol abuse and gallstones. Some hereditary disorders can cause pancreatitis, as can certain medications and viruses. When pancreatitis is caused by medication and viruses, it is usually an acute attack and rarely long-lived.
1 Gallstones and alcohol are common causes of acute pancreatitis. Other causes include high levels of fats in the blood, certain drugs, certain medical procedures, and some infections.  Chronic pancreatitis is inflammation that gets worse over time and leads to permanent damage in the pancreas. Heavy alcohol use is the most common cause. Other causes include heredity, cystic fibrosis, high levels of calcium or fats in the blood, certain medications, and some autoimmune conditions.