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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
Immediate release Ritalin, which contains the drug called methylphenidate, lasts for three to six hours, typically peaking at approximately two hours after dosing. According to the Family Practice Notebook, the length of time methylphenidate's effects last depend on the formulation in which it is delivered.