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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
The ideal frequency of dosing is also determined in the first several weeks. Ritalin's effects last about three to four hours. School lasts about six hours, and most children are awake for at least twelve. Yet many children do very well all day on just one dose of Ritalin, taken before they leave home in the morning.