Bruising or discoloration, Cold feet, Cold hands and Fatigue. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms bruising or discoloration, cold feet, cold hands and fatigue including Bruise or contusion, Raynaud phenomenon, and Hematoma.
The approximate blood volume of a rat is 55-70 ml/kg of body weight. For a 300 g rat this is equivalent to 17-21 ml (5). Single sample: Without fluid replacement, the maximum blood volume which can be safely removed for a one time sample is 10% of the total blood volume or 5.5-7 ml/kg.
An adult mouse has a circulating blood volume of about 1.5-2.5 ml (6-8% of the body weight), however in older and obese animals this may be lower. Up to 10% of the circulating blood volume may be taken on a single occasion from a normal healthy animal on an adequate plane of nutrition with minimal adverse effect.