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Over-the-counter oral antihistamines, such as diphenhydramine (Benadryl), cetirizine (Zyrtec), fexofenadine (Allegra) and loratadine (Claritin), typically don't work nearly as well for nonallergic rhinitis as they do for allergic rhinitis.
Treatment Overview. When you get immunotherapy in the form of allergy shots, your allergist or doctor injects small doses of substances that you are allergic to (allergens) under your skin. This helps your body get used to the allergen, which can result in fewer or less severe symptoms of allergic rhinitis.