Bruising or discoloration, Cold feet, Cold hands and Fatigue. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms bruising or discoloration, cold feet, cold hands and fatigue including Bruise or contusion, Raynaud phenomenon, and Hematoma.
The approximate blood volume of a rat is 55-70 ml/kg of body weight. For a 300 g rat this is equivalent to 17-21 ml (5). Single sample: Without fluid replacement, the maximum blood volume which can be safely removed for a one time sample is 10% of the total blood volume or 5.5-7 ml/kg.
In the rare case of simultaneous trials, the recommendation of 3% remains the maximum. The total volume of blood is estimated at 80 to 90 ml/kg body weight; 3% is 2.4 ml blood per kg body weight.. The guidelines on blood volume are usually based on the amount of blood in percentage of total blood volume (BLV).BLV varies depending on the age and body weight.ational Institute of Health Clinical Center has a guideline M95-9: Guidelines for Blood Drawn for Research Purposes in the Clinical Center, however, the guideline is only accessible for NIH internal use. Two articles from the web actually reflect the limit of blood volume in US.