The plasma protein binding of diazepam and lidocaine was measured in patients with renal disease (those with uremia, nephrotic syndrome, or who had received a transplant) and in age-and sex-matched control subjects.hus, the binding of basic drugs may be increased or decreased in patients with renal disease, depending on the relative contribution of the individual plasma to the total binding and the type of disease. [PubMed-indexed for MEDLINE].
English Wikipedia - The Free Encyclopedia. Microglia are a type of glial cell that are the resident macrophages of the brain and spinal cord, and thus act as the first and main form of active immune defense in the central nervous system (CNS).
Rat microglia As the brain matures, a group of resident immune cells called microglia crawl between the growing neurons and engulf invading microbes or damaged cells. They are also thought to pluck off some of the synapses that connect different neurons. This destructive act is important for the developing brain. The microglia prune away weak or unwanted connections, allowing more productive ones to become stronger.