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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
Overview. Thrombocytopenia, the medical term for a low blood platelet count, occurs when blood platelets die faster than theyâre reproduced. According to the Mayo Clinic, a healthy count ranges between 150,000 and 450,000 platelets for every microliter of circulating blood.