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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
Steady-state mean Cmax and AUC of norquetiapine are about 21-27% and 46-56%, respectively of that observed for quetiapine. Elimination of quetiapine is mainly via hepatic metabolism. The mean-terminal half-life is approximately 7 hours for quetiapine and approximately 12 hours for norquetiapine within the clinical dose range. Steady-state concentrations are expected to be achieved within two days of dosing. Seroquel XR is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P450 enzymes. Absorption Quetiapine fumarate reaches peak plasma concentrations approximately 6 hours following administration.