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Protein-losing enteropathy: A condition in which there is excessive loss of plasma protein into the intestine. Protein-losing enteropathy can be due to a number of different causes including extensive ulceration of the intestine, intestinal lymphatic blockage, gluten enteropathy, and infiltration of leukemic cells into the intestinal wall. Last Editorial Review: 7/1/2016.
Gastrointestinal etiologies of PLE. There are two categories of gastrointestinal diseases that lead to PLEâthose with and those without mucosal erosions ( Table 1). Even without mucosal erosions, conditions that lead to surface epithelial cell loss or malabsorption can cause excess protein loss. The most common nonerosive gastrointestinal condition that may be complicated by the development of PLE is Menetrier's disease, also known as giant hypertrophic gastropathy.