Bruising or discoloration, Cold feet, Cold hands and Fatigue. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms bruising or discoloration, cold feet, cold hands and fatigue including Bruise or contusion, Raynaud phenomenon, and Hematoma.
The approximate blood volume of a rat is 55-70 ml/kg of body weight. For a 300 g rat this is equivalent to 17-21 ml (5). Single sample: Without fluid replacement, the maximum blood volume which can be safely removed for a one time sample is 10% of the total blood volume or 5.5-7 ml/kg.
If sampling will occur every 2 weeks, up to 10% of the total blood volume may be drawn or 5.5-7 ml/kg (4). For a 300 g rat, this is equivalent to about 1.7-2.1 ml every 2 weeks. For repeated blood collection, fluid replacement does not allow for a larger blood volume or more frequent blood collection.