1 Pour over Tuna Steaks and marinade 20 minutes, turning occasionally. 2  Make sure grill is hot â place steaks in hottest section and Sear steaks 1 to 2 minutes per side to seal in the juices. 3  Finish cooking just slightly away from the hottest area â 8 to 10 minutes per inch of thickness.
The FcRI complex forms a high-affinity cell-surface receptor for the Fc region of antigen-specific immunoglobulin E (IgE) molecules. FcRI is multimeric and is a member of a family of related antigen/Fc receptors which have conserved structural features and similar roles in initiating intracellular signalling cascades.
B cells initially produce IgM , but can do class switch to IgA (in the mucus membranes) or IgE, which happens to people more prone to allergies. IgE accumulates and attach by the Fc portion to receptors on mast cells and basophils. There antigen binding sites bind to antigens causing reactions.