1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
In an attempt to further decrease restenosis in the vessel, stents containing a drug (e.g., sirolimus or paclitaxel) that is emitted over a few days to a few weeks are now being used. After implantation, the stent becomes covered with cells after two to three weeks, becoming a permanent part of the blood vessel wall.