1 Select the Triggers tab, and then select New. 2  Set your time and frequency, and then select OK. 3  Open Windows Defender by clicking the Start button. In the search box, type Defender and then, in the list of results, click Windows Defender.  Click Tools, and then click Options.
â Platelet refractoriness is the inability to get an adequate increase in platelet count after transfusion (Arch Pathol Lab Med 2003;127:409, Haematologica 2005;90:247) â Immune causes: anti-platelet or anti-HLA antibodies after multiple exposures from transfusion, pregnancy or transplantation (Transfusion 2005;45:761)
HLA alloantibodies do not cause thrombocytopenia, but are commonly associated with refractoriness to platelet transfusions. This test is designed to detect antibodies to platelet glycoproteins IIb/IIIa (HPA-1a/1b [PlA1 and PlA2], HPA-3a/3b, and HPA-4a), Ia/IIA (HPA-5a/5b), Ib/IX, and IV. In addition, this test will also detect antibodies to HLA Class I antigens (HLA-A-B).