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Protein-losing enteropathy: A condition in which there is excessive loss of plasma protein into the intestine. Protein-losing enteropathy can be due to a number of different causes including extensive ulceration of the intestine, intestinal lymphatic blockage, gluten enteropathy, and infiltration of leukemic cells into the intestinal wall. Last Editorial Review: 7/1/2016.
The most common cause of proteinuria is kidney damage resulting from: 1  Diabetes â proteinuria is one of the first signs of deteriorating kidney function in people with type 1 and 2 diabetes. 2  Hypertension â proteinuria in someone with high blood pressure is also a first sign of declining kidney function.