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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
The biological half life of a substance is the time it takes for a drug to lose half of its pharmacologic activity. This is significant because it affects how soon withdrawal symptoms may appear. The half life of Zyprexa is between 21 and 54 hours. Zyprexa is mainly metabolized through the P450 pathway in the liver and the enzymes primarily handling the metabolism is CYP1A2 and CYP2D6.