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Function. Because the lumen of the gastrointestinal tract is exposed to the external environment, much of it is populated with potentially pathogenic microorganisms. Peyer's patches thus establish their importance in the immune surveillance of the intestinal lumen and in facilitating the generation of the immune response within the mucosa.
Small collections of lymphatic tissue (Peyer patches) are embedded in the ileal wall, and specific receptors for bile salts and vitamin B12 are contained exclusively in its lining; about 95 percent of the conjugated bile salts in the intestinal contents is absorbed by the ileum.