1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
Paclitaxel - Side effects. 1  Common side effects include nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the hands or toes.