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Protein-losing enteropathy: A condition in which there is excessive loss of plasma protein into the intestine. Protein-losing enteropathy can be due to a number of different causes including extensive ulceration of the intestine, intestinal lymphatic blockage, gluten enteropathy, and infiltration of leukemic cells into the intestinal wall. Last Editorial Review: 7/1/2016.
Because protein digestion is expected to be largely dependent on enteropeptidase activity, enterokinase deficiency causes protein malabsorption during early infancy. However, for unknown reasons, protein digestion improves with time and can be adequate in the adult.