1 Pour over Tuna Steaks and marinade 20 minutes, turning occasionally. 2  Make sure grill is hot â place steaks in hottest section and Sear steaks 1 to 2 minutes per side to seal in the juices. 3  Finish cooking just slightly away from the hottest area â 8 to 10 minutes per inch of thickness.
The FcRI complex forms a high-affinity cell-surface receptor for the Fc region of antigen-specific immunoglobulin E (IgE) molecules. FcRI is multimeric and is a member of a family of related antigen/Fc receptors which have conserved structural features and similar roles in initiating intracellular signalling cascades.
IgE antibody secreted in response to (first exposure) an antigen coat to the FcÎµR1 receptors expressed on mast cells. This process is called sensitization. Sensitized mast cells will be activated by cross linking of the same antigen in subsequent exposure. Activated mast cells release granules (mediators)