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Yes, creatine levels can fluctuate. The levels of creatine in your body will change based on many factors, including diet, exercise, medications and overall stress levels. Creatine is a molecule found within the body, and is developed simply by the food that you consume. This food turns into energy as it metabolizes.
Creatinine is a waste product in your blood. It comes from protein in your diet and the normal breakdown of muscles of your body. Creatinine is removed from blood by the kidneys and then passes out of the body in your urine. If you have kidney disease, the level of creatinine in your blood increases. Blood (serum) and urine tests can check your creatinine levels.