More than 60 years later, the Normandy Invasion, or D-Day, remains the largest seaborne invasion in history, involving nearly three million troops crossing the English Channel from England to Normandy in occupied France.
The clinical heterogeneity observed in leptospirosis may be associated with host factors or bacteria virulence. Human serum mannose-binding lectin (MBL) recognizes many pathogens, and low levels of this lectin are associated with susceptibility to infection. MBL is also implicated in the modulation of the inflammatory process. We determined the levels of serum MBL during leptospirosis infection.
The protein binding of furosemide was investigated in plasma from 22 old and 11 young subjects by equilibrium dialysis.The unbound fraction of furosemide was 3.16% in plasma from the elderly and 1.71% in plasma from the young.A significant correlation was found between the unbound fraction of furosemide and the plasma concentration of albumin. The average number of binding sites was 3.8 (elderly) and 2.7 (young) 10 â6 mol/g albumin.The average association constant (K) was 4.3 (elderly) and 4.2 (young) 10 5 M â1. significant correlation was found between the unbound fraction of furosemide and the plasma concentration of albumin. The average number of binding sites was 3.8 (elderly) and 2.7 (young) 10 â6 mol/g albumin. The average association constant (K) was 4.3 (elderly) and 4.2 (young) 10 5 M â1.