Pancreatic cancer typically does not cause symptoms until it has grown, so it is most frequently diagnosed in advanced stages rather than early in the course of the disease. In some cases, jaundice (a yellowish discoloration of the skin and whites of the eyes) without pain can be an early sign of pancreatic cancer. Other symptoms that can occur with more advanced disease are nausea, vomiting, weight loss, itching skin, and decreased appetite. Pale stools, back pain, abdominal pain, dark urine, abdominal bloating, diarrhea, and enlarged lymph nodes in the neck can be present as well. Medically Reviewed by a Doctor on 5/14/2014.
Pepsin is synthesized in an inactive form by the stomach lining; hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity ( pH 1-3) for pepsin function.
For instance, digestive enzymes which hydrolyze proteins are made as zymogens in the stomach and pancreas, in which pepsinogen is the inactive precursor (zymogen) and pepsin is the activated form of the enzyme. Another example is seen in blood clotting which is carried out by a cascade of proteolytic activations.ommon uses in Biological Systems [edit]. Digestive enzymes are activated in the stomach and pancreas using this methodology. They are synthesized first as zymogens. Pepsinogen is the inactive protein which is initially transcribed.