Receptor proteins are located in the cytoplasm, cell membrane, or nuclear membrane. 1. Cytoplasmic receptor proteins include those that respond to steroid hormones. Ligand activated receptors may enter the cell nucleus where they modulate gene expression. 2.Receptors within cell membranes may be peripheral or trans-membrane proteins. Many receptors for hormones and neurotransmission are trans-membrane proteins._ a. Metabotropic receptors are coupled to G proteins, acting through various secondary pathways involving ion channels, enzymes such as adenylyl (adenylate) cyclases, and phospolipases, or PDZ domains.any receptors for hormones and neurotransmission are trans-membrane proteins. _ a. Metabotropic receptors are coupled to G proteins, acting through various secondary pathways involving ion channels, enzymes such as adenylyl (adenylate) cyclases, and phospolipases, or PDZ domains.
It might seem strange that lenders use gross income instead of net income when determining whether borrowers can afford a mortgage loan. After all, net income is the actual amount of money you bring home each month. But lenders use gross income when qualifying individuals because this is a figure that most consumers readily know. If you make a salary of $72,000 a year, you quickly know that your gross monthly income is $6,000. You might not be able to quickly figure your net income, unless you have your paycheck stub in front of you. Your gross income is also stable, while your net income could change from month to month.
Most lenders and loan programs require a borrower to have two years of work history and income and also they will average the two years. $60,000 + $73,500 = $133,500. The average income is $66,750. The monthly mortgage payment would be no more than $1724.38.