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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
The Ritalin brand also comes in a formulation that has a duration of eight hours, utilizing biphasic release to make 50 percent of the drug available immediately and 50 percent available through modified release beads. Other brands, such as Concerta, last for up to 12 hours.