1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
Etanercept also binds and inhibits the action of TNF-Î±, but is not a monoclonal antibody (it is instead a fusion of TNF-receptor and an antibody constant region). Infliximab is administered by intravenous infusion, typically at six-to eight-week intervals, at a clinic or hospital.NF-Î± is a chemical messenger (cytokine) and a key part of the autoimmune reaction. In rheumatoid arthritis, infliximab seems to work by preventing TNF-Î± from binding to its receptor in the cell.