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keratin filaments. Definitions: 1. a class of intermediate filaments that form a network within epithelial cells and anchor to desmosomes, thus imparting tensile strength to the tissue. Synonyms: cytokeratin filaments. The definition information for keratin filaments is provided by Stedman's.
An effective epidermal barrier requires intricate organization and formation of the keratin intermediate filaments. Filaggrin (FLG) is a keratin filament-associated protein necessary for organization of the keratin intermediate filaments. It comes from profilaggrin in the keratohyalin bodies of the granular layer.