Receptor proteins are located in the cytoplasm, cell membrane, or nuclear membrane. 1. Cytoplasmic receptor proteins include those that respond to steroid hormones. Ligand activated receptors may enter the cell nucleus where they modulate gene expression. 2.Receptors within cell membranes may be peripheral or trans-membrane proteins. Many receptors for hormones and neurotransmission are trans-membrane proteins._ a. Metabotropic receptors are coupled to G proteins, acting through various secondary pathways involving ion channels, enzymes such as adenylyl (adenylate) cyclases, and phospolipases, or PDZ domains.any receptors for hormones and neurotransmission are trans-membrane proteins. _ a. Metabotropic receptors are coupled to G proteins, acting through various secondary pathways involving ion channels, enzymes such as adenylyl (adenylate) cyclases, and phospolipases, or PDZ domains.
It might seem strange that lenders use gross income instead of net income when determining whether borrowers can afford a mortgage loan. After all, net income is the actual amount of money you bring home each month. But lenders use gross income when qualifying individuals because this is a figure that most consumers readily know. If you make a salary of $72,000 a year, you quickly know that your gross monthly income is $6,000. You might not be able to quickly figure your net income, unless you have your paycheck stub in front of you. Your gross income is also stable, while your net income could change from month to month.
So, if your target mortgage payment is $2,000 per month and you have consumer debts of $300 per month, you will need $6,388 gross monthly income to offset your housing expenses and consumer obligations.arget mortgage payment + consumer debts Ã· .36 = Gross monthly income needed to qualify. Most lenders limit your debt-to-income ratio (how much of your monthly income pays debt) to between 36 percent and 45 percent.