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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
The platelets aggregate at the site of injury and release other factors that stimulate clot formation. Causes. Bone marrow production of platelets or those that increase platelet destruction in the blood and/or spleen can cause a low platelet count. Thrombocytopenia is a common manifestation of cancer, because sometimes the cancer and drugs used to treat the cancer affect platelet production in the bone marrow.