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You can alternate Tylenol and Ibuprofen as a pain medicine or anti inflammatory because Ibuprofen is metabolized by the kidneys and Acetamenophen is metabolized by the liver.So neither of the organs is overtaxed by overuse. You can take 2800mg of Tylenol daily and 3200mg of Advil daily, so do not exceed those doses.Do not take Advil and Aleve because both of those meds are metabolized by the kidneys. Advil contains Ibuprofen and Aleve contains Naproxen sodium.Both considered NSAID's (non-steroidal anti inflammatory drugs) as well as Acetamenophen (tylenol) .ou can take 2800mg of Tylenol daily and 3200mg of Advil daily, so do not exceed those doses. Do not take Advil and Aleve because both of those meds are metabolized by the kidneys. Advil contains Ibuprofen and Aleve contains Naproxen sodium.
Report Abuse. No problem. Both are NSAID pain relievers, so you can't take the maximum dose of each at the same time-this would be an overdose. If you plan to wait 9 hours between Aleve and ibuprofen, you'll be fine-in fact you could wait just 4-6 hours and you'd still be fine.hey are both anti-inflammatories. You cannot and should not mix them. As a pharmacist I can advise you that ibuprofen adult dose is 400mg tds (three times daily)...ie it lasts 8 hours. Naproxen dosing can be three times daily or once daily depending on the dose.