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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
When not enough platelets are made, the platelet count in your blood is too low. Chemotherapy and some radiation therapy can cause this temporarily. These cancer treatments can slow the production of platelets in the bone marrow. Another cause of a low platelet count is cancer of the bone marrow.