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Dictionary entry overview: What does hopelessness mean? â¢ HOPELESSNESS (noun) The noun HOPELESSNESS has 1 sense: 1. the despair you feel when you have abandoned hope of comfort or success Familiarity information: HOPELESSNESS used as a noun is very rare.
A constant sense of hopelessness and despair is a sign you may have major depression, also known as clinical depression. With major depression, it may be difficult to work, study, sleep, eat, and enjoy friends and activities.