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Dictionary entry overview: What does hopelessness mean? â¢ HOPELESSNESS (noun) The noun HOPELESSNESS has 1 sense: 1. the despair you feel when you have abandoned hope of comfort or success Familiarity information: HOPELESSNESS used as a noun is very rare.
feeling or showing profound hopelessness, dejection, discouragement, or gloom: despondent about failing health. Origin of despondent. Latin.