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Key points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.ey points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.
A. Epithelium. Epithelium lines both the outside (skin) and the inside cavities and lumen of bodies such as the skin, the airways, and the digestive tract. Many glands are also formed from epithelial tissue. It serves functions of protection, secretion, and absorption, and is separated from other tissues.