Conversely, if these conditions are not met, vision can be very poor and unreliable. An eyewitness observation should be evaluated by an expert and its validity assessed. Environmental conditions that limit vision include: low lighting, movement, time constraints, distance, eye disease and other factors.
What is Jakafi? Jakafi (ruxolitinib) works by blocking certain enzymes in the body that affect blood cell production. Jakafi is used to treat myelofibrosis or polycythemia vera, which are bone marrow disorders that affect your body's ability to produce blood cells. Jakafi may also be used for purposes not listed in this medication guide.
JAK2 mutations are acquired as opposed to inherited and result in the change of a single DNA nucleotide base pair, called a point mutation. This change results in a JAK2 protein that is constantly on, leading to uncontrolled blood cell growth.