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Rating Newest Oldest. Best Answer: Denaturation is a process in which proteins or nucleic acids lose their structure by application of some external stress or compound. If proteins in a living cell are denatured, this results in disruption of cell activity and possibly cell death. Source(s): http://en.wikipedia.org/wiki/Denaturatio...
Note 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents.