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At the end of this, Kelly will have a total of 522 days in space (adding on a day for accumlated hours spent), which will beat out Mike Fincke's total record of 382 days in space. Because he's been on a Hubble servicing mission, Kelly has also flown higher than a majority of astronauts since the Apollo era ended.
Padalka logged his own 365th day in orbit back in 2004 on what was just his second mission. Now set to fly on his fifth long-duration flight, he will become the new worldwide record holder for the most cumulative time in space when he completes his current mission, topping 900 days. [One-Year Space Station Mission: Full Coverage]