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Over-the-counter oral antihistamines, such as diphenhydramine (Benadryl), cetirizine (Zyrtec), fexofenadine (Allegra) and loratadine (Claritin), typically don't work nearly as well for nonallergic rhinitis as they do for allergic rhinitis.
The best way to reduce symptoms of allergic rhinitis is to prevent exposure to allergens. Drugs such as antihistamines, decongestants, and nasal corticosteroid sprays may help control allergy symptoms. Some complementary and alternative therapies may also be used to treat the symptoms.