Bruising or discoloration, Cold feet, Cold hands and Fatigue. WebMD Symptom Checker helps you find the most common medical conditions indicated by the symptoms bruising or discoloration, cold feet, cold hands and fatigue including Bruise or contusion, Raynaud phenomenon, and Hematoma.
The approximate blood volume of a rat is 55-70 ml/kg of body weight. For a 300 g rat this is equivalent to 17-21 ml (5). Single sample: Without fluid replacement, the maximum blood volume which can be safely removed for a one time sample is 10% of the total blood volume or 5.5-7 ml/kg.
In case repeated blood samples are required at short intervals, a maximum of 0.6 ml/kg/day or 1.0% of an animal's total blood volume can be removed every 24 hours. The estimated blood volume in adult animals is 55 to 70 ml/kg body weight.