1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
-IV: -EMERGENT LOADING DOSE: 15 to 20 mg/kg by slow IV infusion (to produce plasma concentrations of phenytoin within the generally accepted therapeutic range of 10 to 20 mcg/mL); infusion must be completed within 1 to 4 hours. Maximum rate: 1 to 3 mg/kg/min or 50 mg/min, whichever is slower.