Pancreatic cancer typically does not cause symptoms until it has grown, so it is most frequently diagnosed in advanced stages rather than early in the course of the disease. In some cases, jaundice (a yellowish discoloration of the skin and whites of the eyes) without pain can be an early sign of pancreatic cancer. Other symptoms that can occur with more advanced disease are nausea, vomiting, weight loss, itching skin, and decreased appetite. Pale stools, back pain, abdominal pain, dark urine, abdominal bloating, diarrhea, and enlarged lymph nodes in the neck can be present as well. Medically Reviewed by a Doctor on 5/14/2014.
Pepsin is synthesized in an inactive form by the stomach lining; hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity ( pH 1-3) for pepsin function.
Pepsinogen becomes pepsin when activated by the stomach's Hydrochloric acid. This protein digest proteins, it could not be produced nor stored in the body's cells in its activ â¦ e form because it would destroy the cell that made it. The cells protect themselves by producing and storing the enzyme in an inactivated form.epsinogen becomes pepsin when activated by the stomach's Hydrochloric acid. This protein digest proteins, it could not be produced nor stored in the body's cells in its activ â¦ e form because it would destroy the cell that made it. The cells protect themselves by producing and storing the enzyme in an inactivated form.