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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
For example, the half life of rescue inhalers like albuterol is in the 5 to 7 minute range while the half life of advair is 5 to 7 hours. A number of different things can affect the half life of a drug including age, gender, liver disease, kidney disease, and hydration.