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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary embolism occurs when there is a deep vein thrombosis in which there is a blood clot. The blood clot travels up into the lungs. Symptoms include shortness of breath, chest pain, and cough. Treatment for pulmonary embolism includes surgery and medication. A common drug class used to treat pulmonary embolism is the anticoagulants drug class.