1 Pour over Tuna Steaks and marinade 20 minutes, turning occasionally. 2  Make sure grill is hot â place steaks in hottest section and Sear steaks 1 to 2 minutes per side to seal in the juices. 3  Finish cooking just slightly away from the hottest area â 8 to 10 minutes per inch of thickness.
The FcRI complex forms a high-affinity cell-surface receptor for the Fc region of antigen-specific immunoglobulin E (IgE) molecules. FcRI is multimeric and is a member of a family of related antigen/Fc receptors which have conserved structural features and similar roles in initiating intracellular signalling cascades.
receptor present on the surface of mast cells, basophils and activated eosinophils that binds free IgE with very high affinity. large bone marrow derived cell resident in connective tissues throughout the body. These cells contain large granules that store a variety of chemical mediators including histamine. Mast cells have high affinity FceRI that bind free IgE. Antigen binding to IgE associated with mast cells triggers mast cell activation and degranulation, producing a local or systemic immediate hypersensitivity reaction.