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The peak levels and half life of Ritalin depend on the formulation. But with the immediate release version of Ritalin, methylphenidate reaches peak levels in the blood in about 2 hours. And methylphenidate from Ritalin tablets is eliminated from plasma with an average half-life of about 3.5 hours. As a comparison, in children the average half-life of methylphenidate is about 2.5 hours, with a range of about 1.5 â 5.0 hours.
For instance, fluoxetine - the antidepressant often known by the tradename Prozac - has a half-life of four to six days, which is why it can be given as a once-a-day tablet. Each dose tops up what has been metabolised away in the previous 24 hours.