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The stimulus energy must occur within the receptor's receptive field. The stimulus energy must match the specificity of the receptor. A generator potential in the associated sensory neuron must reach threshold. The stimulus energy must be converted into the energy of a graded potential. called a transduction potential.
The thalamus represents the main relay structure for sensory information destined to the cortex and, involved in the reception, integration, and transfer of the nociceptive potential. The different projections to its nuclei and from them to the cortex define the functional circuitry of pain processing [76].