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Protein-losing enteropathy: A condition in which there is excessive loss of plasma protein into the intestine. Protein-losing enteropathy can be due to a number of different causes including extensive ulceration of the intestine, intestinal lymphatic blockage, gluten enteropathy, and infiltration of leukemic cells into the intestinal wall. Last Editorial Review: 7/1/2016.
Edema. 1  Hypoalbuminemia from chronic protein malabsorption or from loss of protein into the intestinal lumen causes peripheral edema. 2  Extensive obstruction of the lymphatic system, as seen in intestinal lymphangiectasia, can cause protein loss. 3  With severe protein depletion, ascites may develop.