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Dictionary entry overview: What does hopelessness mean? â¢ HOPELESSNESS (noun) The noun HOPELESSNESS has 1 sense: 1. the despair you feel when you have abandoned hope of comfort or success Familiarity information: HOPELESSNESS used as a noun is very rare.
A constant sense of hopelessness and despair is a sign you may have major depression, also known as clinical depression. With major depression, it may be difficult to work, study, sleep, eat, and enjoy friends and activities. Some people have clinical depression only once in their life, while others have it several times in a lifetime.