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Key points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.ey points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.
The epithelium lining the intestine contains many goblet cells. The primary function of the Goblet Cell is to secrete Mucus, a slippery, viscous substance, rich in mucopolysaccharides, that serves to protect and lubricate the lining of the intestine.