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Dictionary entry overview: What does hopelessness mean? â¢ HOPELESSNESS (noun) The noun HOPELESSNESS has 1 sense: 1. the despair you feel when you have abandoned hope of comfort or success Familiarity information: HOPELESSNESS used as a noun is very rare.
1 Pessimism, or feeling a sense that life is hopeless, pointless and futile. This may even lead to a feeling of numbness. 2  Body pains, cramps, digestive problems, headaches, and other aches that don't go away with medication or treatment.  Being irritable or restless a great deal of the time.