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Key points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.ey points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.
The histology of the gastrointestinal tract is largely the histology of epithelial tissues. Be sure you are familiar with the basic properties of epithelial tissue. Mucosal epithelium of the GI tract is variously differentiated and specialized for the functions of digestive secretion and absorption.