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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
MDRO stands for Multi-Drug Resistant Organisms. Most types of bacteria can be treated with antibiotics. Over time, some types of bacteria have become resistant to certain antibiotics. This means the antibiotic does not work to treat the bacteria. Another antibiotic will need to be used to treat the bacteria.