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Key points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.ey points. 1  Intestinal epithelial cells (IECs) provide a physical and biochemical barrier that segregates host tissue and commensal bacteria to maintain intestinal homeostasis. 2  Secretory IECs support this function through the secretion of mucins and antimicrobial peptides.
Epithelial cells may be squamous, cuboidal, or columnar in shape and may be arranged in single or multiple layers. Simple cuboidal epithelium is found in glandular tissue and in the kidney tubules. Simple columnar epithelium lines the stomach and intestines.Pseudostratified columnar epithelium lines portions of the respiratory tract and some of the tubes of the male reproductive tract.hey form the covering of all body surfaces, line body cavities and hollow organs, and are the major tissue in glands. They perform a variety of functions that include protection, secretion, absorption, excretion, filtration, diffusion, and sensory reception.