What happens to your body when you use ice? by Nicola Garrett. Ice has been called the most dangerous and destructive drug of our time. But what exactly does it do to your body?
Definition. An inverse agonist is a molecule that binds to the same site as an agonist and is considered to be a full agonist. However, it elicits the opposite effect to that of a normal agonist, i.e.: demonstrates negative efficacy.n antagonist reduces the effect of an agonist by preventing it from binding to receptors. Both antagonists and inverse agonists reduce the activity if a receptor and, in the presence of an agonist, reduce its activity.
Naloxone on the other hand has no partial agonist effects, and is in fact a partial inverse agonist at mu opioid receptors, and so is the preferred antidote drug for treating opioid overdose.altrexone is also a partial inverse agonist, and this property is exploited in treatment of opioid addiction, as a sustained course of low-dose naltrexone can reverse the altered homeostasis which results from long-term abuse of opioid agonist drugs.