The rate and extend in which the amount of drug substance dissolved over a period of time is called dissolution. It is expressed as percentage release of drug substances present dosage forms such Tablets, Capsules, oral suspensions and ointments. In our present study dissolution method development for various kinds of tablets such as immediate release or instant release, modified, Extended release and Enteric coated.
pKa Definition: pK a is the negative base-10 logarithm of the acid dissociation constant of a solution.
â¢pKa tells you if a given molecule is going to either. give a proton to water at a certain pH, or remove a. proton. â¢A pKa of 2 for substance âXâ means that at a pH of 2, X is at its equilibrium point. â¢If the pH falls to 1, then X will accept a proton. because there are so darn many available (pH 1.