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The endocrine system is responsible for a number of disorders affecting the female reproduction system. Causes. Some conditions affecting female reproduction are caused by endocrine disorders. For example, many women with PCOS have insulin resistance, in which the body cannot use insulin efficiently. This leads to high circulating blood levels of insulin, called hyperinsulinemia.
The drug continued to be prescribed to pregnant women in Europe until 1978 (4). DES is now known to be an endocrine-disrupting chemical, one of a number of substances that interfere with the endocrine system to cause cancer, birth defects, and other developmental abnormalities. The effects of endocrine-disrupting chemicals are most severe when exposure occurs during fetal development.