The rate and extend in which the amount of drug substance dissolved over a period of time is called dissolution. It is expressed as percentage release of drug substances present dosage forms such Tablets, Capsules, oral suspensions and ointments. In our present study dissolution method development for various kinds of tablets such as immediate release or instant release, modified, Extended release and Enteric coated.
pKa Definition: pK a is the negative base-10 logarithm of the acid dissociation constant of a solution.
For an acidic solute with one pK a, the pK a is the number that denotes the pH at which half the molecules of the acid in aqueous solution exist in protonated form and are neutral, and half exist in deprotonated form and carry a negative charge. Base with one pKa.