citizen. noun citÂ·iÂ·zen \Ësi-tÉ-zÉn also-sÉn\. Tweet. : a person who legally belongs to a country and has the rights and protection of that country. : a person who lives in a particular place.itizen is preferred for one owing allegiance to a state in which sovereign power is retained by the people and sharing in the political rights of those people. subject implies allegiance to a personal sovereign such as a monarch.
People with PBC experience fatigue (80%) that leads to sleepiness during the daytime; more than half of those have severe fatigue. 20â70% have itching. Those with more severe disease may have jaundice (yellowing of the eyes and skin). PBC impairs bone density and there is an increased risk of fracture. Xanthelasma (skin lesions around the eyes) or other xanthoma may be present as a result of increased cholesterol levels.
Dexamethasone is currently the standard treatment for PBE, but is associated with debilitating side effects including vision problems, muscle and bone loss, impaired wound healing and opportunistic infections.