The rate and extend in which the amount of drug substance dissolved over a period of time is called dissolution. It is expressed as percentage release of drug substances present dosage forms such Tablets, Capsules, oral suspensions and ointments. In our present study dissolution method development for various kinds of tablets such as immediate release or instant release, modified, Extended release and Enteric coated.
pKa Definition: pK a is the negative base-10 logarithm of the acid dissociation constant of a solution.
pKa and Dissociation Equilibrium. 1. pH. When hydrochloric acid or other acid is added to water, the pH level decreases. The acidity of a solution is determined by its proton (hydrogen ion) concentration ([H+]), where pH provides a simple index for expressing the [H+] level.