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Santee, South Carolina. Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina of the United States. It has become a resort town of note located centrally north-south along the Atlantic Seaboard of South Carolina.
According to our research of South Carolina and other state lists there were 2 registered sex offenders living in Santee, South Carolina as of April 20, 2017. The ratio of number of residents in Santee to the number of sex offenders is 477 to 1. Nearest city with pop. 50,000+: Columbia, SC (48.0 miles , pop. 116,278).