The rate and extend in which the amount of drug substance dissolved over a period of time is called dissolution. It is expressed as percentage release of drug substances present dosage forms such Tablets, Capsules, oral suspensions and ointments. In our present study dissolution method development for various kinds of tablets such as immediate release or instant release, modified, Extended release and Enteric coated.
pKa Definition: pK a is the negative base-10 logarithm of the acid dissociation constant of a solution.
The pKa for binding of calcium ions by tetrabasic EGTA is 11.00, but the protonated forms do not significantly contribute to binding, so at pH 7, the apparent pKa becomes 6.91. See Qin et al. for an example of a pKa calculation.