The cause of Tay-Sachs disease is a genetic defect (mutation) that is passed from parent to child. This genetic defect is located in the HEXA gene, which is found on chromosome 15.The HEXA gene makes part of an enzyme called beta-hexosaminidase A, which plays a critical role in the nervous system.he cause of Tay-Sachs disease is a genetic defect (mutation) that is passed from parent to child. This genetic defect is located in the HEXA gene, which is found on chromosome 15.
A more common cause of bladder pain is urinary tract infection (UTI), which can also produce changes in urine color, difficulty urinating, and a feeling of fullness in the bladder. Sometimes these infections are âsilentâ and donât have any symptoms until they worsen significantly.
Infections. Urinary tract infections (UTIs) are one of the leading causes of painful urination. Infections can occur in any part of the urinary tract, including: 1  Kidneys. 2  Ureters (tubes that carry urine from the kidneys to the bladder).3  Bladder.4  Urethra (tube from the bladder that carries urine out of the body).rinary tract infections (UTIs) are one of the leading causes of painful urination. Infections can occur in any part of the urinary tract, including: 1  Kidneys. 2  Ureters (tubes that carry urine from the kidneys to the bladder).