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The usual dose of naproxen is 250 mg, 375 mg, or 500 mgâtwice a day in the morning and evening for conditions like rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis. Enteric-coated naproxen is usually taken in doses of 375 or 500 mg twice a day.
1 For naproxen sodium (e.g., AnaproxÂ®, AnaproxÂ® DS) tablet dosage form: 2  For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 3  AdultsâAt first, 275 or 550 milligrams (mg) two times a day, in the morning and evening. 4  Your doctor may increase the dose, if necessary, up to a total of 1500 mg per day. Some patients may need 1500 mg (taken as two 750 mg or three 500 mg tablets) per day, for a limited period. 2  However, the dose is usually not more than 1000 mg per day. 3  ChildrenâUse and dose must be determined by your doctor.