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Now, a contemporary doctor is making the case that she may not have been mentally ill at all, but may instead have suffered from pernicious anemia, a disease caused by a vitamin-B12 deficiency. Mary Todd Lincoln has always been a puzzling, polarizing figure.
Lincoln suffered depressed mood after major traumatic events, such as the death of Ann Rutledge in August 1835, the cessation of his (purported) engagement to Mary Todd Lincoln in January 1841 (after which several close associates feared Lincoln's suicide), and after the Second Battle of Bull Run.