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Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. Structure.
Saphris (asenapine) is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Saphris is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults, and for bipolar disorder in pediatric patients (ages 10â17). Saphris may also be used for purposes not listed in this medication guide. Saphris is not approved for use in psychotic conditions related to dementia. Asenapine may increase the risk of death in older adults with dementia-related conditions.