In this condition, the pupil is not centered in the iris. When the pupil is off just a bit, the dogs seem to cope well, but can have trouble when the condition is more pronounced. Microphthalmia, or an abnormally small eye, is the most common eye defect seen in homozygous merles. This can vary from just noticeable to appearing to have no eye at all (anophthalmia).
Children begin to develop hand dominance around 2-3 years and this should be well developed by age 5 and fully developed by age 6. Use of a dominant hand before 2-3 years time may occur because of abnormal fine motor development. It could also be the result of intracranial injury or injury to a limb with appropriate compensation by the other limb.
When partial dominance occurs, a range of phenotypes is usually observed among the offspring. Although the offspring may show a variety of phenotypes, each one will lie along a continuum bracketed by the homozygous parental phenotypes. In Figure 1, for example, neither flower color (red or white) is fully dominant.