Studies using single oral doses of metformin hydrochloride 500 mg to 1500 mg, and 850 mg to 2550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination.
The first all-steel windmill and tower was produced by the United States Wind Engine & Pump Co. The first electricity-generating wind turbine was invented in 1888 in Cleveland, Ohio by Charles F. Brush. The turbineâs diameter was 17 meters (50 feet), it had 144 rotor blades made of cedar wood, and it generated about 12 kilowatts (kW) of power.
The earliest known use of wind power, of course, is the sail boat, and this technology had an important impact on the later development of sail-type windmills. Ancient sailors understood lift and used it every day, even though they didn't have the physics to explain how or why it worked. The first windmills were developed to automate the tasks of grain-grinding and water-pumping and the earliest-known design is the vertical axis system developed in Persia about 500-900 A.D.