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This enzyme is called p450, and several diet supplements and herbs have reported effects on it. Depending on how these products interact with p450, using anti-HIV drugs with them could either raise or lower the blood levels of the anti-HIV drugs. Herbs with reported effects on p450 include St. John's Wort, garlic, ginseng, melatonin, milk thistle (silymarin), geniposide and skullcap. For more detailed information on St. John's Wort, read NIH Study Cautions Use of St. John's Wort with Anti-HIV drugs.
Other common âliver herbsâ include licorice root extract (glycyrrhizin), Phyllanthus, and the mixture of herbs used in traditional Indian medicine called Liv-52. As with milk thistle, lab studies suggest these herbs may have some liver-protective properties.But there are no good human studies.12 and E), and other substances (such as choline, inositol, and chlorophyll) that may be found in liver supplements. Some ingredients may have dangerous side effects. For example, unless licorice is specially processed to remove a particular compound, it can raise blood pressure.ut there are no good human studies. 12 and E), and other substances (such as choline, inositol, and chlorophyll) that may be found in liver supplements. Some ingredients may have dangerous side effects. For example, unless licorice is specially processed to remove a particular compound, it can raise blood pressure.