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Definition and etiology. Pruritus or itch is defined as an unpleasant sensation of the skin that provokes the urge to scratch. It is a characteristic feature of many skin diseases and an unusual sign of some systemic diseases. Pruritus may be localized or generalized and can occur as an acute or chronic condition.
In general, pruritus can be related to a problem with the skin or another underlying disease of the body (systemic disease). When itching is localized to a particular area of skin, it is usually caused by a local skin condition. Generalized itching, however, is related to systemic (whole body) causes roughly half the time.