The rate and extend in which the amount of drug substance dissolved over a period of time is called dissolution. It is expressed as percentage release of drug substances present dosage forms such Tablets, Capsules, oral suspensions and ointments. In our present study dissolution method development for various kinds of tablets such as immediate release or instant release, modified, Extended release and Enteric coated.
pKa Definition: pK a is the negative base-10 logarithm of the acid dissociation constant of a solution.
In this tutorial we have a look at Ka and pKa which is a common method for describing the extent of dissociation for weak acids such as carboxylic acids. pKa also has a very important role to play in medicinal chemistry so a thorough understanding of pKa is very important for medicinal and biochemists.