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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Peripheral vascular disease (PVD) involves damage to or blockage in the blood vessels distant from your heartâthe peripheral arteries and veins. Your peripheral arteries and veins carry blood to and from your arm and leg muscles and the organs in and below your stomach area.