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What are the side-effects of Collagen Peptide? The most commonly reported side-effects of Collagen Peptide are nausea, pruritus, exanthema, gastrointestinal symptoms, and headache. The following is a list of possible side effects that may occur from the use of Collagen Peptide. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
1 Research on the effects of collagen type II in people with RA shows conflicting results. 2  Some research shows that taking collagen type II by mouth for 3 months reduces joint pain, swelling, and time to walk 15 meters in people with RA.hese side effects include nausea, heartburn, diarrhea and constipation, drowsiness, skin reactions, and headache. Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking collagen type II if you are pregnant or breast-feeding. Stay on the safe side and avoid use.