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ANTIBIOTIC PROPHYLAXIS FOR SURGERY GUIDELINE. PURPOSE. The overall goal of surgical prophylaxis is to prevent surgical site infections by using an. antimicrobial agent that is safe, costâeffective, and has a spectrum of activity that covers the. most common pathogens for surgical procedures. Achieving adequate serum and tissue.
Most have an affinity or specificity for 70S (as opposed to 80S) ribosomes, and they achieve their selective toxicity in this manner. The most important antibiotics with this mode of action are the tetracyclines, chloramphenicol, the macrolides (e.g. erythromycin) and the aminoglycosides (e.g. streptomycin).hese antibiotics exert their activity by binding to bacterial ribosomes and preventing the initiation of protein synthesis. Streptomycin binds to 30S subunit of the bacterial ribosome, specifically to the S12 protein which is involved in the initiation of protein synthesis.