The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Pueblo. The Pueblo Indians, whose name is Spanish for stone masonry village dweller, have one of the oldest cultures in the United States. In the Pueblo Indians' early history, shelters consisted of structures integrated into natural caves and on cliffs. Later, they began to build homes out of sand and adobe next to rivers. Clusters of these homes, called pueblos (meaning villages or towns in Spanish), were also built on mesas, cliffs, and in canyons. Pueblos were remarkably similar to today's apartment complexes in that they interconnected several rooms and homes. Some pueblos were very large, with more than 100 rooms, 2 to 6 stories high, able to accommodate a village of 500 dwellers. A family would live in a room 12 by 24 feet in size.