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Santee, South Carolina. Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina of the United States. It has become a resort town of note located centrally north-south along the Atlantic Seaboard of South Carolina.
32%. Source: The Santee, SC weather data displayed above is derived from the NOAA (National Oceanic and Atmospheric). Air quality and pollution data is derived from the EPA (United States Environmental Protection Agency). Air quality and pollution levels measured in a particular area may not be representative of the entire county.