In this condition, the pupil is not centered in the iris. When the pupil is off just a bit, the dogs seem to cope well, but can have trouble when the condition is more pronounced. Microphthalmia, or an abnormally small eye, is the most common eye defect seen in homozygous merles. This can vary from just noticeable to appearing to have no eye at all (anophthalmia).
Children begin to develop hand dominance around 2-3 years and this should be well developed by age 5 and fully developed by age 6. Use of a dominant hand before 2-3 years time may occur because of abnormal fine motor development. It could also be the result of intracranial injury or injury to a limb with appropriate compensation by the other limb.
And by kindergarten, or age 5, a child should be using one hand for all fine motor tasks that require a hand dominance (i.e. holding a pencil, holding scissors, holding food utensils, etc). Gross grasp is usually the first step in the process of developing fine motor skills. And the grasp first starts without any conscious control as an infant. The palmar grasp reflex is present in newborns and lasts until about 5 months.