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The most common cause of high blood calcium is primary hyperparathyroidism, which results in overproduction of parathyroid hormone by the parathyroid glands. The parathyroid glands play a role in the bodyâs regulation of calcium levels in the blood.he most common cause of high blood calcium is primary hyperparathyroidism, which results in overproduction of parathyroid hormone by the parathyroid glands. The parathyroid glands play a role in the bodyâs regulation of calcium levels in the blood.
1 Excessive sodium: High urinary levels of sodium result in increased levels of calcium. 2  Certain defects in the kidney tubules transport system, which cause imbalances in sodium and phosphate, can lead to high calcium levels in the urine. 3  A diet high in salt can also produce this effect.