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Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. Structure.
An overdose of astemizole predisposes the myocar-. dium to ventricular dysrhythmias, including torsades. de pointes. Herein we describe a case of astemizole-. induced torsades de pointes ventricular tachycardia. and also review previous case reports in the literature. All the patients were young, and dysrhythmias devel-. oped only in those with corrected QT intervals greater. than 500 ms.