Studies using single oral doses of metformin hydrochloride 500 mg to 1500 mg, and 850 mg to 2550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination.
The first all-steel windmill and tower was produced by the United States Wind Engine & Pump Co. The first electricity-generating wind turbine was invented in 1888 in Cleveland, Ohio by Charles F. Brush. The turbineâs diameter was 17 meters (50 feet), it had 144 rotor blades made of cedar wood, and it generated about 12 kilowatts (kW) of power.
The Babylonians used wind power for irrigation during the 17th Century BC, 4th Century BC the classic work Sanskirt made reference a contraption that used the wind to lift water. The first documented windmill dates back to 200 BC made by the Persians to girding grain. These early windmills had a vertical access design with sails made out of reeds or wood and were usually x-xft (5-9m) tall.