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A landmark Dutch study, which analyzed data from more than 37,000 people over a period of 13 years, found that moderate coffee drinkers (who consumed between two to four cups daily) had a 20 percent lower risk of heart disease as compared to heavy or light coffee drinkers, and nondrinkers.
The amount of caffeine that causes this effect is about 250 milligrams â or the equivalent of 2 to 2 1/2 cups (473 to 591 milliliters) of plain, brewed coffee â a day. Twenty years ago, a serving of coffee was 1 cup. Today, it's often 2 cups.