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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Cardiovascular disease includes conditions that affect the structures or function of your heart, such as: Coronary artery disease (narrowing of the arteries) Heart attack. Abnormal heart rhythms, or arrhythmias. Heart failure. Heart valve disease. Congenital heart disease. Heart muscle disease (cardiomyopathy)