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Junior Member. It takes approximately 5.5 half lives before the drug is completely out of your system. As the half life is 2 hours it would take about 11 hours (2 hours x 5.5 half lives) before diclofenac would have been out of your system,so theoretically you would have been diclofenac free by 4.30 am. So it was safe for you to take Zoloft at 9.30 am.
Chlorthalidone is an oral diuretic with prolonged action (48â72 hours) and low toxicity. The major portion of the drug is excreted unchanged by the kidneys. The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. The mean half-life following a 50 to 200 mg dose is 40 hours. In the first order of absorption, the elimination half-life is 53 hours following a 50 mg dose, and 60 hours following a 100 mg dose.