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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
As can be expected from an organ responsible for getting blood throughout the body, the root of heart disease is when that blood flow is blocked. Heart disease, or cardiovascular disease, encompasses a range of conditions, including blood vessel diseases such as coronary artery disease, problems with heart rhythm (arrhythmias) and congenital heart defects, according to the Mayo Clinic. Coronary artery disease is the most common type of heart disease in the United States, according to the CDC.