What are the side effects of alteplase (TPA, Activase, Cathflo Activase)? The most common and serious side effect of alteplase is bleeding. Minor bleeding is more common, but significant bleeding such as into the brain (intracranial hemorrhage) or fatal bleeding also occurs. Other important side effects include:
Overview. 1  Surgical treatment for vaginal prolapse involves supporting the vaginal defect that is causing the pelvic organ to prolapse into the vagina. For example, a cystocele is a weakness in the front wall of the vagina, near the bladder. A cystocele repair involves sewing the submucosal vaginal tissue back together where it has stretched.
There may still be a role for mesh in certain transvaginal pelvic organ prolapse procedures, he says. âSome clinicians believe that the use of mesh for transvaginal pelvic organ prolapse is appropriate and is the best treatment option for selective patients such as those with severe pelvic organ prolapse,â he says.