In this condition, the pupil is not centered in the iris. When the pupil is off just a bit, the dogs seem to cope well, but can have trouble when the condition is more pronounced. Microphthalmia, or an abnormally small eye, is the most common eye defect seen in homozygous merles. This can vary from just noticeable to appearing to have no eye at all (anophthalmia).
Children begin to develop hand dominance around 2-3 years and this should be well developed by age 5 and fully developed by age 6. Use of a dominant hand before 2-3 years time may occur because of abnormal fine motor development. It could also be the result of intracranial injury or injury to a limb with appropriate compensation by the other limb.
Babies tend to be older (18 to 24 months) before handedness becomes more consistent. No matter what age your baby starts to prefer one hand over the other, there are a couple of things you should know. First, handedness is really a continuum, meaning that most babies can use both hands but they tend to use one hand more effectively than the other.