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Junior Member. It takes approximately 5.5 half lives before the drug is completely out of your system. As the half life is 2 hours it would take about 11 hours (2 hours x 5.5 half lives) before diclofenac would have been out of your system,so theoretically you would have been diclofenac free by 4.30 am. So it was safe for you to take Zoloft at 9.30 am.
Diflucan has a half life close to 25 hours. This means 25 hours after you take this drug, there will be half as much in your system. And, 50 hours later, there will be one quarter of the Diflucan left in your system. After seven days have passed since taking a 150 mg oral dose, there will only be trace amounts of Diflucan left in your body.