Colors: palm, black, cherry, marseilles, flame, soleil. Sizes: 1 QT. The Signature 1 qt. Round Dutch Oven from Le Creuset features durable and thermally efficient enameled cast iron construction to deliver even heat distribution and excellent heat retention no matter what heat source you use, including induction.
The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.or example, orphan drug regulations generally acknowledge the fact that it may not be possible to test 1,000 patients in a phase III clinical trial, as fewer than that number may be afflicted with the disease in question.
In the US and the EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as an extended period of exclusivity, a time during which that company is the only one allowed to market the orphan drugâall intended to encourage the development of those drugs which might otherwise lack a sufficient profit motive and market to attract companies' research budgets and personnel.