The cause of Tay-Sachs disease is a genetic defect (mutation) that is passed from parent to child. This genetic defect is located in the HEXA gene, which is found on chromosome 15.The HEXA gene makes part of an enzyme called beta-hexosaminidase A, which plays a critical role in the nervous system.he cause of Tay-Sachs disease is a genetic defect (mutation) that is passed from parent to child. This genetic defect is located in the HEXA gene, which is found on chromosome 15.
A more common cause of bladder pain is urinary tract infection (UTI), which can also produce changes in urine color, difficulty urinating, and a feeling of fullness in the bladder. Sometimes these infections are âsilentâ and donât have any symptoms until they worsen significantly.
A number of conditions can cause painful urination. In women, the most common cause of painful urination is a urinary tract infection. In men, urethritis and certain prostate conditions are the most frequent causes of painful urination. Common medical conditions and external causes of painful urination include: 1  Bladder stones. 2  Chlamydia. 3  Cystitis (bladder infection).