In this condition, the pupil is not centered in the iris. When the pupil is off just a bit, the dogs seem to cope well, but can have trouble when the condition is more pronounced. Microphthalmia, or an abnormally small eye, is the most common eye defect seen in homozygous merles. This can vary from just noticeable to appearing to have no eye at all (anophthalmia).
Children begin to develop hand dominance around 2-3 years and this should be well developed by age 5 and fully developed by age 6. Use of a dominant hand before 2-3 years time may occur because of abnormal fine motor development. It could also be the result of intracranial injury or injury to a limb with appropriate compensation by the other limb.
2. In order to test the X-linked recessive theory of language dominance and handedness, it is necessary for cerebral dominance for language to be ascertained accurately for relatively large numbers of the normal population. At present, only fTCD appears to offer this possibility.