In this condition, the pupil is not centered in the iris. When the pupil is off just a bit, the dogs seem to cope well, but can have trouble when the condition is more pronounced. Microphthalmia, or an abnormally small eye, is the most common eye defect seen in homozygous merles. This can vary from just noticeable to appearing to have no eye at all (anophthalmia).
Children begin to develop hand dominance around 2-3 years and this should be well developed by age 5 and fully developed by age 6. Use of a dominant hand before 2-3 years time may occur because of abnormal fine motor development. It could also be the result of intracranial injury or injury to a limb with appropriate compensation by the other limb.
The Gender Schema Theory. Before age 1, children begin to discriminate between male and female voices and faces. After age 2, language forces children to organize their worlds according to gender. At age 3, children start to seek out members of their own gender to play. These stereotypes peak at age 6.