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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Shonda Rhimes has caught a lot of grief -- especially from MerDer shippers -- for killing off the beloved Derek McDreamy Shepherd (Patrick Dempsey) during the latest season of Greyâs Anatomy, but from the showrunner's perspective, her hands were tied.