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Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog. Woltz HH, Thompson FN, Kemppainen RJ, Munnell JF, Lorenz MD.
3. High Blood Sugar. One of the mot common side effects of prednisone is that the drug can worsen or even trigger diabetes. This occurs because corticosteroids increase insulin resistance, which causes blood glucose levels to rise and remain higher (9).