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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
Extensive/intermediate metabolizers: Maximum: 100 mg/day; 37.5 mg/dose. Poor metabolizers: Maximum: 50 mg/day; 25 mg/dose. Concomitant use with strong CYP2D6 inhibitors (eg, fluoxetine, paroxetine, quinidine): Maximum: 50 mg/day; 25 mg/dose. Note: If treatment is interrupted for >5 days, retitration is recommended.