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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
Many studies have shown antibiotics have both short-and long-term effects on the composition and health of the microbes in your gut, and your microbiome plays a crucial role in your overall immune function and general health.