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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
'Grey's Anatomy' Recap: Derek Shepherd to the Rescue. April 24, 2015. Warning: This story contains character and storyline spoilers from the April 23 episode of Greyâs Anatomy. Meredith Grey and Derek Shepherd have been through a lot in 11 seasons of Greyâs Anatomy, including multiple near-deaths. But for one of them, good fortune finally ran out.