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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
The Lewis and Clark Expedition, also known as the Corps of Discovery Expedition, was the first American expedition to cross what is now the western portion of the United States, departing in May 1804, from near St. Louis making their way westward through the continental divide to the Pacific coast.eferences to Lewis and Clark scarcely appeared in history books even during the United States Centennial in 1876 and the expedition was largely forgotten. Lewis and Clark began to gain new attention around the start of the 20th century.