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ESBL stands for Extended-Spectrum beta-Lactamase. Beta lactamases are enzymes that are produced by many types of bacteria (germs) which make them more resistant to antibiotics and can make the infection harder to treat.
Extended Spectrum Beta Lactamase producing bacteria are gram negative bacteria which are responsible for producing beta lactamase and enzyme has the potential to break-down common antibiotics like penicillin, cephalosporin, etc.