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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Grey's Anatomy: Derek Shepherd death tribute video is an emotional rollercoaster. On the heels of Thursday nightâs shocking Greyâs Anatomy episode, the showâs official Twitter account has released a tribute video to Derek Shepherd (played by Patrick Dempsey). The good doctor died during this weekâs episode, ending his 10-year run as Meredith Greyâs soulmate and all-around handsome dude. RIP.