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Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-Î², IGF) signalling. Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts. It is synonymous with bone tissue formation.There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (mesenchyme), while endochondral ossification involves cartilage as a precursor.alcification is synonymous with the formation of calcium-based salts and crystals within cells and tissue. It is a process that occurs during ossification, but not vice versa. The exact mechanisms by which bone development is triggered remains unclear, but it involves growth factors and cytokines in some way.
Intramembranous ossification occurs during mammalian development within the womb and is the process by which flat bones, such as some of the bones of the skull and the collarbones, are created from connective tissue.t also is the process by which injured bones heal and occurs when bones are broken or damaged in order to reconstruct the bone. Also occurring during embryonic development is endochondral ossification, a process in which bones are produced from cartilage.