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Secretin, the digestive hormone that stimulate pancreatic secretion, also increases bile secretion. Its main effect, however, is to increase the secretion of water and sodium bicarbonate from the lining of the bile duct.
The role of the parasympathetic nervous system is not clear. There is no evidence that hepatic secretion of bile salts is under neural control. The tone of the gallbladder and sphincter of Oddi regulates the amount of bile that actually enters the duodenum. CCK is the only known physiologic cholecystokinetic gastrointestinal hormone.