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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
Desvenlafaxine is marketed as âan SNRI with a starting dose that is the proven effective doseâ while venlafaxine XR requires titration to reach the maximum daily recommended dose of 225 mg.hen desvenlafaxine 50 mg and 100 mg daily were compared to placebo, the 50 mg dose had a remission rate significantly higher than placebo in only one of two studies.