Sphere of influence. In the field of international relations, a sphere of influence (SOI) is a spatial region or concept division over which a state or organization has a level of cultural, economic, military, or political exclusivity, accommodating to the interests of powers outside the borders of the state that controls it.
Multiple myeloma is named for the clock face appearance of these cancer cells when seen under a microscope. They infiltrate virtually all of a patient's bone marrow. In x-ray images of multiple myeloma, it looks like holes have been punched out of the bone.
In multiple myeloma, the physical examination is generally normal. Possible exceptions include sausaging of the blood vessels of the eyes and the ability to feel a plasmacytoma. (a collection of plasma cells under the skin that form a mass).here are no specific signs or symptoms of multiple myeloma. Decreased energy level, flu-like symptoms, back pain (especially low back pain), and bone pain, if unexplained and unresolved for 8-12 weeks, may increase suspicion and prompt further testing.