For example, you should not apply heat to a new injury that might be swollen or bruised. The heat will simply cause additional swelling and ice would be a better solution. The accepted rule is to use ice for the first two days following an injury, after which you can then apply heat safely.
Updated PANDAS signs and symptoms. (1) Pediatric onset. The first symptoms of PANDAS are most likely to occur between 5 and 7 years of age. Symptoms can occur as early as 18 months of age or as late as 10 years of age. If the first clinically recognized episode is detected after the age of 10, it is unlikely true initial episode, but the recurrent one.
However, about 0.7 Myr ago, the panda population began to decline due to the two largest Pleistocene glaciations occurring in China, and its first population bottleneck occurred at about 0.3 Myr ago. During that period, pygmy panda was gradually replaced by another subspecies -- baconi panda that has larger body size. After the retreat of the Penultimate Glaciations, giant panda's second population expansion happened and it reached its population peak between 30~50 thousand years (kyr) ago.