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Main areas affected by nodular acne are the face and back, but it can also occur on other parts of the body such as the neck, chest, upper arms, shoulders, and buttocks, ranging from just a few breakouts to more widespread blemishes.
1 These work to reduce oil production and open pores. 2  Women with hormonal acne may be treated with birth control pills or spironolactone. These medications regulate hormones that can cause acne.  Isotretinoin (Accutane) is a vitamin-A-based medication thatâs used to treat certain cases of severe nodular acne.