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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
The definition of coagulate means for a liquid to become a soft mass or a clot. An example of coagulate is for blood to clot and congeal into a mass on the edge of a cut in the skin. -Â·latÂ·ed, -Â·latÂ·ing. to cause (a liquid) to become a soft, semisolid mass; curdle; clot. Origin of coagulate.