From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. conformational epitope is composed of discontinuous sections of the antigen's amino acid sequence. These epitopes interact with the paratope based on the 3-D surface features and shape or tertiary structure of the antigen. The proportion of epitopes that are conformational is unknown.
Dear fortysomething: Yes, we do get questions about itchy nipples or burning nipples. The least common causes, but the most serious, would be inflammatory breast cancer or Paget's Disease (another type of breast cancer).
1 A change in the nipple, such as a nipple retraction, dimpling, itching, a burning sensation, or ulceration. 2  A scaly rash of the nipple is symptomatic of Paget's disease, which may be associated with an underlying breast cancer. 3  Unusual discharge from the nipple that may be clear, bloody, or another color. A lump in the breast or underarm that persists after your menstrual cycle. 2  This is often the first apparent symptom of breast cancer. 3  Lumps associated with breast cancer are usually painless, although some may cause a prickly sensation.