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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Grey's Anatomy: Meredith Mourns Derek's Death, Welcomes New Life. Raise your hand if youâre still crying. Once the tragic news was delivered, everyone at Grey Sloan Memorial had to mourn the abrupt demise of Dr. Derek Shepherd in his or her own way on Thursdayâs two-hour episode of Greyâs Anatomy.