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Patent ductus arteriosus (PDA) is a persistent opening between two major blood vessels leading from the heart. The opening, called the ductus arteriosus, is a normal part of a baby's circulatory system before birth that usually closes shortly after birth.
A large patent ductus arteriosus can lead to Eisenmenger syndrome, an irreversible type of pulmonary hypertension. Heart failure. A patent ductus arteriosus can eventually cause the heart to enlarge and weaken, leading to heart failure, a chronic condition in which the heart can't pump effectively. Heart infection (endocarditis).