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Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog. Woltz HH, Thompson FN, Kemppainen RJ, Munnell JF, Lorenz MD.
Prolonged use of prednisone tablets can damage the adrenal glands, causing them to shrink and stop producing cortisol. When the medication is stopped abruptly, the glands are unable to prepare by producing enough cortisol to prevent withdrawal symptoms, which can include vomiting and shock.