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The cabinet member that is in charge of foreign affairs is the  Secretary of State. The Secretary of State is John Kerry who is a  former Senator of Massachusetts. According to Dictionary.com, foreign affairs are those matters that  do not involve the country you call your home.
The Secretary of State and many other officials of the State Department play major roles in setting foreign policy. The Secretary of State is usually the President's principal foreign policy adviser, and he or she is the chief coordinator of all governmental actions that affect relations with other countries. The Foreign Service consists of ambassadors and other official representatives to more than 160 countries.