Not until the war ended and journalists were able to enter Cambodia did the world really become aware of the enormity of Pol Pot's oppression. ( 1 countable) An act of extreme evil or wickedness. ( 2 uncountable) Hugeness, enormousness, immenseness.
Alpha-1 antitrypsin (an-tee-TRIP-sin) deficiency, or AAT deficiency, is a condition that raises your risk for lung disease (especially if you smoke) and other diseases.Some people who have severe AAT deficiency develop emphysema (em-fi-SE-ma)âoften when they're only in their forties or fifties.lpha-1 antitrypsin, also called AAT, is a protein made in the liver. Normally, the protein travels through the bloodstream. It helps protect the body's organs from the harmful effects of other proteins.
Without enough functional alpha-1 antitrypsin, neutrophil elastase destroys the small air sacs in the lungs (alveoli) and causes lung disease. Excessive damage to the alveoli leads to emphysema, an irreversible lung disease that causes extreme shortness of breath.ore than 120 mutations in the SERPINA1 gene have been identified. Some of these mutations do not affect the production of alpha-1 antitrypsin, while others cause a shortage (deficiency) of the protein.