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Summary Information: Valve Cusps Valve Cusps: Valve cusps are located in the valves of the heart and are flaps of tissue that open in one direction as blood is pumped through them. The valve cusps are made of thin fibrous tissue, covered with a smooth membrane (endocardium) and reinforced by connective tissue.
The tricuspid valve evolves from the atrivoventricular valve in our primitive relatives. The tricuspid valve is on the right side of the heart. The right side of our ancestor's heart has 3 cusps (anterior, posterior, and medial) between the atrium and ventricle. This evolved to the tricuspid valve in mammals.