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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Katherine Heigl may not be on Grey's Anatomy anymore, but she's feeling the fans' pain over the death of Dr. Derek Shepherd. Heigl, who played Dr, Izzie Stevens from 2005-10, told ET that she was devastated over the death of the beloved Grey's character. I just can't imagine the show without McDreamy, Heigl said about Patrick Dempsey's exit. It's just so hard to picture..