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Klinefelter syndrome was first described in 1942 by Dr. Harry Klinefelter, an endocrinologist at Massachusetts General Hospital. He published a case study of nine adult men with a common set of symptoms involving hypogonadism. At the time, chromosomes had not yet been discovered.
Klinefelter syndrome is a rare disorder of the sex chro-. mosomes. Patients with this syndrome have at least one. extra X chromosome in addition to the normal male. karyotype of 46, XY1. Among the clinical manifestations. of dermatological interest, leg ulcers occur in 13% of. cases of Klinefelter syndrome2.Wedescribeapatient. with Klinefelter syndrome who had had refractory leg ul-. cers for 19 years but did not show spontaneous aggrega-. bility of platelets or elevated activity of plasminogen acti-.