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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
Staphylococcus epidermidis. coagulase-negative pathogen; forms part of normal skin flora. Staphylococcus. a genus of spherical, gram-positive bacteria tending to occur in grapelike clusters; they are normal flora on the skin and in the upper respiratory tract and are the most common cause of localized suppurating infections.