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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
On the April 30 episode of Greyâs Anatomy, Meredith (Ellen Pompeo) is forced to tell the staff at Grey-Sloane Memorial Hospital that her husband, Derek Shepherd (Patrick Dempsey), is dead. After he is buried, she runs off â leaving everyone concerned about her well-being.