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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
vigorous and prolonged IV antibiotic therapy, culture or bone biopsy should be done if possible, delaying antibiotic treatment may require surgical debridement and decompression. Usually Central Venous Catheter, or a PICC line and sent home for long term antibiotic treatment. Hyperbaric Chamber.