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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
Definition of coagulate. coagulated. ; coagulating. transitive verb. 1 : to cause to become viscous or thickened into a coherent mass : curdle, clot. 2 : to gather together or form into a mass or group. intransitive verb.