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Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-Î², IGF) signalling. Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts. It is synonymous with bone tissue formation.There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (mesenchyme), while endochondral ossification involves cartilage as a precursor.alcification is synonymous with the formation of calcium-based salts and crystals within cells and tissue. It is a process that occurs during ossification, but not vice versa. The exact mechanisms by which bone development is triggered remains unclear, but it involves growth factors and cytokines in some way.
Intramembranous ossification is also an essential process during the natural healing of bone fractures and the rudimentary formation of bones of the head.t this point, the osteoid becomes mineralized resulting in a nidus consisting of mineralized osteoid that contains osteocytes and is lined by active osteoblasts. The nidus, that began as a diffuse collection of MSCs, has become rudimentary bone tissue.