Patients at extremes of weight should have the dose of enoxaparin adjusted and anticoagulation should be monitored using the low molecular weight heparin assay. In clinical trials using enoxaparin for the treatment of DVT or PE, the 1 mg/kg Q 12 h dose was given to patients up to weights of approximately 150 kg.he maximum dose of enoxaparin should be 150 mg SC Q 12 h. For a patient receiving a dose of enoxaparin of 130 mg to 150 mg (i.e., patient weight 130 kg to 150 kg or greater), the low molecular weight heparin assay may be a useful monitoring tool.
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