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Definition of node 1 a: a pathological swelling or enlargement (as of a rheumatic joint) b: a discrete mass of one kind of tissue enclosed in tissue of a different kind
noun, Cell Biology. 1. a network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum) involved in the transport of materials.