Sphere of influence. In the field of international relations, a sphere of influence (SOI) is a spatial region or concept division over which a state or organization has a level of cultural, economic, military, or political exclusivity, accommodating to the interests of powers outside the borders of the state that controls it.
Multiple myeloma is named for the clock face appearance of these cancer cells when seen under a microscope. They infiltrate virtually all of a patient's bone marrow. In x-ray images of multiple myeloma, it looks like holes have been punched out of the bone.
Myeloma develops when the body overproduces plasma cells. Normally, certain white blood cells leave the bone marrow and mature in other parts of the body. Some of these develop into plasma cells that produce proteins called antibodies that move through the bloodstream to help the body get rid of harmful substances.