The Rails-to-Trails Conservancy compiles the online list of 14 rail-trails that exceed 100 miles. In the latest update, the John Wayne Pioneer Trail jumped from 4th to 1st overall, leapfrogging the Katy Trail (Missouri), Cowboy Trail (Nebraska) and the Great Allegheny Passage (Pennsylvania and Maryland).
For yeast, having clumps of amyloid is not fatal. Researchers exposed amyloid-containing cells of bakerâs yeast to 104 F, a temperature that would be a high fever in a human. When exposed to that environment, the cells activated a stress response that changed the clumping proteins back to the no-clumping shape.
Credit: Erli Jin and Linhao Ruan/Johns Hopkins Medicine. Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal.