In other words: A Permutation is an ordered Combination. There are basically two types of permutation: 1  Repetition is Allowed: such as the lock above. It could be 333.  No Repetition: for example the first three people in a running race. You can't be first and second.
For this reason, the idea that collagen supplementation can be an effective treatment for joint pain, osteoarthritis, or any other condition, is highly implausible, if not impossible in principle.
Collagen is the most important protein in connective tissue, skin, and bones; you actually have more collagen in your body than any other type of protein. Degradation or lack of collagen can cause problems from skin wrinkles to osteoporosis.