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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
In the Season 11 finale, Dr. Shepherd saves four car accident victims. While checking his phone in his car afterward, he is struck by a semi truck and winds up brain dead. Dr. Grey eventually decides to take him off life support.