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The study began with an open-label dose optimization period (4 to 6 weeks) with an initial QUILLIVANT XR dose of 20 mg once daily in the morning. The dose could be titrated weekly in increments of 10 or 20 mg until a therapeutic dose or the maximum dose of 60 mg/day was reached.
Because IR guanfacine is approved only for hypertension in adults, there are no relevant dosing recommendations for youth with ADHD in the package insert. Clinical experience and expert opinion suggest a maximum total daily dose of 4 mg, which is the recommended maximum for treatment of hypertension in adults.â.