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When a mutation occurs within germ cells, it is called a germline mutation. Germline mutations affect every cell in an organism and are passed on to offspring. When a mutation occurs in a somatic cell, it is called a somatic mutation. Somatic mutations only affect new cells that are created from the mutated cell and are not passed on to offspring. To unlock this lesson you must be a Study.com Member.
When the gene is mutated, the enzyme canât protect the motor neurons, and they become damaged by the free radicals. About 20 percent of people with familial ALS have the SOD1 gene mutation. Researchers are still looking for more genes that might be involved. Researchers also know that ALS is most common in Caucasian males, and it often starts when people are between the ages of 40 and 60 (although it can strike at an earlier age).