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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
Jefferson s choice of Lewis as the leader of an American expedition to the Pacific coast reflects a mix of practicality, common sense, regional alliances, and the turbulent political times in America at the turn of the nineteenth century.