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What areas did the Lewis and Clark expedition and the Pike expedition explore? Lewis and Clark explored the Northern part of the Louisiana Purchase, traveling up the Missouri River, and Pike explored the southern half, looking for the start of the Red River. Why were Meriwether Lewis and William Clark chosen to lead the exploration of the Louisiana Purchase? Lewis was chosen because of his experience as a leader, and Clark was chosen for his mapmaking skills.
One of the purposes of the expedition, which was not realized, was to find a water route across the entire United States. By mid-October 1804, the Lewis and Clark expedition reached the Mandan villages on the banks of the upper Missouri River in present-day North Dakota.n May 1804, a group of 50 Americans led by Meriwether Lewis, Jefferson's personal secretary, and William Clark, an army officer, headed northwest along the Missouri River from St. Louis.