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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
After his shocking and tragic death, Derek Shepherd is finally laid to rest by Meredith and their Grey-Sloane Memorial family on this weekâs âGreyâs Anatomy.â But, when Meredith disappears, she takes a huge secret along with her.