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Summary Information: Valve Cusps Valve Cusps: Valve cusps are located in the valves of the heart and are flaps of tissue that open in one direction as blood is pumped through them. The valve cusps are made of thin fibrous tissue, covered with a smooth membrane (endocardium) and reinforced by connective tissue.
The heart is located in a central tissue mass that divides the ribcage into two cavities between the two lungs. This central tissue consists of the heart, its associated blood vessels, the esophagus, and the trachea. The axis of the heart is tilted so that the apex (tip) of the heart points toward the lower left.