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It took about 2 weeks for Tiazac to work for me. I take 300 mgs with no side effects. All the literature etc. says that Diltiazem increases the effect of other bp medicines, so you might well also benefit a lot from a small dose of something else in addition.
People who take a benzodiazepine for more than two or three weeks may develop a tolerance to the drug, and over time may need to take increasing doses to achieve the same effect, only worsening their fatigue. Long-term effects also may include muscle weakness.