Rheumatoid arthritis (RA) is a long lasting autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest.Most commonly the wrist and hands are involved with typically the same joints involved on both sides of the body.heumatoid arthritis (RA) is a long lasting autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest.
tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.
Lichen sclerosus is most often seen in postmenopausal women but can also be present in younger people, even teens and children. Lichen sclerosus is not an infection, is not contagious, and cannot be passed on to a sexual partner. Scarring changes the appearance of the vulva and can cause narrowing of the vaginal opening, which in turn may make intercourse uncomfortable. 2  Lichen sclerosus may cause satellite patches of white skin in other areas of the body, which rarely cause symptoms and do not usually require treatment.