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Endogenous vs Exogenous Antigens. Any molecule or substance that reacts to a product of a specific immune response and stimulates antibody generation is considered as an antigen.The antibody generation by an antigen is called antigenicity of that particular molecule.Antigens can be either a protein or a polysaccharide.he vast majority of antigens are exogenous antigens. They are introduced into the body from outside via various infections agents such as bacteria, viruses, fungi, protozoa, helminthes etc., or environmental substances such as dust mites, foodstuff, pollen etc. by inhalation, ingestion, or injection.
an example of a self antigen can be a Autoantigen: antigen that despite being a normal tissue constituent is the target of a humoral or cell mediated immune response, as in autoimmune disease.Autoantigen: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.elf antigens are antigens present on SELF tissue that would normally not provoke an immune response unless in a diseased state. Autoimmune diseases happen when the body attacks its self antigens with antibodies made against it.