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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
How to Save a Life  episode of Grey's Anatomy, which originally aired April 23, 2015. Dr. Derek Shepherd knows a secret shortcut to the airport. Cell reception on this particular back road is virtually non-existent. A reckless driver zooms by.