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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Patrick Dempsey 's Grey's Anatomy character survived a shooting, a plane crash, and countless natural disasters -- not to mention the loss of several friends and colleagues -- but the last of his nine lives ran out on Thursday, April 23. PHOTOS: Hot TV doctors. As detailed in Us Weekly 's recap of the episode, Derek Shepherd was headed to the airport -- after saving four lives, natch -- when a truck slammed into his vehicle, sending him to a nearby hospital with serious head and chest injuries.