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When a mutation occurs within germ cells, it is called a germline mutation. Germline mutations affect every cell in an organism and are passed on to offspring. When a mutation occurs in a somatic cell, it is called a somatic mutation. Somatic mutations only affect new cells that are created from the mutated cell and are not passed on to offspring. To unlock this lesson you must be a Study.com Member.
Some such de novo mutations arise in the gamete of a parent, but some arise after fertilization during embryonic development, generating somatic mutations. Somatic mutations occur in several neurodevelopmental diseases associated with epilepsy, autism spectrum disorders, and intellectual disability, although their broader relevance for neurological disease is unknown.