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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
We typically think of 2 major PD categories of antibiotics: those with time-dependent bactericidal effect and those with concentration-dependent bactericidal effect. However, a third category has also been described, consisting of antibiotics with both time-dependent and concentration-dependent effects ( Table ). The time-dependent antibiotics exert optimal bactericidal effect when drug concentrations are maintained above the minimum inhibitory concentration (MIC). Typically, concentrations are maintained at 2 to 4 times the MIC throughout the dosing interval.