However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, kidney problems (such as change in the amount of urine). This is not a complete list of possible side effects.
They are more active when it is cooler, but they can and do come out of hiding at any time of the day. Here in the desert, Arizona Rattlesnakes can easily overheat and die if they cannot find a cool place to keep themselves cool.
The California Poison Control Center notes that rattlesnakes account for more than 800 bites each year with one to two deaths. Most bites occur between the months of April and October when snakes and humans are most active outdoors.