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The risk of contralateral breast cancer in women with a mutation of a breast cancer gene (BRCA) is approximately 3% to 5% per year or about 40% at 10 years after the initial diagnosis of breast cancer, with a cumulative lifetime risk of up to 64% in high-risk cohorts.
Carriers of BRCA1 had a cumulative risk for ovarian cancer of 0.27 by age 60 and 0.53 by age 80. Carriers of BRCA2 had a cumulative risk for ovarian cancer of 0.07 by age 60 and 0.62 by age 80. The authors write, In this study, 51% (85 of 167) families harboring BRCA1 or BRCA2 mutations had little or no history of relevant cancer.