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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
Elinor L Baron, MD, DTMH. Coagulase-negative staphylococci (CoNS) are part of the normal flora of human skin [1]. These organisms have relatively low virulence but are increasingly recognized as agents of clinically significant infection of the bloodstream and other sites.