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Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog. Woltz HH, Thompson FN, Kemppainen RJ, Munnell JF, Lorenz MD.
Because of prednisone's side effects, doctors often prescribe it in a step-down dosage â a blast of higher doses at the beginning, then tapering off. Prednisone suppresses the immune system and adrenal function, so doctors say that if you stop cold turkey, the adrenal glands may not respond as they would normally.