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Secretin, the digestive hormone that stimulate pancreatic secretion, also increases bile secretion. Its main effect, however, is to increase the secretion of water and sodium bicarbonate from the lining of the bile duct.
1 Secretin secretion is stimulating by acid chyme (food from stomach). 2  Secretin stimulates the pancreas to secrete sodium bicarbonate, which neutralizes the acidic chyme.  Secretin also stimulates the liver to release bile.