As with the association between clear-cell renal carcinoma and von Hippel Lindau (VHL) syndrome, the association of epithelioid AML with TS suggests that alterations in the TS complex (TSC) pathway are involved in the pathogenesis of epithelioid AML.
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Reverse transcriptase (RT), also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into DNA. This enzyme is able to synthesize a double helix DNA once the RNA has been reverse transcribed in a first step into a single-strand DNA. RNA viruses, such as retroviruses, use the enzyme to reverse-transcribe their RNA genomes into DNA, which is then integrated into the host genome and replicated along with it.