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THURSDAYS 8|7c. The Death of Derek Shepherd. Derek Shepherd (Patrick Dempsey) dies after a tragic car accident on Grey's Anatomy. Watch this scene from Season 11, Episode 21: How to Save a Life to see the heartbreaking moment Meredith Grey (Ellen Pompeo) says her final goodbye to her husband.
Patrick Dempsey played Derek Shepherd. THEN: Dr Shepherd was the McDreamy of the hospital, the target of many a young intern's affections, but really only there for one woman - Meredith Grey. After years of misunderstanding, the couple were happily married by the time of the charater's shock death in 2015.