Introduction. The common disease-common variant (CDCV) hypothesis posits that common, interacting disease alleles underlie most common diseases, perhaps in association with environmental factors [1] , [2] .imilarly, The prevalence of the disease in the population is then: and the PAF is: The sibling recurrence risk is given by: where V a is the additive genetic variance divided by Îº 0 2, V d is the dominance genetic variance divided by Îº 0 2 and K = Îº/Îº 0.
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