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Secretin, the digestive hormone that stimulate pancreatic secretion, also increases bile secretion. Its main effect, however, is to increase the secretion of water and sodium bicarbonate from the lining of the bile duct.
The partially digested food arriving from the stomach stimulates the duodenum to produce hormones. These hormones tell the pancreas to release digestive enzymes, and the gallbladder to release bile. Much of the food digestion takes place in the duodenum.