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Secretin, the digestive hormone that stimulate pancreatic secretion, also increases bile secretion. Its main effect, however, is to increase the secretion of water and sodium bicarbonate from the lining of the bile duct.
Bile acids also induce bile flow and biliary lipid secretion. The enterohepatic circulation of bile acids is âbadâ in the adult because it downregulates hepatocyte low-density lipoprotein receptor activity and thereby elevates plasma cholesterol levels.