The Rails-to-Trails Conservancy compiles the online list of 14 rail-trails that exceed 100 miles. In the latest update, the John Wayne Pioneer Trail jumped from 4th to 1st overall, leapfrogging the Katy Trail (Missouri), Cowboy Trail (Nebraska) and the Great Allegheny Passage (Pennsylvania and Maryland).
For yeast, having clumps of amyloid is not fatal. Researchers exposed amyloid-containing cells of bakerâs yeast to 104 F, a temperature that would be a high fever in a human. When exposed to that environment, the cells activated a stress response that changed the clumping proteins back to the no-clumping shape.
To give an answer from a human standpoint: yeast produces ethanol as a byproduct of fermentation. Concentrated ethanol denatures cell proteins, yeasts stop fermentation when the level of ethanol reaches from ~8% > ~12% depdning on the yeast culture. Yeasts avoid killing themselves off in their own byproduct. Salt in reasonable quantities, causes exosmosis in yeast cells, they become less effective.