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When a mutation occurs within germ cells, it is called a germline mutation. Germline mutations affect every cell in an organism and are passed on to offspring. When a mutation occurs in a somatic cell, it is called a somatic mutation. Somatic mutations only affect new cells that are created from the mutated cell and are not passed on to offspring. To unlock this lesson you must be a Study.com Member.
Mutations that occur during mitosis of non-germ line cells are called somatic mutations and will not be passed to offspring. Another limitation on whether or not mutations are passed onto offspring involves the effects of the mutation. As explained by Nature and Wikipedia, some changes to the DNA sequence are deleterious to the organism.