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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
Since most S. aureus strains produce the enzyme coagulase (see the coagulase test described below), they are often referred to as coagulase-positive staphylococci. 1  Scanning e lectron micrograph of Staphylococcus aureus forming a biofilm in an indwelling catheter.