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It took about 2 weeks for Tiazac to work for me. I take 300 mgs with no side effects. All the literature etc. says that Diltiazem increases the effect of other bp medicines, so you might well also benefit a lot from a small dose of something else in addition.
The injections take about 10 minutes, and you should have no downtime afterward. Normally you would see improvement within a few days. Botox requires two to four days for it to attach to the nerve ending that would normally stimulate the muscle to contract. The maximum effect usually occurs at about 10-14 days. Therefore, whatever effect is obtained two weeks after the injections should be considered the maximum effect that is going to occur.