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Summary Information: Valve Cusps Valve Cusps: Valve cusps are located in the valves of the heart and are flaps of tissue that open in one direction as blood is pumped through them. The valve cusps are made of thin fibrous tissue, covered with a smooth membrane (endocardium) and reinforced by connective tissue.
The heart, actually, is located in the center of the chest, behind the sternum (or the breastbone). However, a part of it is slightly offset to the left, as you can figure out from the picture above. For understanding this, I think prerequisite knowledge of the heart's basic anatomy is required.