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Aldosterone is the main mineralocorticoid secreted by the adrenal cortex. When low blood pressure is detected by the kidneys, we see the start of the renin-angiotensin system, which is a hormonal cascade that leads to the production of angiotensin II. Angiotensin II is a powerful stimulator of aldosterone release.
1 Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K 2  + . Aldosterone stimulates secretion of H + in exchange for K + in the intercalated cells of the cortical collecting tubules, regulating plasma bicarbonate (HCO 3 â) levels and its acid/base balance. (The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which opens the voltage-dependent calcium channels .) The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by renin, a hormone secreted in the kidneys.