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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
The coagulase test is used to distinguish between pathogenic and nonpathogenic members of the genus Staphylococcus. All pathogenic strains of S. aureus are coagulase positive whereas the nonpathogenic species(S. epidermidis) are coagulase negative.