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Secretin, the digestive hormone that stimulate pancreatic secretion, also increases bile secretion. Its main effect, however, is to increase the secretion of water and sodium bicarbonate from the lining of the bile duct.
Conclusion: Glucose and insulin are major postprandial factors that stimulate bile acid synthesis to maintain hepatic metabolic homeostasis. Significance: Nutrient regulation of bile acid synthesis is impaired in diabetes and obesity.