âThree Billboards Outside Ebbing, Missouriâ is the latest offering from writer-director Martin McDonagh, who once again delights with an original premise, tight writing, and interesting characters.
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Dihydropyrimidine dehydrogenase (DPD), an enzyme encoded by the DPYD gene, is the rate-limiting step in pyrimidine catabolism and deactivates more than 80% of standard doses of 5FU and the oral 5FU prodrug capecitabine. True deficiency of DPD affects approximately 5% of the overall population.