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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Call your doctor if you have any of these signs of thyroid nodules: 1  Swelling in your neck for more than 2 weeks. 2  A hoarse or scratchy voice that is not caused by a cold or throat infection and lasts longer than 1 month. 3  A hard time swallowing.