Hedges against a white fence. noun. The definition of a hedge is a boundary or fence formed by closely planted bushes or trees. An example of hedge is a line of bushes planted close together creating a border. Hedge is defined as something you do to minimize loss.
Almost without exception, as the level of the medication in the mother's plasma begins its rise, the concentration in milk begins its rise as well. Drugs both enter milk, and in most cases, exit milk as a function of the mother's plasma level.
The amount of drug excreted into milk depends on a number of kinetic factors: 1) the lipid solubility of the drug, 2) the molecular size of the drug, 3) the blood level attained in the maternal circulation, 4) protein binding in the maternal circulation, 5) oral bioavailability in the infant, and the mother, and.