Constitutive exocytosis is performed by all cells and serves the release of components of the extracellular matrix, or just delivery of newly synthesized membrane proteins that are incorporated in the plasma membrane after the fusion of the transport vesicle.
There are no human studies demonstrating that minoxidil causes collagen depletion or wrinkles as a side effect (and there are many studies of minoxidil effects on humans).ou are smart to ask a professional when faced with internet rumors, especially when it comes health issues, because side effects of medications and even over-the-counter products are largely personal.
Either way--don't play with plutonium. The most toxic substance I could come up with is botulinum toxin--yes, the same material that is purified and injected (Botox) to remove wrinkles! When injected, the fatal dose is 1.3 to 2.1 nanograms per kilogram. So for an 80 kg adult, 104 to 168 nanograms (0.000168 mg).