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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
For over two hundred years, however, the English claimed that the whole east coast of America as far south as Cape Florida had been discovered in 1497-1498 by John Cabot and his son Sebastian, from Bristol, England.