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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Among expedition papers discovered by Biddle's grandsons in their grandfather's papers in 1913 were the three-volume journal of Sergeant John Ordway and a journal kept by Lewis and later Clark of the preliminary trip from Pittsburgh to Camp Dubois, from August 30 to December 12, 1803.