Members of the DEWS Definition and Classification. Subcommittee developed a contemporary definition of dry eye disease and a three-. part classification system based on etiology, causative mechanisms and disease. severity.
Metaplasia. Definition: Metaplasia is the reversible replacement of one differentiated cell type with another differentiated cell type. Metaplasia causes precursor cells to change their cell fate, and do not change existing differentiated cells.he most common epithelial metaplasia is columnar to squamous (squamous metaplasia), as occurs in the respiratory tract in response to chronic irritation.
Paneth Cell Metaplasia Paneth cell metaplasia is a form of intestinal metaplasia where paneth cells are located outside the small bowel such as seen in colonic paneth cell metaplasia. This is usually seen in the setting of chronic inflammation associated with ulcerative colitis, Crohn's Colitis, diverticulitis, or radiation colitis.