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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
The pigment in melanosis coli is localized within the colon as there is usually no pigment deposition in the small intestine Anthraquinone laxatives cause damage to the colonocytes; the damaged organelles are sequestrated in the autolysosomes of macrophages and result in lipofuscin bodies.