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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Thiazide is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart, liver, or kidney disease).he term thiazide is also often used for drugs with a similar action that do not have the thiazide chemical structure, such as chlortalidone and metolazone. These agents are more properly termed thiazide-like diuretics. Thiazide diuretics also increase calcium reabsorption at the distal tubule.