Some birth defects are caused by a mutation (change) in a single gene. In 1991, Stephen Warren, PhD, a March of Dimes grantee at Emory University in Atlanta, Georgia, identified the gene that causes fragile X syndrome, the most common inherited cause of intellectual disabilities.
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The horizontal position, lying intensifies breathing. Patients with asthma, heart disease, hypertension, and stenocardia often have acute states at night. If they lie down during the day time, or lie for 2-3 hours; the breathing gets heavier, the attacks come. Many severely sick patients sit, afraid to lie down.