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Finasteride reduces PSA levels to varying degrees in different men, making it difficult to track what the âtrueâ PSA values are over time. Finasteride fails to reduce PSA velocity (increases) in men with high-grade prostate cancer and fails to induce objective responses in men with metastases. Finasterideâs so-called âpreventiveâ effects in the Prostate Cancer Prevention Trial occurred far too early and did not increase much over time.
Daily dosing of finasteride at 5 mg/day for up to 4 years has been shown to reduce the serum DHT concentration by approximately 70%. The median circulating level of testosterone increased by approximately 10-20% but remained within the physiologic range.