MTHFR C677T Mutation Basics. The MTHFR C677T mutation affects the enzyme methylenetetrahydrofolate reductase, which is the rate-limiting enzyme in the formation of 5-methyltetraydrofolate (5-MTHF), or methylfolate.If you have the C677T mutation, your ability to convert folic acid into methylfolate is significantly reduced.olate found naturally in foods, such as leafy green vegetables, does not pose a problem.The MTHFR C677T mutation may also cause high homocysteine levels, as methylfolate plays an important role in homocysteine metabolism. Elevated homocysteine levels can cause oxidative stress and increase your risk of heart disease.
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Date Posted: Jan 14, 2006 #5. lol, i have the same problem! I esp. hate it when both sides have the same menu screen, and options... so if you have the wrong side, your ussualy allready back on your couch, when you hit 'play movie', and you get the 'please turn disc over' message.