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Missense mutation: A genetic change that results in the substitution of one amino acid in protein for another. A missense mutation is responsible for sickle hemoglobin, the molecular basis of sickle cell trait and sickle cell anemia. Search MedTerms:
Answers. Best Answer: These mutations refer to protein coding regions of the genes. A silent mutation is one that changes a DNA nucleotide, but the DNA still codes for the same amino acid in the resulting protein (some amino acids have multiple DNA triplets that code for them).A missense mutation changes the coding for an amino acid such that a different amino acid is put into the resulting protein.A nonsense mutation changes the DNA triplet so that no amino acid has that coding (such as a stop sequence). missense mutation changes the coding for an amino acid such that a different amino acid is put into the resulting protein. A nonsense mutation changes the DNA triplet so that no amino acid has that coding (such as a stop sequence).