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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Rarely, patients with thyroid nodules. may complain of pain in the neck, jaw, or ear. If a nodule is. large enough to compress the windpipe or esophagus, it. may cause difficulty with breathing, swallowing, or cause a. âtickle in the throatâ. Even less commonly, hoarseness can. be caused if the nodule invades the nerve that controls the. vocal cords but this is usually related to thyroid cancer.