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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
The principal cause of melanosis coli is the ongoing use of stimulant laxatives to treat constipation. Such laxatives are only intended for occasional use. Melanosis coli does not generally cause any symptoms; however, some health concerns may arise from the condition, most notably laxative dependence.The abuse of laxatives can result in the degeneration of intestinal nerves and dulling of natural bodily responses that stimulate bowel movements.elanosis coli occurs when the normally pink-colored lining of the colon turns dark brown or black from an accumulation of pigment in its connective tissue layer. The condition is often discovered during a routine colorectal cancer screening exam using a camera (endoscope) inserted through the anus.