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From Wikipedia, the free encyclopedia. Acetic anhydride, or ethanoic anhydride, is the chemical compound with the formula (CH 3 CO) 2 O. Commonly abbreviated Ac 2 O, it is the simplest isolable anhydride of a carboxylic acid and is widely used as a reagent in organic synthesis.ike most acid anhydrides, the carbonyl carbon of acetic anhydride is a potent electrophile as the leaving group for each carbonyl carbon (a carboxylate) is a good electron-withdrawing group.
Carboxylic derivatives are described as compounds that can be converted to carboxylic acids via simple acidic or. basic hydrolysis. The most important acid derivatives are esters, amides and nitriles, although acid halides and anhydrides are also. derivatives (really activated forms of a carboxylic acid).