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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Rarely, patients with thyroid nodules. may complain of pain in the neck, jaw, or ear. If a nodule is. large enough to compress the windpipe or esophagus, it. may cause difficulty with breathing, swallowing, or cause a. âtickle in the throatâ. Even less commonly, hoarseness can.