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Many mutations have no effect at all. These are called silent mutations. But the mutations we hear about most often are the ones that cause disease. Some well-known inherited genetic disorders include cystic fibrosis, sickle cell anemia, Tay-Sachs disease, phenylketonuria and color-blindness, among many others.All of these disorders are caused by the mutation of a single gene.Most inherited genetic diseases are recessive, which means that a person must inherit two copies of the mutated gene to inherit a disorder.any mutations have no effect at all. These are called silent mutations. But the mutations we hear about most often are the ones that cause disease. Some well-known inherited genetic disorders include cystic fibrosis, sickle cell anemia, Tay-Sachs disease, phenylketonuria and color-blindness, among many others.
Through a steadily growing program of research in genetics and genomics, our investigators are answering key questions about the causes and underlying biology of disease. Genetics is the study of individual genes, the DNA sequences that are passed down from parents to children. Genomics addresses all genes, the interrelationships among them, and their combined impact on an individualâs development, disease risk, and response to certain types of treatment.