Paul Walker has topped the Google UK Zeitgeist chart of the most searched for people on the internet in 2013. The late Fast & Furious star, who died in a car crash on 30 November, was laid to rest during a funeral on Sunday.
Understanding First Pass Metabolism. The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver. For example, first pass metabolism occurs in the gut for benzylpenicillin and insulin and in the liver for propranolol, lignocane, chloromethiasole and GTN.
Buccal administration; Naloxone; Naltrexone; opioid antagonist; Pharmacokinetics; First-pass metabolism Summary The opioid antagonists naloxone and naltrexone are both known to undergo extensive first-pass metabolism after oral dosing. The buccal route was investigated as a potential alternative to oral administration. Oral and buccal bioavailabilities of naloxone and naltrexone were determined in rats. Less than 1 % of oral naloxone or naltrexone was bioavailable, but buccal administration resulted in approximately 70% bioavailability for each drug.