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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Ethacrynic acid does not contain a sulfa group and is a possible alternative in sulfonamide-allergic patients. Bumetanide and furosemide product labeling contain statements that patients may also be allergic to these drugs if they are allergic to sulfonamides.autious use recommended with serious or life-threatening sulfa allergy. 13 Tipranavir (Aptivus) Precaution 10 The potential for cross-sensitivity between drugs in the sulfonamide class and tipranavir (a protease inhibitor) is unknown.