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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
18 Oct 2016. Medrol Dosepak (methylprednisolone) has a medium half life range of 18 to 36 hours - meaning it takes the body 18 to 36 hours to clear 50% of the drug from your plasma. For a drug to be totally eliminated from your system it takes around 5.5 times the half life. As an estimate then, after taking a single dose of methylprednisolone it should be out of your system after 8 days. (5.5 x 36 hours = 198 hours or just over 8 days) Other factors to consider: 1. How much and how often you have taken the drug. 2. Your metabolic rate â a slower metabolism will increase the time a drug remains in your system. 3.