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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
When this happens, the colon. instead relies on the laxatives to bring on bowel movements. In addition, the ongoing use of laxatives may cause a potassium imbalance in the body, which in. rare cases can become a serious health threat. Treatment Options. No medical treatment is necessary for melanosis coli. Patients are advised to stop taking laxatives, which usually reverses the discoloration of the colon after a fairly short period of time. If constipation â generally defined as the passage of small, hard and dry bowel movements fewer.