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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
4.6 John White searches for the colonists. The Fifth Voyage of M. John White, 1590, from Henry S. Burrage, ed., Early English and French Voyages, Chiefly from Hakluyt, 1534â1608 (New York: Charles Scribner's Sons, 1906), pp. 315â320. John White drew this map of the coast of North Carolina and Virginia in 1585 and 1586. (Note that west, not north, is up.) Although his efforts to map the coast helped him find Roanoke Island, the colonists he left behind had disappeared. (Map by Theodor de Bry. More about the map). This page has comments.