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Addisonâs disease most commonly affects female dogs around four or five years old. This condition is typically caused by injury to the adrenal glandsâ tissue from infection, hemorrhaging, or autoimmune disorders. If your pet is coming off of steroid treatment, the steroid withdrawal may also be causing an imbalance.
Most cases of Addisonâs disease are caused by autoimmune disorders. Our bodyâs immune system makes antibodies that fight against germs, bacteria, and viruses that enter our bodies. When an autoimmune disease such as Addisonâs exists, the immune system makes antibodies against a part of the body, which in this case would attach to the surface of the adrenals.