Other Skin Diseases. 1  Rosacea is a skin condition where there is extreme redness of the skin often with pus-filled blisters. 2  Atopic dematitis, often referred to as eczema, is a condition that often arises in childhood. 3  Acne vulgaris is a common condition especially among teens.
Otezla is a pill you take twice a day, starting low and increasing your dose over a week to limit side effects. Typical doses are a 20 mg tablet or a 30 mg tablet, twice a day. What are the common side effects? The most common one is a short-term risk of diarrhea, especially in the beginning.
Thus, an inhibitor of PDE4 results in an increase in cAMP, which is similar to CF101's mechanism of action (discussed below). Otezla(R) was approved for the treatment of psoriatic arthritis in March 2014, and then for the treatment of psoriasis in September 2014. The drug was approved for the treatment of psoriasis based on two Phase 3 clinical trials involving over 1,200 patients.