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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
In April 1915, after giving a lecture in Moscow on âIn Search of the Miraculous,â Ouspensky was approached by Vladimir Pohl, a composer, and Sergei Dmitrievich Mercourov, a sculptor, who encouraged him to meet the man who was leading a group studying occult investigations and experiments. Ouspensky was not interested.