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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
A type 1 IgE mediated immune reaction is the most type of allergic reaction to sulfonamides, and caused by the release of histamine into the blood. The most common symptom of this allergic reaction is the development of a maculopapular or urticarial rash within one to three days of drug administration.