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Tobacco would be the salvation not only of Jamestown but of the  state of Virginia. Tobacco remain a profitable case crop in the  region until the negative campaign against â¦the tobacco industry  decreased the demand.
More than the infusion of population, colonist John Rolfe's discovery of a profitable cash crop-tobacco-sealed the fate of the Virginia colony. Economically, tobacco became to the Chesapeake what sugar was to West Indies and silver was to Mexico. However, tobacco required a great deal of labor to cultivate.