Paul Walker has topped the Google UK Zeitgeist chart of the most searched for people on the internet in 2013. The late Fast & Furious star, who died in a car crash on 30 November, was laid to rest during a funeral on Sunday.
Understanding First Pass Metabolism. The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver. For example, first pass metabolism occurs in the gut for benzylpenicillin and insulin and in the liver for propranolol, lignocane, chloromethiasole and GTN.
drug molecules are moved from an area of lower concentration to one of higher concentration. requires a carrier substance and the release of cellular energy. A nurse practitioner has just changed a patient's medication from an oral form to a patch formulation to avoid the first-pass effect. The NP has explained it to the patient, but the patient still has questions and asks the nurse to explain again what is meant by the first-pass effect.