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CHARGE syndrome (formerly known as CHARGE association), is a syndrome caused by a genetic disorder. It was first described in 1979. In 1981, the term CHARGE came into use as an acronym for the set of unusual congenital features seen in a number of newborn children.
CHARGE syndrome is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. Most cases result from new mutations in the CHD7 gene and occur in people with no history of the disorder in their family.hese resources address the diagnosis or management of CHARGE syndrome and may include treatment providers. 1  Gene Review: CHARGE Syndrome. 2  Genetic Testing Registry: CHARGE association. 3  MedlinePlus Encyclopedia: Choanal atresia. 4  MedlinePlus Encyclopedia: Coloboma.