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Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions.Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.he oxidative conversion of pyruvate into acetyl-CoA is referred to as the pyruvate dehydrogenase reaction. It is catalyzed by the pyruvate dehydrogenase complex. Other conversions between pyruvate and acetyl-CoA are possible.
The acetyl group of acetyl-CoA is linked by a high energy thioester to the sulfhydryl portion of the Î²-mercaptoethylamine. It is this thioester bond that makes acetyl-CoA one of the high energy compounds.