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Denosumab is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. The Prolia brand of denosumab is used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.Prolia is also used to increase bone mass in women and men with a high risk of bone fracture caused by receiving treatments for certain types of cancer.This medication guide provides information about the Prolia brand of denosumab.rolia is also used to increase bone mass in women and men with a high risk of bone fracture caused by receiving treatments for certain types of cancer. This medication guide provides information about the Prolia brand of denosumab.
Denosumab is also sold under the brand name Xgeva, which comes in a different strength and is used to treat bone loss in people with certain types of cancer. It's also used to help raise calcium levels in the blood. Prolia belongs to group of drugs known as RANK ligand inhibitors.Prolia was originally approved by the Food and Drug Administration (FDA) in 2010 and was manufactured by Amgen Pharmaceuticals.Xgeva was approved in 2013.ou should not take Prolia if: 1  You are allergic to Prolia or any of the other ingredient found in the drug. 2  You are prone to infections and get sick easily. 3  You have poor kidney function.