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Finasteride reduces PSA levels to varying degrees in different men, making it difficult to track what the âtrueâ PSA values are over time. Finasteride fails to reduce PSA velocity (increases) in men with high-grade prostate cancer and fails to induce objective responses in men with metastases. Finasterideâs so-called âpreventiveâ effects in the Prostate Cancer Prevention Trial occurred far too early and did not increase much over time.
Other symptoms include wetting and staining of clothes, urinary burning, and urgency. Prostate gland enlargement (benign prostatic hyperplasia or BPH), is directly dependent on DHT (a hormone converted from the male hormone testosterone).Finasteride inhibits the enzyme necessary for the conversion of testosterone to DHT in the prostate.Therefore, administration of finasteride lowers blood and tissue DHT levels and helps reduce the size of the prostate gland.inasteride inhibits the enzyme necessary for the conversion of testosterone to DHT in the prostate. Therefore, administration of finasteride lowers blood and tissue DHT levels and helps reduce the size of the prostate gland.