Once asleep again, the muscles relax and the airway becomes blocked, cutting off the airway again. This cycle can occur hundreds of times per night. Obstructive Sleep Apnea is the most common form of sleep apnea. It ranges in severity from mild to moderate, to severe. Other forms of sleep apnea include Central and Mixed Sleep Apnea.
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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.