Members of the DEWS Definition and Classification. Subcommittee developed a contemporary definition of dry eye disease and a three-. part classification system based on etiology, causative mechanisms and disease. severity.
Metaplasia. Definition: Metaplasia is the reversible replacement of one differentiated cell type with another differentiated cell type. Metaplasia causes precursor cells to change their cell fate, and do not change existing differentiated cells.he most common epithelial metaplasia is columnar to squamous (squamous metaplasia), as occurs in the respiratory tract in response to chronic irritation.
Metaplasia is the potentially reversible change from a fully differentiated cell type to another cell type. Metaplasia is associated with significantly increased risk of cancer.Therefore, it is defined as a precancerous condition.ntestinal metaplasia is also a common in Barrett esophagus. It this condition it is the esophageal squamous epithelial cells that undergo metaplasia. Approximately, 60% of esophageal cancers diagnosed in the U.S. stem from focal intestinal metaplasia.