The leading modifiable risk factors worldwide are: 1  tobacco smoking, which is strongly associated with lung cancer, mouth, and throat cancer; 2  drinking alcohol, which is associated with a small increase in oral, esophageal, breast, liver and other cancers; 3  a diet low in fruit and vegetables,
Trier Tourism: Best of Trier. Trier, Germany. Trier, which lies in the Moselle wine region along the banks of the Moselle River, is the oldest city in Germany. The city is home to the University of Trier.
German, Pfalz. either of two historic regions of Germany that constituted an electorate of the Holy Roman Empire: one (Lower Palatinate or Rhine Palatinate) is now part of Rhineland-Palatinate, and the other (Upper Palatinate) is now part of Bavaria.he Lower Palatinate is in southwest Germany between Luxembourg and the Rhine River; the Upper Palatinate is to the east in eastern Bavaria. They were once under the jurisdiction of the counts palatine, who became electors of the Holy Roman Empire in 1356 and were then known as electors palatine.