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Tobacco would be the salvation not only of Jamestown but of the  state of Virginia. Tobacco remain a profitable case crop in the  region until the negative campaign against â¦the tobacco industry  decreased the demand.
Famine, disease and conflict with local Native American tribes in the first two years brought Jamestown to the brink of failure before the arrival of a new group of settlers and supplies in 1610. Tobacco became Virginiaâs first profitable export, and a period of peace followed the marriage of colonist John Rolfe to Pocahontas, the daughter of an Algonquian chief.