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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Thiazide - Contraindications. 1  Contraindications include... 2  Hypotension. 3  Allergy to sulphur-containing medications. 4  Renal failure. 5  Lithium therapy. 6  Hypokalemia. 7  May worsen diabetes. 8  Thiazides reduce the clearance of uric acid since they compete for the same transporter, and therefore raise the levels of uric acid in the blood.