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Q: How often do doctors give cortisone injections to a patient? A: We try to limit the injection to one every three months for any single joint, but also we like to limit it to a total of six injections a year for the whole body. We know that the cortisone can sometimes weaken or suppress the immune system and, in diabetics, it raises blood sugar.
While cortisone shots can help reduce knee pain by treating inflammation, it might not be a perfect solution for everyone. Nevertheless, you should keep the followings in mind: 1  The injection works fast. You should feel better within 1 to 2 days after getting it.  The effect only last for a short time.