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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
John Wesley (/ËdÊÉn ËwÉsli/ or /ËdÊÉn ËwÉzli/; 28 June [O.S. 17 June] 1703 â 2 March 1791) was an Anglican cleric and theologian who, with his brother Charles and fellow cleric George Whitefield, founded Methodism. Educated at Charterhouse School and Oxford University, Wesley was elected a fellow of Lincoln College, Oxford in 1726 and ordained a priest two years later.