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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
You are not going to be taking apirin daily or in large amounts. On the day that you have menstrual pain (usually first day of period) take aspirin (or in your case the Midol) about once every 3 1/2 hours as it does take that 1/2 hour for the Midol to get into your system. You will not have to worry about over-dosing and in this way you can keep the pain medication working for you.