Self-actualization, according to Maslow, represents the growth of an individual toward fulfillment of the highest needs. Maslow argues that only high acheivers are self-actualizers, but we are all in fact capable of self-actualization.
In a thrombotic stroke, a blood clot (thrombus) forms inside one of the brain's arteries. The clot blocks blood flow to a part of the brain. This causes brain cells in that area to stop functioning and die quickly.
In general, as the atherosclerotic burden increases - leading to carotid artery diameter reduction - the risk of active carotid disease, or stroke, increases as well. The explanation as to why higher degrees of stenoses equate with a higher risk of stroke is basically two-fold.