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Q: How often do doctors give cortisone injections to a patient? A: We try to limit the injection to one every three months for any single joint, but also we like to limit it to a total of six injections a year for the whole body. We know that the cortisone can sometimes weaken or suppress the immune system and, in diabetics, it raises blood sugar.
Quick Answer. A cortisone shot typically starts providing relief from symptoms within 48 to 72 hours, according to About.com. Cortisone shots relieve pain by reducing inflammation. Inflammation begins to subside immediately after the shot although significant pain relief can take a few days to a few weeks. Continue Reading.