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Fabrication is the practice of inventing data or results and recording and/or reporting them in the research record. Both of these schemes are probably among the most serious offenses in scientific research as they challenge the credibility of everyone and everything involved in a research effort.
Fabrication, is the building of something brand new, that's never been seen before, or invented. Manufacturing, is the duplication of something on a mass scale. Generally, the way it works is, you fabricate something that you need, then manufacture what you fabricate. A good example is, a car company decides to design a brand new car from the ground up.