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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Sulfonamides What are Sulfonamides. Sulfonamides are a group of man-made (synthetic) medicines that contain the sulfonamide chemical group. They are also called sulfa drugs (sometimes spelled as sulpha drugs or sulphonamides). Sulfanilamide was the first sulfonamide developed in 1906, although it was not used as an antimicrobial until the late 1930s.