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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
When we did JNC7, we looked to see if there were comparative studies between chlorthalidone and thiazide diuretics, but we could find nothing after 1979. Recently, a group from the US Naval Base in San Diego looked at a variety of other properties that chlorthalidone might have that a thiazide diuretic does not.