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Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions.Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.he oxidative conversion of pyruvate into acetyl-CoA is referred to as the pyruvate dehydrogenase reaction. It is catalyzed by the pyruvate dehydrogenase complex. Other conversions between pyruvate and acetyl-CoA are possible.
Acetyl Coenzyme A (Molecular Biology). Acetyl coenzyme A (acetylCoA) consists of a two-carbon activated acetyl unit attached to coenzyme A in thioester linkage.AcetylCoA is central to energy generation from the degradative pathways of oxidative fuel metabolism and to a number of biosynthetic pathways that utilize the activated two-carbon acetyl unit.. Structure. The ability of acetylCoA to participate in these diverse metabolic pathways is derived from the thioester bond formed between the acyl carbon of the acetyl unit and the sulfhydryl group of coenzyme A (CoASH) (Fig.