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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Referral to an. allergist may be warranted for patients who have had a severe allergic reaction to a. sulfonamide. Ethacrynic acid does not contain a sulfa group and is a possible alternative in. sulfonamide-allergic patients. Bumetanide and furosemide product labeling contain statements that patients may also be. allergic to these drugs if they are allergic to sulfonamides.