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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
There are a few different drugs that work in a similar way, known as thiazide diuretics or thiazide-related diuretics. Each of these drugs in different (they are a different chemical substance) but they way they work in the body is very similar, which is why we group them together as a âclassâ of drugs.