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The DEPO will stay in your system for 3 months but you can become pregnant and conceive, before the 3 month time frame is up. One in a 100 women getting a Depo shot every 12 weeks will get pregnant in a year. After stopping it takes on average a further 9-10 months to get pregnant.he DEPO will stay in your system for 3 months but you can become pregnant and conceive, before the 3 month time frame is up. One in a 100 women getting a Depo shot every 12 weeks will get pregnant in a year. After stopping it takes on average a further 9-10 months to get pregnant.
How is Depo-Provera given? Depo-Provera injection is usually given into the muscle of the buttock or upper arm. The injection produces a reservoir of medroxyprogesterone in the muscle, which is then continuously released into the bloodstream over a period of 12 weeks.