The leading modifiable risk factors worldwide are: 1  tobacco smoking, which is strongly associated with lung cancer, mouth, and throat cancer; 2  drinking alcohol, which is associated with a small increase in oral, esophageal, breast, liver and other cancers; 3  a diet low in fruit and vegetables,
Trier Tourism: Best of Trier. Trier, Germany. Trier, which lies in the Moselle wine region along the banks of the Moselle River, is the oldest city in Germany. The city is home to the University of Trier.
The film was shot in the German state of North Rhine-Westphalia. Locations were used in Rhein-Sieg-Kreis, part of the Cologne region, and Wuppertal. It was the first film by Trier to be entirely filmed in Germany. The fictional setting of the film however is near Seattle, USA.The film was shot on digital video, primarily using Red One cameras in 4K resolution. The slow motion sequences were shot with a Phantom V4 in 1,000 frames per second.o get into the right mood before filming started, both Dafoe and Gainsbourg were shown Andrei Tarkovsky 's The Mirror from 1975. Dafoe was also shown Trier's own 1998 film The Idiots, and Gainsbourg The Night Porter to study Charlotte Rampling 's character.