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High HDL. High levels of good, or HDL, cholesterol can significantly decrease a person's risk for heart disease. According to the latest guidelines, a level of 60 mg/dL and above is considered high.. In most cases, the cause is unknown, but it does seem to run in families. High HDL levels can also be caused by certain cholesterol medications, aerobic exercise, and regular alcohol consumption.
A low blood level of HDL cholesterol may increase heart attack risk. Related Articles. A low level of high-density lipoprotein, or HDL cholesterol, in the blood is a risk factor for cardiovascular disease, heart attack and stroke. Scientific studies indicate that HDL can remove cholesterol from fatty plaques in artery walls.