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Full Definition of DIPHTHERIA. : an acute febrile contagious disease typically marked by the formation of a false membrane especially in the throat and caused by a gram-positive bacterium (Corynebacterium diphtheriae) that produces a toxin causing inflammation of the heart and nervous system.
Diphtheria is a serious bacterial infection that affects the mucous membranes of the throat and nose. Although it spreads easily from one person to another, diphtheria can be prevented through the use of vaccines. Call your doctor right away if you believe you have diphtheria.