Paul Walker has topped the Google UK Zeitgeist chart of the most searched for people on the internet in 2013. The late Fast & Furious star, who died in a car crash on 30 November, was laid to rest during a funeral on Sunday.
Understanding First Pass Metabolism. The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver. For example, first pass metabolism occurs in the gut for benzylpenicillin and insulin and in the liver for propranolol, lignocane, chloromethiasole and GTN.
1 The rate and extent of first-pass intestinal metabolism of a drugafter oral administration are dependent on various physiologicalfactors1. 2  Site of absorption: If the absorption site in the intestine is differentfrom the metabolic site, first-pass intestinal metabolism of a drugmay not be significant.2. â¢ Phase I metabolism is sometimes called a â¢ Phase II metabolism includes what are known âfunctionalization reaction,â as conjugation reactions.â¢ Results in the introduction of new hydrophilic functional groups to compounds.