Van Pelt in Jumanji: The Animated Series. Van Pelt returns as a recurring villain in the animated series based on the movie. He is revealed to be a part of the game, and when he actually dies in an episode, Peter starts to become him little by little, but is saved by Alan and Judy.
http://www.chacha.com/question/which-episode-of-grey's-anatomy-does-izzy-get-diagnosed-with-cancer. Izzie discovers she has metastatic melanoma (Stage IV) in season 5 episode 17 I Will Follow You Into the Dark of Grey's Anatomy.
Izzy, Willy-Nilly. One moment can change a life forever. Fifteen-year-old Izzy has it all -- a loving family, terrific friends, a place on the cheerleading squad. But her comfortable world crumbles when a date with a senior ends in a car crash and she loses her right leg. Suddenly nothing is the same. The simplest tasks become enormous challenges.