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Missense mutation: A genetic change that results in the substitution of one amino acid in protein for another. A missense mutation is responsible for sickle hemoglobin, the molecular basis of sickle cell trait and sickle cell anemia. Search MedTerms:
Best Answer: Missense mutations With a missense mutation, the new nucleotide alters the codon so as to produce an altered amino acid in the protein product.Nonsense mutations With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA).Therefore, translation of the messenger RNA transcribed from this mutant gene will stop prematurely.uch mutations are said to be silent because they cause no change in their product and cannot be detected without sequencing the gene (or its mRNA). Insertions and Deletions (Indels) Extra base pairs may be added (insertions) or removed (deletions) from the DNA of a gene. The number can range from one to thousands.