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High HDL. High levels of good, or HDL, cholesterol can significantly decrease a person's risk for heart disease. According to the latest guidelines, a level of 60 mg/dL and above is considered high.. In most cases, the cause is unknown, but it does seem to run in families. High HDL levels can also be caused by certain cholesterol medications, aerobic exercise, and regular alcohol consumption.
People who have familial hypercholesterolemia have high levels of LDL cholesterol because they can not remove the LDL from the blood stream properly. The organ responsible for the removal of the LDL is the liver. High levels of LDL cholesterol in the blood increase the risk for heart attacks and heart disease.