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Finasteride reduces PSA levels to varying degrees in different men, making it difficult to track what the âtrueâ PSA values are over time. Finasteride fails to reduce PSA velocity (increases) in men with high-grade prostate cancer and fails to induce objective responses in men with metastases. Finasterideâs so-called âpreventiveâ effects in the Prostate Cancer Prevention Trial occurred far too early and did not increase much over time.
Semen samples were obtained at least 48 hours after the last ejaculation but not more than 7 days afterward. Of 4,400 men seen at the clinic, 27 (0.6%) were taking finasteride 1 mg/d for alopecia areata.one of the patients had a decrease in sperm count after stopping finasteride. Discontinuation of the drug did not affect hormone parameters, sperm motility, or sperm morphology, they reported online in Fertility and Sterility.