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Carboxylic derivatives are described as compounds that can be converted to carboxylic acids via simple acidic or. basic hydrolysis. The most important acid derivatives are esters, amides and nitriles, although acid halides and anhydrides are also. derivatives (really activated forms of a carboxylic acid).
We can also consider the conjugate base of a carboxylic acid, a carboxylate anion, as a functional derivative of the carboxylic acid. Two additional functional group derivatives will be considered in this chapter, viz ., amides and acid chlorides.s background for the acid catalyzed hydrolysis of amides, letâs consider the basicity of amides. q As in the case of esters or carboxylic acids, there are two basic sites in an amide function which could potentially be protonated, namely the carbonyl oxygen and the amide nitrogen.