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Effects of substituents on the acidity of phenols: Existence of electron attracting group, (for example-NO2, -X, - NR, -CN, -CHO, -COOH) on the benzene ring increases the acidity of phenol since it enables the ring to draw much more electrons from the phenoxy oxygen and so releasing easily the proton.
The superoxide scavenging activities of the rosmarinic acid derivatives were 15â20 times stronger than trolox. Being the major polyphenols in sage (or sage residue), the rosmarinic acid derivatives were more likely to be responsible for most of the observed antioxidant activity of the non-diterpenoid component in sage.