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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Lumps in the Thyroid. Lumps or swellings in the center of the throat (on the front of the neck) may represent small cysts or nodules in the thyroid gland. Thyroid lumps are typically painless and are not symmetrical (i.e., not equal on both sides of the throat).