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High HDL. High levels of good, or HDL, cholesterol can significantly decrease a person's risk for heart disease. According to the latest guidelines, a level of 60 mg/dL and above is considered high.. In most cases, the cause is unknown, but it does seem to run in families. High HDL levels can also be caused by certain cholesterol medications, aerobic exercise, and regular alcohol consumption.
Familial hypercholesterolemia is a genetic disorder caused by a defect on chromosome 19. The defect makes the body unable to remove low density lipoprotein (LDL, or bad) cholesterol from the blood. This results in high levels of LDL in the blood.igh levels of LDL cholesterol make you more likely to have narrowing of the arteries from atherosclerosis at an early age. Those with familial hypercholesterolemia are more likely to have a family history of high cholesterol and heart disease at a younger age than normal.