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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
Melanosis coli usually results from chronic use of laxatives of the anthranoid group. Some examples of anthranoid laxatives are senna (sennosides; Senocot, Senokot EXTRA and others) and rhubarb derivatives.Many of these laxatives have been in use for hundreds of years.elanosis coli usually results from chronic use of laxatives of the anthranoid group. Some examples of anthranoid laxatives are senna (sennosides; Senocot, Senokot EXTRA and others) and rhubarb derivatives.