These studies are now being done by GWAS in 2 patient groups, examining both baseline HbF and the HbF response to hydroxyurea. Genetic modulation of sickle cell disease: Homozygosity for a single Î²-globin gene mutation (HBB; glu6val) causes sickle cell anemia.hese studies are now being done by GWAS in 2 patient groups, examining both baseline HbF and the HbF response to hydroxyurea. Genetic modulation of sickle cell disease: Homozygosity for a single Î²-globin gene mutation (HBB; glu6val) causes sickle cell anemia.
Spiral Galaxies. Spiral galaxy M100. Spiral galaxies have three main components: a bulge, disk, and halo (see right). The bulge is a spherical structure found in the center of the galaxy. This feature mostly contains older stars. The disk is made up of dust, gas, and younger stars. The disk forms arm structures.
Spiral arms. The structure of the arms of spiral galaxies depends on the galaxy type, and there is also a great deal of variability within each type. Generally, the early Hubble types have smooth, indistinct spiral arms with small pitch angles. The later types have more-open arms (larger pitch angles).