Paul Walker has topped the Google UK Zeitgeist chart of the most searched for people on the internet in 2013. The late Fast & Furious star, who died in a car crash on 30 November, was laid to rest during a funeral on Sunday.
Understanding First Pass Metabolism. The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation. First pass metabolism can occur in the gut and the liver. For example, first pass metabolism occurs in the gut for benzylpenicillin and insulin and in the liver for propranolol, lignocane, chloromethiasole and GTN.
Drugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.rugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.