Maternal serum alpha-fetoprotein (MSAFP). Screening at 15-20 weeks gestation, is optimal at 18-18 weeks gestation.Alpha fetoprotein (AFP) screening during pregnancy has had a major impact on the prenatal detection of fetal abnormalities.or example, in a 25-year-old woman the risk of delivering an infant with Down syndrome, based on age alone, is one in 1,250. If her MSAFP level is 0.36 MOM at 16 weeks of gestation, however, the risk is increased to one in 257.
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