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Probably limited a small bit by structural strength, i.e. more acceleration means a stronger and heavier structure. For manned rockets, the G forces are even lower to accomodate the astronauts. So I'm assuming that even lower accelerations are only possible if you trade off fuel efficiency.
With the development of faster and more maneuverable planes, G forces became more dangerous. Based on rates of survival (or lack thereof) during crashes, it became accepted wisdom that no pilot could withstand more than 18 G's, or 18 times the force of gravity at sea level.