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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
This will determine how fast it takes effect. An injection or IV takes effect in 5 to 15 minutes with maximum effect in 15 to 60 minutes and has effects lasting for about 2 hours but with a range of 1 to 6 hours. The amnesia effect lasts for 20 minutes to an hour depending on how it is administered. Taking the syrup, effects in children are seen in 10 to 20 minutes. Midazolam is broken down in the liver to both active and inactive metabolites, so it has two phases of elimination from the body.