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Probably limited a small bit by structural strength, i.e. more acceleration means a stronger and heavier structure. For manned rockets, the G forces are even lower to accomodate the astronauts. So I'm assuming that even lower accelerations are only possible if you trade off fuel efficiency.
To put things in perspective, all values are stated in g. 1  In roller coaster design, speed is of the essence. 2  Despite the immense power of its engines, the acceleration of the Space Shuttle is kept below 3 g. 3  Fighter pilots can experience accelerations of up to 8 g for brief periods during tactical maneuvers.