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Missense mutation: A genetic change that results in the substitution of one amino acid in protein for another. A missense mutation is responsible for sickle hemoglobin, the molecular basis of sickle cell trait and sickle cell anemia. Search MedTerms:
Thus the amino acid sequence encoded by the gene is not changed and the mutation is said to be silent. Missence: When base substitution results in the generation of a codon that specifies a different amino acid and hence leads to a different polypeptide sequence.Depending on the type of amino acid substitution the missense mutation is either conservative or nonconservative.ypes of Mutations. There are three types of DNA Mutations: base substitutions, deletions and insertions. 1. Base Substitutions. Transition: this occurs when a purine is substituted with another purine or when a pyrimidine is substituted with another pyrimidine.