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Mitochondrial DNA and Diseases. Abstract. The mitochondrial genome (mtDNA, mitochondrial deoxyribonucleic acid) is an essential source of extranuclear DNA in mammalian cells, located in the matrix of the organelle.
In eukaryotic cells, like in the maize cell shown here, DNA is located in the nucleus, the mitochondria and the chloroplasts (occuring only in plants and some protists). The nucleus contains most DNA. It is present in this compartment in the form of linear chromosomes that together constitute the genome.