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Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions.Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.he oxidative conversion of pyruvate into acetyl-CoA is referred to as the pyruvate dehydrogenase reaction. It is catalyzed by the pyruvate dehydrogenase complex. Other conversions between pyruvate and acetyl-CoA are possible.
Structure of coenzyme A (CoASH or CoA) consists of a Î²-mercaptoethylamine group linked to the vitamin pantothenic acid through an amide linkage. The acetyl group of acetyl-CoA is linked by a high energy thioester to the sulfhydryl portion of the Î²-mercaptoethylamine.It is this thioester bond that makes acetyl-CoA one of the high energy compounds.holine, in combination with acetyl-CoA, is catalyzed by the enzyme choline acetyltransferase to produce acetylcholine and a Coenzyme A byproduct. Konrad Bloch and Feodor Lynen were awarded the 1964 Nobel Prize in Physiology and Medicine for their discoveries linking acetyl-CoA and fatty acid metabolism.