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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Later, the Florida territory was sold to Britain. The royal botanist in America to King George III, John Bartram, explored the St. Johns River in 1765. It was John Bartram who gave the lake the name Lake George, in honor of his king.