Postgraduate programs are getting a lot more practical with hands-on learning and job-focused training. By Christopher J. Gearon, Contributor | March 13, 2013, at 8:30 a.m. Focus on Job Skills With a Professional Master's Degree.
PARK2 (OMIM *602544) is the parkin gene that may cause a form of autosomal recessive juvenile Parkinson disease (OMIM 600116) due to a mutation in the parkin protein. This form of genetic mutation may be one of the most common known genetic causes of early-onset Parkinson disease.In one study of patients with onset of Parkinson disease prior to age 40 (10% of all PD patients), 18% had parkin mutations, with 5% homozygous mutations.his form of genetic mutation may be one of the most common known genetic causes of early-onset Parkinson disease. In one study of patients with onset of Parkinson disease prior to age 40 (10% of all PD patients), 18% had parkin mutations, with 5% homozygous mutations.
1 The PARK7 gene is not a common locus for early onset autosomal recessive parkinsonism. 2  Mutations in the DJ-1 gene are rare in early-onset Parkinson's disease in both sporadic and familial cases. 3  We describe clinical and neuroimaging features of the 4 patients in the original PARK7-linked kindred. PARK7 protein loss of function could be due to impaired caspase-6 proteolysis and we document the fact that various PARK7 protein mutations could lead to PD pathology through distinct molecular mechanisms. 2  LRRK2 with other Parkinson's disease causing genes, Parkin, DJ-1 and PINK-1.