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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Symptoms of goiter -- an enlarged thyroid -- include a swollen, tender or tight feeling in the neck or throat, hoarseness or coughing, and difficulty swallowing or breathing. Sometimes, the goiter is visible to yourself or others. Symptoms of nodules depend on what action they are having. Some cause no symptoms, while others may cause difficulty swallowing, a feeling of fullness, pain or pressure in the neck, a hoarse voice, or neck tenderness. Some nodules trigger hyperthyroid-like symptoms such as palpitations, insomnia, weight loss, anxiety, and tremors.