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Q: How often do doctors give cortisone injections to a patient? A: We try to limit the injection to one every three months for any single joint, but also we like to limit it to a total of six injections a year for the whole body. We know that the cortisone can sometimes weaken or suppress the immune system and, in diabetics, it raises blood sugar.
Immediate Care. Cortisone shots can cause a flare reaction in the first 24 to 48 hours. This can be caused by the body responding to the needle injury or from small crystals that form in the injected tissue. A flare reaction causes a temporary increase in inflammation, which may also worsen pain in the shoulder.