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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Thiazides are the only type of diuretic that dilates (widens) the blood vessels, which also helps to lower blood pressure. 2. Potassium-sparing diuretics are used to reduce the amount of water in the body. Unlike the other diuretic medicines, these medicines do not cause your body to lose potassium. 3. Loop-acting diuretics cause the kidneys to increase the flow of urine. This helps reduce the amount of water in your body and lower your blood pressure.