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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
The Death of John AndrÃ©. September 29, 1780 -- John AndrÃ© to Henry Clinton. In April 1779 John AndrÃ© was placed in charge of the British Secret Intelligence. In this role he continued the negotiations with Benedict Arnold, which had been in progress since 1778. As Arnold was promoted to commander of West Point in August 1780, the British began to take his offerings seriously.