Its competitor, Otrexup, costs $500 to $600 a month for a 25 mg dose â more than a vial of methotrexate and far more than pills, which cost $20 to $30 for a dozen 2.5 mg tablets.
The leaders of Britain, France, Italy, and Germany held a conference in Munich, Germany, on September 29-30, 1938, in which they agreed to the German annexation of the Sudetenland in exchange for a pledge of peace from Hitler. Czechoslovakia, which was not a party to the Munich negotiations, agreed under significant pressure from Britain and France. On March 15, 1939, Hitler violated the Munich agreement and moved against the Czechoslovak state. The Czech provinces of Bohemia and Moravia were proclaimed a German protectorate and were occupied by German forces. Slovakia became an independent state, closely allied with Germany.
The 1938 Munich conference was part of the policy called  'appeasement or giving in towards the demands of Adolf Hitler in  order to ensure peace. Appeasement is a generalâ¦ term used in  diplomacy to  give in or to placate an aggressive enemy. The term  was popularized when the Munich conference agreement was later  termed to be a worthless agreement as within a year, Europe was at  war.