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Taking Medication. 1  1. Recognize a migraine. Learn to recognize the warning signs of a migraine. 2  2. Act fast. Many of the steps you can take to stop or minimize a migraine work best when taken at the first sign of migraine symptoms. 3  3. Take basic painkillers.
Vitamin B-2. High doses of Vitamin B-2 (riboflavin) may help prevent migraine headaches, a European study reports in the journal Neurology. The beneficial effects in reducing migraine frequency appeared after a month of daily doses of 400 mg, and increased over the next two months, researchers said.