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Definition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.efinition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.
For instance, an antibody deficiency can be diagnosed in the presence of low immunoglobulins, recurrent infections and failure of the development of antibodies on exposure to antigens. The 1999 criteria also distinguish between definitive, probable and possible in the diagnosis of primary immunodeficiency.