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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
Timolol and betaxolol are beta-blocking drugs that work against glaucoma by decreasing the production of aqueous humor (fluid) in the eye. Unless they have a history of heart failure or asthma, most patients with glaucoma can use a beta blocker. Beta-blocking drugs account for most of the glaucoma medications sold.