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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
These drugs are in the categories pyrazolopyrimidines, imidazopyridines or cyclopyrrones, but they are not all in the same category. Therefore, we prefer the term Z-drugs. The generic names for these drugs all contain the letter Z, and it is as good a name as any. Eszopiclone is sold under the brand name LunestaÂ® (manufactured by Sepracor). It is less effective than some other insomnia treatments, but has several unique advantages. Eszopiclone has a much smaller chance of causing user dependence than other sleep aids, and is less likely to be used recreationally.