Its competitor, Otrexup, costs $500 to $600 a month for a 25 mg dose â more than a vial of methotrexate and far more than pills, which cost $20 to $30 for a dozen 2.5 mg tablets.
The leaders of Britain, France, Italy, and Germany held a conference in Munich, Germany, on September 29-30, 1938, in which they agreed to the German annexation of the Sudetenland in exchange for a pledge of peace from Hitler. Czechoslovakia, which was not a party to the Munich negotiations, agreed under significant pressure from Britain and France. On March 15, 1939, Hitler violated the Munich agreement and moved against the Czechoslovak state. The Czech provinces of Bohemia and Moravia were proclaimed a German protectorate and were occupied by German forces. Slovakia became an independent state, closely allied with Germany.
At 6am on a wintery March morning in 1939 Adolf Hitler shattered the fragile European peace brokered six months earlier at the Munich conference by sending the Wehrmacht across the border into what remained of Czechoslovakia.