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Taking Medication. 1  1. Recognize a migraine. Learn to recognize the warning signs of a migraine. 2  2. Act fast. Many of the steps you can take to stop or minimize a migraine work best when taken at the first sign of migraine symptoms. 3  3. Take basic painkillers.
Your doctor may prescribe you one of the medications below: 1  Triptans: As with cluster headaches, triptans can work to treat your migraine-related pain and other symptoms. 2  You can take them as a tablet, nasal spray, or injection.or example, you may need a daily prescription medication to relieve chronic migraines, or you may need to take a medication to prevent migraines and headaches. To learn more about preventing migraines and headaches with medication, read our article on preventive medications for migraines and headaches.