âº They act as a framework along which motor proteins can move structures in the cell. Microtubules are assembled from molecules of the protein tubulin. Tubulin is a dimerâa molecule made up of two monomers. The polypeptide monomers that make up this protein are known as a-tubulin and b-tubulin.
Prior to initiation of cefuroxime therapy, careful inquiry should be made concerning previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs. Cefuroxime axetil /is/ contraindicated in patients who are hypersensitive to cefuroxime or other cephalosporins and should be used with caution in patients with a history of hypersensitivity to penicillins.
Following oral administration of cefuroxime axetil, the drug is absorbed as the 1-(acetyloxy)ethyl ester from the GI tract and rapidly hydrolyzed to cefuroxime by nonspecific esterases in the intestinal mucosa and blood. Cefuroxime remaining within the intestinal lumen following hydrolysis of the ester is not absorbed appreciably.