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The gene responsible for HGPS is called LMNA (pronounced âlamin-aâ). Within this gene there is a change in one piece of DNA that is responsible for Progeria. This type of gene change is called a point mutation. The LMNA gene makes a protein called Lamin A, which is an important protein for most cells of our bodies. Lamin A is found in the cell nucleus (the part of each cell that contains the DNA), and helps maintain the shape and function of the cell. The point mutation compromises that cell integrity, causing Progeria.
For people with progeria, a genetic condition that causing rapid aging, it's not uncommon to look 30 or more years older than they actually are. While progeria is typically associated with Hutchinson-Gilford progeria, the term may also refer to Werner syndrome, also known as adult progeria. Hutchinson-Gilford progeria is incredibly rare, affecting around 1 in 4 to 8 million children. Children with progeria have a normal appearance when they are born. Symptoms of the condition begin to show anytime before two years of age when the baby fails to gain weight and skin changes occur. Over time. the child begins to resemble an elderly person. This may include: Hair loss and baldness.