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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Quote from http://www.benzo.org.uk/ashbristol.htm Not to be outdone, the drug companies rapidly produced a series of drugs that were not chemically benzodiazepines but produced the same effects. These were the Z-drugs zopiclone, zolpidem, zaleplon and now eszopiclone (Lunesta).B that Lunesta is eszopiclone, a cousin of the three Z drugs: zolpidem (Ambien), zopiclone (Zimovane) and zaleplon (Sonata), and it is being marketed as safe for long-term use.