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Causes of Cross-eyed. Some of the causes of Cross-eyed are included in the list below: 1  Weak eye muscles. 2  Eye muscle paralysis (see Paralysis symptoms). 3  Eye muscle disease. 4  Eye muscle nerve disorders. 5  Eye vision disorder-especially if the eyes are affected differently.
Amblyopia can be caused by the misalignment of the two eyesâa condition called strabismus. With strabismus, the eyes can cross in (esotropia) or turn out (exotropia). Occasionally, amblyopia is caused by a clouding of the front part of the eye, a condition called cataract. A common cause of amblyopia is the inability of one eye to focus as well as the other one.