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Ganciclovir is a synthetic guanine derivative active against cytomegalovirus (CMV). CYTOVENE-IV is the brand name for ganciclovir sodium for injection. CYTOVENE (ganciclovir) -IV is available as sterile lyophilized powder in strength of 500 mg per vial for intravenous administration only. Each vial of CYTOVENE-IV contains the equivalent of 500 mg ganciclovir as the sodium salt (46 mg sodium).
1 tk, a gene that encodes thymidine kinase, an enzyme that phosphorylates the nucleoside analog ganciclovir. 2  DNA polymerase fails to discriminate against the resulting nucleotide and inserts this nonfunctional nucleotide into freshly-replicating DNA. 3  So ganciclovir kills cells that contain the tk gene.f the replacement gene (A* in the diagram) is nonfunctional (a null allele), mating of the heterozygous transgenic mice will produce a strain of  knockout mice  homozygous for the nonfunctional gene (both copies of the gene at that locus have been knocked out).