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Definition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.efinition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.
Primary immunodeficiencies can affect only a single component of the immune system or multiple cells and proteins. To better understand the immune deficiencies discussed later, this section will describe the organization and maturation of the immune system.