NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
Medical Definition of BILIRUBIN. : a reddish yellow pigment C33H36N4O6 that occurs especially in bile and blood and causes jaundice if accumulated in excess.
Bilirubin is a breakdown product of red blood cells that is usually cleared from the body by the liver. Anything that causes decreased liver function or increase in breakdown of red blood cells can result in jaundice. As a pediatrician, newborn jaundice is the most common form of jaundice that we see.