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Clamp (tool) For other uses, see Clamp. A clamp is a fastening device used to hold or secure objects tightly together to prevent movement or separation through the application of inward pressure.
The voltage clamp is a current generator. Transmembrane voltage is recorded through a voltage electrode, relative to ground, and a current electrode passes current into the cell. The experimenter sets a holding voltage, or command potential, and the voltage clamp uses negative feedback to maintain the cell at this voltage.