Patients with chronic hepatitis B have antibodies against hepatitis B, but these antibodies are not enough to clear the infection of the affected liver cells. The continued production of virus combined with antibodies is a likely cause of the immune complex disease seen in these patients.
1 Hydrolytic Degradation: ï This process occurs in polymers that are watersensitive active groups, especially those that take a lot of moisture. ï 2  Polymers that have an ability for hydrolytic destruction usually have heteroatoms in the main or side chain. Mechanism of Hydrolytic Degradation ï Hydrolytic degradation of members of the polylactide/glycolide family proceeds through four stages as represented in Figure 2: First stage of water diffusion followed by second stage, in which oligomers with acidic endgroups autocatalyze the hydrolysis reaction.
Hydrolytic processes are not expected to be a major contributing factor in the environmental degradation of chlorsulfuron, and would only be significant at acidic pH. While the hydrolysis of chlorsulfuron is significant at pH 5, with a first-order half-life of â¼23 days at 25 Â°C, it is essentially stable at pH 7 and 9.