Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.
noun. 1  a big deal. 2  See more words with the same meaning: exclamations (list of) . 3  See more words with the same meaning: unimportant, useless.
The most prevalent way Iâve seen someone referred to as âsimpleâ is that the person is uncomplicatedâ no drama, no serious psychological aberrations, what-you-see-is-what-you-get. Being around a simple person, thus defined, can be restorative.