Its competitor, Otrexup, costs $500 to $600 a month for a 25 mg dose â more than a vial of methotrexate and far more than pills, which cost $20 to $30 for a dozen 2.5 mg tablets.
The leaders of Britain, France, Italy, and Germany held a conference in Munich, Germany, on September 29-30, 1938, in which they agreed to the German annexation of the Sudetenland in exchange for a pledge of peace from Hitler. Czechoslovakia, which was not a party to the Munich negotiations, agreed under significant pressure from Britain and France. On March 15, 1939, Hitler violated the Munich agreement and moved against the Czechoslovak state. The Czech provinces of Bohemia and Moravia were proclaimed a German protectorate and were occupied by German forces. Slovakia became an independent state, closely allied with Germany.
The Munich Agreement stated that Hitler could have the Sudetenland region of Czechoslovakia provided that he promised not to invade the rest of Czechoslovakia. Hitler was not a man of his word and in March 1939 invaded the rest of Czechoslovakia.