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dobutamine hydrochloride. A synthetic beta-agonist whose primary effect is to increase cardiac contractility, with little effect on systemic vascular resistance. It produces less tachycardia than dopamine and has no effect on renal blood flow. It is of use in congestive heart failure and cardiogenic shock.
Dobutamine is a synthetic catecholamine that is generally considered the inotropic drug of choice for the acute management of severe (systolic) heart failure. It is primarily a b1-receptor agonist (cardiac stimulation), but it also has mild b-2 effects (vasodilation).s mentioned, dobutamine is the preferred inotropic agent for the acute management of low output states due to systolic heart failure. Because dobutamine does not usually raise the arterial blood pressure, it is not indicated as monotherapy in patients with cardiogenic shock. DRUG ADMINISTRATION.