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Definition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.efinition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.
Primary immunodeficiency disorders are classified by which part of the immune system is affected: 1  Humoral immunity, which involves B cells (lymphocytes), a type of white blood cell that produces antibodies (immunoglobulins)