A sprain is an injury to a ligament. Ligaments are the connective tissues that connect bones to bones across a joint. The most common thumb sprain involves the collateral ligaments of the Metacarpophalangeal (MCP) joint. These types of injuries are common in sports and falls on to an outstretched hand.
Nicotinamide is a water-soluble component of the vitamin B complex group. In vivo, Nicotinamide is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD and NADP function as coenzymes in a wide variety of enzymatic oxidation-reduction reactions essential for tissue respiration, lipid metabolism, and glycogenolysis.
Nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. Niacin is found in variety of foods, including liver, chicken, beef, fish, cereal, peanuts, and legumes, and is also synthesized from tryptophan, an essential amino acid found in most forms of protein.