NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
Medical Definition of BILIRUBIN. : a reddish yellow pigment C33H36N4O6 that occurs especially in bile and blood and causes jaundice if accumulated in excess.
Bilirubin is the main bile pigment that is formed from the breakdown of heme in red blood cells. The broken down heme travels to the liver, where it is secreted into the bile by the liver.Normally, a small amount of bilirubin circulates in the blood.Serum bilirubin is considered a true test of liver function, as it reflects the liver's ability to take up, process, and secrete bilirubin into the bile.he free, or unconjugated, bilirubin is carried by albumin to the liver, where it is converted or conjugated and made water soluble. Once it is conjugated into a water-soluble form, bilirubin can be excreted in the urine. An enzyme, glucuronyl transferase, is necessary for the conjugation of bilirubin.