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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period. To treat schizophrenia: 40-1,280 mg CBD by mouth daily for up to four weeks. To treat glaucoma: a single CBD dose of 20-40 mg under the tongue. Doses greater than 40 mg may actually increase eye pressure.