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dobutamine hydrochloride. A synthetic beta-agonist whose primary effect is to increase cardiac contractility, with little effect on systemic vascular resistance. It produces less tachycardia than dopamine and has no effect on renal blood flow. It is of use in congestive heart failure and cardiogenic shock.
Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock.Its primary mechanism is direct stimulation of Î²1 receptors of the sympathetic nervous system. Dobutamine was developed in the 1970s by Drs.Ronald Tuttle and Jack Mills at Eli Lilly and Company, as a structural analogue of isoprenaline.obutamine is administered as a racemic mixture consisting of both (+) and (â) isomers; the (+) isomer is a potent Î² 1 agonist and Î± 1 antagonist, while the (â) isomer is an Î± 1 agonist.