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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
BRAND NAME: Lunesta (formerly known as Estorra). DRUG CLASS AND MECHANISM: Eszopiclone is a non-benzodiazepine, oral, sedative drug (sleeping pill) that is used for treating insomnia. According to the National Institutes of Health, more than 50 million Americans suffer from insomnia.ost drugs that have been used to treat insomnia are benzodiazepines, for example, flurazepam (Dalmane), lorazepam (Ativan), triazolam (Halcion), and temazepam (Restoril). Zolpidem (Ambien) was the first non-benzodiazepine approved for insomnia in over 20 years. Eszopiclone was approved by the FDA in December 2004.