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dobutamine hydrochloride. A synthetic beta-agonist whose primary effect is to increase cardiac contractility, with little effect on systemic vascular resistance. It produces less tachycardia than dopamine and has no effect on renal blood flow. It is of use in congestive heart failure and cardiogenic shock.
Dobutamine is a potent beta-agonist with major activity on the beta-1 (heart) and weaker activity on beta-2 (blood vessels and lungs) receptors. It also has weak alpha-1 activ â¦ ity (blood vessels). The beta actions would cause an increase in heart rate and vasodilation. The alpha action could cause vasoconstriction but it would only be seen if the beta effects were over-ridden or opposed (for instance if the person was also on a beta blocking drug).