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Drugs can cause a pupil to change in two ways by dilation making the pupil larger or constricting the pupils.â¦ Only two drugs constrict the pupils those being opiates and alcohol. So anything but, these can cause the pupils to dilate.
Examples of eye drops that cause the pupil to dilate: 1  phenylephrine. 2  tropicamide. 3  hydroxyamphetimaine. cyclopentolate.  atropine.