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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Ambien CR, on the other hand, is an extended release sleeping pill prescribed for adult insomniac patients. This drug is proven to actually work on patients who have trouble falling asleep and staying asleep. What sets Ambien CR apart from Ambien is that it has two layers of Zolpidem.mbien vs Ambien CR. Insomnia is a difficulty in sleeping or lack of sleep. The rate of those who have insomnia has gone to 15% of the entire American population. But the problem commonly occurs in women who are more exposed to alcoholic substances, cigarette smoking, use of narcotics, and depressing activities.