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Hematologic malignancy Hematological malignancies are cancers that affect the blood and lymph system. The cancer may begin in blood-forming tissue (e.g., bone marrow), or in the cells of the immune system. Some types of hematologic malignancies include: Leukemia; Non-Hodgkin lymphoma; Hodgkin lymphoma; Multiple myeloma; For more information about hematologic malignancies, including common symptoms and treatment options, see blood cancers.
In chronic leukemias, there is an accumulation of malignant hematopoietic cells in the bone marrow that ultimately may lead to bone marrow failure states. Cytopenias may result in hemorrhage, infection, and organ compromise (e.g., congestive heart failure from severe anemia).