Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.
noun. 1  a big deal. 2  See more words with the same meaning: exclamations (list of) . 3  See more words with the same meaning: unimportant, useless.
noun inÂ·grate \Ëin-ËgrÄt\. : a person who does not show proper appreciation or thanks for something : an ungrateful person. See words that rhyme with ingrate Spanish Central: Translation of ingrate Nglish: Translation of ingrate for Spanish speakers.