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Causes of Cross-eyed. Some of the causes of Cross-eyed are included in the list below: 1  Weak eye muscles. 2  Eye muscle paralysis (see Paralysis symptoms). 3  Eye muscle disease. 4  Eye muscle nerve disorders. 5  Eye vision disorder-especially if the eyes are affected differently.
Sometimes an eye may look crossed and it really is not, this is called pseudo-strabismus. Pseudo-strabismus is most often found in infants due to a wide, flat nose and a fold of skin at the inner eyelid (called epicanthal folds) that makes the eyes appear crossed (See Example of Pseudo-Strabismus).