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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
Common side effects of prescription sleeping pills such as Lunesta, Sonata, Ambien, Rozerem, and Halcion may include: 1  Burning or tingling in the hands, arms, feet, or legs. 2  Changes in appetite. 3  Constipation. 4  Diarrhea.5  Difficulty keeping balance. 6  Dizziness. 7  Daytime drowsiness. 8  Dry mouth or throat.ou won't know, though, whether you will experience side effects with a particular sleeping pill until you try it. Your doctor may be able to alert you to the possibility of side effects if you have asthma or other health conditions. Sleeping pills make you breathe more slowly and less deeply.