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When you crack your knuckles, you're actually doing more bursting than cracking. The popping noise you hear is caused by small bubbles bursting in your synovial fluid, a yolk-like substance that lubricates the areas between bones and reduces friction for ease of movement.
It takes about 25 to 30 minutes for the gas to redissolve into the joint fluid. During this period of time, your knuckles won't crack. Once the gas is redissolved, cavitation is once again possible, and you can start popping your knuckles again.