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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
Acetazolamide is a carbonic anhydrase inhibitor and has been used for many relatively common disorders such as congestive heart failure, some forms of epilepsy glaucoma, IHH, and also for some rare diseases such as acute mountain sickness.