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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
LUNESTAÂ® (eszopiclone) is the #1 prescription branded sleep aid with over 31 million prescriptions written to date. Some sleep aids are approved to help you fall asleep and others to help you stay asleep. LUNESTA is approved to do both.*. *In clinical studies LUNESTA was proven effective to help the majority of patients with insomnia fall asleep quickly and stay asleep for up to 7 hours. Individual results may vary. Based on the number of prescriptions for brand name sleep aids only.