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Definition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.efinition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.
Skin conditions due to autoimmunity or immune dysregulation are not unique to people with primary immunodeficiency diseases. Common skin conditions like eczema or psoriasis are seen in people with normal immune systems as well. Sometimes, skin disease is one of the earliest symptoms of a primary immunodeficiency disease and can lead to further clinical or laboratory evaluation to identify immune deficiency.