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Phenylalanine has been around as long as life itself, if not longer. It's not something that someone invented one day. It's like oxygen: no one invented it, it's been here as long as anyone can remember, and far longer! J. Heinrich Matthaei and Marshall W. Nirenberg figured out a way to make a bacterium produce long chains of phenylalanine molecules in 1961.
(He informed Searle in 1971 that aspartic acid caused holes in the brains of mice.) Phenylalanine (50 percent of aspartame) Phenylalanine is an amino acid normally found in the brain. Persons with the genetic disorder phenylketonuria (PKU) cannot metabolize phenylalanine.