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The narcotic in both medications is the oxycodone, the only difference between the two is the additiâ¦on of Tylenol (aka acetaminophen). The addition of Tylenol does not necessarily make the combo drug more powerful than the straight oxycodone, but is an adjunctive therapy so to speak.
Weâll address these questions and other differences between the two: 1  Oxycodone hydrochloride is an opioid painkiller. It can be found in a number of prescription medications. 2  The main difference between the two relates to the onset of action. Oxycontin is a time released drug.