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In 1881, Carl Wernicke first described an illness that consisted of paralysis of eye movements, ataxia, and mental confusion, in 3 patients. The patients, 2 males with alcoholism and a female with persistent vomiting following sulfuric acid ingestion, exhibited these findings, developed coma, and eventually died.
Wernicke-Korsakoffâs Syndrome (WKS) Wernickeâs Encephalopathy (WE) â Wernickeâs encephalopathy is an acute potentially reversible neuropsychiatric disorder caused by a deficiency in or depletion of thiamine of which chronic alcohol use is one cause.