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Summary. 1  Ambien and Lunesta are both prescription drugs intended for the treatment of insomnia. 2  Both can be availed of in tablet form. 3  Ambien and Lunesta have an immediate sedative effect that last 7-8 hours per dosage.  Ambienâs efficacy last up to 35 days, while Lunesta remains effective up to 6 months.
AmbienÂ® (Zolpidem), a short acting nonbenzodiazepine hypnotic, is used to treat insomnia on a short term basis, usually one to two weeks. Ambien initiates sleep by slowing down brain activity and producing calmness so that patient can fall asleep quickly. Ambien comes in the form of a tablet taken orally or slipped under the tongue as well as an oral spray form that is used by spraying it over the tongue.