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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
Precautions: Use isosorbide dinitrate with caution in patients with glaucoma. Isosorbide dinitrate is a potent vasodilator and causes a slight decrease in mean blood pressure (approx. 10 to 15 mm Hg) in some patients when used in therapeutic doses. Caution should be exercised in using the drug in patients who are prone to, or might be affected by, hypotension.