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Brinzolamide is a carbonic anhydrase inhibitor which has been found to be effective in lowering the elevated intraocular pressure associated with ocular hypertension and glaucoma. The distribution coefficient, IC50 and Ki values for brinzolamide are 6.56, 3.19 nM and 0.13 nM respectively.
The 1989 Glaucoma Laser Trial was one of the first major studies to confirm that argon laser trabeculoplasty (ALT) effectively lowers IOP and is effective as a primary treatment of glaucoma. 1.