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Causes of Cross-eyed. Some of the causes of Cross-eyed are included in the list below: 1  Weak eye muscles. 2  Eye muscle paralysis (see Paralysis symptoms). 3  Eye muscle disease. 4  Eye muscle nerve disorders. 5  Eye vision disorder-especially if the eyes are affected differently.
Acquired (or secondary) esotropia, which develops later in life, can occur for a variety of reasons: Accommodative esotropia is eye crossing that results from the focusing efforts of the eyes. It is the most common form of esotropia in children, and it is caused by uncorrected farsightedness (also known as hyperopia). The eyes cross when they converge in an attempt to focus.