In the open-label trial of out- and in-patients with depression who had not responded to adequate monotherapy with two antidepressants, the addition of mirtazapine (15â30 mg/day) to either an SSRI (n= 23) or venlafaxine (n= 12) led to remission in half of the patients.
Other, rare causes of discolored nails include the yellow nail syndrome, an inherited condition that results in slow-growing, yellowing, discolored nails and is associated with lymphedema (swelling of tissues due to the accumulation of fluid) and lung diseases.ails may also appear lightened to a whitish-yellow color if there has been separation of the nail from the nail bed, termed onycholysis. The skin, mucous membranes, and nails may appear blue when there is inadequate oxygenation of blood (cyanosis), but this is not true discoloration of the nail itself.
In an advanced fungal nail infection, a discolored toenail is a minor symptom compared to the thick flaky distorted appearance of the nail and the discomfort of fungal spread to the skin of the toes.ther possible explanations would include a recent blow to the tip of the toe, causing bleeding and blackening under the nail, bacterial growth beneath the nail (often a green color), continuous use of nail polish on the nail, or some other uncommon medical condition. The problem, however, is usually fungus.