Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.
noun. 1  a big deal. 2  See more words with the same meaning: exclamations (list of) . 3  See more words with the same meaning: unimportant, useless.
For example, the indispensible Fowlerâs Modern English Usage says: âThat can also replace who (or whom), especially when the reference is non-specific, as in The person that I saw was definitely a woman.â And examples of this usage can be found in work by Chaucer, Shakespeare and in the King James Version of the Bible.