A, B, and C are all correct. The Aztecs believed the Spanish were fulfilling a prophecy from one of their gods (I forget which, but the god had light skin and would return from over the sea) and they welcomed them with gifts. The Spanish were carriers of small pox, which the Aztecs had no natural defense against.
I have gone back and forth between 50mg and 100mg Toprol xl. My dr just prescribes the 100 mg tablet and tells me to split it in half. As Lenin said just don't crush the half or chew it and you should be fine. I have split mine for a long time.
In these studies, TOPROL-XL was administered once a day and immediate-release metoprolol was administered once to four times a day. A sixth controlled study compared the beta 1 -blocking effects of a 50 mg daily dose of the two formulations.sing an Emax model, the maximum effect is a 30% reduction in exercise heart rate, which is attributed to beta 1 -blockade. Beta1-blocking effects in the range of 30-80% of the maximal effect (approximately 8-23% reduction in exercise heart rate) correspond to metoprolol plasma concentrations from 30-540 nmol/L.