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What are quinolones? Quinolones are antimicrobial agents effective in the treatment of selected community-acquired and nosocomial infections. They are usually administered orally, but some can be given intravenously for treatment of serious infections. Quinolones are bactericidal and exhibit concentration-dependent killing.
Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s. Used clinically from 1967. Nalidixic acid is effective primarily against gram-negative bacteria, with minor anti-gram-positive activity.In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction.t has historically been used for treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella. It is no longer clinically used for this indication in the USA as less toxic and more effective agents are available.