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It's not clear what causes Hodgkin's lymphoma. Doctors know that most Hodgkin's lymphoma occurs when an infection-fighting cell called a B cell develops a mutation in its DNA. The mutation tells the cells to divide rapidly and to continue living when a healthy cell would die.eople diagnosed with classical Hodgkin's lymphoma have large, abnormal cells called Reed-Sternberg cells in their lymph nodes. Subtypes of classical Hodgkin's lymphoma include: 1  Nodular sclerosis Hodgkin's lymphoma. 2  Mixed cellularity Hodgkin's lymphoma.
Hodgkin lymphoma (HL, formerly called Hodgkin's disease) is a neoplasm characterized by the presence of clonal malignant Hodgkin/Reed-Sternberg (HRS) cells (and) in a reactive cellular background comprised of variable numbers of granulocytes, macroph