Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.
noun. 1  a big deal. 2  See more words with the same meaning: exclamations (list of) . 3  See more words with the same meaning: unimportant, useless.
a prefix of Latin origin, corresponding to English un-, having a negative or privative force, freely used as an English formative, especially of adjectives and their derivatives and of nouns (inattention; indefensible; inexpensive; inorganic; invariable). It assumes the same phonetic phases as in-2.