Put at its simplest, the main difference between prokaryotic cells and eukaryotic cells is that prokaryotes do not have a nucleus while eukaryotes do. There are, however, other differences as well. Both types of cells have a plasma membrane, DNA, and cytoplasm. All cells share these features.Even though a prokaryotic cell does not have a nucleus, it still has DNA that is contained as a complex with proteins in the cytoplasm. Golgi apparatus and lysosomes/peroxisomes, however, are only found in eukaryotic cells and not prokaryotic cells.oth types of cells have a plasma membrane, DNA, and cytoplasm. All cells share these features. Even though a prokaryotic cell does not have a nucleus, it still has DNA that is contained as a complex with proteins in the cytoplasm.
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