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The narcotic in both medications is the oxycodone, the only difference between the two is the additiâ¦on of Tylenol (aka acetaminophen). The addition of Tylenol does not necessarily make the combo drug more powerful than the straight oxycodone, but is an adjunctive therapy so to speak.
Oxycodone, on the other hand, is considered to be more potent than the former because it is about 5 times more effective in pain suppression. Therefore, oxycodone is given to patients suffering from more severe pain like those related to trauma, chronic pain injuries and even cancer-related pains.