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dobutamine hydrochloride. A synthetic beta-agonist whose primary effect is to increase cardiac contractility, with little effect on systemic vascular resistance. It produces less tachycardia than dopamine and has no effect on renal blood flow. It is of use in congestive heart failure and cardiogenic shock.
Indications. As mentioned, dobutamine is the preferred inotropic agent for the acute management of low output states due to systolic heart failure. Because dobutamine does not usually raise the arterial blood pressure, it is not indicated as monotherapy in patients with cardiogenic shock.DRUG ADMINISTRATION. The drug is available in 250-mg vials and is infused in a concentration of 1 mg/mL.The usual dose range is 5 to 15 ug/kg/min, but doses as high as 200 ug/kg/min have been used to achieve a hyperdynamic state in patients with septic shock and multiple organ failure.s mentioned, dobutamine is the preferred inotropic agent for the acute management of low output states due to systolic heart failure. Because dobutamine does not usually raise the arterial blood pressure, it is not indicated as monotherapy in patients with cardiogenic shock. DRUG ADMINISTRATION.