Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of connective tissue. It has a variable clinical presentation, ranging from mild to severe systemic disease. The most serious manifestations involve defects of the heart valves and aorta, which may lead to early death if not properly managed.
noun. 1  a big deal. 2  See more words with the same meaning: exclamations (list of) . 3  See more words with the same meaning: unimportant, useless.
inâ¢tegâ¢riâ¢ty. 1. uncompromising adherence to moral and ethical principles; soundness of moral character; honesty. 2. the state of being whole or entire: to preserve the integrity of the empire. 3. a sound or unimpaired condition. [1400â50; late Middle English integrite integritÄs. See integer, -ity ].