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Causes of Cross-eyed. Some of the causes of Cross-eyed are included in the list below: 1  Weak eye muscles. 2  Eye muscle paralysis (see Paralysis symptoms). 3  Eye muscle disease. 4  Eye muscle nerve disorders. 5  Eye vision disorder-especially if the eyes are affected differently.
1 Muscle imbalance (strabismus). The most common cause of lazy eye is an imbalance in the muscles that position the eyes. This imbalance can cause the eyes to cross in or turn out, and prevents them from tracking together in a coordinated way.  Difference in sharpness of vision between the eyes (refractive anisometropia).