Normal RAS signalling pathways. RAS proteins: diversity and processing. The RAS proteins are members of a large superfamily of low-molecular-weight GTP-binding proteins, which can be divided into several families according to the degree of sequence conservation.
Microsoft originally marketed a spreadsheet program called Multiplan in 1982, which was very popular on CP/M systems, but on MS-DOS systems it lost popularity to Lotus 1-2-3. This promoted development of a new spreadsheet called Excel which started with the intention to 'do everything 1-2-3 does and do it better'. The first version of Excel was released for the Mac in 1985 and the first Windows version was released in November 1987. Lotus was slow to bring 1-2-3 to Windows and by 1988 Excel had started to outsell 1-2-3 and helped Microsoft achieve the position of leading PC software developer.
Both Sega and Nintendo dominated the video gaming scene in that decade. The first console ever released by Sega was the SG-1000 in 1983. It was not exactly well-known since it was mostly distributed in Asia and never launched in North America.tariâs PONG arcade machine was so popular in 1973 that Atari decided to market the game as a home console two years later in 1975. In that same year, Magnavox decided to improve its Odyssey system and released not one, but two different improved versions of the original console, the Magnavox Odyssey 100 and 200.