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Definition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.efinition. Primary immunodeficiency disorders â also called primary immune disorders or primary immunodeficiency â weaken the immune system, allowing infections and other health problems to occur more easily.
Autoimmunity. The immune system is a complex set of organs, cells, proteins and other substances that function to prevent infection. Primary immunodeficiency diseases are characterized by abnormalities in specific components of the immune system that lead to an increased susceptibility to infection.