A collection of particular persons or items, formed into one body; as a corporation aggregate, which is one formed of a number of natural persons; the union of individual charges make an aggregate charge.
Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is that the gene codes for a product that is, for example, used by various cells, or has a signaling function on various targets.A classic example of pleiotropy is the human disease phenylketonuria (PKU).nsourced material may be challenged and removed. (September 2013). Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits, an example being phenylketonuria, which is a human disease that affects multiple systems but is caused by one gene defect.
Pleiotropic, autosomal dominant disorder affecting connective tissue: Related Diseases. Pleiotropic, autosomal dominant disorder affecting connective tissue: Pleiotropic, autosomal dominant disorder affecting connective tissue is listed as a type of (or associated with) the following medical conditions in our database:1  Heart conditions.ffice of Rare Diseases (ORD) of the National Institutes of Health (NIH). Pleiotropic, autosomal dominant disorder affecting connective tissue is listed as a  rare disease  by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).