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Humans absorb xylitol slowly, and the sweetener when ingested orally is absorbed at from 50 to 95 percent. However, in dogs, xylitol is rapidly and totally absorbed within about 30 minutes. Just a small amount of xylitol can cause a dangerous insulin surge and a rapid drop in blood sugar. The toxicity of xylitol in dogs is dose-dependent. The dose required to trigger hypoglycemia (low blood glucose) is approximately 0.1 grams/kg, while the amount needed to cause liver failure is about 0.5 grams/kg.
For example, xylitol, an artificial sweetener that is toxic to dogs, can be found in some OTC melatonin products. Melatonin supplements are available in several forms including tablet, powder, capsule, and liquid that can be administered directly or incorporated into pet food. The regular tablet form is recommended for dogs. It can be administered on a regular basis or whenever your dog exhibits signs of fear, anxiety, or panic. While effects can vary from dog to dog, melatonin typically takes effect within 10 to 15 minutes for dogs.