The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
The Tsukiji Market (ç¯å°å¸å ´, Tsukiji shijÅ), supervised by the Tokyo Metropolitan Central Wholesale Market (æ±äº¬é½ä¸­å¤®å¸å£²å¸å ´, TÅkyÅ-to ChÅ«Å Oroshiuri ShijÅ) of the Tokyo Metropolitan Bureau of Industrial and Labor Affairs, is the biggest wholesale fish and seafood market in the world and also one of the largest wholesale food markets of any kind.