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Then there were the scary side effects. Though rare, some of Neulastaâs serious side effects include acute respiratory distress syndrome (ARDS), severe allergic reactions and fatal splenic rupture. The scariest one for me, however, was the more commonly reported reaction: bone pain.
What are the side effects of alteplase (TPA, Activase, Cathflo Activase)? The most common and serious side effect of alteplase is bleeding. Minor bleeding is more common, but significant bleeding such as into the brain (intracranial hemorrhage) or fatal bleeding also occurs. Other important side effects include: