Like some of the chemical weapons, biological weapons may also be useful as area denial weapons. These agents may be lethal or non-lethal, and may be targeted against a single individual, a group of people, or even an entire population.
Acetylcholine is a chemical messenger, a neurotransmitter, released by nerve cells in many parts of the peripheral nervous system. It controls the contraction of all skeletal or voluntary muscles, for instance. It also affects the contraction of smooth and cardiac muscle.
Contraction of smooth muscle by acetylcholine is mediated by activation of muscarinic receptors of which M2 and M3 subtypes are present in longitudinal muscle of guinea pig intestine.he rise in internal calcium suppresses the voltage-dependent inward calcium current. A third important effect is the opening of channels which cause depolarization of the membrane and so increase action potential discharge and contraction in the whole muscle.