In mammals, the corresponding gene is SIRT1, a principal modulator of pathways, also activated by CR, that improve control of glucose homeostasis, insulin sensitivity and vascular function; boost endurance; and inhibit tumor formation.
Durian Perangin Waterfall is located in northeastern Langkawi, surrounded by lush greenery and natural rocks formations. This 14-tier waterfall tumbles down Mount Raya, the highest mountain on the island, into a crystal clear lake at the bottom.
Kaieteur Falls. Kaieteur Falls is the world's largest single drop waterfall by the volume of water flowing over it. Located on the Potaro River in the Kaieteur National Park, it sits in a section of the Amazon rainforest included in the Potaro-Siparuni region of Guyana and claimed by Venezuela as Guayana Esequiba.