In mammals, the corresponding gene is SIRT1, a principal modulator of pathways, also activated by CR, that improve control of glucose homeostasis, insulin sensitivity and vascular function; boost endurance; and inhibit tumor formation.
Durian Perangin Waterfall is located in northeastern Langkawi, surrounded by lush greenery and natural rocks formations. This 14-tier waterfall tumbles down Mount Raya, the highest mountain on the island, into a crystal clear lake at the bottom.
By far the largest of the islands is the eponymous Pulau Langkawi with a population of some 65000, the only other inhabited island being nearby Pulau Tuba. Langkawi is also an administrative district with the town of Kuah as the capital and largest town. Langkawi is a duty-free island.