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1. of or relating to an interstice or interstices. 2. (Chemistry) physics forming or occurring in an interstice: an interstitial atom. 3. (Chemistry) chem containing interstitial atoms or ions: an interstitial compound. 4. (Biology) anatomy zoology occurring in the spaces between organs, tissues, etc: interstitial cells.
Interstitial fluid or tissue fluid is a solution that bathes and surrounds the tissue cells of multicellular animals.t is the main component of the extracellular fluid, which also includes plasma and transcellular fluid. The interstitial fluid is found in the interstices-the spaces between cells (also known as the tissue spaces).