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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
A primary cause of leg pain is a muscle cramp or spasm thatâs often known as âa charley horse.â A cramp usually triggers sudden, sharp pain as the leg muscles contract. The tightening muscles often form a visible, hard lump beneath the skin. There may be some redness and swelling in the surrounding area.