Plasma half-life (T1/2) of unchanged lorazepam in the patient group (11.3 +/- 0.6 h) was not different from that obtained in normals (11.1 +/- 0.9 h).rinary excretion of lorazepam-glucuronide was found to be considerably decreased in chronic renal failure associated with accumulation of high concentrations of this conjugate in plasma during days after a single oral dose. The plasma T1/2 of this conjugate in normals was 20.7 +/- 2.1 h.
A: Microfilaments are the thinnest filament of a eukaryotic cell's cytoskeleton. The linear microfilament chains are composed of actin proteins, which are flexible and relatively strong. A cell's cytoskeleton is a cellular scaffolding consisting of these actin microfilaments, along with intermediate filaments and microtubules. Continue Reading
In association with myosin, microfilaments help to generate the forces used in cellular contraction and basic cell movements. The filaments also enable a dividing cell to pinch off into two cells and are involved in amoeboid movements of certain types of cells.