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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Throbbing pain in both kidneys is usually caused by increased pressure in the kidneys due to obstruction of the urine flow, usually after drinking large amount of fluid in ureteropelvic junction obstruction (UPJ) or, rarely, due to obstruction by kidney stones.