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Also, another important concept is that acute lung injury. temporally associated with multiple transfusions can be TRALI, be-. cause each unit of blood or blood component can carry one or more. of the possible causative agents: antileukocyte antibody, biologically. active substances, and other yet unidentiï¬ed agents.
1 Massive blood transfusions can cause a temporary platelet deficiency, exacerbated at times by an immune reaction to the donorâs blood that leads to platelet destruction.  Various genetic defects can cause inherited platelet disorders.