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The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.he origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.
The origin of replication are classified in two ways: Narrow or broad host range; High- or low-copy number. There are also no significant differences between prokaryotic and eukaryotic origins of replication: Most bacteria have a single circular molecule of DNA, and typically only a single origin of replication per circular chromosome.