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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
However, the afatinib efficacy in the LUX-Lung 3 study is the best among all previous gefitinib and erlotinib studies of this kind that have been independently reviewed, he added. The LUX-Lung 3 team thinks afatinib could be considered a standard option in patients with metastatic lung cancer with EGFR mutations.