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Finally, with further decreases in the levels of CD4 cells, the person develops AIDS. According to the CDC, for an HIV-infected person, some signs that AIDS has developed (known as AIDS-defining conditions) are: The CD4 cell count has decreased to fewer than 200 cells per cubic milliliter of blood.
Following initial infection with HIV, the rapid emergence of cytolytic T-cell responses, largely CD8+ T-cell responses, is associated temporally with a decrease in plasma levels of HIV.(21) CD8+ T cells may help control HIV replication in several ways.