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Researchers say consumption of artificial sweeteners such as saccharin, sucralose and aspartame led to increased risk of glucose intolerance, a condition linked to diabetes. Sweet âN Low contains saccharin. Equal original contains aspartame. Splenda contains sucralose.
1 On the other hand, some research has suggested that consuming artificial sweeteners may be associated with increased weight, but the cause is not yet known. 2  Diabetes. 3  Artificial sweeteners may be a good alternative to sugar if you have diabetes.