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Zostavax is made using a live but weakened chickenpox virus; the new vaccine, just called HZ/su for now, uses a piece of DNA from the virus and a compound called an adjuvant to boost the immune system.
BRAND NAME: Zostavax. DRUG CLASS AND MECHANISM: Zoster vaccine contains live, attenuated (weakened) varicella-zoster virus (VZV). Varicella-zoster causes chickenpox and then becomes dormant in nerves.VZV reactivates and causes herpes zoster (shingles or zoster) later in life (usually 60 years of age or older) when immunity against VZV declines. Zoster vaccine stimulates the immune system to develop immunity against VZV.The FDA approved zoster vaccine in May 2006.RAND NAME: Zostavax. DRUG CLASS AND MECHANISM: Zoster vaccine contains live, attenuated (weakened) varicella-zoster virus (VZV). Varicella-zoster causes chickenpox and then becomes dormant in nerves.