The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
Located only blocks from Tokyo's glittering Ginza, Tsukijiâthe world's largest marketplace for seafoodâis a prominent landmark, well known but little understood by most Tokyoites: a supplier for countless fishmongers and sushi chefs, and a popular and fascinating destination for foreign tourists.Bestor seems to know better than anyone in the world about Tsukiji, the worldâs largest fish market in size...Bestorâs book conveys the pre-dawn excitement of the market...[he] is as thorough and helpful a guide on the printed page as he is in person. Do not go to Tsukiji without reading this book.