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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
It was the first targeted therapy for cancer. âBefore imatinib, metastasized GIST patients had a median survival of nine to 18 months, depending on what source you quote,â explains Anthony P. Conley, a sarcoma specialist at The University of Texas MD Anderson Cancer Center in Houston.