UNICEF defines child marriage as marriage before 18 years of age and considers this practise as a violation of human rights. The harmful consequences of child marriage are segregation from family and friends, limiting the child's interactions with the community and peers, lack of opportunities for education.
Buprenorphine/naloxone. Buprenorphine/naloxone (trade name Suboxone) is a combination drug formulation of buprenorphine, a Î¼-opioid receptor (MOR) weak partial agonist and Îº-opioid receptor antagonist, and naloxone, a MOR silent antagonist, in a 4:1 ratio. It is used in the treatment of opioid dependence.
Methadone is a full agonist; there is no ceiling to respiratory depression or sedation effects and an overdose can be fatal. Buprenorphine also has a long half-life but because it is a partial agonist, it has a ceiling effect (effect plateaus at higher doses) and thus the risk of overdose is decreased.