If antibody binds to normal tissues it can cause damage to the body or create other disease symptoms. Rheumatoid arthritis is a good example of an autoimmune disease. Antibodies that react with body tissues are felt to contribute to joint swelling and pain.
In eukaryotic cells the pyruvate decarboxylation occurs inside the mitochondria, after transport of the substrate, pyruvate, from the cytosol. The transport of pyruvate into the mitochondria is via a transport protein and is active, consuming energy. Passive diffusion of pyruvate into the mitochondria is impossible because it is a polar molecule. On entry to the mitochondria the pyruvate decarboxylation occurs, producing acetyl CoA.
1 In eukaryotes, it occurs in the cytosol. 2  It converts a molecule of glucose into 2 molecules of pyruvic acid. 3  C 6 H 12 O 6 + 2NAD + 3 H 4 O 3 + 2 NADH + 2H 4  +. The free energy stored in 2 molecules of pyruvic acid is somewhat less than that in the original glucose molecule.lycolysis is the anaerobic catabolism of glucose. 1  It occurs in virtually all cells. 2  In eukaryotes, it occurs in the cytosol. 3  It converts a molecule of glucose into 2 molecules of pyruvic acid. 4  C 6 H 12 O 6 + 2NAD + 3 H 4 O 3 + 2 NADH + 2H +.