When the wheel bearing goes bad, you will notice several symptoms. 1  Listen carefully. 2  The most common and often most-identifiable symptom associated with a bad wheel bearing is noise coming from the wheel or tire area of the moving vehicle.
Rare Disease Day takes place on the last day of February each year. The main objective of Rare Disease Day is to raise awareness amongst the general public and decision-makers about rare diseases and their impact on patients' lives. The campaign targets primarily the general public and also serarediseaseday.org.
The NIH's Office of Rare Diseases Research (ORDR) was established by H.R. 4013/Public Law 107-280 in 2002. H.R. 4014, signed the same day, refers to the Rare Diseases Orphan Product Development Act. Similar initiatives have been proposed in Europe.