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Goldthread (Coptis genus) is a medicinal herb native to North America and Asia. Goldthread was one of the herbs that Rene Caisse used in her Cancer Clinic in Bracebridge, Ontario.
Oregon Grape root is a much better substitute for Goldthread even though Goldthread has a slightly higher berberine content by weight than both Oregon Grape root and Goldenseal root. Oregon Grape has much bigger roots while Goldthread roots are very fine threads.