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Finally, with further decreases in the levels of CD4 cells, the person develops AIDS. According to the CDC, for an HIV-infected person, some signs that AIDS has developed (known as AIDS-defining conditions) are: The CD4 cell count has decreased to fewer than 200 cells per cubic milliliter of blood.
The importance of helper T cells can be seen from HIV, a virus that infects CD4 + cells. Towards the end of an HIV infection, once the viral load has increased enough, the number of functional CD4 + T cells falls, which leads to the symptomatic stage of infection known as the acquired immunodeficiency syndrome (AIDS).