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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Chronic pain or persistent pain without trauma may be caused by problems in the bones, muscles, ligaments, joints tendons, nerves, nerves, blood vessels, and skin. The root cause of the pain is the inflammation of the tissue of the affected area. Woman having aching leg.