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slide 2 of 4. Causes of Lipomas One common cause of lipomas is genetic. A patient may have several close relatives with histories of fatty tumors. Also, minor injuries may cause lipomas to develop, so it is important to monitor your body when you experience an injury.
Lipomas - Pathophysiology. 1  Lipomas are common benign mesenchymal tumors. 2  In the GI tract, lipomas present as submucosal fatty tumors. 3  Duodenal lipomas are mostly small but may become pedunculated with obstruction of the lumen. 4  Colonic lipomas are usually discovered on endoscopy. Gentle palpation with a biopsy forceps reveals the soft nature of the submucosal mass. A biopsy specimen of the mucosa may reveal underlying fat, the so-called naked fat sign. As with lipomas in other locations, colonic lipomas may cause pain with obstruction or intussusception. As noted above, a fatty protrusion of preperitoneal fat termed a lipoma of the spermatic cord is a common finding on groin exploration for hernia repair.