If antibody binds to normal tissues it can cause damage to the body or create other disease symptoms. Rheumatoid arthritis is a good example of an autoimmune disease. Antibodies that react with body tissues are felt to contribute to joint swelling and pain.
In eukaryotic cells the pyruvate decarboxylation occurs inside the mitochondria, after transport of the substrate, pyruvate, from the cytosol. The transport of pyruvate into the mitochondria is via a transport protein and is active, consuming energy. Passive diffusion of pyruvate into the mitochondria is impossible because it is a polar molecule. On entry to the mitochondria the pyruvate decarboxylation occurs, producing acetyl CoA.
Pyruvate decarboxylation. The pyruvate decarboxylation reaction links the metabolic pathways glycolysis and the citric acid cycle. This reaction is the conversion of pyruvate, the end product of glycolysis, into acetyl CoA.The pyruvate decarboxylation reaction may be simply referred to as the transition reaction, the link reaction, or the oxidative decarboxylation reaction.This reaction is catalyzed by the pyruvate dehydrogenase complex. The reaction is part of the aerobic respiration pathway.he pyruvate decarboxylation reaction may be simply referred to as the transition reaction, the link reaction, or the oxidative decarboxylation reaction. This reaction is catalyzed by the pyruvate dehydrogenase complex.