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Antipsychotics. Antipsychotic medicines, also known as neuroleptics, are usually recommended as the first treatment for psychosis. They work by blocking the effect of dopamine (a chemical that transmits messages in the brain). However, they're not suitable or effective for everyone, as side effects can affect people differently.
Treatment for delusional disorder most often includes medication and psychotherapy (a type of counseling). Delusional disorder can be very difficult to treat in part because its sufferers often have poor insight and do not recognize that a psychiatric problem exists. These drugs include Risperdal, Clozaril, Seroquel, Geodon, and Zyprexa. 2  Other medications: Tranquilizers and antidepressants might also be used to treat anxiety or mood symptoms if they occur in combination with delusional disorder.