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Generally, laboratory mice become sexually mature between fi ve and eight weeks of age. Males of most. strains usually mature sexually by six weeks of age. DBA/2J (000671) and C3H/HeJ (000659) mice are precocious: females can. conceive when they are as young as 23 days old.
Overview of Reproductive Process. As mice breed throughout the year, a single female produces between five and 10 litters annually. Each brood can contain up to 12 young, but the average litter size hovers around five or six babies. Young mice grow quickly and usually only need three weeks before they're fully weaned from their mothers. The pests achieve sexual maturity after five to seven weeks.