1 The original definition of evidence-based medicine makes this clear: âThe practice of evidence based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic researchâ (Sackett et al.hat is, the research evidence, however strong, cannot provide clear guidance for treating every client in every circumstance. The clinician needs to adapt an evidence-based practice to the needs and characteristics of the client and to the local treatment setting.
A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber.he neuromuscular junction is the site of the signal exchange. The steps of this process in vertebrates occur as follows:(`) The action potential reaches the axon terminal. (2) Voltage-dependent calcium gates open, allowing calcium to enter the axon terminal.
The neuromuscular junction consists of amotor neurone and a muscle cell separated bya narrow synaptic cleft. The nerve and muscledo not come into direct contact.