In mammals, the corresponding gene is SIRT1, a principal modulator of pathways, also activated by CR, that improve control of glucose homeostasis, insulin sensitivity and vascular function; boost endurance; and inhibit tumor formation.
Durian Perangin Waterfall is located in northeastern Langkawi, surrounded by lush greenery and natural rocks formations. This 14-tier waterfall tumbles down Mount Raya, the highest mountain on the island, into a crystal clear lake at the bottom.
Rock Creek Falls is a scenic tiered waterfall in the Unaka Mountains of Cherokee National Forest. The trailhead is located in the Rock Creek Recreation Area, just east of Erwin and the total hike is about 3 miles round trip. This area has a day use fee, payable at self-serve kiosks in the parking lot.