The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
As the moon scatters golden reflections on the garden pond below, you watch, speechless, as it rises, past the sweeping branches of the pines. Itâs o-tsukimi, the harvest moon festival, and this is the ideal setting in which to celebrate it. While few Japanese are lucky enough to have tearooms, let alone a pond with a view to the east, this ancient festival is meant to celebrate the beauty of the moon, and the fall harvest.