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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Woman having aching leg Leg Pain (Aches) Causes. Causes of leg aches can be classified into the following: Traumatic; Non-Traumatic; Traumatic. Injuries, falls, and twisted muscles and bones are the most common cause of leg ache. This is what we call traumatic cause.