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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Although pancreatic cancer has been classed as a tumour that is largely resistant to chemotherapy, 5-fluorouracil (5-FU) and 5-FU-based combination regimens have been shown to be superior to observation alone or no treatment arms in adjuvant trials, and to best supportive care in palliative therapy trials (Table 1).ancreatic cancer is a common, highly lethal disease that is rising in incidence. Chemotherapy based on 5-fluorouracil (5-FU) has been shown to prolong survival in advanced pancreatic cancer. Gemcitabine improves major symptoms and survival outcomes compared with bolus 5-FU.