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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
Glucosamine and chondroitin sulfate may not provide sufficient pain relief for all osteoarthritis patients. 1  Many patients find it is best to use glucosamine and chondroitin sulfate nutritional supplements in conjunction with other nonsurgical treatments (under the guidance of their treating physician), such as: