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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Cancer is always something to consider if hematuria persists and another cause is not discovered, and can develop anywhere among the kidneys, ureters, prostate and bladder. Kidney stones trapped within the ureters (the tubes connecting the kidney to the bladder) can also cause hematuria. Inflammation of the bladder (cystitis), bladder stones, and lower urinary tract infections (UTIs) can also cause hematuria. Sexually transmitted diseases could also cause hematuria, though isolated hematuria without other symptoms such as penile discharge and burning would be uncommon. If your husband has not had his urine analyzed yet, this would be the recommended first step, as not all dark urine is due to blood. For example, an elevated bilirubin level in the blood can cause the urine to appear dark.