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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
In addition, the great success of imatinib in treating chronic myeloid leukemia was very quickly interpreted as being similarly relevant to Ph+ ALL. Hence, studies in adult patients in which the drug imatinib was not included at all in any treatment arm became impossible to conduct.