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Also, another important concept is that acute lung injury. temporally associated with multiple transfusions can be TRALI, be-. cause each unit of blood or blood component can carry one or more. of the possible causative agents: antileukocyte antibody, biologically. active substances, and other yet unidentiï¬ed agents.
1 Blood can âback up in the pulmonary veins (the vessels that return oxygen-rich blood from the lungs to the heart.) which can cause fluid to back up into the lungs. 2  When AFib causes heart failure, fluid in the lungs can cause fatigue and shortness of breath.