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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Hemosiderin staining refers to a process where iron from the blood can stain the skin. In the process of some surgical procedures particularly light liposuction leading can happen. If this blood sits around there is the potential for the breakdown products of this blood to cause a staining of the skin directly over it.