The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
LEUKINEÂ® (sargramostim) is a recombinant human granulocyte macrophage colony stimulating factor (rhu GM-CSF) produced by recombinant DNA technology in a yeast (S. cerevisiae) expression system. GM-CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells.