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Neulasta side effects. Get emergency medical help if you have signs of an allergic reaction to Neulasta: hives, skin rash, flushing (warmth, redness, or tingly feeling); wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat. A rare but serious side effect of Neulasta is called capillary leak syndrome.
Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.