Clean wound of debris & digested material by gently rubbing with a gauze pad saturated with NS (or other desired cleansing agent compatible with Santyl), follow with a NS rinse. If an antibiotic powder is used in case of infection, it should be applied prior to the application of Santyl.
Your body also converts some substances -- sugar and alcohol in particular -- to triglycerides. If using Splenda, an artificial sweetener, helps you reduce the amount of sugar in your diet, you could enjoy lower levels of triglycerides.
Bottom line, the safety of Splenda for diabetics is inconclusive according to the research documents submitted by McNeil to the FDA. And we must never forget to listen to the people with diabetes who use Splenda. Many have noted blood sugar spikes after using products with Splenda.