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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Certain medical conditions commonly lead to leg pain. These include: 1  atherosclerosis (hardening of the arteries). 2  deep vein thrombosis (a blood clot caused by long periods of bed rest). 3  arthritis. 4  gout. 5  varicose (spider) veins.