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Polycystic kidney disease symptoms may include: 1  High blood pressure. 2  Back or side pain. 3  Headache. 4  Increase in the size of your abdomen.5  Blood in your urine. 6  Frequent urination. 7  Kidney stones.8  Kidney failure.9  Urinary tract or kidney infections.olycystic kidney disease symptoms may include: 1  High blood pressure. 2  Back or side pain. 3  Headache. 4  Increase in the size of your abdomen. 5  Blood in your urine. 6  Frequent urination. 7  Kidney stones. 8  Kidney failure. 9  Urinary tract or kidney infections.
Cause of leg pain in Polycystic Kidney Disease. Muscle cramps and leg pain are common for those with kidney disease, especially when kidney function is impaired. Cramps and leg pain are thought to be caused by imbalances in fluid and electrolytes, but may also be caused by nerve damage or blood flow problems.