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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
Posted In: I cannot get a diagnosis. I have severe groin pain on the right side, which is causing severe throbbing leg pain. I'm only effected on the right hand side. This has been going on for a little over a year. I did have a vaginal ultrasound, and did have an ovarian cyst which was 4mm.