If antibody binds to normal tissues it can cause damage to the body or create other disease symptoms. Rheumatoid arthritis is a good example of an autoimmune disease. Antibodies that react with body tissues are felt to contribute to joint swelling and pain.
In eukaryotic cells the pyruvate decarboxylation occurs inside the mitochondria, after transport of the substrate, pyruvate, from the cytosol. The transport of pyruvate into the mitochondria is via a transport protein and is active, consuming energy. Passive diffusion of pyruvate into the mitochondria is impossible because it is a polar molecule. On entry to the mitochondria the pyruvate decarboxylation occurs, producing acetyl CoA.
Besides the absence of nucleus in prokaryotes, the lower level of cell compartmentalization is the main difference compared to eukaryotes. In prokaryote cells the ribosomes are scattered in the cytoplasm, so it is correct to say that the protein synthesis in prokaryotes takes place in the cytoplasm. In eukaryotes the ribosomes also reside in the cytoplasm, but could be also found bound to the endoplasmic reticulum (ER). The membranes of the endoplasmic reticulum form a complex and continuous network in the inner core of the cytoplasm and is both to the outer membrane of the nucleus and with the plasma membrane.