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Liver Pain Causes. Causes of liver pain are not just a few but in fact quite a few owing to the importance of the organ. They give rise to liver pain of differing nature which may be categorized as acute or chronic liver pain, and sharp or dull liver pain. The causes can be listed as the following:-. 1  The most common cause of liver pain is a condition known as fatty liver, which is characterized by the excess accumulation of lipid molecules in the liver which causes it to swell. 2  Liver disorder of a chronic nature may be responsible for cirrhosis liver pain.
Liver problems often cause right upper quadrant abdominal pain. The liver helps remove toxins from the blood and when the liver becomes infected or diseased, abdominal pain is often the first symptom. An infection may also cause abdominal swelling and jaundice (yellow or sallow colored eyes and skin).