In mammals, the corresponding gene is SIRT1, a principal modulator of pathways, also activated by CR, that improve control of glucose homeostasis, insulin sensitivity and vascular function; boost endurance; and inhibit tumor formation.
Durian Perangin Waterfall is located in northeastern Langkawi, surrounded by lush greenery and natural rocks formations. This 14-tier waterfall tumbles down Mount Raya, the highest mountain on the island, into a crystal clear lake at the bottom.
Some of Langkawi's most rustic and memorable views are along the road that circles the island. You'll pass small villages with wooden houses framed by palm trees, and children pedalling their old bicycles on errands. Aside from experiencing the local lifestyle, there is no shortage of things to do in Langkawi.