Symptoms of Hashimoto's Thyroiditis: Introduction. The types and severity of symptoms of Hashimoto's disease vary between individuals. Many people have no symptoms at all. If Hasimoto's disease leads to hypothyroidism, symptoms of an underactive thyroid may develop. At the onset of hypothyroidism, symptoms can be vague and develop slowly. They may not include weakness, weight gain, cold sensitivity, cold hands and feet, fatigue, dry skin, brittle nails, and thinning, brittle hair.
Ligand Binding Assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand molecules to receptors, antibodies or other macromolecules.on specific binding refers to the binding of a ligand to something other than its designated receptor such as various other receptors, or different types of transporters in the cell membrane. For example, various antagonists can bind to multiple types receptors.
1 A ligand is any molecule that binds to a specific site on a protein or other molecule. 2  In this case, the estrogen hormone 17-beta-estradiol is the ligand, and the estrogen receptor is the protein.lick here to read about Steroid Hormone Receptors... When steroid and thyroid hormones bind with hormone receptors inside the cell, they trigger the gene expression that ultimately leads to protein production. But first, the hormones must get to the cell, enter it, and bind to a receptor to produce an effect.