The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1, Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes, including in development and metabolism, as well as cancer and cardiovascular disease.
In music, vamping is the repeated use of a phrase through an entire song or the improvisation on top of a repeated phrase through a song. Looping, samples and grooves are all examples of vamping, as is almost all popular music with repeated chord progressions. It is not a negative attribute, but implies building on top of a groove to create a song. The keyboardist used extensive vamping to create an intricate song based on a funk groove.
Derby shoe: the laces are tied to two pieces of leather independently attached to the vamp; also known as open lacing and is a step down in dressiness. If the laces are not independently attached to the vamp, the shoe is known as a blucher shoe. This name is, in American English, often used about derbys.