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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Cisplatin is a chemotherapy medication used to treat a number of cancers. This includes testicular cancer, ovarian cancer, breast cancer, bladder cancer, head and neck cancer, cervical cancer, lung cancer, mesothelioma, esophageal cancer, brain tumors, and neuroblastoma. It is used by injection into a vein.