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Hemosiderin collects throughout the body in hemochromatosis. Hemosiderin deposition in the liver is a common feature of hemochromatosis and is the cause of liver failure in the disease. Deposition in the pancreas leads to diabetes and in the skin leads to hyperpigmentation.
Hemosiderin is an insoluble form of tissue storage iron, being found at the level of different cells (not in the circulating blood). This is actually a protein that is insoluble and contains irons, being produced by the digestion of the hematin by the phagocytes.