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Goldthread (Coptis genus) is a medicinal herb native to North America and Asia. Goldthread was one of the herbs that Rene Caisse used in her Cancer Clinic in Bracebridge, Ontario.
Goldthread is not easy to find in the woods and North American herb companies do not normally sell this herb. The yellow root is very thin so one must pick a lot of Goldthread plants to obtain an ounce of the herb, which contains a very beneficial yellow substance called berberine. Herbalists can substitute Goldthread with other berberine-containing herbs such as Goldenseal, Barberry or Oregon Grape root.