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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
Glucosamine in the body is used to make cartilage, a cushion that surrounds joints. In osteoarthritis, this cushion becomes thinner and stiff.Taking glucosamine sulfate as a supplement might help to supply the materials needed to rebuild cartilage. Glucosamine sulfate seems to be safe for most people.It can cause some mild side effects including nausea, heartburn, diarrhea, and constipation.ome preliminary research suggests that glucosamine sulfate might raise blood sugar in people with diabetes. However, more reliable research indicates that glucosamine sulfate does not seem to significantly affect blood sugar control in people with type 2 diabetes.