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Polycystic kidney disease symptoms may include: 1  High blood pressure. 2  Back or side pain. 3  Headache. 4  Increase in the size of your abdomen.5  Blood in your urine. 6  Frequent urination. 7  Kidney stones.8  Kidney failure.9  Urinary tract or kidney infections.olycystic kidney disease symptoms may include: 1  High blood pressure. 2  Back or side pain. 3  Headache. 4  Increase in the size of your abdomen. 5  Blood in your urine. 6  Frequent urination. 7  Kidney stones. 8  Kidney failure. 9  Urinary tract or kidney infections.
People who have more severe and long-term (chronic) kidney disease may have symptoms such as: 1  Fatigue most of the time. 2  General ill feeling. 3  Headache. 4  Nausea and vomiting. 5  Poor appetite. 6  Swelling of the legs. 7  Itchy skin.