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A follow-up test that measures free prostate-specific antigen (free PSA) may be used to see if a prostate biopsy should be done to check for cancer. Free PSA is the percent of prostate-specific antigen that is not attached to proteins in the blood. The lower a man's free PSA percentage, the more likely he is to have prostate cancer. A man with a total PSA between 4 and 10 ng/mL may have a test to find out his free PSA, to see if cancer is likely to be present.
Free PSA Test Helps in Prostate Cancer Diagnosis by William J. Catalona, M.D. A relatively new and helpful addition in the diagnosis of prostate cancer is the free PSA Test. This blood test is done in addition to the PSA Test and the finger (digital) examination. The PSA Test measures a protein in the blood that is produced only by the prostate gland. Some of the PSA in blood is bound to other proteins and the rest circulates freely. This free PSA is a damaged variant of PSA that no longer is able to bind to other proteins and thus circulates in the blood in the unbound (free) form.