The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
From Wikipedia, the free encyclopedia. TSIG (Transaction SIGnature) is a computer networking protocol defined in RFC 2845. It is used primarily by the Domain Name System (DNS) to provide a means of authenticating updates to a DNS database. It is most commonly used to update Dynamic DNS or a secondary/slave DNS server. TSIG uses shared secret keys and one-way hashing to provide a cryptographically secure means of authenticating each endpoint of a connection as being allowed to make or respond to a DNS update.