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Also, another important concept is that acute lung injury. temporally associated with multiple transfusions can be TRALI, be-. cause each unit of blood or blood component can carry one or more. of the possible causative agents: antileukocyte antibody, biologically. active substances, and other yet unidentiï¬ed agents.
Transfusion of red blood cells should be based on the patient's clinical condition. Indications for transfusion include symptomatic anemia (causing shortness of breath, dizziness, congestive heart failure, and decreased exercise tolerance), acute sickle cell crisis, and acute blood loss of more than 30 percent of blood volume.