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Individuals most impacted by the rising cost of insulin are the uninsured and the under-insured. These patients are forced to pay the ever-increasing retail sale price (which is increasing due to a variety of factors, including increased wholesale price) or a percentage of this price when buying insulin.
Analogs cost about $270 per 10 mL vial, while regular human insulins such as Novolin and Humulin run about $120 per 10 mL vial. The advantage of having a U-500 formulation is that it can deliver far more units of insulin (500 units per mL) at less overall volume than any of those other options.