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The freeMD virtual doctor has found 9 conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. Mouse over to view each condition's most common symptoms. There are 2 common conditions that can cause Leg Pain (below the knee, one leg) and Throbbing Leg Pain. 1  Calf Strain.  Muscle Strains.
The following medical conditions are some of the possible causes of Constant leg pain. There are likely to be other possible causes, so ask your doctor about your symptoms. 1  Sciatica. 2  Diabetes. 3  High cholesterol. 4  Smoking. 5  Hypertension. 6  Lack of physical activity.