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Glucosamine and Chondroitin Sulfate Side Effects. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea.ombined with other osteoarthritis treatments (as deemed appropriate by a physician), taking glucosamine and chondroitin sulfate dietary supplements may help some patients attain optimal levels of relief from osteoarthritis-related joint pain.
2 How long will it take to see effects? Glucosamine and chondroitin sulfate are âslow-actingâ and can take up to 2 to 3 months to show anyeffect. If you do not experience improvement in your condition after 3 months, most doctorsrecommend that you stop taking the supplements. They may not work for everyone. In addition, thesesupplements may lose their effectiveness after 6 to 12 months of use. If that happens, you should alsostop using the supplement.