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Antipsychotics. Antipsychotic medicines, also known as neuroleptics, are usually recommended as the first treatment for psychosis. They work by blocking the effect of dopamine (a chemical that transmits messages in the brain). However, they're not suitable or effective for everyone, as side effects can affect people differently.
Certain medications are associated with triggering psoriasis, including: 1  Lithium: Used to treat manic depression and other psychiatric disorders. 2  Lithium aggravates psoriasis in about half of those with psoriasis who take it.