In mammals, the corresponding gene is SIRT1, a principal modulator of pathways, also activated by CR, that improve control of glucose homeostasis, insulin sensitivity and vascular function; boost endurance; and inhibit tumor formation.
Durian Perangin Waterfall is located in northeastern Langkawi, surrounded by lush greenery and natural rocks formations. This 14-tier waterfall tumbles down Mount Raya, the highest mountain on the island, into a crystal clear lake at the bottom.
Langkawi is an archipelago of islands, most of which are uninhabited. Kedah was called Kadaram (Tamil:à®à®¾à®à®¾à®°à®®à¯) by ancient and medieval Tamil people and Syburi (Thai: à¹à¸à¸£à¸à¸¸à¸£à¸µ; rtgs: Sai Buri) by the Siamese when it was under their influence.