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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Imatinib (Gleevec) â for leukaemia and some other cancers â costs $31,867 in the UK but $28,675 in France and just $8,370 in Russia. Sorafenib (Nexavar), for liver cancer, costs $57,232 in the UK but $49,715 in Spain and $44,543 in France.