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In the afatinib group, the most common treatment-related adverse events were diarrhea, rash/acne, and stomatitis; in the chemotherapy group, they were nausea, fatigue, and decreased appetite. Patient-reported outcomes favored afatinib, with better control of cough, dyspnea, and pain, the investigators say.
Imatinib mesylate is approved to treat: 1  Acute lymphoblastic leukemia in adults and children that is Philadelphia chromosome positive. In adults, it is used for disease that has recurred (come back) or is refractory (does not respond to treatment). 2  Chronic eosinophilic leukemia or hypereosinophilic syndrome.