The first term determines the nature of the drug's effect and how much drug is needed at the site of action to engage that site to a clinically meaningful extent in the usual patient. The second term in the equation determines the magnitude of the drug's effect by determining how much drug reaches the site of action.
Tsuki (çªã) , is the Japanese word for thrust, coming from the verb tsuku (çªã) , meaning to thrust. The second syllable is accented, with Japanese's unvoiced vowels making it pronounced almost like  ski  (but preceded by a t sound).
Please keep this in mind, and be sure to visit other parts of our site for more recent information! The interleukins are a family of cytokines (chemical messengers) that include IL-1, IL-d (sometimes called T-cell growth factor), IL-10 and IL-12.